LOCUS       NM_030810               2938 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens thioredoxin domain containing 5 (TXNDC5), transcript
            variant 1, mRNA.
ACCESSION   NM_030810
VERSION     NM_030810.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2938)
  AUTHORS   Sheng,Y., Deng,Y., Li,X., Ji,P., Sun,X., Liu,B., Zhu,J., Zhao,J.,
            Nan,Y., Zhou,E.-M., Hiscox,J.A., Stewart,J.P., Sun,Y. and Zhao,Q.
  TITLE     Hepatitis E virus ORF3 protein hijacking thioredoxin
            domain-containing protein 5 (TXNDC5) for its stability to promote
            viral particle release
  JOURNAL   J Virol 98 (4), e0164923 (2024)
   PUBMED   38548704
  REMARK    GeneRIF: Hepatitis E virus ORF3 protein hijacking thioredoxin
            domain-containing protein 5 (TXNDC5) for its stability to promote
            viral particle release.
REFERENCE   2  (bases 1 to 2938)
  AUTHORS   Jiao,M., Zhang,Y., Song,X. and Xu,B.
  TITLE     The role and mechanism of TXNDC5 in disease progression
  JOURNAL   Front Immunol 15, 1354952 (2024)
   PUBMED   38629066
  REMARK    GeneRIF: The role and mechanism of TXNDC5 in disease progression.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2938)
  AUTHORS   Kocaturk,B.
  TITLE     Identification of thioredoxin domain containing family members'
            expression pattern and prognostic value in diffuse gliomas via in
            silico analysis
  JOURNAL   Cancer Med 12 (3), 3830-3844 (2023)
   PUBMED   36106447
  REMARK    GeneRIF: Identification of thioredoxin domain containing family
            members' expression pattern and prognostic value in diffuse gliomas
            via in silico analysis.
REFERENCE   4  (bases 1 to 2938)
  AUTHORS   Hung,C.T., Tsai,Y.W., Wu,Y.S., Yeh,C.F. and Yang,K.C.
  TITLE     The novel role of ER protein TXNDC5 in the pathogenesis of organ
            fibrosis: mechanistic insights and therapeutic implications
  JOURNAL   J Biomed Sci 29 (1), 63 (2022)
   PUBMED   36050716
  REMARK    GeneRIF: The novel role of ER protein TXNDC5 in the pathogenesis of
            organ fibrosis: mechanistic insights and therapeutic implications.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2938)
  AUTHORS   Wang,X., Li,H. and Chang,X.
  TITLE     The role and mechanism of TXNDC5 in diseases
  JOURNAL   Eur J Med Res 27 (1), 145 (2022)
   PUBMED   35934705
  REMARK    GeneRIF: The role and mechanism of TXNDC5 in diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2938)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 2938)
  AUTHORS   Wang,Y., Ma,Y., Lu,B., Xu,E., Huang,Q. and Lai,M.
  TITLE     Differential expression of mimecan and thioredoxin
            domain-containing protein 5 in colorectal adenoma and cancer: a
            proteomic study
  JOURNAL   Exp Biol Med (Maywood) 232 (9), 1152-1159 (2007)
   PUBMED   17895523
  REMARK    GeneRIF: upregulation of TXNDC5 are involved in the early
            development of colorectal cancer
REFERENCE   8  (bases 1 to 2938)
  AUTHORS   Nissom,P.M., Lo,S.L., Lo,J.C., Ong,P.F., Lim,J.W., Ou,K.,
            Liang,R.C., Seow,T.K. and Chung,M.C.
  TITLE     Hcc-2, a novel mammalian ER thioredoxin that is differentially
            expressed in hepatocellular carcinoma
  JOURNAL   FEBS Lett 580 (9), 2216-2226 (2006)
   PUBMED   16574106
REFERENCE   9  (bases 1 to 2938)
  AUTHORS   Sullivan,D.C., Huminiecki,L., Moore,J.W., Boyle,J.J., Poulsom,R.,
            Creamer,D., Barker,J. and Bicknell,R.
  TITLE     EndoPDI, a novel protein-disulfide isomerase-like protein that is
            preferentially expressed in endothelial cells acts as a stress
            survival factor
  JOURNAL   J Biol Chem 278 (47), 47079-47088 (2003)
   PUBMED   12963716
  REMARK    GeneRIF: Member of the protein disulphide isomerase family and
            highly expressed in endothelial cells.  Protects endothelial cells
            from apoptosis under hypoxia.
REFERENCE   10 (bases 1 to 2938)
  AUTHORS   Knoblach,B., Keller,B.O., Groenendyk,J., Aldred,S., Zheng,J.,
            Lemire,B.D., Li,L. and Michalak,M.
  TITLE     ERp19 and ERp46, new members of the thioredoxin family of
            endoplasmic reticulum proteins
  JOURNAL   Mol Cell Proteomics 2 (10), 1104-1119 (2003)
   PUBMED   12930873
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358646.1 and BQ181185.1.
            
            On May 17, 2019 this sequence version replaced NM_030810.4.
            
            Summary: This gene encodes a member of the disulfide isomerase
            (PDI) family of endoplasmic reticulum (ER) proteins that catalyze
            protein folding and thiol-disulfide interchange reactions. The
            encoded protein has an N-terminal endoplasmic reticulum (ER)-signal
            sequence, three catalytically active thioredoxin domains and a
            C-terminal ER-retention sequence. Its expression is induced by
            hypoxia and its role may be to protect hypoxic cells from
            apoptosis. Alternative splicing results in multiple transcript
            variants. Read-through transcription also exists between this gene
            and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec
            2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833008.1, DRR138524.360040.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267775, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379757.9/ ENSP00000369081.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2936              AY358646.1         21-2956
            2937-2938           BQ181185.1         22-23               c
FEATURES             Location/Qualifiers
     source          1..2938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p24.3"
     gene            1..2938
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /note="thioredoxin domain containing 5"
                     /db_xref="GeneID:81567"
                     /db_xref="HGNC:HGNC:21073"
                     /db_xref="MIM:616412"
     exon            1..275
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1311
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /EC_number="5.3.4.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; thioredoxin related protein; protein disulfide
                     isomerase family A, member 15; endothelial protein
                     disulphide isomerase; thioredoxin-like protein p46;
                     endoplasmic reticulum protein ERp46; ER protein 46;
                     endoplasmic reticulum resident protein 46; thioredoxin
                     domain containing 5 (endoplasmic reticulum); epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 5 isoform
                     1 precursor"
                     /protein_id="NP_110437.2"
                     /db_xref="CCDS:CCDS4505.1"
                     /db_xref="GeneID:81567"
                     /db_xref="HGNC:HGNC:21073"
                     /db_xref="MIM:616412"
                     /translation="MPARPGRLLPLLARPAALTALLLLLLGHGGGGRWGARAQEAAAA
                     AADGPPAADGEDGQDPHSKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDL
                     GDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTL
                     ENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCG
                     HCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQ
                     YKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDD
                     TIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYS
                     VRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQAKDEL"
     exon            276..425
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /inference="alignment:Splign:2.1.0"
     exon            426..531
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /inference="alignment:Splign:2.1.0"
     exon            532..628
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /inference="alignment:Splign:2.1.0"
     exon            629..744
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /inference="alignment:Splign:2.1.0"
     exon            745..831
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /inference="alignment:Splign:2.1.0"
     exon            832..975
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1058
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1188
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..2938
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2917..2922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /note="hexamer: AATAAA"
     polyA_site      2938
                     /gene="TXNDC5"
                     /gene_synonym="ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8;
                     UNQ364"
                     /note="major polyA site"
ORIGIN      
        1 agccccgccg cgatgcccgc gcgcccagga cgcctcctcc cgctgctggc ccggccggcg
       61 gccctgactg cgctgctgct gctgctgctg ggccatggcg gcggcgggcg ctggggcgcc
      121 cgggcccagg aggcggcggc ggcggcggcg gacgggcccc ccgcggcaga cggcgaggac
      181 ggacaggacc cgcacagcaa gcacctgtac acggccgaca tgttcacgca cgggatccag
      241 agcgccgcgc acttcgtcat gttcttcgcg ccctggtgtg gacactgcca gcggctgcag
      301 ccgacttgga atgacctggg agacaaatac aacagcatgg aagatgccaa agtctatgtg
      361 gctaaagtgg actgcacggc ccactccgac gtgtgctccg cccagggggt gcgaggatac
      421 cccaccttaa agcttttcaa gccaggccaa gaagctgtga agtaccaggg tcctcgggac
      481 ttccagacac tggaaaactg gatgctgcag acactgaacg aggagccagt gacaccagag
      541 ccggaagtgg aaccgcccag tgcccccgag ctcaagcaag ggctgtatga gctctcagca
      601 agcaactttg agctgcacgt tgcacaaggc gaccacttta tcaagttctt cgctccgtgg
      661 tgtggtcact gcaaagccct ggctccaacc tgggagcagc tggctctggg ccttgaacat
      721 tccgaaactg tcaagattgg caaggttgat tgtacacagc actatgaact ctgctccgga
      781 aaccaggttc gtggctatcc cactcttctc tggttccgag atgggaaaaa ggtggatcag
      841 tacaagggaa agcgggattt ggagtcactg agggagtacg tggagtcgca gctgcagcgc
      901 acagagactg gagcgacgga gaccgtcacg ccctcagagg ccccggtgct ggcagctgag
      961 cccgaggctg acaagggcac tgtgttggca ctcactgaaa ataacttcga tgacaccatt
     1021 gcagaaggaa taaccttcat caagttttat gctccatggt gtggtcattg taagactctg
     1081 gctcctactt gggaggaact ctctaaaaag gaattccctg gtctggcggg ggtcaagatc
     1141 gccgaagtag actgcactgc tgaacggaat atctgcagca agtattcggt acgaggctac
     1201 cccacgttat tgcttttccg aggagggaag aaagtcagtg agcacagtgg aggcagagac
     1261 cttgactcgt tacaccgctt tgtcctgagc caagcgaaag acgaacttta ggaacacagt
     1321 tggaggtcac ctctcctgcc cagctcccgc accctgcgtt taggagttca gtcccacaga
     1381 ggccactggg ttcccagtgg tggctgttca gaaagcagaa catactaagc gtgaggtatc
     1441 ttctttgtgt gtgtgttttc caagccaaca cactctacag attctttatt aagttaagtt
     1501 tctctaagta aatgtgtaac tcatggtcac tgtgtaaaca ttttcagtgg cgatatatcc
     1561 cctttgacct tctcttgatg aaatttacat ggtttccttt gagactaaaa tagcgttgag
     1621 ggaaatgaaa ttgctggact atttgtggct cctgagttga gtgattttgg tgaaagaaag
     1681 cacatccaaa gcatagttta cctgcccacg agttctggaa aggtggcctt gtggcagtat
     1741 tgacgttcct ctgatcttaa ggtcacagtt gactcaatac tgtgttggtc cgtagcatgg
     1801 agcagattga aatgcaaaaa cccacacctc tggaagatac cttcacggcc gctgctggag
     1861 cttctgttgc tgtgaatact tctctcagtg tgagaggtta gccgtgatga aagcagcgtt
     1921 acttctgacc gtgcctgagt aagagaatgc tgatgccata actttatgtg tcgatacttg
     1981 tcaaatcagt tactgttcag gggatccttc tgtttctcac ggggtgaaac atgtctttag
     2041 ttcctcatgt taacacgaag ccagagccca catgaactgt tggatgtctt ccttagaaag
     2101 ggtaggcatg gaaaattcca cgaggctcat tctcagtatc tcattaactc attgaaagat
     2161 tccagttgta tttgtcacct ggggtgacaa gaccagacag gctttcccag gcctgggtat
     2221 ccagggaggc tctgcagccc tgctgaaggg ccctaactag agttctagag tttctgattc
     2281 tgtttctcag tagtcctttt agaggcttgc tatacttggt ctgcttcaag gaggtcgacc
     2341 ttctaatgta tgaagaatgg gatgcatttg atctcaagac caaagacaga tgtcagtggg
     2401 ctgctctggc cctggtgtgc acggctgtgg cagctgttga tgccagtgtc ctctaactca
     2461 tgctgtcctt gtgattaaac acctctatct cccttgggaa taagcacata caggcttaag
     2521 ctctaagata gataggtgtt tgtcctttta ccatcgagct acttcccata ataaccactt
     2581 tgcatccaac actcttcacc cacctcccat acgcaagggg atgtggatac ttggcccaaa
     2641 gtaactggtg gtaggaatct tagaaacaag accacttata ctgtctgtct gaggcagaag
     2701 ataacagcag catctcgacc agcctctgcc ttaaaggaaa tctttattaa tcacgtatgg
     2761 ttcacagata attctttttt taaaaaaacc caacctccta gagaagcaca actgtcaaga
     2821 gtcttgtaca cacaacttca gctttgcatc acgagtcttg tattccaaga aaatcaaagt
     2881 ggtacaattt gtttgtttac actatgatac tttctaaata aactcttttt ttttaaaa
//
