LOCUS       NM_020784               4557 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens thioredoxin domain containing 16 (TXNDC16), transcript
            variant 1, mRNA.
ACCESSION   NM_020784 XM_051699
VERSION     NM_020784.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4557)
  AUTHORS   Harz,C., Ludwig,N., Lang,S., Werner,T.V., Galata,V., Backes,C.,
            Schmitt,K., Nickels,R., Krause,E., Jung,M., Rettig,J., Keller,A.,
            Menger,M., Zimmermann,R. and Meese,E.
  TITLE     Secretion and immunogenicity of the meningioma-associated antigen
            TXNDC16
  JOURNAL   J Immunol 193 (6), 3146-3154 (2014)
   PUBMED   25122923
  REMARK    GeneRIF: in addition to reported occurrence as a soluble
            endoplasmic reticulum-luminal glycoprotein, TXNDC16 shows
            endoplasmic reticulum-associated subcellular localization in
            cytosol, as confirmed by confocal microscopy, molecular mass shift,
            flow cytometry
REFERENCE   2  (bases 1 to 4557)
  AUTHORS   Zeng,Z., Feingold,E., Wang,X., Weeks,D.E., Lee,M., Cuenco,D.T.,
            Broffitt,B., Weyant,R.J., Crout,R., McNeil,D.W., Levy,S.M.,
            Marazita,M.L. and Shaffer,J.R.
  TITLE     Genome-wide association study of primary dentition pit-and-fissure
            and smooth surface caries
  JOURNAL   Caries Res 48 (4), 330-338 (2014)
   PUBMED   24556642
REFERENCE   3  (bases 1 to 4557)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   4  (bases 1 to 4557)
  AUTHORS   Shi,M., Murray,J.C., Marazita,M.L., Munger,R.G., Ruczinski,I.,
            Hetmanski,J.B., Wu,T., Murray,T., Redett,R.J., Wilcox,A.J.,
            Lie,R.T., Jabs,E.W., Wu-Chou,Y.H., Chen,P.K., Wang,H., Ye,X.,
            Yeow,V., Chong,S.S., Shi,B., Christensen,K., Scott,A.F., Patel,P.,
            Cheah,F. and Beaty,T.H.
  TITLE     Genome wide study of maternal and parent-of-origin effects on the
            etiology of orofacial clefts
  JOURNAL   Am J Med Genet A 158A (4), 784-794 (2012)
   PUBMED   22419666
REFERENCE   5  (bases 1 to 4557)
  AUTHORS   Riemer,J., Hansen,H.G., Appenzeller-Herzog,C., Johansson,L. and
            Ellgaard,L.
  TITLE     Identification of the PDI-family member ERp90 as an interaction
            partner of ERFAD
  JOURNAL   PLoS One 6 (2), e17037 (2011)
   PUBMED   21359175
  REMARK    GeneRIF: The function of ERp90 is related to substrate recruitment
            or delivery to the ERAD retrotranslocation machinery by ERFAD.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4557)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC142650.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020784.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.13484.1, BC142650.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281741.9/ ENSP00000281741.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4557              BC142650.1         2-4558
FEATURES             Location/Qualifiers
     source          1..4557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..4557
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /note="thioredoxin domain containing 16"
                     /db_xref="GeneID:57544"
                     /db_xref="HGNC:HGNC:19965"
                     /db_xref="MIM:616179"
     exon            1..190
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            191..298
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            299..531
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..2849
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; thioredoxin domain-containing protein 16"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 16 isoform
                     1 precursor"
                     /protein_id="NP_065835.2"
                     /db_xref="CCDS:CCDS32083.1"
                     /db_xref="GeneID:57544"
                     /db_xref="HGNC:HGNC:19965"
                     /db_xref="MIM:616179"
                     /translation="MFSGFNVFRVGISFVIMCIFYMPTVNSLPELSPQKYFSTLQPGK
                     ASLAYFCQADSPRTSVFLEELNEAVRPLQDYGISVAKVNCVKEEISRYCGKEKDLMKA
                     YLFKGNILLREFPTDTLFDVNAIVAHVLFALLFSEVKYITNLEDLQNIENALKGKANI
                     IFSYVRAIGIPEHRAVMEAAFVYGTTYQFVLTTEIALLESIGSEDVEYAHLYFFHCKL
                     VLDLTQQCRRTLMEQPLTTLNIHLFIKTMKAPLLTEVAEDPQQVSTVHLQLGLPLVFI
                     VSQQATYEADRRTAEWVAWRLLGKAGVLLLLRDSLEVNIPQDANVVFKRAEEGVPVEF
                     LVLHDVDLIISHVENNMHIEEIQEDEDNDMEGPDIDVQDDEVAETVFRDRKRKLPLEL
                     TVELTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCA
                     DWSDVCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFIQLNRISYPVNITSIQE
                     AEEYLSGELYKDLILYSSVSVLGLFSPTMKTAKEDFSEAGNYLKGYVITGIYSEEDVL
                     LLSTKYAASLPALLLARHTEGKIESIPLASTHAQDIVQIITDALLEMFPEITVENLPS
                     YFRLQKPLLILFSDGTVNPQYKKAILTLVKQKYLDSFTPCWLNLKNTPVGRGILRAYF
                     DPLPPLPLLVLVNLHSGGQVFAFPSDQAIIEENLVLWLKKLEAGLENHITILPAQEWK
                     PPLPAYDFLSMIDAATSQRGTRKVPKCMKETDVQENDKEQHEDKSAVRKEPIETLRIK
                     HWNRSNWFKEAEKSFRRDKELGCSKVN"
     exon            532..614
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            615..688
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            689..763
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            764..885
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            886..976
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1127
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1294
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1355
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1479
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1623
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1683
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1852
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1989
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2074
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2213
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2374
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2565
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..4557
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4533..4538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /note="hexamer: AATAAA"
     polyA_site      4557
                     /gene="TXNDC16"
                     /gene_synonym="ERp90; KIAA1344"
                     /note="major polyA site"
ORIGIN      
        1 gagtcggtgg cggctgcagg ctgggaggga gaagtgctac gcctttgcag gttggcgaag
       61 tggttccagg ctacccggct agtctggcac ggccccgtct tctgcctcct cctccgtcgc
      121 gtggcggcgg gaactgttgg ccgcgcggcc tcgggaacgg cccaggtccc cgcccgcagg
      181 tcccgggcag ataacataga tcatcagtag aaaacttctt gaagttgttc aagaaaaatt
      241 tgaaagtagc aaaatagaaa ataaagaatt aacagcagat acagaggaca gcatggaagt
      301 gttgtcttag gaaacagaac acagcagtga aaaaacagac aaaatccgct cagatacaac
      361 tgcagctgat aatgttttcc ggcttcaatg tctttagagt tgggatctct tttgtcataa
      421 tgtgcatttt ttacatgcca acagtaaact ctttaccaga actgagtcct cagaaatatt
      481 ttagtacatt gcaaccagga aaagcctctt tagcttattt ttgtcaagct gattccccaa
      541 gaacatctgt atttcttgaa gaactgaatg aggctgttag acctctgcag gactatggaa
      601 tttcagttgc caaggttaat tgtgtcaaag aagaaatatc aagatactgt ggaaaagaaa
      661 aggatttgat gaaagcatat ttattcaagg gcaacatatt gctcagagaa ttccctactg
      721 acaccttgtt tgatgtgaat gccattgtcg cccatgttct ctttgctctt ctttttagtg
      781 aagtgaaata tattaccaac ctggaagacc ttcagaacat agaaaatgct ctgaaaggaa
      841 aagcaaatat tatattctca tatgtaagag ccattggaat accagagcac agagcagtca
      901 tggaagccgc ttttgtgtat gggactacat accaatttgt cttaaccaca gaaattgccc
      961 ttttggaaag tattggctct gaggatgtgg aatatgcaca tctctacttt tttcattgta
     1021 aactagtctt ggacttgacc cagcaatgta gaagaacact aatggaacag ccattgacta
     1081 cactgaacat tcacctgttt attaagacaa tgaaagcacc tctgttgact gaagttgctg
     1141 aagatcctca acaagtttca actgtccatc tccaactggg cttaccactg gtttttattg
     1201 ttagccaaca ggctacttat gaagctgata gaagaactgc agaatgggtt gcttggcgtc
     1261 ttctgggaaa agcaggagtt ctactcttgt taagggactc tttggaagtg aacattcctc
     1321 aagatgctaa tgtggtcttc aaaagagcag aagagggagt tccagtggaa tttttggtat
     1381 tacatgatgt tgatttaata atatctcatg tggaaaataa tatgcacatt gaggaaatac
     1441 aagaagatga agacaatgac atggaaggtc cagatataga tgttcaggat gatgaagtgg
     1501 cagaaactgt tttcagagat aggaagagaa aattaccttt ggaacttaca gtggaactaa
     1561 cagaagaaac atttaatgca acagtgatgg cttctgacag catagtactc ttctatgctg
     1621 gttggcaagc agtatccatg gcatttttgc aatcctatat tgatgtggca gttaaactga
     1681 aaggcacatc tactatgctt cttactagaa taaactgtgc agattggtct gatgtatgta
     1741 ctaagcaaaa tgttactgaa tttcctatca taaagatgta caagaaaggc gagaacccag
     1801 tatcttatgc tggaatgtta ggaaccgaag atctcctaaa atttatccag ctcaacagga
     1861 tttcatatcc agtgaatata acatcgatcc aagaagcaga agaatattta agtggggaat
     1921 tatataaaga cctcatcttg tattctagtg tgtcagtatt gggactattt agtccaacca
     1981 tgaaaacagc aaaagaagat tttagtgaag caggaaacta cctaaaagga tatgttatca
     2041 ctggaattta ttctgaagaa gatgttttgc tactgtcaac caaatatgct gcaagtcttc
     2101 cagccctgct gcttgccaga cacacagaag gcaaaataga gagcatccca ctagctagca
     2161 cacatgcaca agacatagtt caaataataa cagatgcact actggaaatg tttccggaaa
     2221 tcactgtgga aaatcttccc agttatttca gacttcagaa accattattg attttgttca
     2281 gtgatggcac tgtaaatcct cagtataaaa aagcaatatt gacactggta aagcagaaat
     2341 acttggattc atttactcca tgctggttaa atctaaagaa tactccagtg gggagaggaa
     2401 tcttgagggc atattttgat cctctgcctc cccttcctct tcttgttttg gtgaatctgc
     2461 attcaggtgg ccaagtattt gcatttcctt cagaccaggc tataattgaa gaaaaccttg
     2521 tattgtggct gaagaaatta gaagcaggac tagaaaatca tatcacaatt ttacctgctc
     2581 aagaatggaa acctcctctt ccagcttatg attttctaag tatgatagat gccgcaacat
     2641 ctcaacgtgg cactaggaaa gttcccaagt gtatgaaaga aacagatgtg caggagaatg
     2701 ataaggaaca acatgaagat aaatcggcag tcagaaaaga accgattgaa actctgagaa
     2761 taaagcattg gaatagaagt aattggttta aagaagcaga aaaatcattt agacgtgata
     2821 aagagttagg atgctcaaaa gtgaactaat tttatagggc tgtggtttcc aaaatttttt
     2881 tggcatgata gacttaattt atttccttaa agaataatat taaatcattt caagtttgca
     2941 gactagtgcc atccaataga attataatat aagtcacata ttttatttaa aattttctag
     3001 taactacatt aaacaaagta aaagtgagca gggcaaaata attttgatat tacttttcac
     3061 ccagtagtat acccaaaata gcgaaatata gaaattatta atgagatatt ttacatcctt
     3121 ttttgtacca agtcttctaa atgcagtaca tattttatac ttactgcatt tcttacttcc
     3181 gagtagccat atttcaagtg ttccttgcca catgtggcct gtgactactg tattggacag
     3241 ttcagtacta gacaaaaact agcataatta acttagttct agccatgatt tctatttgga
     3301 ttaaaattaa actctaatca cagttaactc cacagtgcat tcatgcagct gacagttata
     3361 tttgttttat tggagtcatg atattaaaat cagcgtttgt caacctcagg ggatatttag
     3421 caattgtcgg gagacatttt tgatgtcatg actagggcag ttattgacat ttagtgagta
     3481 gaggccaggg atcctgctaa ataacctgca ttggacagcg ccccacaaca aagaattatc
     3541 ctgcccgaaa tggtagtcgt gccaaggctg agtaaccttg tgttaaaagt aacctgtggc
     3601 agactaggtt tccagaattt cctggttctg ctcacgtatc atgtttgaaa aaattttggc
     3661 tattaaagat atgtattaga tggtcttatc ctgattatta cctggataca acttgatctt
     3721 ttctaatatt ttcagaaagt gatgggataa ccctagaaga ggactcagaa tgatatttat
     3781 attttaagtg agtcttaaaa cctcctctta tttctacaag ttatatggct aaatttcaga
     3841 ttgaacaggg attcagcatt ctgccatctc ctcatggaaa gagaggctcc ctcatctgaa
     3901 gcgtctctga aatctaccct tgcaagcttc agacaaatca gttgatctcc ctgagccaca
     3961 cggcctcatt ctgtgaggga gggaaagatt agccaaagag ttaattttca ttccaaatca
     4021 cttagctgtt agactgatct gtttgtagca gttgtttgtc tcatttttgc tctgtgcatt
     4081 ttttgagaca tttgttgaga atattctatt tggtgctcta ctgtattttt ctttttaata
     4141 tctacttgat atcttgttct ttaaattttc ttcacatatg gtttgcctga tacaactgat
     4201 ttttataact gaaatttaag gaatctaaca gctaaaactc agtaagtgca tatatttcct
     4261 tataacatag acccgttgct actctcagca ccctctcctc aatttttttt cctgtagcat
     4321 gtgatgcctg attaaactca ttttcatttg cttttatttc taatatggga acaatgagag
     4381 tgaactctaa atataggttg tagtaataaa acatcattag cctaattatt agaaaatgct
     4441 aattaagtac cagcacatag aaacatgaaa ttgcttagtc attgtacctt tgtcagcaat
     4501 tttgacagtc attaatgttt gtcataattt taaataaagt gtctgggttt cagaata
//
