LOCUS       NM_006293               8032 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens TYRO3 protein tyrosine kinase (TYRO3), transcript
            variant 1, mRNA.
ACCESSION   NM_006293
VERSION     NM_006293.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8032)
  AUTHORS   de Aguiar,A.C.F., Ferreira,N.C.F.L., Borba,M.A.C.S.M.,
            Filho,D.L.F., Leitao,G.M., Mattos,L.A., Filho,J.L.L. and
            Martins,D.B.G.
  TITLE     TYRO3 and EPHA2 Expression Are Dysregulated in Breast Cancer
  JOURNAL   Cell Biochem Funct 42 (7), e4128 (2024)
   PUBMED   39327735
  REMARK    GeneRIF: TYRO3 and EPHA2 Expression Are Dysregulated in Breast
            Cancer.
REFERENCE   2  (bases 1 to 8032)
  AUTHORS   Xiong,Y., Wang,B., Jiao,J., Tang,M., Li,K., Jiang,R. and Huang,W.
  TITLE     Expression and clinical association of MFG-E8 and TAM receptors in
            diabetic patients with different stages of microvascular
            complication: An experimental study
  JOURNAL   Medicine (Baltimore) 102 (44), e35788 (2023)
   PUBMED   37933040
  REMARK    GeneRIF: Expression and clinical association of MFG-E8 and TAM
            receptors in diabetic patients with different stages of
            microvascular complication: An experimental study.
REFERENCE   3  (bases 1 to 8032)
  AUTHORS   Wang,Z., Zhao,Z., Li,Z., Xu,L., Li,H., Zhu,H., Cheng,G., Yao,R.,
            Pei,W., Liang,R., Liang,R., Ye,H., Jiang,S., Niu,H., Sun,X. and
            Su,Y.
  TITLE     Tyro3 receptor tyrosine kinase contributes to pathogenic phenotypes
            of fibroblast-like synoviocytes in rheumatoid arthritis and
            disturbs immune cell balance in experimental arthritis
  JOURNAL   Clin Immunol 255, 109753 (2023)
   PUBMED   37678714
  REMARK    GeneRIF: Tyro3 receptor tyrosine kinase contributes to pathogenic
            phenotypes of fibroblast-like synoviocytes in rheumatoid arthritis
            and disturbs immune cell balance in experimental arthritis.
REFERENCE   4  (bases 1 to 8032)
  AUTHORS   Wang,J., Cheng,Z., Dai,D., Li,H., Shao,X. and Xu,M.
  TITLE     Overexpression of TYRO3 indicates poor prognosis and induces
            gastric cancer progression via AKT-mTOR pathway
  JOURNAL   Mol Carcinog 62 (9), 1325-1337 (2023)
   PUBMED   37212497
  REMARK    GeneRIF: Overexpression of TYRO3 indicates poor prognosis and
            induces gastric cancer progression via AKT-mTOR pathway.
REFERENCE   5  (bases 1 to 8032)
  AUTHORS   Shao,X., Sun,Y., Zhong,K., Gu,J., Yu,Y., Hu,T., Kuai,X. and Xing,Y.
  TITLE     TYRO3 promotes tumorigenesis and drug resistance in colorectal
            cancer by enhancing the epithelial-mesenchymal transition process
  JOURNAL   Aging (Albany NY) 15 (8), 3035-3051 (2023)
   PUBMED   37116196
  REMARK    GeneRIF: TYRO3 promotes tumorigenesis and drug resistance in
            colorectal cancer by enhancing the epithelial-mesenchymal
            transition process.
REFERENCE   6  (bases 1 to 8032)
  AUTHORS   Godowski,P.J., Mark,M.R., Chen,J., Sadick,M.D., Raab,H. and
            Hammonds,R.G.
  TITLE     Reevaluation of the roles of protein S and Gas6 as ligands for the
            receptor tyrosine kinase Rse/Tyro 3
  JOURNAL   Cell 82 (3), 355-358 (1995)
   PUBMED   7634325
REFERENCE   7  (bases 1 to 8032)
  AUTHORS   Toshima,J., Ohashi,K., Iwashita,S. and Mizuno,K.
  TITLE     Autophosphorylation activity and association with Src family kinase
            of Sky receptor tyrosine kinase
  JOURNAL   Biochem Biophys Res Commun 209 (2), 656-663 (1995)
   PUBMED   7537495
REFERENCE   8  (bases 1 to 8032)
  AUTHORS   Mark,M.R., Scadden,D.T., Wang,Z., Gu,Q., Goddard,A. and
            Godowski,P.J.
  TITLE     rse, a novel receptor-type tyrosine kinase with homology to
            Axl/Ufo, is expressed at high levels in the brain
  JOURNAL   J Biol Chem 269 (14), 10720-10728 (1994)
   PUBMED   7511603
REFERENCE   9  (bases 1 to 8032)
  AUTHORS   Ohashi,K., Mizuno,K., Kuma,K., Miyata,T. and Nakamura,T.
  TITLE     Cloning of the cDNA for a novel receptor tyrosine kinase, Sky,
            predominantly expressed in brain
  JOURNAL   Oncogene 9 (3), 699-705 (1994)
   PUBMED   8108112
REFERENCE   10 (bases 1 to 8032)
  AUTHORS   Crosier,K.E., Hall,L.R., Lewis,P.M., Morris,C.M., Wood,C.R.,
            Morris,J.C. and Crosier,P.S.
  TITLE     Isolation and characterization of the human DTK receptor tyrosine
            kinase
  JOURNAL   Growth Factors 11 (2), 137-144 (1994)
   PUBMED   7857658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D17517.1, BC051756.1 and
            AC016134.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006293.3.
            
            Summary: The gene is part of a 3-member transmembrane receptor
            kinase receptor family with a processed pseudogene distal on
            chromosome 15. The encoded protein is activated by the products of
            the growth arrest-specific gene 6 and protein S genes and is
            involved in controlling cell survival and proliferation,
            spermatogenesis, immunoregulation and phagocytosis. The encoded
            protein has also been identified as a cell entry factor for Ebola
            and Marburg viruses. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D17517.1, SRR1803615.46825.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263798.8/ ENSP00000263798.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                D17517.1           179-209
            32-792              BC051756.1         1-761
            793-793             AC016134.7         60883-60883
            794-3781            BC051756.1         763-3750
            3782-8032           AC016134.7         75117-79367
FEATURES             Location/Qualifiers
     source          1..8032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..8032
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /note="TYRO3 protein tyrosine kinase"
                     /db_xref="GeneID:7301"
                     /db_xref="HGNC:HGNC:12446"
                     /db_xref="MIM:600341"
     exon            1..170
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2719
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tyrosine-protein kinase receptor TYRO3;
                     tyrosine-protein kinase DTK; tyrosine-protein kinase RSE;
                     tyrosine-protein kinase SKY; tyrosine-protein kinase byk;
                     tyrosine-protein kinase TIF"
                     /codon_start=1
                     /product="tyrosine-protein kinase receptor TYRO3 isoform 1
                     precursor"
                     /protein_id="NP_006284.2"
                     /db_xref="CCDS:CCDS10080.1"
                     /db_xref="GeneID:7301"
                     /db_xref="HGNC:HGNC:12446"
                     /db_xref="MIM:600341"
                     /translation="MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLK
                     LMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFL
                     SLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSC
                     EAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTAT
                     VHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVV
                     PVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRT
                     DSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIV
                     RVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALIL
                     LRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKL
                     EDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFL
                     REAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENP
                     FNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYS
                     GDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAE
                     IYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSA
                     SQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGL
                     AEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC"
     exon            171..354
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            355..455
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            456..626
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            627..713
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            714..829
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1007
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1153
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1298
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1428
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1529
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1625
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1706
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1799
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1921
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2031
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2191
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2328
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..8032
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3756..3761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /note="hexamer: AATAAA"
     polyA_site      3781
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /note="major polyA site"
     regulatory      8008..8013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
                     /note="hexamer: TATAAA"
     polyA_site      8032
                     /gene="TYRO3"
                     /gene_synonym="BYK; Dtk; Etk-2; Rek; RSE; Sky; Tif"
ORIGIN      
        1 ctcctcgctc gcgggccggg cccggcatgg tgcggcgtcg ccgccgatgg cgctgaggcg
       61 gagcatgggg cggccggggc tcccgccgct gccgctgccg ccgccaccgc ggctcgggct
      121 gctgctggcg gctctggctt ctctgctgct cccggagtcc gccgccgcag gtctgaagct
      181 catgggagcc ccggtgaagc tgacagtgtc tcaggggcag ccggtgaagc tcaactgcag
      241 tgtggagggg atggaggagc ctgacatcca gtgggtgaag gatggggctg tggtccagaa
      301 cttggaccag ttgtacatcc cagtcagcga gcagcactgg atcggcttcc tcagcctgaa
      361 gtcagtggag cgctctgacg ccggccggta ctggtgccag gtggaggatg ggggtgaaac
      421 cgagatctcc cagccagtgt ggctcacggt agaaggtgtg ccatttttca cagtggagcc
      481 aaaagatctg gcagtgccac ccaatgcccc tttccaactg tcttgtgagg ctgtgggtcc
      541 ccctgaacct gttaccattg tctggtggag aggaactacg aagatcgggg gacccgctcc
      601 ctctccatct gttttaaatg taacaggggt gacccagagc accatgtttt cctgtgaagc
      661 tcacaaccta aaaggcctgg cctcttctcg cacagccact gttcaccttc aagcactgcc
      721 tgcagccccc ttcaacatca ccgtgacaaa gctttccagc agcaacgcta gtgtggcctg
      781 gatgccaggt gctgatggcc gagctctgct acagtcctgt acagttcagg tgacacaggc
      841 cccaggaggc tgggaagtcc tggctgttgt ggtccctgtg ccccccttta cctgcctgct
      901 ccgggacctg gtgcctgcca ccaactacag cctcagggtg cgctgtgcca atgccttggg
      961 gccctctccc tatgctgact gggtgccctt tcagaccaag ggtctagccc cagccagcgc
     1021 tccccaaaac ctccatgcca tccgcacaga ttcaggcctc atcttggagt gggaagaagt
     1081 gatccccgag gcccctttgg aaggccccct gggaccctac aaactgtcct gggttcaaga
     1141 caatggaacc caggatgagc tgacagtgga ggggaccagg gccaatttga caggctggga
     1201 tccccaaaag gacctgatcg tacgtgtgtg cgtctccaat gcagttggct gtggaccctg
     1261 gagtcagcca ctggtggtct cttctcatga ccgtgcaggc cagcagggcc ctcctcacag
     1321 ccgcacatcc tgggtacctg tggtccttgg tgtgctaacg gccctggtga cggctgctgc
     1381 cctggccctc atcctgcttc gaaagagacg gaaagagacg cggtttgggc aagcctttga
     1441 cagtgtcatg gcccggggag agccagccgt tcacttccgg gcagcccggt ccttcaatcg
     1501 agaaaggccc gagcgcatcg aggccacatt ggacagcttg ggcatcagcg atgaactaaa
     1561 ggaaaaactg gaggatgtgc tcatcccaga gcagcagttc accctgggcc ggatgttggg
     1621 caaaggagag tttggttcag tgcgggaggc ccagctgaag caagaggatg gctcctttgt
     1681 gaaagtggct gtgaagatgc tgaaagctga catcattgcc tcaagcgaca ttgaagagtt
     1741 cctcagggaa gcagcttgca tgaaggagtt tgaccatcca cacgtggcca aacttgttgg
     1801 ggtaagcctc cggagcaggg ctaaaggccg tctccccatc cccatggtca tcttgccctt
     1861 catgaagcat ggggacctgc atgccttcct gctcgcctcc cggattgggg agaacccctt
     1921 taacctaccc ctccagaccc tgatccggtt catggtggac attgcctgcg gcatggagta
     1981 cctgagctct cggaacttca tccaccgaga cctggctgct cggaattgca tgctggcaga
     2041 ggacatgaca gtgtgtgtgg ctgacttcgg actctcccgg aagatctaca gtggggacta
     2101 ctatcgtcaa ggctgtgcct ccaaactgcc tgtcaagtgg ctggccctgg agagcctggc
     2161 cgacaacctg tatactgtgc agagtgacgt gtgggcgttc ggggtgacca tgtgggagat
     2221 catgacacgt gggcagacgc catatgctgg catcgaaaac gctgagattt acaactacct
     2281 cattggcggg aaccgcctga aacagcctcc ggagtgtatg gaggacgtgt atgatctcat
     2341 gtaccagtgc tggagtgctg accccaagca gcgcccgagc tttacttgtc tgcgaatgga
     2401 actggagaac atcttgggcc agctgtctgt gctatctgcc agccaggacc ccttatacat
     2461 caacatcgag agagctgagg agcccactgc gggaggcagc ctggagctac ctggcaggga
     2521 tcagccctac agtggggctg gggatggcag tggcatgggg gcagtgggtg gcactcccag
     2581 tgactgtcgg tacatactca cccccggagg gctggctgag cagccagggc aggcagagca
     2641 ccagccagag agtcccctca atgagacaca gaggcttttg ctgctgcagc aagggctact
     2701 gccacacagt agctgttagc ccacaggcag agggcatcgg ggccatttgg ccggctctgg
     2761 tggccactga gctggctgac taagccccgt ctgaccccag cccagacagc aaggtgtgga
     2821 ggctcctgtg gtagtcctcc caagctgtgc tgggaagccc ggactgacca aatcacccaa
     2881 tcccagttct tcctgcaacc actctgtggc cagcctggca tcagtttagg ccttggcttg
     2941 atggaagtgg gccagtcctg gttgtctgaa cccaggcagc tggcaggagt ggggtggtta
     3001 tgtttccatg gttaccatgg gtgtggatgg cagtgtgggg agggcaggtc cagctctgtg
     3061 ggccctaccc tcctgctgag ctgcccctgc tgcttaagtg catgcattga gctgcctcca
     3121 gcctggtggc ccagctatta ccacacttgg ggtttaaata tccaggtgtg cccctccaag
     3181 tcacaaagag atgtccttgt aatattccct tttaggtgag ggttggtaag gggttggtat
     3241 ctcaggtctg aatcttcacc atctttctga ttccgcaccc tgcctacgcc aggagaagtt
     3301 gaggggagca tgcttccctg cagctgaccg ggtcacacaa aggcatgctg gagtacccag
     3361 cctatcaggt gcccctcttc caaaggcagc gtgccgagcc agcaagagga aggggtgctg
     3421 tgaggcttgc ccaggagcaa gtgaggccgg agaggagttc aggaaccctt ctccataccc
     3481 acaatctgag cacgctacca aatctcaaaa tatcctaaga ctaacaaagg cagctgtgtc
     3541 tgagcccaac ccttctaaac ggtgaccttt agtgccaact tcccctctaa ctggacagcc
     3601 tcttctgtcc caagtctcca gagagaaatc aggcctgatg agggggaatt cctggaacct
     3661 ggaccccagc cttggtgggg gagcctctgg aatgcatggg gcgggtccta gctgttaggg
     3721 acatttccaa gctgttagtt gctgtttaaa atagaaataa aattgaagac taaagaccta
     3781 aggttttgtc tctttttttt tttctttttt tttgagacag tctcactgtg ttgcccaggc
     3841 tggagtgcat ggtgtgatct tggttcactg caacctctgc ctcctgggtt caagcgattc
     3901 ttgtgcctca gtcaccagag tagctgggat tacaggggct cactaccatg cccaggtaat
     3961 ttttgtattt ttagtagaga tgtggtttcg ccatgttggc cagggtggtc ttgaactcat
     4021 gacctcaagt gatctgcctg ccttggcctc ccaaagtgct gggattacag tcctgagcca
     4081 ccacacctgg ccccagcttt gtctcttaaa tgtttacttt ttttgagatc acaaagatga
     4141 aagattttta tagagagaaa agtctggaaa gacatatgcc aaaatgttaa cagctgttat
     4201 cttttttttt ttttttttga gaccgagtct cactctgtcg cccaggctgg agtgcaattg
     4261 cgcgatctga gctcactgca agctctgcct cccaggttca cgccattctc ctgcctcagc
     4321 ctcccgagta gctgggacta caggtgcctg ccaccacgcc cggctaattt tttgtatttt
     4381 tagtagagat agggtttcac cgtattagcc aggatgatct caatctcctg acctcgtgat
     4441 ccgcctgcct cagcctccca aagtgttggg attacaggcg tgagccaccg cacctggcaa
     4501 cagctgttac ctttaaatga tggggttaag gggacgttct tctttgtgct ttccaagttt
     4561 tctgcattga gcacaaaatg cttttgtaat tagatacagg atcccaatga atcttattat
     4621 actgaagata atacagagtc accgtgggca gttagaaaaa tgcaaaaaat cggctgggcg
     4681 cagtggctca cgcctgtaat cccagcactt tgggagacct gggtgtgtgg atcacgaggt
     4741 cagaagttca agactagtct gaccaacatg gtgacacccc gtctttacta aaaatacaaa
     4801 aattagctgg gcatggtggc gcgtgtctgt aatcccagct actcaggaca ctgaggcagg
     4861 agaattgctt gaactcagga ggcggaggtt gcagtgagtc gagatcccgg cagcctaggt
     4921 gacaggcgag actccatctc aaaaataaaa taaaaataaa aatgcaaaaa ataataaaag
     4981 gtgccagtta cctatactcc caccacctag agataatcac cattgatctt ttgaaaatgc
     5041 aaatattcag ctgggcacag tggcgtgtat tttttttttt ttttgagacg gagtctcgag
     5101 tctctctctg tcgcccaggc tagagtgcag tggtgtgatc tcggctcact gtaacctctg
     5161 tctcccaggt ttaatcaagt ctcttgtctt ggcttcccga gtagttggga ctacaggcac
     5221 gagccactgt gtccggctat tttttgtatt tttttgtaga gacagggttt cgccatgttg
     5281 gccaggctgg tctcgaactc ctgatttcaa gtgatctgcc tgccttagcc tcccaaagtg
     5341 ctgtgataac aggggtgaga caccataccc agcttgtaat cccagcactt tgggaggctg
     5401 aggcgggtgg atcacttcag gccgggagtt cgagaccagc ctgggcaaca tgaaacccca
     5461 tctcaactaa aaattcaaaa aagtttagcc aggcttggtg gcgcaggttt gtcatctcag
     5521 ctactgggtg actgaggcat gagaatcact taaacctggg aggaggaggt tgcagtaagc
     5581 tgagatcttg ccactaaact tcggcctggg tgacagatta agactgtctc agaaacaaaa
     5641 caaaacaaca aaaaagcttt tagagcaagt tcatgggaga tgcagcagga ggcgcaggaa
     5701 ccacacatgt gctagtgagg agtgtgggga gactgggagg gcccacaggt attgtgctgc
     5761 ttctggctga gggcagggga atagggtggc tgcttctgaa agcaaatatc ctgaaaaacc
     5821 tgttgctggt actccaaatt ctggttccca tgtagatcat gaaacctgaa aaacttccag
     5881 gcaagtagct ttcagaatct ttcctgctgt gattagcttt cactgcaggt agtgattacc
     5941 tgtgagataa catctgggaa ttattgattg aaaagacctt cactatcggt tgggggcggt
     6001 ggctgatgcc tgtaatccca gcactttgtg aggctgaggc gggtggatca cctgaggtca
     6061 ggggttcaag accagcctgg ccaacatggt gaaaccccat ctctactaaa aaatacaaaa
     6121 actagccagg agtggtggca ggcacctgta atcccagcta cttgggaggc taaggcagga
     6181 gaatcacttg aaccctggag gcggaggttg cagtgaactg agatggcacc agtgcactcc
     6241 agcctgggtg acagagcgag actccatctc aaaaaaaaaa aaaaaaaaaa gaggccaggc
     6301 atggtggctc acgcctataa tcccagcgct ttgggatttt ctgtctcaaa aaaaaaaaga
     6361 gagagactct ggatcaaaaa ggattttcac aaacagatcc aaagaaccag catccagatt
     6421 aagaaacagc attaacagca acccagaagc aacccttggg acctgcctca atctctgcct
     6481 cctccctact ccccataggt aacctctatc ctgacctctt aacaccatgg atcagtgaag
     6541 ctccttttaa aagtatataa atggagtcat gtagatttga ttactttgcg tttggcttct
     6601 ttccctcagc aacatgttta taaggatcat ctaacaacag cagttttgaa aagtgagtct
     6661 caaagaggca agaatggccg ggcatggtgg ctcacacccg taatcccagc gctttgggag
     6721 gccgaggcgg gcggatcaca aggtcaggag tttgagacca gcctggctaa cagggtgaaa
     6781 ccctgtcttt actaaaccct gtctttacta aaaatacaca aaattagcca ggtatggtgg
     6841 caggcacgtg taatcctagc tactcgggag gctgaggcag gagaatcact tgaacctggg
     6901 agggggaggt tgcagtgagc cactacattc cagcttgggt gagagagtga gactccatct
     6961 cggaaaaaaa aaaaattagc tgggcgtgct ggtgggtgcc tgtaatccca gctacttggg
     7021 aggctgaggt aggagaattg cttgaacctg ggaggtggaa gttgctgtga gacgagattg
     7081 tgccatggca ctccagcctg gacaagagtg agactccatc tcaaaaaaga aaataataat
     7141 aatatagttt atttttcagt atttcatgtt gatttatctc aaatttattg ttgaataaga
     7201 agtgatacag agattcaaag ttatttttcc cagatacttt ttattgtccc aataccacca
     7261 tttattgaac aatctatatt ttatgcacat ttcttttttt tttctttttt ttgatacagg
     7321 gtcttgctct gtttctgcct gggctggagt aaagtgatag taaactgatt ctcccacctc
     7381 agcgtcctga atagctggga ccacaggcac acgccactgc acctggcaaa tttttaagtg
     7441 tttttttttt tttttaatac agagccttgc tctgtcgccc aggctggagt gcagtggtgt
     7501 gatctcggct cactgcaacc tccgcctctc agttcaagcg agtctcctcc tgcctcacac
     7561 tcccaattag ctgggactac aggcacgtgc caccacaaca tgctaatttt ttgtattttt
     7621 agtagagaca gggtttcacc atgttagcca ggatggtctc gatctcctga cctcgtgatc
     7681 tgcccgcctc agcctcccaa agtgctggga ttacaggctt cagccaccgc gcccggccca
     7741 gtttttaagt gttgtagaga tggagtcttg ctttgttgcc caggctggtc ttgaactctg
     7801 ggctgaagcg atctgcccac cttggcctct caaagtgcgg agattacagg tgtgagccac
     7861 cacacccagc cagaatttct tgaataatct gtctccattt ctctatatag cctcattgat
     7921 ctatctaaac tcccatatct attttggttg ctagactgtt catcccaatt acatgtgcca
     7981 gtgtcactgc tacactaatt gaattactat aaatgtataa tgttttccta ta
//
