LOCUS       NM_006472               2905 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens thioredoxin interacting protein (TXNIP), transcript
            variant 1, mRNA.
ACCESSION   NM_006472
VERSION     NM_006472.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2905)
  AUTHORS   Du,Y., Wu,M., Song,S., Bian,Y. and Shi,Y.
  TITLE     TXNIP deficiency attenuates renal fibrosis by modulating
            mTORC1/TFEB-mediated autophagy in diabetic kidney disease
  JOURNAL   Ren Fail 46 (1), 2338933 (2024)
   PUBMED   38616177
  REMARK    GeneRIF: TXNIP deficiency attenuates renal fibrosis by modulating
            mTORC1/TFEB-mediated autophagy in diabetic kidney disease.
REFERENCE   2  (bases 1 to 2905)
  AUTHORS   Jolibois,J., Domingues,A., El Hamaoui,D., Awaida,R.,
            Berger-de-Gaillardo,M., Guerin,D., Smadja,D.M., Marquet-DeRouge,P.,
            Margaill,I., Rossi,E. and Nivet-Antoine,V.
  TITLE     Targeting TXNIP in endothelial progenitors mitigates IL-8-induced
            neutrophil recruitment under metabolic stress
  JOURNAL   Stem Cell Res Ther 15 (1), 225 (2024)
   PUBMED   39075518
  REMARK    GeneRIF: Targeting TXNIP in endothelial progenitors mitigates
            IL-8-induced neutrophil recruitment under metabolic stress.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2905)
  AUTHORS   Beothe,T., Docs,J., Kovacs,G. and Peterfi,L.
  TITLE     Increased level of TXNIP and nuclear translocation of TXN is
            associated with end stage renal disease and development of
            multiplex renal tumours
  JOURNAL   BMC Nephrol 25 (1), 227 (2024)
   PUBMED   39020292
  REMARK    GeneRIF: Increased level of TXNIP and nuclear translocation of TXN
            is associated with end stage renal disease and development of
            multiplex renal tumours.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2905)
  AUTHORS   Zhou,W., Zhu,C. and Zhou,F.
  TITLE     TXNIP mediated by EZH2 regulated osteogenic differentiation in
            hBmscs and MC3T3-E1 cells through the modulation of oxidative
            stress and PI3K/AKT/Nrf2 pathway
  JOURNAL   Connect Tissue Res 65 (4), 293-303 (2024)
   PUBMED   38884152
  REMARK    GeneRIF: TXNIP mediated by EZH2 regulated osteogenic
            differentiation in hBmscs and MC3T3-E1 cells through the modulation
            of oxidative stress and PI3K/AKT/Nrf2 pathway.
REFERENCE   5  (bases 1 to 2905)
  AUTHORS   Lee,S., Min Kim,S., Dotimas,J., Li,L., Feener,E.P., Baldus,S.,
            Myers,R.B., Chutkow,W.A., Patwari,P., Yoshioka,J. and Lee,R.T.
  TITLE     Thioredoxin-interacting protein regulates protein disulfide
            isomerases and endoplasmic reticulum stress
  JOURNAL   EMBO Mol Med 6 (6), 732-743 (2014)
   PUBMED   24843047
  REMARK    GeneRIF: Txnip is located in the endoplasmic reticulum and
            interacts with endogenous PDIA6. Txnip increases PDI activity.
REFERENCE   6  (bases 1 to 2905)
  AUTHORS   Ludwig,D.L., Kotanides,H., Le,T., Chavkin,D., Bohlen,P. and
            Witte,L.
  TITLE     Cloning, genetic characterization, and chromosomal mapping of the
            mouse VDUP1 gene
  JOURNAL   Gene 269 (1-2), 103-112 (2001)
   PUBMED   11376942
REFERENCE   7  (bases 1 to 2905)
  AUTHORS   Yamanaka,H., Maehira,F., Oshiro,M., Asato,T., Yanagawa,Y., Takei,H.
            and Nakashima,Y.
  TITLE     A possible interaction of thioredoxin with VDUP1 in HeLa cells
            detected in a yeast two-hybrid system
  JOURNAL   Biochem Biophys Res Commun 271 (3), 796-800 (2000)
   PUBMED   10814541
REFERENCE   8  (bases 1 to 2905)
  AUTHORS   Nishiyama,A., Matsui,M., Iwata,S., Hirota,K., Masutani,H.,
            Nakamura,H., Takagi,Y., Sono,H., Gon,Y. and Yodoi,J.
  TITLE     Identification of thioredoxin-binding protein-2/vitamin D(3)
            up-regulated protein 1 as a negative regulator of thioredoxin
            function and expression
  JOURNAL   J Biol Chem 274 (31), 21645-21650 (1999)
   PUBMED   10419473
REFERENCE   9  (bases 1 to 2905)
  AUTHORS   Bennett,R.A., Wilson,D.M. 3rd, Wong,D. and Demple,B.
  TITLE     Interaction of human apurinic endonuclease and DNA polymerase beta
            in the base excision repair pathway
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7166-7169 (1997)
   PUBMED   9207062
REFERENCE   10 (bases 1 to 2905)
  AUTHORS   Chen,K.S. and DeLuca,H.F.
  TITLE     Isolation and characterization of a novel cDNA from HL-60 cells
            treated with 1,25-dihydroxyvitamin D-3
  JOURNAL   Biochim Biophys Acta 1219 (1), 26-32 (1994)
   PUBMED   8086474
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC243547.1, BC093704.1 and
            BQ030003.1.
            
            On May 17, 2019 this sequence version replaced NM_006472.5.
            
            Summary: This gene encodes a thioredoxin-binding protein that is a
            member of the alpha arrestin protein family. Thioredoxin is a
            thiol-oxidoreductase that is a major regulator of cellular redox
            signaling which protects cells from oxidative stress. This protein
            inhibits the antioxidative function of thioredoxin resulting in the
            accumulation of reactive oxygen species and cellular stress. This
            protein also functions as a regulator of cellular metabolism and of
            endoplasmic reticulum (ER) stress. This protein may also function
            as a tumor suppressor. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.262530.1,
                                           SRR1803611.206713.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000582401.6/ ENSP00000462521.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC243547.1         38641-38879
            240-1510            BC093704.1         1-1271
            1511-2491           AC243547.1         41391-42371
            2492-2905           BQ030003.1         27-440              c
FEATURES             Location/Qualifiers
     source          1..2905
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.1"
     gene            1..2905
                     /gene="TXNIP"
                     /gene_synonym="ARRDC6; EST01027; HHCPA78; THIF; VDUP1"
                     /note="thioredoxin interacting protein"
                     /db_xref="GeneID:10628"
                     /db_xref="HGNC:HGNC:16952"
                     /db_xref="MIM:606599"
     exon            1..563
                     /gene="TXNIP"
                     /gene_synonym="ARRDC6; EST01027; HHCPA78; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1489
                     /gene="TXNIP"
                     /gene_synonym="ARRDC6; EST01027; HHCPA78; THIF; VDUP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     upregulated by 1,25-dihydroxyvitamin D-3; thioredoxin
                     binding protein 2; vitamin D3 up-regulated protein 1"
                     /codon_start=1
                     /product="thioredoxin-interacting protein isoform 1"
                     /protein_id="NP_006463.3"
                     /db_xref="CCDS:CCDS72876.1"
                     /db_xref="GeneID:10628"
                     /db_xref="HGNC:HGNC:16952"
                     /db_xref="MIM:606599"
                     /translation="MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAV
                     RILACGVAKVLWMQGSQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFG
                     FELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPV
                     SAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVAR
                     HTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSL
                     LIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCY
                     MDVIPEDHRLESPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ"
     exon            564..636
                     /gene="TXNIP"
                     /gene_synonym="ARRDC6; EST01027; HHCPA78; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..784
                     /gene="TXNIP"
                     /gene_synonym="ARRDC6; EST01027; HHCPA78; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..887
                     /gene="TXNIP"
                     /gene_synonym="ARRDC6; EST01027; HHCPA78; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1144
                     /gene="TXNIP"
                     /gene_synonym="ARRDC6; EST01027; HHCPA78; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1301
                     /gene="TXNIP"
                     /gene_synonym="ARRDC6; EST01027; HHCPA78; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1453
                     /gene="TXNIP"
                     /gene_synonym="ARRDC6; EST01027; HHCPA78; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..2905
                     /gene="TXNIP"
                     /gene_synonym="ARRDC6; EST01027; HHCPA78; THIF; VDUP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1917..1922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNIP"
                     /gene_synonym="ARRDC6; EST01027; HHCPA78; THIF; VDUP1"
                     /note="hexamer: AACAAA"
     polyA_site      1929
                     /gene="TXNIP"
                     /gene_synonym="ARRDC6; EST01027; HHCPA78; THIF; VDUP1"
     polyA_site      1937
                     /gene="TXNIP"
                     /gene_synonym="ARRDC6; EST01027; HHCPA78; THIF; VDUP1"
                     /note="major polyA site"
ORIGIN      
        1 aaactaaccc ctctttttct ccaaaggagt gcttgtggag atcggatctt ttctccagca
       61 attgggggaa agaaggcttt ttctctgaat tagcttagtg taaccagcgg cgtatatttt
      121 ttaggcgcct tttcgaaaac ctagtagtta atattcattt gtttaaatct tattttattt
      181 ttaagctcaa actgcttaag aataccttaa ttccttaaag tgaaataatt ttttgcaaag
      241 gggtttcctc gatttggagc tttttttttc ttccaccgtc atttctaact cttaaaacca
      301 actcagttcc atcatggtga tgttcaagaa gatcaagtct tttgaggtgg tctttaacga
      361 ccctgaaaag gtgtacggca gtggcgagaa ggtggctggc cgggtgatag tggaggtgtg
      421 tgaagttact cgtgtcaaag ccgttaggat cctggcttgc ggagtggcta aagtgctttg
      481 gatgcaggga tcccagcagt gcaaacagac ttcggagtac ctgcgctatg aagacacgct
      541 tcttctggaa gaccagccaa caggtgagaa tgagatggtg atcatgagac ctggaaacaa
      601 atatgagtac aagttcggct ttgagcttcc tcaggggcct ctgggaacat ccttcaaagg
      661 aaaatatggg tgtgtagact actgggtgaa ggcttttctt gaccgcccga gccagccaac
      721 tcaagagaca aagaaaaact ttgaagtagt ggatctggtg gatgtcaata cccctgattt
      781 aatggcacct gtgtctgcta aaaaagaaaa gaaagtttcc tgcatgttca ttcctgatgg
      841 gcgggtgtct gtctctgctc gaattgacag aaaaggattc tgtgaaggtg atgagatttc
      901 catccatgct gactttgaga atacatgttc ccgaattgtg gtccccaaag ctgccattgt
      961 ggcccgccac acttaccttg ccaatggcca gaccaaggtg ctgactcaga agttgtcatc
     1021 agtcagaggc aatcatatta tctcagggac atgcgcatca tggcgtggca agagccttcg
     1081 ggttcagaag atcaggcctt ctatcctggg ctgcaacatc cttcgagttg aatattcctt
     1141 actgatctat gttagcgttc ctggatccaa gaaggtcatc cttgacctgc ccctggtaat
     1201 tggcagcaga tcaggtctaa gcagcagaac atccagcatg gccagccgaa ccagctctga
     1261 gatgagttgg gtagatctga acatccctga taccccagaa gctcctccct gctatatgga
     1321 tgtcattcct gaagatcacc gattggagag cccaaccact cctctgctag atgacatgga
     1381 tggctctcaa gacagcccta tctttatgta tgcccctgag ttcaagttca tgccaccacc
     1441 gacttatact gaggtggatc cctgcatcct caacaacaat gtgcagtgag catgtggaag
     1501 aaaagaagca gctttaccta cttgtttctt tttgtctctc ttcctggaca ctcacttttt
     1561 cagagactca acagtctctg caatggagtg tgggtccacc ttagcctctg acttcctaat
     1621 gtaggaggtg gtcagcaggc aatctcctgg gccttaaagg atgcggactc atcctcagcc
     1681 agcgcccatg ttgtgataca ggggtgtttg ttggatgggt ttaaaaataa ctagaaaaac
     1741 tcaggcccat ccattttctc agatctcctt gaaaattgag gccttttcga tagtttcggg
     1801 tcaggtaaaa atggcctcct ggcgtaagct tttcaaggtt ttttggaggc tttttgtaaa
     1861 ttgtgatagg aactttggac cttgaactta cgtatcatgt ggagaagagc caatttaaca
     1921 aactaggaag atgaaaaggg aaattgtggc caaaactttg ggaaaaggag gttcttaaaa
     1981 tcagtgtttc ccctttgtgc acttgtagaa aaaaaagaaa aaccttctag agctgatttg
     2041 atggacaatg gagagagctt tccctgtgat tataaaaaag gaagctagct gctctacggt
     2101 catctttgct tagagtatac tttaacctgg cttttaaagc agtagtaact gccccaccaa
     2161 aggtcttaaa agccattttt ggagcctatt gcactgtgtt ctcctactgc aaatattttc
     2221 atatgggagg atggttttct cttcatgtaa gtccttggaa ttgattctaa ggtgatgttc
     2281 ttagcacttt aattcctgtc aaattttttg ttctcccctt ctgccatctt aaatgtaagc
     2341 tgaaactggt ctactgtgtc tctagggtta agccaaaaga caaaaaaaat tttactactt
     2401 ttgagattgc cccaatgtac agaattatat aattctaacg cttaaatcat gtgaaagggt
     2461 tgctgctgtc agccttgccc actgtgactt caaacccaag gaggaactct tgatcaagat
     2521 gcccaaccct gtgatcagaa cctccaaata ctgccatgag aaactagagg gcaggtcttc
     2581 ataaaagccc tttgaacccc cttcctgccc tgtgttagga gatagggata ttggcccctc
     2641 actgcagctg ccagcacttg gtcagtcact ctcagccata gcactttgtt cactgtcctg
     2701 tgtcagagca ctgagctcca cccttttctg agagttatta cagccagaaa gtgtgggctg
     2761 aagatggttg gtttcatgtt tttgtattat gtatcttttt gtatggtaaa gactatattt
     2821 tgtacttaac cagatatatt tttaccccag atggggatat tctttgtaaa aaatgaaaat
     2881 aaagtttttt taatggaaaa aaaaa
//
