LOCUS       NM_003331               4243 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens tyrosine kinase 2 (TYK2), transcript variant 2, mRNA.
ACCESSION   NM_003331
VERSION     NM_003331.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4243)
  AUTHORS   Chen,H., Ge,X., Li,C., Zeng,J. and Wang,X.
  TITLE     Structure and assembly of the human IL-12 signaling complex
  JOURNAL   Structure 32 (10), 1640-1651 (2024)
   PUBMED   39111304
REFERENCE   2  (bases 1 to 4243)
  AUTHORS   Lesgidou,N. and Vlassi,M.
  TITLE     Community analysis of large-scale molecular dynamics simulations
            elucidated dynamics-driven allostery in tyrosine kinase 2
  JOURNAL   Proteins 92 (4), 474-498 (2024)
   PUBMED   37950407
  REMARK    GeneRIF: Community analysis of large-scale molecular dynamics
            simulations elucidated dynamics-driven allostery in tyrosine kinase
            2.
REFERENCE   3  (bases 1 to 4243)
  AUTHORS   Zhang,M., Liu,Z., Zhu,Y., Wu,K., Zhou,L., Peng,Y., Pan,J., Chen,B.,
            Wang,X. and Chen,S.
  TITLE     Associations of genetic variants within TYK2 with pulmonary
            tuberculosis among Chinese population
  JOURNAL   Mol Genet Genomic Med 12 (2), e2386 (2024)
   PUBMED   38337161
  REMARK    GeneRIF: Associations of genetic variants within TYK2 with
            pulmonary tuberculosis among Chinese population.
REFERENCE   4  (bases 1 to 4243)
  AUTHORS   Benmansour,R., Tagajdid,M.R., El Hamzaoui,H., Fjouji,S., Doghmi,N.,
            Houba,A., Belbacha,I., Elkochri,S., Aabi,R., Elannaz,H.,
            Laraqui,A., El Mchichi,B., Chmitah,T., Touil,N., Ennibi,K.,
            Eljaoudi,R., Elmir,E., Amine Lahlou,I. and Oumzil,H.
  TITLE     TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among
            severe COVID-19 ICU patients in Morocco
  JOURNAL   Int J Immunopathol Pharmacol 38, 3946320241257241 (2024)
   PUBMED   38760017
  REMARK    GeneRIF: TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide
            polymorphisms among severe COVID-19 ICU patients in Morocco.
REFERENCE   5  (bases 1 to 4243)
  AUTHORS   Yang,Z., Xiang,Q. and Nicholas,J.
  TITLE     Direct and biologically significant interactions of human
            herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus
            kinase TYK2
  JOURNAL   PLoS Pathog 19 (11), e1011806 (2023)
   PUBMED   37983265
  REMARK    GeneRIF: Direct and biologically significant interactions of human
            herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus
            kinase TYK2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4243)
  AUTHORS   Shuai,K., Horvath,C.M., Huang,L.H., Qureshi,S.A., Cowburn,D. and
            Darnell,J.E. Jr.
  TITLE     Interferon activation of the transcription factor Stat91 involves
            dimerization through SH2-phosphotyrosyl peptide interactions
  JOURNAL   Cell 76 (5), 821-828 (1994)
   PUBMED   7510216
REFERENCE   7  (bases 1 to 4243)
  AUTHORS   Velazquez,L., Fellous,M., Stark,G.R. and Pellegrini,S.
  TITLE     A protein tyrosine kinase in the interferon alpha/beta signaling
            pathway
  JOURNAL   Cell 70 (2), 313-322 (1992)
   PUBMED   1386289
REFERENCE   8  (bases 1 to 4243)
  AUTHORS   Partanen,J., Makela,T.P., Alitalo,R., Lehvaslaiho,H. and Alitalo,K.
  TITLE     Putative tyrosine kinases expressed in K-562 human leukemia cells
  JOURNAL   Proc Natl Acad Sci U S A 87 (22), 8913-8917 (1990)
   PUBMED   2247464
REFERENCE   9  (bases 1 to 4243)
  AUTHORS   Firmbach-Kraft,I., Byers,M., Shows,T., Dalla-Favera,R. and
            Krolewski,J.J.
  TITLE     tyk2, prototype of a novel class of non-receptor tyrosine kinase
            genes
  JOURNAL   Oncogene 5 (9), 1329-1336 (1990)
   PUBMED   2216457
REFERENCE   10 (bases 1 to 4243)
  AUTHORS   Krolewski,J.J., Lee,R., Eddy,R., Shows,T.B. and Dalla-Favera,R.
  TITLE     Identification and chromosomal mapping of new human tyrosine kinase
            genes
  JOURNAL   Oncogene 5 (3), 277-282 (1990)
   PUBMED   2156206
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA864169.1, BC014243.2 and
            AK308360.1.
            
            On May 17, 2019 this sequence version replaced NM_003331.4.
            
            Summary: This gene encodes a member of the tyrosine kinase and,
            more specifically, the Janus kinases (JAKs) protein families. This
            protein associates with the cytoplasmic domain of type I and type
            II cytokine receptors and promulgate cytokine signals by
            phosphorylating receptor subunits. It is also a component of both
            the type I and type III interferon signaling pathways. As such, it
            may play a role in anti-viral immunity. A mutation in this gene has
            been associated with Immunodeficiency 35. [provided by RefSeq, Sep
            2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: MN842724.1, BC014243.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000525621.6/ ENSP00000431885.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                DA864169.1         1-37
            38-3423             BC014243.2         1-3386
            3424-3424           AK308360.1         2639-2639
            3425-4243           BC014243.2         3388-4206
FEATURES             Location/Qualifiers
     source          1..4243
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..4243
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /note="tyrosine kinase 2"
                     /db_xref="GeneID:7297"
                     /db_xref="HGNC:HGNC:12440"
                     /db_xref="MIM:176941"
     exon            1..193
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..358
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..571
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             379..3942
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /EC_number="2.7.10.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     non-receptor tyrosine-protein kinase TYK2"
                     /codon_start=1
                     /product="non-receptor tyrosine-protein kinase TYK2
                     isoform 2"
                     /protein_id="NP_003322.3"
                     /db_xref="CCDS:CCDS12236.1"
                     /db_xref="GeneID:7297"
                     /db_xref="HGNC:HGNC:12440"
                     /db_xref="MIM:176941"
                     /translation="MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWV
                     TFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLY
                     FRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEF
                     VNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRS
                     FRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVP
                     VCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVN
                     KEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHC
                     VSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDG
                     IHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIE
                     QQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRG
                     ARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDE
                     DPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPE
                     NIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNI
                     LLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKW
                     GFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQR
                     PSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLY
                     CYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEK
                     SLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVL
                     LDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFG
                     VTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYH
                     LMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC"
     exon            572..695
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..843
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1007
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1389
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1587
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1745
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1854
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2047
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2151
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2337
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2425
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2553
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2689
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2844
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..2995
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3093
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3286
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..3405
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3578
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3696
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3807
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3808..4243
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4223..4228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /note="hexamer: AATAAA"
     polyA_site      4243
                     /gene="TYK2"
                     /gene_synonym="IMD35; JTK1"
                     /note="major polyA site"
ORIGIN      
        1 aagcagtagc tacccgcggg agcggggagg ggtccgggtt cgagcttgtg ttcccccgga
       61 agggtgagtc tggacgcggg cgcggaagga gcgcggccgg aggtcctcag gaagaagccg
      121 cggggactgg ctgcgcttga caggctgcac ttggatggga gcacctggtg cctcgggact
      181 gctccgatgc ccgggtctgt gctgaatgtg taatatgcgg aactatattg aaacattaca
      241 accatctttt gatggcaaca ccctgaggac ctcccttttc cagatgggga aactgaggcc
      301 cagaattgct aagtggcttg cttgagttga cacagggagc tccaggactc accctcagct
      361 gagccacctg ccgggagcat gcctctgcgc cactggggga tggccagggg cagtaagccc
      421 gttggggatg gagcccagcc catggctgcc atgggaggcc tgaaggtgct tctgcactgg
      481 gctggtccag gcggcgggga gccctgggtc actttcagtg agtcatcgct gacagctgag
      541 gaagtctgca tccacattgc acataaagtt ggtatcactc ctccttgctt caatctcttt
      601 gccctcttcg atgctcaggc ccaagtctgg ttgcccccaa accacatcct agagatcccc
      661 agagatgcaa gcctgatgct atatttccgc ataaggtttt atttccggaa ctggcatggc
      721 atgaatcctc gggaaccggc tgtgtaccgt tgtgggcccc caggaaccga ggcatcctca
      781 gatcagacag cacaggggat gcaactcctg gacccagcct catttgagta cctctttgag
      841 cagggcaagc atgagtttgt gaatgacgtg gcatcactgt gggagctgtc gaccgaggag
      901 gagatccacc actttaagaa tgagagcctg ggcatggcct ttctgcacct ctgtcacctc
      961 gctctccgcc atggcatccc cctggaggag gtggccaaga agaccagctt caaggactgc
     1021 atcccgcgct ccttccgccg gcatatccgg cagcacagcg ccctgacccg gctgcgcctt
     1081 cggaacgtct tccgcaggtt cctgcgggac ttccagccgg gccgactctc ccagcagatg
     1141 gtcatggtca aatacctagc cacactcgag cggctggcac cccgcttcgg cacagagcgt
     1201 gtgcccgtgt gccacctgag gctgctggcc caggccgagg gggagccctg ctacatccgg
     1261 gacagtgggg tggcccctac agaccctggc cctgagtctg ctgctgggcc cccaacccac
     1321 gaggtgctgg tgacaggcac tggtggcatc cagtggtggc cagtagagga ggaggtgaac
     1381 aaggaggagg gttctagtgg cagcagtggc aggaaccccc aagccagcct gtttgggaag
     1441 aaggccaagg ctcacaaggc agtcggccag ccggcagaca ggccgcggga gccactgtgg
     1501 gcctacttct gtgacttccg ggacatcacc cacgtggtgc tgaaagagca ctgtgtcagc
     1561 atccaccggc aggacaacaa gtgcctggag ctgagcttgc cttcccgggc tgcggcgctg
     1621 tccttcgtgt cgctggtgga cggctatttc cgcctgacgg ccgactccag ccactacctg
     1681 tgccacgagg tggctccccc acggctggtg atgagcatcc gggatgggat ccacggaccc
     1741 ctgctggagc catttgtgca ggccaagctg cggcccgagg acggcctgta cctcattcac
     1801 tggagcacca gccaccccta ccgcctgatc ctcacagtgg cccagcgtag ccaggcacca
     1861 gacggcatgc agagcttgcg gctccgaaag ttccccattg agcagcagga cggggccttc
     1921 gtgctggagg gctggggccg gtccttcccc agcgttcggg aacttggggc tgccttgcag
     1981 ggctgcttgc tgagggccgg ggatgactgc ttctctctgc gtcgctgttg cctgccccaa
     2041 ccaggagaaa cctccaatct catcatcatg cggggggctc gggccagccc caggacactc
     2101 aacctcagcc agctcagctt ccaccgggtt gaccagaagg agatcaccca gctgtcccac
     2161 ttgggccagg gcacaaggac caacgtgtat gagggccgcc tgcgagtgga gggcagcggg
     2221 gaccctgagg agggcaagat ggatgacgag gaccccctcg tgcctggcag ggaccgtggg
     2281 caggagctac gagtggtgct caaagtgctg gaccctagtc accatgacat cgccctggcc
     2341 ttctacgaga cagccagcct catgagccag gtctcccaca cgcacctggc cttcgtgcat
     2401 ggcgtctgtg tgcgcggccc tgaaaatatc atggtgacag agtacgtgga gcacggaccc
     2461 ctggatgtgt ggctgcggag ggagcggggc catgtgccca tggcttggaa gatggtggtg
     2521 gcccagcagc tggccagcgc cctcagctac ctggagaaca agaacctggt tcatggtaat
     2581 gtgtgtggcc ggaacatcct gctggcccgg ctggggttgg cagagggcac cagccccttc
     2641 atcaagctga gtgatcctgg cgtgggcctg ggcgccctct ccagggagga gcgggtggag
     2701 aggatcccct ggctggcccc cgaatgccta ccaggtgggg ccaacagcct aagcaccgcc
     2761 atggacaagt gggggtttgg cgccaccctc ctggagatct gctttgacgg agaggcccct
     2821 ctgcagagcc gcagtccctc cgagaaggag catttctacc agaggcagca ccggctgccc
     2881 gagccctcct gcccacagct ggccacactc accagccagt gtctgaccta tgagccaacc
     2941 cagaggccat cattccgcac catcctgcgt gacctcaccc ggctgcagcc ccacaatctt
     3001 gctgacgtct tgactgtgaa cccggactca ccggcgtcgg accctacggt tttccacaag
     3061 cgctatttga aaaagatccg agatctgggc gagggtcact tcggcaaggt cagcttgtac
     3121 tgctacgatc cgaccaacga cggcactggc gagatggtgg cggtgaaagc cctcaaggca
     3181 gactgcggcc cccagcaccg ctcgggctgg aagcaggaga ttgacattct gcgcacgctc
     3241 taccacgagc acatcatcaa gtacaagggc tgctgcgagg accaaggcga gaagtcgctg
     3301 cagctggtca tggagtacgt gcccctgggc agcctccgag actacctgcc ccggcacagc
     3361 atcgggctgg cccagctgct gctcttcgcc cagcagatct gcgagggcat ggcctatctg
     3421 cacgcgcagc actacatcca ccgagaccta gccgcgcgca acgtgctgct ggacaacgac
     3481 aggctggtca agatcgggga ctttggccta gccaaggccg tgcccgaagg ccacgagtac
     3541 taccgcgtgc gcgaggatgg ggacagcccc gtgttctggt atgccccaga gtgcctgaag
     3601 gagtataagt tctactatgc gtcagatgtc tggtccttcg gggtgaccct gtatgagctg
     3661 ctgacgcact gtgactccag ccagagcccc cccacgaaat tccttgagct cataggcatt
     3721 gctcagggtc agatgacagt tctgagactc actgagttgc tggaacgagg ggagaggctg
     3781 ccacggcccg acaaatgtcc ctgtgaggtc tatcatctca tgaagaactg ctgggagaca
     3841 gaggcgtcct ttcgcccaac cttcgagaac ctcataccca ttctgaagac agtccatgag
     3901 aagtaccaag gccaggcccc ttcagtgttc agcgtgtgct gaggcacaat ggcagccctg
     3961 cctgggagga ctggaccagg cagtggctgc agagggagcc tcctgctccc tgctccagga
     4021 tgaaaccaag agggggatgt cagcctcacc cacaccgtgt gccttactcc tgtctagaga
     4081 ccccacctct gtgaacttat ttttctttct tggccgtgag cctaaccatg atcttgaggg
     4141 acccaacatt tgtaggggca ctaatccagc ccttaaatcc cccagcttcc aaacttgagg
     4201 cccaccatct ccaccatctg gtaataaact catgttttct ctg
//
