LOCUS       NM_032731               1917 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens thioredoxin domain containing 17 (TXNDC17), mRNA.
ACCESSION   NM_032731
VERSION     NM_032731.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1917)
  AUTHORS   Montero-Calle,A., Garranzo-Asensio,M., Poves,C., Sanz,R.,
            Dziakova,J., Pelaez-Garcia,A., de Los Rios,V., Martinez-Useros,J.,
            Fernandez-Acenero,M.J. and Barderas,R.
  TITLE     In-Depth Proteomic Analysis of Paraffin-Embedded Tissue Samples
            from Colorectal Cancer Patients Revealed TXNDC17 and SLC8A1 as Key
            Proteins Associated with the Disease
  JOURNAL   J Proteome Res 23 (11), 4802-4820 (2024)
   PUBMED   39441737
  REMARK    GeneRIF: In-Depth Proteomic Analysis of Paraffin-Embedded Tissue
            Samples from Colorectal Cancer Patients Revealed TXNDC17 and SLC8A1
            as Key Proteins Associated with the Disease.
REFERENCE   2  (bases 1 to 1917)
  AUTHORS   Marti-Andres,P., Finamor,I., Torres-Cuevas,I., Perez,S.,
            Rius-Perez,S., Colino-Lage,H., Guerrero-Gomez,D., Morato,E.,
            Marina,A., Michalska,P., Leon,R., Cheng,Q., Juranyi,E.P.,
            Borbenyi-Galambos,K., Millan,I., Nagy,P., Miranda-Vizuete,A.,
            Schmidt,E.E., Martinez-Ruiz,A., Arner,E.S. and Sastre,J.
  TITLE     TRP14 is the rate-limiting enzyme for intracellular cystine
            reduction and regulates proteome cysteinylation
  JOURNAL   EMBO J 43 (13), 2789-2812 (2024)
   PUBMED   38811853
  REMARK    GeneRIF: TRP14 is the rate-limiting enzyme for intracellular
            cystine reduction and regulates proteome cysteinylation.
REFERENCE   3  (bases 1 to 1917)
  AUTHORS   Chatterji,A. and Sengupta,R.
  TITLE     Cellular S-denitrosylases: Potential role and interplay of
            Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent
            protein denitrosylation
  JOURNAL   Int J Biochem Cell Biol 131, 105904 (2021)
   PUBMED   33359085
  REMARK    GeneRIF: Cellular S-denitrosylases: Potential role and interplay of
            Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent
            protein denitrosylation.
            Review article
REFERENCE   4  (bases 1 to 1917)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1917)
  AUTHORS   Zhang,S.F., Wang,X.Y., Fu,Z.Q., Peng,Q.H., Zhang,J.Y., Ye,F.,
            Fu,Y.F., Zhou,C.Y., Lu,W.G., Cheng,X.D. and Xie,X.
  TITLE     TXNDC17 promotes paclitaxel resistance via inducing autophagy in
            ovarian cancer
  JOURNAL   Autophagy 11 (2), 225-238 (2015)
   PUBMED   25607466
  REMARK    GeneRIF: TXNDC17, through participation of BECN1, induces autophagy
            and consequently results in paclitaxel resistance in ovarian cancer
REFERENCE   6  (bases 1 to 1917)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1917)
  AUTHORS   Jung,Y., Kim,H., Min,S.H., Rhee,S.G. and Jeong,W.
  TITLE     Dynein light chain LC8 negatively regulates NF-kappaB through the
            redox-dependent interaction with IkappaBalpha
  JOURNAL   J Biol Chem 283 (35), 23863-23871 (2008)
   PUBMED   18579519
  REMARK    GeneRIF: LC8 binds IkappaBalpha in a redox-dependent manner and
            thereby prevents its phosphorylation by IKK. TRP14 contributes to
            this inhibitory activity by maintaining LC8 in a reduced state.
REFERENCE   8  (bases 1 to 1917)
  AUTHORS   Woo,J.R., Kim,S.J., Jeong,W., Cho,Y.H., Lee,S.C., Chung,Y.J.,
            Rhee,S.G. and Ryu,S.E.
  TITLE     Structural basis of cellular redox regulation by human TRP14
  JOURNAL   J Biol Chem 279 (46), 48120-48125 (2004)
   PUBMED   15355959
  REMARK    GeneRIF: Data report the crystal structure of human
            thioredoxin-related protein 14 determined at 1.8-angstrom
            resolution.
REFERENCE   9  (bases 1 to 1917)
  AUTHORS   Jeong,W., Yoon,H.W., Lee,S.R. and Rhee,S.G.
  TITLE     Identification and characterization of TRP14, a thioredoxin-related
            protein of 14 kDa. New insights into the specificity of thioredoxin
            function
  JOURNAL   J Biol Chem 279 (5), 3142-3150 (2004)
   PUBMED   14607844
  REMARK    GeneRIF: TRP14 is a thioredoxin-related protein of 14 kDa
REFERENCE   10 (bases 1 to 1917)
  AUTHORS   Jeong,W., Chang,T.S., Boja,E.S., Fales,H.M. and Rhee,S.G.
  TITLE     Roles of TRP14, a thioredoxin-related protein in tumor necrosis
            factor-alpha signaling pathways
  JOURNAL   J Biol Chem 279 (5), 3151-3159 (2004)
   PUBMED   14607843
  REMARK    GeneRIF: TRP14 is a thioredoxin-related protein with roles in tumor
            necrosis factor-alpha signaling pathways
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC006405.2 and AC004706.1.
            
            On May 17, 2019 this sequence version replaced NM_032731.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.281281.1,
                                           SRR1803615.59320.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250101.10/ ENSP00000250101.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-499               BC006405.2         37-535
            500-1917            AC004706.1         18832-20249
FEATURES             Location/Qualifiers
     source          1..1917
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1917
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
                     /note="thioredoxin domain containing 17"
                     /db_xref="GeneID:84817"
                     /db_xref="HGNC:HGNC:28218"
                     /db_xref="MIM:616967"
     exon            1..168
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..395
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
                     /note="thioredoxin (Trx)-related protein, 14 kDa;
                     thioredoxin-like 5; protein 42-9-9; thioredoxin-like
                     protein 5; 14 kDa thioredoxin-related protein; testicular
                     tissue protein Li 214"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 17"
                     /protein_id="NP_116120.1"
                     /db_xref="CCDS:CCDS11077.1"
                     /db_xref="GeneID:84817"
                     /db_xref="HGNC:HGNC:28218"
                     /db_xref="MIM:616967"
                     /translation="MARYEEVSVSGFEEFHRAVEQHNGKTIFAYFTGSKDAGGKSWCP
                     DCVQAEPVVREGLKHISEGCVFIYCQVGEKPYWKDPNNDFRKNLKVTAVPTLLKYGTP
                     QKLVESECLQANLVEMLFSED"
     exon            169..250
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
                     /inference="alignment:Splign:2.1.0"
     exon            251..326
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
                     /inference="alignment:Splign:2.1.0"
     exon            327..1917
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      480..485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
                     /note="hexamer: AATAAA"
     polyA_site      499
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
                     /note="major polyA site"
     regulatory      528..533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
                     /note="hexamer: ATTAAA"
     polyA_site      550
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
                     /note="hexamer: AATACA"
     regulatory      1802..1807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
                     /note="hexamer: ATTATA"
     polyA_site      1815
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
     polyA_site      1819
                     /gene="TXNDC17"
                     /gene_synonym="TRP14; TXNL5"
ORIGIN      
        1 agtagcggct gcacgtcgtg ccaatggccc gctatgagga ggtgagcgtg tccggcttcg
       61 aggagttcca ccgggccgtg gaacagcaca atggcaagac cattttcgcc tactttacgg
      121 gttctaagga cgccgggggg aaaagctggt gccccgactg cgtgcaggct gaaccagtcg
      181 tacgagaggg gctgaagcac attagtgaag gatgtgtgtt catctactgc caagtaggag
      241 aaaagcctta ttggaaagat ccaaataatg acttcagaaa aaacttgaaa gtaacagcag
      301 tgcctacact acttaagtat ggaacacctc aaaaactggt agaatctgag tgtcttcagg
      361 ccaacctggt ggaaatgttg ttctctgaag attaagattt taggatggca atcatgtctt
      421 gatgtcctga tttgttctag tatcaataaa ctgtatactt gctttgaatt catgttagca
      481 ataaatgatg ttaaaaaaac tggcatgtgt ctaaacaata gagtgctatt aaaatgccca
      541 tgaaccttta gtttgcctgt aatacatgga tatttttaag atataaagaa gtcttcagaa
      601 atagcagtaa aggctcaaag gaacgtattc ttgaaggtga cggaaatacc taaaaactcc
      661 taaaggtgca gagcacacct tccaaatctc tcaaaagatc agtatctttt attttaagtt
      721 atctccatct gcaaagcaac tgatgatatt cctgaaaccc cttctttgat tttggaatgt
      781 agaacctaac ctcaccactg aaggaaagca catgacctct aatctagcct ctgcttaatt
      841 caggcagttt tgttttgttt aataaaaaac agactcctga gcactagaag cagtttgttt
      901 tgcagctgtc tcaatgtgct ttacttggga tgaggcaggt ggcggagagc ggccggaaag
      961 actctataac ccagttctgg gaagaactcc aagctgggag tcagtcacac tgactctacc
     1021 acttactagc tgtgtaacca caggcaagtt actcaccccg tccaaacctc agttttctct
     1081 tctataaaca aggttcttag aataaaatga gaattcaagg aagcacttaa catagcacct
     1141 ggtttgtggt acctcccaaa tcaatggtag ctttcccaaa tgaacacaag tatttgaggc
     1201 tcctcatgtt tgttctaaag tcaagagtcc agttagtaac taaccactag ttgtcctgcc
     1261 atgactaggt caagtgaggc cacagtgatt cagtgattct taaagccacc ttgcaaagca
     1321 ggtaatacag ttatttcctg tcctgcagaa ttcaagaacc tttatgcagt tcctgtccta
     1381 tgatttaaag aggtcagtga ctccgctact ctcactacat cttagagtag agtggtagag
     1441 tagttgatct gagacagtaa ggttccagga gatggtcttg ccctactata tgtcaggaac
     1501 agctagcctt agaattcagt atacttggtg gcccacccct accccatgcc ccagtgcctt
     1561 atttggtcta aagcacctaa cttttccatt cttaatcagc tgattatgct aaatgcgtaa
     1621 aaaagaaaaa caccttacaa atccacaggg aaatcaaaga acaattcagg tttaacagaa
     1681 atagtctatt aacaataaaa agttggatga aaaagcacac taaaggttct aggggctacc
     1741 ataataaagg tagataggaa gagttttcat tttttttgtc ttcactgtac aaaagaaata
     1801 cattatatac atgtattaag tgcctcgttt gtatccagtt tttcattttc ccgatgtgtt
     1861 attttgctgt tgctgctctg ccaaggcttg ctgaaggcgc atccgcttcc gggaata
//
