LOCUS       NM_032243               2795 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens thioredoxin domain containing 2 (TXNDC2), transcript
            variant 1, mRNA.
ACCESSION   NM_032243 NM_001098530 XM_001721366 XM_001721367
VERSION     NM_032243.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2795)
  AUTHORS   Javadirad,S.M. and Mokhtari,M.
  TITLE     TXNDC2 joint molecular marker is associated with testis pathology
            and is an accurate predictor of sperm retrieval
  JOURNAL   Sci Rep 11 (1), 13064 (2021)
   PUBMED   34158577
  REMARK    GeneRIF: TXNDC2 joint molecular marker is associated with testis
            pathology and is an accurate predictor of sperm retrieval.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2795)
  AUTHORS   Chan,M.C., Savela,J., Ollikainen,R.K., Teppo,H.R., Miinalainen,I.,
            Pirinen,R., Kari,E.J.M., Kuitunen,H., Turpeenniemi-Hujanen,T.,
            Kuittinen,O. and Kuusisto,M.E.L.
  TITLE     Testis-Specific Thioredoxins TXNDC2, TXNDC3, and TXNDC6 Are
            Expressed in Both Testicular and Systemic DLBCL and Correlate with
            Clinical Disease Presentation
  JOURNAL   Oxid Med Cell Longev 2021, 8026941 (2021)
   PUBMED   33603952
  REMARK    GeneRIF: Testis-Specific Thioredoxins TXNDC2, TXNDC3, and TXNDC6
            Are Expressed in Both Testicular and Systemic DLBCL and Correlate
            with Clinical Disease Presentation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2795)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2795)
  AUTHORS   Hancock,D.B., Soler Artigas,M., Gharib,S.A., Henry,A.,
            Manichaikul,A., Ramasamy,A., Loth,D.W., Imboden,M., Koch,B.,
            McArdle,W.L., Smith,A.V., Smolonska,J., Sood,A., Tang,W.,
            Wilk,J.B., Zhai,G., Zhao,J.H., Aschard,H., Burkart,K.M.,
            Curjuric,I., Eijgelsheim,M., Elliott,P., Gu,X., Harris,T.B.,
            Janson,C., Homuth,G., Hysi,P.G., Liu,J.Z., Loehr,L.R., Lohman,K.,
            Loos,R.J., Manning,A.K., Marciante,K.D., Obeidat,M., Postma,D.S.,
            Aldrich,M.C., Brusselle,G.G., Chen,T.H., Eiriksdottir,G.,
            Franceschini,N., Heinrich,J., Rotter,J.I., Wijmenga,C.,
            Williams,O.D., Bentley,A.R., Hofman,A., Laurie,C.C., Lumley,T.,
            Morrison,A.C., Joubert,B.R., Rivadeneira,F., Couper,D.J.,
            Kritchevsky,S.B., Liu,Y., Wjst,M., Wain,L.V., Vonk,J.M.,
            Uitterlinden,A.G., Rochat,T., Rich,S.S., Psaty,B.M., O'Connor,G.T.,
            North,K.E., Mirel,D.B., Meibohm,B., Launer,L.J., Khaw,K.T.,
            Hartikainen,A.L., Hammond,C.J., Glaser,S., Marchini,J., Kraft,P.,
            Wareham,N.J., Volzke,H., Stricker,B.H., Spector,T.D.,
            Probst-Hensch,N.M., Jarvis,D., Jarvelin,M.R., Heckbert,S.R.,
            Gudnason,V., Boezen,H.M., Barr,R.G., Cassano,P.A., Strachan,D.P.,
            Fornage,M., Hall,I.P., Dupuis,J., Tobin,M.D. and London,S.J.
  TITLE     Genome-wide joint meta-analysis of SNP and SNP-by-smoking
            interaction identifies novel loci for pulmonary function
  JOURNAL   PLoS Genet 8 (12), e1003098 (2012)
   PUBMED   23284291
REFERENCE   5  (bases 1 to 2795)
  AUTHORS   Maeda,R., Tabata,C., Tabata,R., Eguchi,R., Fujimori,Y. and
            Nakano,T.
  TITLE     Is serum thioredoxin-1 a useful clinical marker for malignant
            pleural mesothelioma?
  JOURNAL   Antioxid Redox Signal 15 (3), 685-689 (2011)
   PUBMED   21375472
  REMARK    GeneRIF: The patients with advanced-stagemalignant pleural
            mesothelioma (MPM) showed higher levels of TRX than those with
            early-stage MPM.
REFERENCE   6  (bases 1 to 2795)
  AUTHORS   Jimenez,A., Johansson,C., Ljung,J., Sagemark,J., Berndt,K.D.,
            Ren,B., Tibbelin,G., Ladenstein,R., Kieselbach,T., Holmgren,A.,
            Gustafsson,J.A. and Miranda-Vizuete,A.
  TITLE     Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain
            protein with oxidizing activity
  JOURNAL   FEBS Lett 530 (1-3), 79-84 (2002)
   PUBMED   12387870
  REMARK    GeneRIF: spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain
            protein with oxidizing activity
REFERENCE   7  (bases 1 to 2795)
  AUTHORS   Sadek,C.M., Damdimopoulos,A.E., Pelto-Huikko,M., Gustafsson,J.A.,
            Spyrou,G. and Miranda-Vizuete,A.
  TITLE     Sptrx-2, a fusion protein composed of one thioredoxin and three
            tandemly repeated NDP-kinase domains is expressed in human testis
            germ cells
  JOURNAL   Genes Cells 6 (12), 1077-1090 (2001)
   PUBMED   11737268
  REMARK    GeneRIF: sperm specific expression, together with chromosomal
            assignment to a position as a potential locus for flagellar
            anomalies and male infertility phenotypes, suggests that it might
            be a novel component of the human sperm axonemal organization.
REFERENCE   8  (bases 1 to 2795)
  AUTHORS   Miranda-Vizuete,A., Ljung,J., Damdimopoulos,A.E., Gustafsson,J.A.,
            Oko,R., Pelto-Huikko,M. and Spyrou,G.
  TITLE     Characterization of Sptrx, a novel member of the thioredoxin family
            specifically expressed in human spermatozoa
  JOURNAL   J Biol Chem 276 (34), 31567-31574 (2001)
   PUBMED   11399755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC050132.1, AF080095.1 and AC006238.1.
            
            On May 17, 2019 this sequence version replaced NM_032243.5.
            
            Transcript Variant: This variant (1) encodes the predominant
            protein (isoform 1) and represents the variant originally described
            in PMID: 11399755.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF080095.1, BC050132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357775.6/ ENSP00000350419.4
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BC050132.1         36-55
            21-1678             AF080095.1         1-1658
            1679-1679           BC050132.1         1714-1714
            1680-2795           AC006238.1         109830-110945       c
FEATURES             Location/Qualifiers
     source          1..2795
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.22"
     gene            1..2795
                     /gene="TXNDC2"
                     /gene_synonym="SPTRX; SPTRX1"
                     /note="thioredoxin domain containing 2"
                     /db_xref="GeneID:84203"
                     /db_xref="HGNC:HGNC:16470"
                     /db_xref="MIM:617790"
     exon            1..108
                     /gene="TXNDC2"
                     /gene_synonym="SPTRX; SPTRX1"
                     /inference="alignment:Splign:2.1.0"
     exon            109..2795
                     /gene="TXNDC2"
                     /gene_synonym="SPTRX; SPTRX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1661
                     /gene="TXNDC2"
                     /gene_synonym="SPTRX; SPTRX1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sperm-specific thioredoxin 1; thioredoxin
                     domain-containing protein 2; sptrx-1; spermatid-specific
                     thioredoxin-1; thioredoxin domain containing 2
                     (spermatozoa); testicular tissue protein Li 215"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 2 isoform
                     1"
                     /protein_id="NP_115619.4"
                     /db_xref="CCDS:CCDS11846.1"
                     /db_xref="GeneID:84203"
                     /db_xref="HGNC:HGNC:16470"
                     /db_xref="MIM:617790"
                     /translation="MVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEET
                     IQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASV
                     KPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKT
                     SVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIS
                     KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGD
                     IPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKE
                     IDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDF
                     EASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVKHEDVVFLEVDADNCEEVVREC
                     AIMCVPTFQFYKKEEKVDELCGALKEKLEAVIAELK"
     regulatory      1657..1662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC2"
                     /gene_synonym="SPTRX; SPTRX1"
                     /note="hexamer: AGTAAA"
     polyA_site      1679
                     /gene="TXNDC2"
                     /gene_synonym="SPTRX; SPTRX1"
                     /note="major polyA site"
     regulatory      1824..1829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC2"
                     /gene_synonym="SPTRX; SPTRX1"
                     /note="hexamer: ATTAAA"
     polyA_site      1845
                     /gene="TXNDC2"
                     /gene_synonym="SPTRX; SPTRX1"
     regulatory      2649..2654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC2"
                     /gene_synonym="SPTRX; SPTRX1"
                     /note="hexamer: AATAAA"
     polyA_site      2686
                     /gene="TXNDC2"
                     /gene_synonym="SPTRX; SPTRX1"
ORIGIN      
        1 agtgaatgcg tagtcccagc ctcagcacag gggagccacc ttgaagctct caaatatcac
       61 tgttgtgaat acagagaggg aaaaccaact gtaacgtgcc acccaaataa agctcattac
      121 tagtcctgtc cagcaacgtg cctctcctgg ccctagagtt cttggaaata gcccaggcca
      181 aagagaaggc ctttctcccc atggtcagcc acacgttcca catgcgcaca gaggagtctg
      241 atgcctcaca ggagggcgat gacctaccca agtcctcagc aaacaccagc catcccaagc
      301 aggatgacag ccccaagtcc tcagaagaaa ccatccagcc caaggagggt gacatcccca
      361 aggccccaga agaaaccatc caatccaaga aggaggacct ccccaagtcc tcagaaaaag
      421 ccatccagcc caaagagagt aacatcccca agtcctcagc aaaacccatc cagcccaagc
      481 tgggcaatat tcccaaggcc tcagtgaagc ccagccagcc caaggagggt gacatcccca
      541 aggccccaga agaaaccatc caatccaaga aggaggacct ccccaagtcc tcagaagaag
      601 ccatccagcc caaagagggt gacatcccca agtcctcagc aaaacccatc cagcccaagc
      661 tgggcaatat tgccaagacc tcagtgaagc ccagccagcc caaggagagt gatatcccca
      721 agtccccaga agaaaccatc cagcccaagg agggtgacat ccccaagtcc tcagcaaagc
      781 ccatccagcc caagctgggc aatattccca aggcctcagt gaagcccagc cagcccaagg
      841 agggtgacat ctccaagtcc ccagaagaag ccatccagcc caaggagggt gacctcccca
      901 agtccctaga ggaagccatc cagcccaagg agggtgacat ccccaagtcc ccagaagaag
      961 ccatccagcc caaggagggt gacatcccca agtccctaga ggaagccatc cagcctaagg
     1021 agggtgacat ccccaagtcc ccagaagaaa ccatccagcc caagaagggt gacatcccca
     1081 agtccccaga agaagccatc cagcccaagg agggtgacat tcccaagtct ccaaaacaag
     1141 ccatccagcc caaggagggt gacattccca agtccctaga ggaagccatc ccacccaagg
     1201 agattgacat ccccaagtcc ccagaagaaa ccatccagcc caaggaggat gacagcccca
     1261 agtccctaga agaagccacc ccatccaagg agggtgacat cctaaagcct gaagaagaaa
     1321 caatggagtt cccggagggg gacaaggtga aagtgatcct gagcaaggag gactttgagg
     1381 catcactgaa ggaggccggg gagaggctgg tggctgtgga cttctcggcc acgtggtgtg
     1441 ggccctgcag gaccatcaga ccattcttcc atgccctgtc tgtgaagcat gaggatgtgg
     1501 tgttcctgga ggtggacgct gacaactgtg aggaggtggt gagagagtgc gccatcatgt
     1561 gtgtcccaac ctttcagttt tataaaaaag aagaaaaggt ggatgaactt tgcggcgccc
     1621 ttaaggaaaa acttgaagca gtcattgcag aattaaagta aacatgtatt ctgaaaacat
     1681 tgcagacagt caggtgttta tagcttttga gttctctttt attatttaca caaagtgatc
     1741 aggtataaca aaagtgtatg tccaaatggc actgcttgta catgataata ttaactctac
     1801 ccttttcaaa aaacagtcca agcattaaag tacattgcga ctgtgtttct gttagtggga
     1861 gagtataaaa ttagaaattc ccatggtgaa gactgctaag tcccatggtt tcctattttt
     1921 caatcttgat atgtatttat ttttcacttg tctttgaaaa tttcacgcat ttagtgtttg
     1981 cagcaagact gaaaatttag ataatttttc tatagaggta gatgactgaa aggtgaatgg
     2041 aaacttcttt tctcatgtca cacatctttg gggattctga taagatatgt ttggaaataa
     2101 ggaatttgaa agattcacat cttagctaac ctccttcttg tgccggaagt gctacggagg
     2161 ccttgggaaa ttcagtgggt tttccaagat ctgatttgtt ggtgacggaa atgagatcaa
     2221 ggccgcttcc agatttcaag tccagggctc tacctactat aatctacgct cacaaaatct
     2281 cagacaagag gtcggaactt caggtttctc ggaggttgaa gtcctctgga tctttgctgc
     2341 ctttatgaca tcagtgccct gatggcagag ttcctggttc gtctccctgg taattgagtt
     2401 cataatacct agaccttcct ctgacttttt tacttaaatt tgttcttatt ttcaatattg
     2461 aacaagccag cctttaacat gactctacca gcttagacat ataggcctag actttaatga
     2521 attaacctaa tcacagtgct accagagtct tgtttggaca acttagtgag ccccagatgt
     2581 ctatgagccc aaagtcccag gtctgaacca tagacagagg cttagtccag agtgggtttt
     2641 taaaaatgaa taaaaccagc ttcattaggt ataattgata tacaaagaac agcacatatt
     2701 taatggaggg agttggatga gtttggatgt gttgcatatg cccttgattg ccatctccac
     2761 catcaaagta attaacacct tcattgcctc cagaa
//
