LOCUS       NM_173555               3758 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens trypsin like peroxisomal matrix peptidase 1 (TYSND1),
            transcript variant 1, mRNA.
ACCESSION   NM_173555
VERSION     NM_173555.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3758)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3758)
  AUTHORS   Okumoto,K., Kametani,Y. and Fujiki,Y.
  TITLE     Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal
            lon protease (PsLon), cooperatively regulate fatty acid
            beta-oxidation in peroxisomal matrix
  JOURNAL   J Biol Chem 286 (52), 44367-44379 (2011)
   PUBMED   22002062
  REMARK    GeneRIF: The proteolytic activity of oligomeric Tysnd1 is in turn
            controlled by self-cleavage of Tysnd1 and degradation of Tysnd1
            cleavage products by PsLon.
REFERENCE   3  (bases 1 to 3758)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 3758)
  AUTHORS   Kurochkin,I.V., Mizuno,Y., Konagaya,A., Sakaki,Y., Schonbach,C. and
            Okazaki,Y.
  TITLE     Novel peroxisomal protease Tysnd1 processes PTS1- and
            PTS2-containing enzymes involved in beta-oxidation of fatty acids
  JOURNAL   EMBO J 26 (3), 835-845 (2007)
   PUBMED   17255948
  REMARK    GeneRIF: characterization of protease function and self-cleavage of
            mouse Tysnd1
REFERENCE   5  (bases 1 to 3758)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   6  (bases 1 to 3758)
  AUTHORS   Kurochkin,I.V., Nagashima,T., Konagaya,A. and Schonbach,C.
  TITLE     Sequence-based discovery of the human and rodent peroxisomal
            proteome
  JOURNAL   Appl Bioinformatics 4 (2), 93-104 (2005)
   PUBMED   16128611
REFERENCE   7  (bases 1 to 3758)
  AUTHORS   Wistow,G., Bernstein,S.L., Ray,S., Wyatt,M.K., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human iris for the NEIBank
            Project: steroid-response factors and similarities with retinal
            pigment epithelium
  JOURNAL   Mol Vis 8, 185-195 (2002)
   PUBMED   12107412
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC047424.1, BC042629.1,
            AL731540.4, BC111501.1 and BC030242.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173555.3.
            
            Summary: This gene encodes a protease that removes the N-terminal
            peroxisomal targeting signal (PTS2) from proteins produced in the
            cytosol, thereby facilitating their import into the peroxisome. The
            encoded protein is also capable of removing the C-terminal
            peroxisomal targeting signal (PTS1) from proteins in the
            peroxisomal matrix. The full-length protein undergoes self-cleavage
            to produce shorter, potentially inactive, peptides. Alternative
            splicing results in multiple transcript variants for this gene.
            [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.263137.1,
                                           SRR1803614.64460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287078.7/ ENSP00000287078.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BC047424.1         41-60
            21-306              BC042629.1         1-286
            307-307             AL731540.4         88936-88936         c
            308-887             BC111501.1         287-866
            888-1280            BC030242.1         844-1236
            1281-2531           BC111501.1         1260-2510
            2532-3758           AL731540.4         80523-81749         c
FEATURES             Location/Qualifiers
     source          1..3758
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..3758
                     /gene="TYSND1"
                     /gene_synonym="NET41"
                     /note="trypsin like peroxisomal matrix peptidase 1"
                     /db_xref="GeneID:219743"
                     /db_xref="HGNC:HGNC:28531"
                     /db_xref="MIM:611017"
     exon            1..1280
                     /gene="TYSND1"
                     /gene_synonym="NET41"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1815
                     /gene="TYSND1"
                     /gene_synonym="NET41"
                     /note="isoform a is encoded by transcript variant 1;
                     peroxisomal leader peptide-processing protease; trypsin
                     domain-containing protein 1; peroxisomal cysteine
                     endopeptidase; trypsin domain containing 1; peroxisome
                     leader peptide-processing protease; peroxisomal matrix
                     protein-processing protease"
                     /codon_start=1
                     /product="peroxisomal leader peptide-processing protease
                     isoform a"
                     /protein_id="NP_775826.2"
                     /db_xref="CCDS:CCDS31213.1"
                     /db_xref="GeneID:219743"
                     /db_xref="HGNC:HGNC:28531"
                     /db_xref="MIM:611017"
                     /translation="MRRQWGSAMRAAEQAGCMVSASRAGQPEAGPWSCSGVILSRSPG
                     LVLCHGGIFVPFLRAGSEVLTAAGAVFLPGDSCRDDLRLHVQWAPTAAGPGGGAERGR
                     PGLCTPQCASLEPGPPAPSRGRPLQPRLPAELLLLLSCPAFWAHFARLFGDEAAEQWR
                     FSSAARDDEVSEDEEADQLRALGWFALLGVRLGQEEVEEERGPAMAVSPLGAVPKGAP
                     LLVCGSPFGAFCPDIFLNTLSCGVLSNVAGPLLLTDARCLPGTEGGGVFTARPAGALV
                     ALVVAPLCWKAGEWVGFTLLCAAAPLFRAARDALHRLPHSTAALAALLPPEVGVPWGL
                     PLRDSGPLWAAAAVLVECGTVWGSGVAVAPRLVVTCRHVSPREAARVLVRSTTPKSVA
                     IWGRVVFATQETCPYDIAVVSLEEDLDDVPIPVPAEHFHEGEAVSVVGFGVFGQSCGP
                     SVTSGILSAVVQVNGTPVMLQTTCAVHSGSSGGPLFSNHSGNLLGIITSNTRDNNTGA
                     TYPHLNFSIPITVLQPALQQYSQTQDLGGLRELDRAAEPVRVVWRLQRPLAEAPRSKL
                     "
     exon            1281..1411
                     /gene="TYSND1"
                     /gene_synonym="NET41"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1597
                     /gene="TYSND1"
                     /gene_synonym="NET41"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..3758
                     /gene="TYSND1"
                     /gene_synonym="NET41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2509..2514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TYSND1"
                     /gene_synonym="NET41"
                     /note="hexamer: AATAAA"
     polyA_site      2531
                     /gene="TYSND1"
                     /gene_synonym="NET41"
                     /note="major polyA site"
     regulatory      3740..3745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TYSND1"
                     /gene_synonym="NET41"
                     /note="hexamer: AATAAA"
     polyA_site      3758
                     /gene="TYSND1"
                     /gene_synonym="NET41"
ORIGIN      
        1 ctctcgcttc cagctgtggg tggcgctagg cagcttcagc cggaccgggt aggggtcctc
       61 gctcgctagc ttgctgtttc tcggagaagc tcccgagtgt ccggcctaga ggccatgaga
      121 aggcagtggg ggtctgccat gagggcggcc gagcaggcgg gctgcatggt gagcgcctcc
      181 cgggccggac agcccgaggc gggcccgtgg agctgcagcg gggtaatcct gagccgtagc
      241 ccgggcctgg tgctttgcca cgggggcatc ttcgtcccct tcctgcgagc tggcagcgaa
      301 gtcctgaccg cggccggcgc cgtcttcctg cctggcgaca gttgcaggga cgacctgcgc
      361 ctgcacgtgc agtgggcccc aacggccgcg ggtcccgggg gcggcgcgga gcggggccgc
      421 ccagggctgt gcacgcccca gtgcgcgagc ctcgagcccg gcccacctgc cccgtcccgc
      481 gggcgtcccc tgcagccccg gcttcctgct gagctgctgc tgctgctgag ctgcccggcc
      541 ttctgggccc acttcgcgcg cctcttcggg gacgaggcag cggaacagtg gcgcttctcg
      601 agcgcggcgc gggatgacga agtgtcggag gacgaggagg cggatcaact gagagcgctg
      661 ggctggtttg cgctgctggg cgtgcggcta ggccaggagg aggtggagga ggagcgcggg
      721 ccagccatgg cggtgtcgcc tctcggggcc gtgcccaagg gtgcgccatt gctggtctgc
      781 ggctcccctt tcggcgcctt ctgccccgac atctttctca acacgctgag ctgcggggtg
      841 ctcagcaacg tggccggccc actgctgctt accgacgcac gctgcctgcc cggcaccgag
      901 ggcggcggcg tgttcaccgc gcggcccgcg ggggcgctgg tggcgctggt ggtggcgccg
      961 ctctgttgga aggccggcga atgggtgggc ttcacgctgc tctgcgccgc cgcccccctt
     1021 ttccgcgccg cccgcgacgc gcttcaccgc ctgccgcaca gcaccgctgc cctggccgcc
     1081 cttctgccgc cagaggtggg cgtcccgtgg ggtctgcccc tccgagactc cgggcccctg
     1141 tgggcagccg cggcagtgtt ggtggagtgc ggcaccgtat ggggctccgg agtggctgtg
     1201 gcaccccgcc ttgtagtgac ctgtcggcac gtgtcccctc gggaagcagc cagggtcctg
     1261 gtgcgctcca ccacccccaa gagtgtggcc atctggggcc gtgtggtatt tgccactcag
     1321 gagacatgtc cctatgacat agcagtggtg agcctggagg aggacctgga tgatgtcccc
     1381 atccctgtgc ccgctgagca cttccatgaa ggcgaggctg tgagtgtggt gggctttggc
     1441 gtctttggcc agtcttgcgg gccctcggtg acctcaggca tcctttcggc tgtggtgcag
     1501 gtgaatggca cgcccgtaat gctgcagacc acgtgtgctg tgcacagcgg ctccagtggg
     1561 ggacccctct tctccaacca ctcaggaaac ctccttggca taatcaccag caacacccgg
     1621 gacaataata cgggggccac ctacccccac ctgaacttca gcattcccat cacggtgctc
     1681 cagccggccc tgcagcagta cagccagacc caagacctag gtggcctccg tgagctggac
     1741 cgcgctgctg agccagtcag ggtggtgtgg cggttgcagc ggcccctggc agaggccccg
     1801 cggagcaagc tctgaggctg tgttaccacc tttggaaaga agagtgacct ttttctgctg
     1861 taggaagtga tgttgaggtg acggtggcct caggattcag ggcccagccc ctgcaggggc
     1921 ccaggctgcc tctcatctcc acccactgac tgcagactgg gctttgggct ctggggcaaa
     1981 cttctcttca gccccatgga tccttaacct ggcagcccgt tttggggtgc tttcttgagc
     2041 ccccagttct ctgtccccta gcactagact cagctgtatt gtttttcctt ctggggagcc
     2101 cactccaact gcacagaagt tctgggcctg acaggtagat tccagctgga aggcaggccc
     2161 gtgcctggtt ttgcgtctgt tcccctgagg gccatcgtca tcctggagct tcaatggggc
     2221 cttggctcct gtctgcctct cagtcagagt cagggctgac aaaggactca gcttccttag
     2281 catctcagca gaaaccttgc tctgaagacc agagacagaa gggacagaaa caggagtgcc
     2341 tcctgctgtg ccaggcccat gggcagtgca ggcagatccc tgaaggtcag cactcctggg
     2401 tcttcatatg ccaacagggg cgctcttgac actgtgcctt cattttccag cccacagcct
     2461 gggtctcagg gatcttgagg ggtagaacat gtctggttgg ggcttgggaa taaacatgat
     2521 ctattgaaaa acctctgtat ttatatatca aattgtttct ttttttcagg agttgaactg
     2581 ggaataggca agtaccaggc aaagaaacac accctttcct tttttttttt tttttttctt
     2641 tagagctgtg gtcttgctct ctcacccagg ctggagtgca gtgttgcgat cacagctcac
     2701 tgcagcctca aactcctggg ctccaggaga cctcctgcct cagcctcctg aatagctggg
     2761 actacagtcg cgcaccacca cgcctggcta attttttatt tttgtagaaa tggggtattg
     2821 ctttgttgcc cgtgctggct tcagccttct ggtttcaagc agtcctcctg cctcagcttc
     2881 ccaaagtgct gggattacag gtgtgagcca ctgtgcccaa cccagaaata caccctttct
     2941 gtgctgtttt ctcagcaggg tgtgagctca cgggatacgg tcctgccaga ctggccctca
     3001 tagctggtca tgtgccagtc agagctgggt ggggcttgca ggtcccggaa ggtggtggtc
     3061 ttgacctggc agcagatgct taaagaatgc ctaaggtggg tggcagttgg ggagttcaag
     3121 ggtgaatgag gccagggcag cccccaggag ctgaggccaa ctctttgagt caggactgtg
     3181 ccgtgtgccc agggccttgc atgtgtgggc cctcgagtga tttctactgg caggctgaaa
     3241 gccctgtgag gggcggctgt gggcggaggc cacgcaggaa gagtgcttag gagtaacttg
     3301 tttctaacac ctgtgtgctg agtgccaatg ctgggtgtgg tgttatgata tatattggtt
     3361 ttcatccagc attcctgact cgtaactctc atagtccttg ttccagtctt tgttagaata
     3421 ctgggtatgt tagggcttgg gacaggcctc tgacctctgg gtatcctttc actaatgttc
     3481 gcccaccttt ttcacagtgg gtcctaaaga ccttcccatg agagggtctc aatcctaggg
     3541 gaaggaatgt tgatgtcatg aaccttccat aaaaacccaa gaggacaggg ttcagagagc
     3601 ttctggatag ctgaacacct ggcacttcct ggagtgtggc gtgcccaggg agggcacgga
     3661 agctctgcac tccttcccct tccctcattc cttgctctat gtgcatctct tcatctgtat
     3721 cctttgcgat atcctttata ataaaccggt aaacataa
//
