LOCUS       NM_004786               6840 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens thioredoxin like 1 (TXNL1), transcript variant 1,
            mRNA.
ACCESSION   NM_004786
VERSION     NM_004786.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6840)
  AUTHORS   Yu,D., Mathews,C.A., Scharf,J.M., Neale,B.M., Davis,L.K.,
            Gamazon,E.R., Derks,E.M., Evans,P., Edlund,C.K., Crane,J.,
            Fagerness,J.A., Osiecki,L., Gallagher,P., Gerber,G., Haddad,S.,
            Illmann,C., McGrath,L.M., Mayerfeld,C., Arepalli,S., Barlassina,C.,
            Barr,C.L., Bellodi,L., Benarroch,F., Berrio,G.B., Bienvenu,O.J.,
            Black,D.W., Bloch,M.H., Brentani,H., Bruun,R.D., Budman,C.L.,
            Camarena,B., Campbell,D.D., Cappi,C., Silgado,J.C., Cavallini,M.C.,
            Chavira,D.A., Chouinard,S., Cook,E.H., Cookson,M.R., Coric,V.,
            Cullen,B., Cusi,D., Delorme,R., Denys,D., Dion,Y., Eapen,V.,
            Egberts,K., Falkai,P., Fernandez,T., Fournier,E., Garrido,H.,
            Geller,D., Gilbert,D.L., Girard,S.L., Grabe,H.J., Grados,M.A.,
            Greenberg,B.D., Gross-Tsur,V., Grunblatt,E., Hardy,J., Heiman,G.A.,
            Hemmings,S.M., Herrera,L.D., Hezel,D.M., Hoekstra,P.J.,
            Jankovic,J., Kennedy,J.L., King,R.A., Konkashbaev,A.I.,
            Kremeyer,B., Kurlan,R., Lanzagorta,N., Leboyer,M., Leckman,J.F.,
            Lennertz,L., Liu,C., Lochner,C., Lowe,T.L., Lupoli,S.,
            Macciardi,F., Maier,W., Manunta,P., Marconi,M., McCracken,J.T.,
            Mesa Restrepo,S.C., Moessner,R., Moorjani,P., Morgan,J., Muller,H.,
            Murphy,D.L., Naarden,A.L., Nurmi,E., Ochoa,W.C., Ophoff,R.A.,
            Pakstis,A.J., Pato,M.T., Pato,C.N., Piacentini,J., Pittenger,C.,
            Pollak,Y., Rauch,S.L., Renner,T., Reus,V.I., Richter,M.A.,
            Riddle,M.A., Robertson,M.M., Romero,R., Rosario,M.C., Rosenberg,D.,
            Ruhrmann,S., Sabatti,C., Salvi,E., Sampaio,A.S., Samuels,J.,
            Sandor,P., Service,S.K., Sheppard,B., Singer,H.S., Smit,J.H.,
            Stein,D.J., Strengman,E., Tischfield,J.A., Turiel,M., Valencia
            Duarte,A.V., Vallada,H., Veenstra-VanderWeele,J., Walitza,S.,
            Wang,Y., Weale,M., Weiss,R., Wendland,J.R., Westenberg,H.G.,
            Shugart,Y.Y., Hounie,A.G., Miguel,E.C., Nicolini,H., Wagner,M.,
            Ruiz-Linares,A., Cath,D.C., McMahon,W., Posthuma,D., Oostra,B.A.,
            Nestadt,G., Rouleau,G.A., Purcell,S., Jenike,M.A., Heutink,P.,
            Hanna,G.L., Conti,D.V., Arnold,P.D., Freimer,N.B., Stewart,S.E.,
            Knowles,J.A., Cox,N.J. and Pauls,D.L.
  TITLE     Cross-disorder genome-wide analyses suggest a complex genetic
            relationship between Tourette's syndrome and OCD
  JOURNAL   Am J Psychiatry 172 (1), 82-93 (2015)
   PUBMED   25158072
REFERENCE   2  (bases 1 to 6840)
  AUTHORS   Xu,W., Wang,S., Chen,Q., Zhang,Y., Ni,P., Wu,X., Zhang,J.,
            Qiang,F., Li,A., Roe,O.D., Xu,S., Wang,M., Zhang,R. and Zhou,J.
  TITLE     TXNL1-XRCC1 pathway regulates cisplatin-induced cell death and
            contributes to resistance in human gastric cancer
  JOURNAL   Cell Death Dis 5 (2), e1055 (2014)
   PUBMED   24525731
  REMARK    GeneRIF: TXNL1-XRCC1 is a novel regulatory pathway that has an
            independent role in cisplatin resistance, indicating a putative
            drug target for reversing cisplatin resistance in gastric cancer.
            GeneRIF: TXNL1 is a novel regulatory molecule that inhibits
            cisplatin resistance in gastric cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6840)
  AUTHORS   Ishii,T., Funato,Y. and Miki,H.
  TITLE     Thioredoxin-related protein 32 (TRP32) specifically reduces
            oxidized phosphatase of regenerating liver (PRL)
  JOURNAL   J Biol Chem 288 (10), 7263-7270 (2013)
   PUBMED   23362275
  REMARK    GeneRIF: Results suggest that TRP32 maintains the reduced state of
            PRL and thus regulates the biological function of PRL.
REFERENCE   4  (bases 1 to 6840)
  AUTHORS   Gemoll,T., Roblick,U.J., Szymczak,S., Braunschweig,T., Becker,S.,
            Igl,B.W., Bruch,H.P., Ziegler,A., Hellman,U., Difilippantonio,M.J.,
            Ried,T., Jornvall,H., Auer,G. and Habermann,J.K.
  TITLE     HDAC2 and TXNL1 distinguish aneuploid from diploid colorectal
            cancers
  JOURNAL   Cell Mol Life Sci 68 (19), 3261-3274 (2011)
   PUBMED   21290163
  REMARK    GeneRIF: Distinct protein expression patterns, affecting TXNL1 and
            HDAC2, distinguish aneuploid with poor prognosis from diploid
            colorectal cancers.
REFERENCE   5  (bases 1 to 6840)
  AUTHORS   Goroncy,A.K., Koshiba,S., Tochio,N., Tomizawa,T., Inoue,M.,
            Tanaka,A., Sugano,S., Kigawa,T. and Yokoyama,S.
  TITLE     Solution structure of the C-terminal DUF1000 domain of the human
            thioredoxin-like 1 protein
  JOURNAL   Proteins 78 (9), 2176-2180 (2010)
   PUBMED   20455272
  REMARK    GeneRIF: Solution structure of the C-terminal DUF1000 domain of the
            human thioredoxin-like 1 protein.
REFERENCE   6  (bases 1 to 6840)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   7  (bases 1 to 6840)
  AUTHORS   Jin,J., Chen,X., Zhou,Y., Bartlam,M., Guo,Q., Liu,Y., Sun,Y.,
            Gao,Y., Ye,S., Li,G., Rao,Z., Qiang,B. and Yuan,J.
  TITLE     Crystal structure of the catalytic domain of a human
            thioredoxin-like protein
  JOURNAL   Eur J Biochem 269 (8), 2060-2068 (2002)
   PUBMED   11985582
REFERENCE   8  (bases 1 to 6840)
  AUTHORS   Miranda-Vizuete,A. and Spyrou,G.
  TITLE     Genomic structure and chromosomal localization of human
            thioredoxin-like protein gene (txl)
  JOURNAL   DNA Seq 10 (6), 419-424 (2000)
   PUBMED   10826702
REFERENCE   9  (bases 1 to 6840)
  AUTHORS   Lee,K.K., Murakawa,M., Takahashi,S., Tsubuki,S., Kawashima,S.,
            Sakamaki,K. and Yonehara,S.
  TITLE     Purification, molecular cloning, and characterization of TRP32, a
            novel thioredoxin-related mammalian protein of 32 kDa
  JOURNAL   J Biol Chem 273 (30), 19160-19166 (1998)
   PUBMED   9668102
  REMARK    Erratum:[J Biol Chem 1998 Oct 16;273(42):27755]
REFERENCE   10 (bases 1 to 6840)
  AUTHORS   Miranda-Vizuete,A., Gustafsson,J.A. and Spyrou,G.
  TITLE     Molecular cloning and expression of a cDNA encoding a human
            thioredoxin-like protein
  JOURNAL   Biochem Biophys Res Commun 243 (1), 284-288 (1998)
   PUBMED   9473519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV750604.1, AF003938.1 and AC007052.4.
            
            On Nov 22, 2018 this sequence version replaced NM_004786.2.
            
            Transcript Variant: This variant (1) represents the protein coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.292281.1,
                                           SRR1660809.120908.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217515.11/ ENSP00000217515.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AV750604.1         98-370
            274-1227            AF003938.1         327-1280
            1228-6840           AC007052.4         77370-82982         c
FEATURES             Location/Qualifiers
     source          1..6840
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.31"
     gene            1..6840
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /note="thioredoxin like 1"
                     /db_xref="GeneID:9352"
                     /db_xref="HGNC:HGNC:12436"
                     /db_xref="MIM:603049"
     exon            1..250
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1022
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /note="thioredoxin-related 32 kDa protein;
                     thioredoxin-related protein 1; 32 kDa thioredoxin-related
                     protein; epididymis secretory protein Li 114"
                     /codon_start=1
                     /product="thioredoxin-like protein 1"
                     /protein_id="NP_004777.1"
                     /db_xref="CCDS:CCDS11961.1"
                     /db_xref="GeneID:9352"
                     /db_xref="HGNC:HGNC:12436"
                     /db_xref="MIM:603049"
                     /translation="MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAF
                     SSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEK
                     IKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLESD
                     CDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQAL
                     ELTEDDIKEDGIVPLRYVKFQNVNSVTIFVQSNQGEEETTRISYFTFIGTPVQATNMN
                     DFKRVVGKKGESH"
     exon            251..347
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /inference="alignment:Splign:2.1.0"
     exon            348..521
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /inference="alignment:Splign:2.1.0"
     exon            522..644
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /inference="alignment:Splign:2.1.0"
     exon            645..714
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /inference="alignment:Splign:2.1.0"
     exon            715..887
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /inference="alignment:Splign:2.1.0"
     exon            888..992
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /inference="alignment:Splign:2.1.0"
     exon            993..6840
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1128..1133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /note="hexamer: AATAAA"
     polyA_site      1149
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
     regulatory      1198..1203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /note="hexamer: AATAAA"
     polyA_site      1227
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /note="major polyA site"
     regulatory      4948..4953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /note="hexamer: ATTAAA"
     polyA_site      4978
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
     regulatory      6820..6825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
                     /note="hexamer: ATTAAA"
     polyA_site      6840
                     /gene="TXNL1"
                     /gene_synonym="HEL-S-114; TRP32; Txl; TXL-1; TXNL"
ORIGIN      
        1 actgagagtc ccgggagaag actcggcggt cgccacctct tctgtccagg cctcggcctt
       61 cctgagcatc tctccttcct ctcccagatc gtcttctcct tcagtttcaa agccagtggc
      121 gtcgcggcca ccctgccggg ctctctgtga ggatggtggg ggtgaagccc gtcgggagcg
      181 acccggattt ccagccagag ctgagcggcg cgggctccag actcgccgtg gtcaagttca
      241 ccatgagagg gtgtgggcca tgtttgagga ttgccccagc attcagttct atgagtaata
      301 aatatccaca ggctgttttc ttggaagtcg atgtacatca gtgtcaggga acagctgcca
      361 ccaacaatat atcagcaaca cctacatttt tgttttttcg aaacaaagtg agaattgatc
      421 aatatcaagg agcagatgct gtgggattag aagaaaaaat caagcagcac ttagaaaatg
      481 accctggaag caatgaggac acagatattc caaaaggcta tatggattta atgcctttta
      541 ttaacaaagc tggttgtgaa tgtcttaatg aaagtgatga gcatggattt gacaactgtt
      601 tacgaaaaga cacaaccttc ttggaatctg actgtgatga acagctgctt attactgtgg
      661 cattcaatca acctgttaag ctttattcca tgaaatttca agggccagat aatggtcagg
      721 gccctaaata tgtaaaaatt tttatcaacc taccccgatc tatggatttt gaagaggcag
      781 aaagaagtga accaactcaa gctctggaac tgacagagga tgatattaaa gaagatggca
      841 ttgttccact tcgttatgtt aagtttcaga atgttaacag tgtaactata tttgttcagt
      901 cgaatcaagg tgaagaggaa acaacaagaa tttcatattt tacttttatt ggtactccag
      961 tccaggcaac aaatatgaat gacttcaaac gagtagttgg caaaaaagga gaaagccact
     1021 aaggtacaaa agacactgga caaccatatt gcaatcagat ctacagctcc tggataattg
     1081 cttgattctc gccagagact gtcaatgttt cattcattgc cattaccaat aaatcattgc
     1141 ttttgttcag atggtatcac tagtgtttcc attgtaatct tgacacatgc aattgtaaat
     1201 aaaagtcacc acttttgcca agcttaattt ttgtctttct aaatcagtat tttctctttc
     1261 catgtatttg aaaactggtt aacttctgat tttagtagag acttaagtgt ctggtagtat
     1321 attgattgaa agccagtttc tttagaaaag gagaaactgt tctagggaat taagaagtac
     1381 atgtgtacac attcatggca agttattttg ataagtgaac ctggaacagc taaccatgtt
     1441 aaattattac tgcattttta ttaaaggaca tttgtatatc tgagctatgg aaattactca
     1501 aattataaat tagaagaaat aaacaggttt aatgagattt agctactctt acctaaaact
     1561 tagctaatgg gtccacagat tctttcttgg tatatatcaa gattttaatc tcttctggta
     1621 aactttaaaa tttgagtcag cctttttttt tttttttttt tttttaacta atagaagaat
     1681 gtggaaatca gacagttggg gaaaaaatac agcatagtga attcagaaaa caggaattgg
     1741 ccaggtgtgg tggctaatgt ctgtaatccc agtactttgg gaggccaagg cgggcgaatc
     1801 accagaggtc aggagttcga gtccagcttg gccaacatgg tgaaacctcg tctctactaa
     1861 aaatacaaaa attagccagg catggtggcg ggtgtctgta atcccagcta cttgggaggc
     1921 tgagacagaa gaatcggctg aacccgggag gcagaggttg cagtgagctg agattgcgcc
     1981 attgcgcccc agcctgagcg acaagagcaa aactccgtct ccaaaaaaaa aagggaatta
     2041 ttacccttaa tcaagtattt attacctgaa ctaccaaaac gtgcagtgta aatatacaga
     2101 gaacatgatt taaggttgaa aatgaggtgc tcaaatagaa atgtttaaaa ggtctttcac
     2161 aaaaggctgg taaaatacct attcgttacc ttttttatct taaaattgta atctaaaaag
     2221 tattggtagt tttaatttta aaatttctga gtattttgaa aactattttt aaagagtaca
     2281 taagactgta aaattgtgat tcagttaaac atttgagggc attcttgtct aggaatatgg
     2341 tagagatacc atttgccttt gtgagagcag tgtgtttata cttgtttatg aaaaaattct
     2401 acagaagttt tagtgttgaa agagtccctt tctgaaaccc aagtgtcatt agatagttta
     2461 gttcatttgt atatgggcac attaactggt ctgtgatgat cttaacactc cttaaataga
     2521 ccatctcaga ttaatcacat ctgaaattaa ggataagatt aatatgcagg gttttggttt
     2581 acagttttgt acacttaacc tttctgagta attgttaaag tgcctcatcc taagtattgc
     2641 tgaccttttc ctatttatac ttgatagttt gaaaacccag tgaaacaaat ttcgtatttg
     2701 taaaggattg gacatcagat ttatattgtc tatgtgactc ttctataaca attagttgca
     2761 gtatgcaagt attacataat tcaaattgta aatagtgaaa aatgaacgtt tataggtaac
     2821 tataacgttt cacttaatgg gaaatcttac tattataaat gtgcataatt ggcatttaaa
     2881 atatcaaact gaaatgctgt tttctcctaa aacagtatat atatatacac acatatgtat
     2941 atgtaacatt tatatataac actgaatttt ccagatgaat aagagcattt gaaaaaatgt
     3001 aactctagtt attttaactg aagttattta ttagtgcatc tagaaaactg gtattcagtt
     3061 tcttgttcat tttgtcggac atagcaaaaa agaatttcat gatctctgta ttttgataca
     3121 ttgacatcag gtgcttttga tgagaaacaa cagtgaaata tcgtgttcat aatagaaacg
     3181 aaagtcaggt attgcagtag gaagtctttg tcagcttaat gctgaagcca agagtagcac
     3241 aaggtaccac attcttgtgc ccacgacagg cttttataat ccttctgagt tctctttgac
     3301 atcaagcccc acgttgttcc ccagtctcaa tattctgttg gaggcagcca cgtaacaatt
     3361 agagttgaaa cctgccccac gttgttcccc agtctcaata tactgttgga ggcagccacg
     3421 taacaattag agttgaaacc tgccccacgt tgttccccag tctcaatata ctgttggagg
     3481 cagccacata acaattagag ttgaaacctg ccccacgttg ttccccagtc tcaatattct
     3541 gttggaggca gccacgtaac aattagagtt gaaacctgcc ccacattgtt ccccagtctc
     3601 aatattctgt tggaggcagc cacgtaacaa ttagagttga aacctgcccc actttgttcc
     3661 ccagtctcaa tattctgttg gaggcagcca cgtaacaatt agagttgaaa cctgccccac
     3721 attgttcccc agtctcaata ttctgttgga ggcagccact taacaattag agttgaaacc
     3781 tgtctgccat cctttgtctc aatgtttgag gatgtatgca gtgtttttgg cagcgattat
     3841 aggaatgcag ttgtttattt ggcctcagca gtttatttat ggctgcaatt aatatccctg
     3901 atcatgggct tttaaaccta aaatagttca gatcctccct tgttcctctt aatgtctaaa
     3961 agctttgatt ctgtaataag aataaagtgt tggagttgaa taaattagtt acaccctttg
     4021 taagctttaa aaacatgaaa tttaaggctt actcatgttg cttgtattga tactcatata
     4081 gttcaattta gtaggttaat ttttgtgtta ggtatatctc ttctggaact gataatttgt
     4141 aatcttagac tatttttttt ttaagataag taacttagag taagaaatcc agctgggaac
     4201 agtggctcat gcctgtaatc ccagcatttt gggaggccga ggcggctgga tcacttgagg
     4261 tcaggagttt gagaccagcc tggctaacat ggagaaaccc tgtctctact aaaaatacaa
     4321 aaaattagcc aggcatggtg gcaggtgcca cacccagcta cttgggaggc tgaggcagta
     4381 gaatcgcttg aacccgggag gcggaggttg cagtgagcca agatcgcatg actgcacact
     4441 agcccgggca acagagtgag actgtctcaa aagaaaaaaa aaaaaaatcc attcacagaa
     4501 ctgctaaaga aaaactagag gaatattttg ctcatttagc tttaaaactc attattagag
     4561 gtgtgtattt tacagttttg taaatataga ttatgcttta taatacacat aaagcaagta
     4621 tatataacat gcatatagta aataaatttt aaaatattga ctattcccca gttaagccta
     4681 tacttcttaa ggaagactac tgatgtcatt ttaagcatgt ttcaaaattc aagttttatt
     4741 tttgatcaat aaggtttttt ttttttttta acatgctcag cactatagga ataagaggac
     4801 agtggagatt tgtaggctaa taagatcgct tttaaacttt gtggtccatg taaaattatt
     4861 agttggagaa tgtgtaatta gagaactata agataaagag ataaccttta gaatttgaat
     4921 gtactaaaat tgtacacagc ttggaatatt aaaatcttaa ggatatgcaa tgttaaaact
     4981 gctagagtat ttttccttcg tgcttgctat gcttctctat gggaagagga attttatttt
     5041 ggaattattt ctaagttgaa cagaccagaa ttaattgtga aaacatgatc tgttggttta
     5101 taattggaca cgcatttgga gatactggct catcatacta cctaggagca aaatctctga
     5161 agtttgaatc cctgctcttc cacttgttag ctgtgtcatc ttgagcaagt aacatccttc
     5221 agagctcaaa tttcttcttg tgtaaaaata ggaacatcta tctcttagac ttgttctgaa
     5281 gatgcgcctt actttgtatc tggaacaagg ataagtatct tctgtatcct gctctcagct
     5341 gtcactgctt tttaggccat cattacttgc ttggcatact gcagtgcctc ctaattgtct
     5401 ctttgtttct gctctggcct ctctcatgta tcccccacat ggccgctggt tctcttttct
     5461 ttatggggtc tttgtaatgt aatctctcct cctctagcct ccccatgccc ctcatttctc
     5521 cagtgtgctg tgctgtatta ccaggtagca gaacgtaccc taatatcgca tgccttcctc
     5581 tgacctaact tttccatctg accaattcct acttatctac aaggctcagt ccaaggaaaa
     5641 ctgataccgg gaataatcat aacaattgtg cacgcctcct cagctgctat gacaccttgc
     5701 cattatttca tccggatact tatcaagcta cttgtaatga tctgtagtct tatttggact
     5761 actagattgt gagctgtaat acaagtattt tgtctctagt attaagccag tttatttggt
     5821 ttctatcatt aaatacaatg ttgaaaaaat tctcagggtc caaggggaga tgcttgggtt
     5881 gagtcagaga taaagtagga atatgcagtt gaggaaggta aggaagataa tttagctgaa
     5941 gtaaaggaaa agtgcatagt gtgttcatag agtgggagtt aagtgtaaga gacattctag
     6001 ggaagtgaag gagaagctga aagagcaagt agagacggta aggtgaagct cctcttgcca
     6061 tgtgaaagag atcaaacttt ctccttaatt tatgggagga gcgagcatag agaagtctgt
     6121 gatgtctcac aaggttctca cttttacaat tgaatataga agtagctctt aggagaagca
     6181 gaacgttcag aggggaagat gaatatggtt ttgggtacat tgccttaaat tgcatttttg
     6241 gtatttgggt ggcgatgtct agtaagtaaa aagccaggaa tgtgatttta gagcttagag
     6301 ctagaagcaa ggaactagga gttgtttaga tgatgaaaac tgaaatatgt atatgaatgg
     6361 gaatttttag aatataaagg gagagaatga aactaaggag caaatgttag ggaatcctaa
     6421 gaaatattaa agaattggga aaagaggaac ctggaaggta gagtagtaaa caggaaaggg
     6481 aggaaaaaca ggaggtggta ataaagtagt gttaatgaat ccaagaggga gcagtcacca
     6541 tcttcaaatg tgatattgaa attagctggg atgtccagtt gtttaatcca ttaaattgtg
     6601 gaaacagtct ttctagtgct taattatagg aatcattgat catattaata aactttcagt
     6661 tgaagcatca gcagataatt attccaaaac cctctggcaa agaaatgtag atgcttttat
     6721 agtctaccat tgaacacagt tttacatgac acttggcaaa acttggagat ggatggcact
     6781 attttgtaag agaatatgaa acactgcttt gaagttgtca ttaaaggatc ttatcaggtg
//
