LOCUS       NM_017853               2521 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens thioredoxin like 4B (TXNL4B), transcript variant 1,
            mRNA.
ACCESSION   NM_017853
VERSION     NM_017853.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2521)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2521)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2521)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2521)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2521)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   6  (bases 1 to 2521)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 2521)
  AUTHORS   Simeoni,F., Arvai,A., Bello,P., Gondeau,C., Hopfner,K.P.,
            Neyroz,P., Heitz,F., Tainer,J. and Divita,G.
  TITLE     Biochemical characterization and crystal structure of a Dim1 family
            associated protein: Dim2
  JOURNAL   Biochemistry 44 (36), 11997-12008 (2005)
   PUBMED   16142897
  REMARK    GeneRIF: crystal structure; in contrast to hDim1, hDim2 forms
            stable homodimers
REFERENCE   8  (bases 1 to 2521)
  AUTHORS   Schelling,P., Claus,M.T., Johner,R., Marquez,V.E., Schulz,G.E. and
            Scapozza,L.
  TITLE     Biochemical and structural characterization of
            (South)-methanocarbathymidine that specifically inhibits growth of
            herpes simplex virus type 1 thymidine kinase-transduced
            osteosarcoma cells
  JOURNAL   J Biol Chem 279 (31), 32832-32838 (2004)
   PUBMED   15163659
REFERENCE   9  (bases 1 to 2521)
  AUTHORS   Sun,X., Zhang,H., Wang,D., Ma,D., Shen,Y. and Shang,Y.
  TITLE     DLP, a novel Dim1 family protein implicated in pre-mRNA splicing
            and cell cycle progression
  JOURNAL   J Biol Chem 279 (31), 32839-32847 (2004)
   PUBMED   15161931
  REMARK    GeneRIF: DLP is implicated in not only cell cycle progression but
            also in a more specific molecular process such as pre-mRNA splicing
REFERENCE   10 (bases 1 to 2521)
  AUTHORS   Zhang,Y.Z., Gould,K.L., Dunbrack,R.L. Jr., Cheng,H., Roder,H. and
            Golemis,E.A.
  TITLE     The evolutionarily conserved Dim1 protein defines a novel branch of
            the thioredoxin fold superfamily
  JOURNAL   Physiol Genomics 1 (3), 109-118 (1999)
   PUBMED   11015569
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP355646.1, BC009646.1 and AC009087.4.
            
            On Nov 23, 2018 this sequence version replaced NM_017853.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000518.1, SRR3476690.964036.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268483.8/ ENSP00000268483.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BP355646.1         21-59
            40-1376             BC009646.1         1-1337
            1377-1464           BC009646.1         1339-1426
            1465-1465           AC009087.4         31465-31465
            1466-2521           BC009646.1         1428-2483
FEATURES             Location/Qualifiers
     source          1..2521
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.2"
     gene            1..2521
                     /gene="TXNL4B"
                     /gene_synonym="Dim2; DLP"
                     /note="thioredoxin like 4B"
                     /db_xref="GeneID:54957"
                     /db_xref="HGNC:HGNC:26041"
                     /db_xref="MIM:617722"
     exon            1..254
                     /gene="TXNL4B"
                     /gene_synonym="Dim2; DLP"
                     /inference="alignment:Splign:2.1.0"
     exon            255..423
                     /gene="TXNL4B"
                     /gene_synonym="Dim2; DLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..741
                     /gene="TXNL4B"
                     /gene_synonym="Dim2; DLP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Dim1-like protein; thioredoxin-like protein 4B"
                     /codon_start=1
                     /product="thioredoxin-like protein 4B isoform 1"
                     /protein_id="NP_060323.1"
                     /db_xref="CCDS:CCDS10906.1"
                     /db_xref="GeneID:54957"
                     /db_xref="HGNC:HGNC:26041"
                     /db_xref="MIM:617722"
                     /translation="MSFLLPKLTSKKEVDQAIKSTAEKVLVLRFGRDEDPVCLQLDDI
                     LSKTSSDLSKMAAIYLVDVDQTAVYTQYFDISYIPSTVFFFNGQHMKVDYGSPDHTKF
                     VGSFKTKQDFIDLIEVIYRGAMRGKLIVQSPIDPKNIPKYDLLYQDI"
     exon            424..575
                     /gene="TXNL4B"
                     /gene_synonym="Dim2; DLP"
                     /inference="alignment:Splign:2.1.0"
     exon            576..2521
                     /gene="TXNL4B"
                     /gene_synonym="Dim2; DLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1033..1038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNL4B"
                     /gene_synonym="Dim2; DLP"
                     /note="hexamer: AATACA"
     polyA_site      1053
                     /gene="TXNL4B"
                     /gene_synonym="Dim2; DLP"
     regulatory      2500..2505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNL4B"
                     /gene_synonym="Dim2; DLP"
                     /note="hexamer: AATAAA"
     polyA_site      2521
                     /gene="TXNL4B"
                     /gene_synonym="Dim2; DLP"
                     /note="major polyA site"
ORIGIN      
        1 cgtttattgg gctgttgagc gggggccgac cgacggccag gagtttcttt tctgcgcttg
       61 tgcgttttct gttcggtttc cttcccgcta gcggggccac gagggttgct aggcaacagc
      121 ccctgggtga cttggtctta gggtcctgtc cggcttgggg ctgatgaaag gagctgtccg
      181 cgcccgggct cttccgagaa gtggttgctg acagccacaa agtgaaaggg agtgaggcgg
      241 cgtggacgag taaggagtga cagtgaggat tcacatttgg gttatttcaa gatgagcttc
      301 ctactgccca agctgactag caaaaaggaa gtagaccagg cgataaaaag tactgctgag
      361 aaggtgttgg ttctcaggtt tgggagagat gaagatcctg tctgtctgca gctagatgat
      421 attctttcta agacctcttc tgacttaagt aaaatggctg ctatatacct ggtagatgtg
      481 gaccaaactg cagtttatac acagtatttt gacatcagtt atattccatc tactgtcttt
      541 ttcttcaatg ggcagcatat gaaagtggat tatggatctc cagatcacac taagtttgtg
      601 ggaagcttca aaaccaaaca agacttcata gatttgattg aagtaatcta tcgaggagca
      661 atgaggggga agcttattgt ccaaagtcct attgatccca agaatattcc caaatatgac
      721 cttctctatc aagacattta gtacattaat tgctgtcaaa gatgaagaag aaggcacatc
      781 ttgacacagt acctgaatcc agctgtgctg tgtttctgga gtcctttgga aacatgtgtc
      841 ccagaggaga agaggtttga cttgcgtgta gaaaacccgg cccctgagga aaagacccca
      901 ctggttctct gatgacctgg gatgcctaac tgtctactcc ctgcaagcct cagagcagcc
      961 aagtcattgg tgttcatttt ccccacagtg atttttgtaa cttctctttc taatgttttt
     1021 ctttatccct ttaatacaga accctcccaa acattggcta gtacaacttg atttcatcat
     1081 gttcatttga tacacaagtg aactggaaag tcacttccca tagaagcaaa agtacttatt
     1141 ttctacccta gctgggtgca tgtgtgtgca cacacacaca cacacacacc cccacacccc
     1201 tttgccggtt cctcgactca tacatccctc gtgctttccc atctccagtc tgtattactg
     1261 taggttctct tcaaataatt aattgagcag acaagtttgt tttattttgg agcctttttg
     1321 gctctggctt ttaaacattg tcctggttgg ctcatttaat tttttttttt ttttttgaga
     1381 ccgagtcact cttgtcaccc aggctggagt gcagtggcgc gatctcggct cactgcaagc
     1441 tccacctcct gggttcatgc cattttcctg cttcagcctc ctgagtagct gggactacag
     1501 gcgcccgcca ccatgcccag ctaatttttt gtatttttat agaggcgcag tttcaccgtg
     1561 ttagccaaga tggtctcgat ctcctgacct cgtgatctgc cctcctcagc ctcccaggtg
     1621 ctgggattat aggcgtgagc caccgcgcgc accccattta attatttttt atgttataaa
     1681 atttaatatg gaaagtgaga atttgaacct tcaccatcca ccactctatt caggtaaaac
     1741 aatgaatgag ccaccttagc aggagcagat ttttcccaga agctgctgcc tcttcctgag
     1801 gcagaaaatt ggattactaa ggctcaaaac taaaagagat gtcagcattg ttggatagaa
     1861 atgtcaccta tatgggattt gcctgtttta ataactttgt aaggaattct tgctcttcta
     1921 ggggtgcctg gcgcaaccgt gggcaagtta ctgctcctct ttaaacctcg tggtggttat
     1981 tgaaacagat ttattagaag gagagggtag gtgcagagct ggagagccat gggtgaggca
     2041 gcttgtgacc tgcctagcag ccgctgacca cctctccaac agaagcctag tcctgttcag
     2101 agcagcactg tcactgcaag tccagccccc tttgccaggg gctccattcc acccctttcc
     2161 tgcagggagg ggtgccatga gtcttgcttt tggctcatac aggagagagg gaaggctgcc
     2221 aggcactgct tgtatccctg ctgataagag gagggagtca ctccaggaat aagacaaaag
     2281 gagaggagga ggccatcacc tctggcctct tccatcgtac acttcctgtc tctggtttaa
     2341 tcatgatgca tggagctaca acagccatct taggtccccg aggtgcccag catcacgtaa
     2401 aacatcgata tgctaagaag aacaaaaaga gcccaatctc tgatgttatt gagctcctgc
     2461 atgaactctg gacctgcctg cctcagactt ctgtgaaaga ataaaatttc tttttgccta
     2521 a
//
