LOCUS       NM_005783               1508 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens thioredoxin domain containing 9 (TXNDC9), mRNA.
ACCESSION   NM_005783
VERSION     NM_005783.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1508)
  AUTHORS   Xiao,Z., Xu,Q., Wang,H., Zhou,X., Zhu,Y., Bao,C., Chen,L.,
            Zhang,P., Lin,M., Ji,C. and Gong,T.
  TITLE     Thioredoxin domain-containing protein 9 protects cells against
            UV-B-provoked apoptosis via NF-kappaB/p65 activation in cutaneous
            squamous cell carcinoma
  JOURNAL   Oncol Res 31 (1), 71-82 (2023)
   PUBMED   37303736
  REMARK    GeneRIF: Thioredoxin domain-containing protein 9 protects cells
            against UV-B-provoked apoptosis via NF-kappaB/p65 activation in
            cutaneous squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1508)
  AUTHORS   Wang,J., Pan,X., Li,J. and Zhao,J.
  TITLE     TXNDC9 knockdown inhibits lung adenocarcinoma progression by
            targeting YWHAG
  JOURNAL   Mol Med Rep 25 (6) (2022)
   PUBMED   35485284
  REMARK    GeneRIF: TXNDC9 knockdown inhibits lung adenocarcinoma progression
            by targeting YWHAG.
REFERENCE   3  (bases 1 to 1508)
  AUTHORS   Yang,Q.C., Hao,N., Li,R.H., Duan,Y.Y. and Zhang,Y.
  TITLE     High level of TXNDC9 predicts poor prognosis and contributes to the
            NF-kappaB-regulated metastatic potential in gastric cancer
  JOURNAL   Neoplasma 69 (1), 103-112 (2022)
   PUBMED   34846159
  REMARK    GeneRIF: High level of TXNDC9 predicts poor prognosis and
            contributes to the NF-kappaB-regulated metastatic potential in
            gastric cancer.
REFERENCE   4  (bases 1 to 1508)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1508)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1508)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1508)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   8  (bases 1 to 1508)
  AUTHORS   Stirling,P.C., Cuellar,J., Alfaro,G.A., El Khadali,F., Beh,C.T.,
            Valpuesta,J.M., Melki,R. and Leroux,M.R.
  TITLE     PhLP3 modulates CCT-mediated actin and tubulin folding via ternary
            complexes with substrates
  JOURNAL   J Biol Chem 281 (11), 7012-7021 (2006)
   PUBMED   16415341
  REMARK    GeneRIF: antagonistic actions of PhLP3 and prefoldin serve to
            modulate CCT activity and play a key role in establishing a
            functional cytoskeleton in vivo
REFERENCE   9  (bases 1 to 1508)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   10 (bases 1 to 1508)
  AUTHORS   Ogawa,S., Matsubayashi,Y. and Nishida,E.
  TITLE     An evolutionarily conserved gene required for proper microtubule
            architecture in Caenorhabditis elegans
  JOURNAL   Genes Cells 9 (2), 83-93 (2004)
   PUBMED   15009089
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG772935.1, BC070183.1 and
            AC079447.4.
            
            On Nov 23, 2018 this sequence version replaced NM_005783.3.
            
            Summary: The protein encoded by this gene is a member of the
            thioredoxin family. The exact function of this protein is not known
            but it is associated with cell differentiation. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.535210.1,
                                           SRR1660807.128754.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264255.8/ ENSP00000264255.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               BG772935.1         132-402
            272-1466            BC070183.1         270-1464
            1467-1508           AC079447.4         122356-122397       c
FEATURES             Location/Qualifiers
     source          1..1508
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..1508
                     /gene="TXNDC9"
                     /gene_synonym="APACD; PHLP3"
                     /note="thioredoxin domain containing 9"
                     /db_xref="GeneID:10190"
                     /db_xref="HGNC:HGNC:24110"
                     /db_xref="MIM:612564"
     exon            1..95
                     /gene="TXNDC9"
                     /gene_synonym="APACD; PHLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            96..316
                     /gene="TXNDC9"
                     /gene_synonym="APACD; PHLP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..808
                     /gene="TXNDC9"
                     /gene_synonym="APACD; PHLP3"
                     /note="ATP binding protein associated with cell
                     differentiation; protein 1-4"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 9"
                     /protein_id="NP_005774.2"
                     /db_xref="CCDS:CCDS2044.1"
                     /db_xref="GeneID:10190"
                     /db_xref="HGNC:HGNC:24110"
                     /db_xref="MIM:612564"
                     /translation="MEADASVDMFSKVLEHQLLQTTKLVEEHLDSEIQKLDQMDEDEL
                     ERLKEKRLQALRKAQQQKQEWLSKGHGEYREIPSERDFFQEVKESENVVCHFYRDSTF
                     RCKILDRHLAILSKKHLETKFLKLNVEKAPFLCERLHIKVIPTLALLKDGKTQDYVVG
                     FTDLGNTDDFTTETLEWRLGSSDILNYSGNLMEPPFQNQKKFGTNFTKLEKKTIRGKK
                     YDSDSDDD"
     exon            317..435
                     /gene="TXNDC9"
                     /gene_synonym="APACD; PHLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            436..690
                     /gene="TXNDC9"
                     /gene_synonym="APACD; PHLP3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..1508
                     /gene="TXNDC9"
                     /gene_synonym="APACD; PHLP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1445..1450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC9"
                     /gene_synonym="APACD; PHLP3"
                     /note="hexamer: AATAAA"
     polyA_site      1466
                     /gene="TXNDC9"
                     /gene_synonym="APACD; PHLP3"
                     /note="major polyA site"
     regulatory      1484..1489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC9"
                     /gene_synonym="APACD; PHLP3"
                     /note="hexamer: CATAAA"
     polyA_site      1508
                     /gene="TXNDC9"
                     /gene_synonym="APACD; PHLP3"
ORIGIN      
        1 gcagccgccg gcagctactg caaggcaaaa gccggagtgg acgtgtcttt tgaaactgct
       61 gctctttcac ttctcaggcg tcaccgagag ctcagcaccc aggctgaact ctgtaccatt
      121 tggaagaatg gaagctgatg catctgttga catgttttcc aaagtcctgg agcatcagct
      181 gcttcagact accaaactgg tggaagaaca tttggattct gaaattcaaa aactggatca
      241 gatggatgag gatgaattgg aacgccttaa agaaaagaga ctccaggcac taaggaaagc
      301 tcaacagcag aaacaagaat ggctttctaa aggacatggg gaatacagag aaatccctag
      361 tgaaagagac ttttttcaag aagtcaagga gagtgaaaat gtggtttgcc atttctacag
      421 agactccaca ttcaggtgta aaatactaga cagacatctg gcaatattgt ccaagaaaca
      481 cctcgagacc aaatttttga agctgaatgt ggaaaaagca cctttccttt gtgagagact
      541 gcatatcaaa gtcattccca cactagcact gctaaaagat gggaaaacac aagattatgt
      601 tgttgggttt actgacctag gaaatacaga tgacttcacc acagaaactt tagaatggag
      661 gctcggttct tctgacattc ttaattacag tggaaattta atggagccac catttcagaa
      721 ccaaaagaaa tttggaacaa acttcacaaa gctggaaaag aaaactatcc gaggaaagaa
      781 atatgattca gactctgatg atgattagag ctcaataatt ctttgtaaat tgtctttttt
      841 tttctgcttc agatttaaat gtgtttttaa aattctatta atgtctatac attggtcacc
      901 taaatactca tattctcgag ttttatacag ttgtatcaca tcgaaaagtg tctttactgt
      961 tttctgtgtg gccatcatgt ttaagttgag gaaaactcag ttcttaaatt atctgggaag
     1021 ggtctggatt ctctattttt gagattgact ttatcacaat atgattctta catctttata
     1081 ccatttacaa ttgtgtttta gatctacaga gttagaaatt cgaaaactat tccaggacta
     1141 attcttaatc ggcattattt atacaagagg tcaagtaaca tttactagcg caatactgca
     1201 cttgtaaatg aattataaac gctcttctgg aatatattta aataaccatt aaagaactgc
     1261 ttattcattc tggacactgc atgttgatgt tgaatcaact gatgccagca gaaagctatt
     1321 ttgatttgtg aacatactgc cttatttaaa gggtcctgat tgcttgtatt ttaagacatt
     1381 cattaaaaag aaaccaggaa acacttttga aataacagca taaggaactt cactgtctct
     1441 gctcaataaa atacctgtaa ctggaagttt atgtggaaat tgtcataaaa gcatacatcc
     1501 aacaaaaa
//
