LOCUS       NM_001424031             496 bp    mRNA    linear   PRI 10-APR-2024
DEFINITION  Homo sapiens thioredoxin domain containing 8 (TXNDC8), transcript
            variant 5, mRNA.
ACCESSION   NM_001424031 XM_017014581 XM_054362610
VERSION     NM_001424031.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 496)
  AUTHORS   Ahlering,P., Sutovsky,M., Gliedt,D., Branson,K., Miranda Vizuete,A.
            and Sutovsky,P.
  TITLE     Sperm content of TXNDC8 reflects sperm chromatin structure,
            pregnancy establishment, and incidence of multiple births after ART
  JOURNAL   Syst Biol Reprod Med 66 (5), 311-321 (2020)
   PUBMED   32851881
  REMARK    GeneRIF: Sperm content of TXNDC8 reflects sperm chromatin
            structure, pregnancy establishment, and incidence of multiple
            births after ART.
REFERENCE   2  (bases 1 to 496)
  AUTHORS   Buckman,C., Ozanon,C., Qiu,J., Sutovsky,M., Carafa,J.A., Rawe,V.Y.,
            Manandhar,G., Miranda-Vizuete,A. and Sutovsky,P.
  TITLE     Semen levels of spermatid-specific thioredoxin-3 correlate with
            pregnancy rates in ART couples
  JOURNAL   PLoS One 8 (5), e61000 (2013)
   PUBMED   23734172
  REMARK    GeneRIF: Data indicate that the elevated semen content of
            SPTRX3/TXNDC8 from assisted reproductive therapy (ART) couples
            coincided with reduced incidence of pregnancy by in vitro
            fertilization (IVF) or intracytoplasmic sperm injection (ICSI).
            Erratum:[PLoS One. 2013;8(10).
            doi:10.1371/annotation/5ec7a768-7129-460f-9290-57ae5d631dd9]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 496)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 496)
  AUTHORS   Jimenez,A., Zu,W., Rawe,V.Y., Pelto-Huikko,M., Flickinger,C.J.,
            Sutovsky,P., Gustafsson,J.A., Oko,R. and Miranda-Vizuete,A.
  TITLE     Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi
            apparatus-associated thioredoxin, is a specific marker of aberrant
            spermatogenesis
  JOURNAL   J Biol Chem 279 (33), 34971-34982 (2004)
   PUBMED   15181017
  REMARK    GeneRIF: SPTRX3 is a novel Golgi apparatus-associated thioredoxin,
            and has a role in aberrant spermatogenesis
REFERENCE   5  (bases 1 to 496)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158158.14.
            
            On or before Aug 31, 2023 this sequence version replaced
            XM_017014581.2, XM_054362610.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374511.8/ ENSP00000363635.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AL158158.14        102086-102176       c
            92-196              AL158158.14        98529-98633         c
            197-256             AL158158.14        93545-93604         c
            257-322             AL158158.14        90488-90553         c
            323-388             AL158158.14        68780-68845         c
            389-496             AL158158.14        67789-67896         c
FEATURES             Location/Qualifiers
     source          1..496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..496
                     /gene="TXNDC8"
                     /gene_synonym="bA427L11.2; SPTRX-3; SPTRX3; TRX6"
                     /note="thioredoxin domain containing 8"
                     /db_xref="GeneID:255220"
                     /db_xref="HGNC:HGNC:31454"
                     /db_xref="MIM:617789"
     exon            1..91
                     /gene="TXNDC8"
                     /gene_synonym="bA427L11.2; SPTRX-3; SPTRX3; TRX6"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..451
                     /gene="TXNDC8"
                     /gene_synonym="bA427L11.2; SPTRX-3; SPTRX3; TRX6"
                     /note="isoform e is encoded by transcript variant 5;
                     spermatocyte/spermatid-specific thioredoxin-3;
                     sperm-specific thioredoxin 3; thioredoxin
                     domain-containing protein 8; thioredoxin 6; thioredoxin
                     domain containing 8 (spermatozoa)"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 8 isoform
                     e"
                     /protein_id="NP_001410960.1"
                     /db_xref="GeneID:255220"
                     /db_xref="HGNC:HGNC:31454"
                     /db_xref="MIM:617789"
                     /translation="MVQIIKDTNEFKTFLTAAGHKLAVVQFSSKRCGPCKRMFPVFHA
                     MSVKYQNVFFANVDVNNSPELAETCHIKTIPTFQMFKKSQKVTLFSRIKRIICCYRSG
                     FMSNLIFEFCGADAKKLEAKTQELM"
     exon            92..196
                     /gene="TXNDC8"
                     /gene_synonym="bA427L11.2; SPTRX-3; SPTRX3; TRX6"
                     /inference="alignment:Splign:2.1.0"
     exon            197..256
                     /gene="TXNDC8"
                     /gene_synonym="bA427L11.2; SPTRX-3; SPTRX3; TRX6"
                     /inference="alignment:Splign:2.1.0"
     exon            257..322
                     /gene="TXNDC8"
                     /gene_synonym="bA427L11.2; SPTRX-3; SPTRX3; TRX6"
                     /inference="alignment:Splign:2.1.0"
     exon            323..388
                     /gene="TXNDC8"
                     /gene_synonym="bA427L11.2; SPTRX-3; SPTRX3; TRX6"
                     /inference="alignment:Splign:2.1.0"
     exon            389..496
                     /gene="TXNDC8"
                     /gene_synonym="bA427L11.2; SPTRX-3; SPTRX3; TRX6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      469..474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC8"
                     /gene_synonym="bA427L11.2; SPTRX-3; SPTRX3; TRX6"
                     /note="hexamer: AATACA"
     polyA_site      496
                     /gene="TXNDC8"
                     /gene_synonym="bA427L11.2; SPTRX-3; SPTRX3; TRX6"
                     /note="major polyA site"
ORIGIN      
        1 aggagacagc tacagtgatc caactaaacc aacaggggat tttcatcagc acttccctgg
       61 tgtaatcatg gtacagatta ttaaagacac gaatgaattt aaaacatttt tgacagctgc
      121 cggacacaaa ctcgcagtgg ttcaattttc ttcgaaacgg tgtggtccct gcaaaaggat
      181 gtttcctgtt ttccatgcta tgtctgtgaa ataccaaaat gtattttttg ctaatgtgga
      241 tgtgaacaat tctccggagc tggctgaaac ttgtcacatc aaaacaatac ccacatttca
      301 gatgttcaag aaaagccaga aggtaaccct attctcaaga atcaaaagaa taatttgctg
      361 ttatagaagt ggattcatga gcaacctgat ttttgagttt tgtggagccg atgctaaaaa
      421 attggaagcc aagactcaag aattaatgta agctgatctc caaggcaaaa tacacttgtg
      481 acatttgaaa aggcaa
//
