LOCUS       NM_015913               1416 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens thioredoxin domain containing 12 (TXNDC12), transcript
            variant 1, mRNA.
ACCESSION   NM_015913
VERSION     NM_015913.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1416)
  AUTHORS   Wang,X., Yang,Q., Liu,N., Bian,Q., Gao,M. and Hou,X.
  TITLE     Clinical Value of TXNDC12 Combined With IDH and 1p19q as Biomarkers
            for Prognosis of Glioma
  JOURNAL   Pathol Oncol Res 27, 1609825 (2021)
   PUBMED   34629960
  REMARK    GeneRIF: Clinical Value of TXNDC12 Combined With IDH and 1p19q as
            Biomarkers for Prognosis of Glioma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1416)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1416)
  AUTHORS   Yuan,K., Xie,K., Lan,T., Xu,L., Chen,X., Li,X., Liao,M., Li,J.,
            Huang,J., Zeng,Y. and Wu,H.
  TITLE     TXNDC12 promotes EMT and metastasis of hepatocellular carcinoma
            cells via activation of beta-catenin
  JOURNAL   Cell Death Differ 27 (4), 1355-1368 (2020)
   PUBMED   31570854
  REMARK    GeneRIF: TXNDC12 promotes EMT and metastasis of hepatocellular
            carcinoma cells via activation of beta-catenin.
REFERENCE   4  (bases 1 to 1416)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1416)
  AUTHORS   Oka,O.B., van Lith,M., Rudolf,J., Tungkum,W., Pringle,M.A. and
            Bulleid,N.J.
  TITLE     ERp18 regulates activation of ATF6alpha during unfolded protein
            response
  JOURNAL   EMBO J 38 (15), e100990 (2019)
   PUBMED   31368601
  REMARK    GeneRIF: Data demonstrate that ERp18 monitors ATF6a endoplasmic
            reticulum quality control to ensure optimal processing following
            trafficking to the Golgi.
REFERENCE   6  (bases 1 to 1416)
  AUTHORS   Rowe,M.L., Ruddock,L.W., Kelly,G., Schmidt,J.M., Williamson,R.A.
            and Howard,M.J.
  TITLE     Solution structure and dynamics of ERp18, a small endoplasmic
            reticulum resident oxidoreductase
  JOURNAL   Biochemistry 48 (21), 4596-4606 (2009)
   PUBMED   19361226
  REMARK    GeneRIF: the solution structure of oxidized ERp18 as determined
            using NMR spectroscopy
REFERENCE   7  (bases 1 to 1416)
  AUTHORS   Jeong,W., Lee,D.Y., Park,S. and Rhee,S.G.
  TITLE     ERp16, an endoplasmic reticulum-resident thiol-disulfide
            oxidoreductase: biochemical properties and role in apoptosis
            induced by endoplasmic reticulum stress
  JOURNAL   J Biol Chem 283 (37), 25557-25566 (2008)
   PUBMED   18628206
  REMARK    GeneRIF: ERp16 mediates disulfide bond formation in the ER and
            plays an important role in cellular defense against prolonged ER
            stress
REFERENCE   8  (bases 1 to 1416)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   9  (bases 1 to 1416)
  AUTHORS   Liu,F., Rong,Y.P., Zeng,L.C., Zhang,X. and Han,Z.G.
  TITLE     Isolation and characterization of a novel human thioredoxin-like
            gene hTLP19 encoding a secretory protein
  JOURNAL   Gene 315, 71-78 (2003)
   PUBMED   14557066
REFERENCE   10 (bases 1 to 1416)
  AUTHORS   Alanen,H.I., Williamson,R.A., Howard,M.J., Lappi,A.K., Jantti,H.P.,
            Rautio,S.M., Kellokumpu,S. and Ruddock,L.W.
  TITLE     Functional characterization of ERp18, a new endoplasmic
            reticulum-located thioredoxin superfamily member
  JOURNAL   J Biol Chem 278 (31), 28912-28920 (2003)
   PUBMED   12761212
  REMARK    GeneRIF: putative physiological role for endoplasmic reticulum
            thioredoxin superfamily member p18(ERp18) in native disulfide bond
            formation is discussed
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445685.18.
            
            On Jul 29, 2019 this sequence version replaced NM_015913.3.
            
            Summary: This gene encodes a member of the thioredoxin superfamily.
            Members of this family are characterized by a conserved active
            motif called the thioredoxin fold that catalyzes disulfide bond
            formation and isomerization. This protein localizes to the
            endoplasmic reticulum and has a single atypical active motif. The
            encoded protein is mainly involved in catalyzing native disulfide
            bond formation and displays activity similar to protein-disulfide
            isomerases. This protein may play a role in defense against
            endoplasmic reticulum stress. Alternate splicing results in both
            coding and non-coding variants. [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF543416.1, AF131758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267769 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371626.9/ ENSP00000360688.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AL445685.18        121689-121880       c
            193-253             AL445685.18        108226-108286       c
            254-306             AL445685.18        95267-95319         c
            307-380             AL445685.18        93964-94037         c
            381-450             AL445685.18        91199-91268         c
            451-534             AL445685.18        90180-90263         c
            535-1416            AL445685.18        86820-87701         c
FEATURES             Location/Qualifiers
     source          1..1416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..1416
                     /gene="TXNDC12"
                     /gene_synonym="AG1; AGR1; ERP16; ERP18; ERP19; hAG-1;
                     hTLP19; PDIA16; TLP19"
                     /note="thioredoxin domain containing 12"
                     /db_xref="GeneID:51060"
                     /db_xref="HGNC:HGNC:24626"
                     /db_xref="MIM:609448"
     exon            1..192
                     /gene="TXNDC12"
                     /gene_synonym="AG1; AGR1; ERP16; ERP18; ERP19; hAG-1;
                     hTLP19; PDIA16; TLP19"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..614
                     /gene="TXNDC12"
                     /gene_synonym="AG1; AGR1; ERP16; ERP18; ERP19; hAG-1;
                     hTLP19; PDIA16; TLP19"
                     /EC_number="1.8.4.2"
                     /note="thioredoxin-like protein p19; endoplasmic reticulum
                     thioredoxin superfamily member, 18 kDa; protein disulfide
                     isomerase family A, member 16; anterior gradient homolog
                     1; thioredoxin domain-containing protein 12; endoplasmic
                     reticulum protein ERp19; ER protein 18; ER protein 19;
                     endoplasmic reticulum resident protein 18; endoplasmic
                     reticulum resident protein 19; thioredoxin domain
                     containing 12 (endoplasmic reticulum)"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 12
                     precursor"
                     /protein_id="NP_056997.1"
                     /db_xref="CCDS:CCDS561.1"
                     /db_xref="GeneID:51060"
                     /db_xref="HGNC:HGNC:24626"
                     /db_xref="MIM:609448"
                     /translation="METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLE
                     DGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKD
                     EDFSPDGGYIPRILFLDPSGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTG
                     DAFRKKHLEDEL"
     exon            193..253
                     /gene="TXNDC12"
                     /gene_synonym="AG1; AGR1; ERP16; ERP18; ERP19; hAG-1;
                     hTLP19; PDIA16; TLP19"
                     /inference="alignment:Splign:2.1.0"
     exon            254..306
                     /gene="TXNDC12"
                     /gene_synonym="AG1; AGR1; ERP16; ERP18; ERP19; hAG-1;
                     hTLP19; PDIA16; TLP19"
                     /inference="alignment:Splign:2.1.0"
     exon            307..380
                     /gene="TXNDC12"
                     /gene_synonym="AG1; AGR1; ERP16; ERP18; ERP19; hAG-1;
                     hTLP19; PDIA16; TLP19"
                     /inference="alignment:Splign:2.1.0"
     exon            381..450
                     /gene="TXNDC12"
                     /gene_synonym="AG1; AGR1; ERP16; ERP18; ERP19; hAG-1;
                     hTLP19; PDIA16; TLP19"
                     /inference="alignment:Splign:2.1.0"
     exon            451..534
                     /gene="TXNDC12"
                     /gene_synonym="AG1; AGR1; ERP16; ERP18; ERP19; hAG-1;
                     hTLP19; PDIA16; TLP19"
                     /inference="alignment:Splign:2.1.0"
     exon            535..1416
                     /gene="TXNDC12"
                     /gene_synonym="AG1; AGR1; ERP16; ERP18; ERP19; hAG-1;
                     hTLP19; PDIA16; TLP19"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1368
                     /gene="TXNDC12"
                     /gene_synonym="AG1; AGR1; ERP16; ERP18; ERP19; hAG-1;
                     hTLP19; PDIA16; TLP19"
     regulatory      1397..1402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC12"
                     /gene_synonym="AG1; AGR1; ERP16; ERP18; ERP19; hAG-1;
                     hTLP19; PDIA16; TLP19"
                     /note="hexamer: AATAAA"
     polyA_site      1416
                     /gene="TXNDC12"
                     /gene_synonym="AG1; AGR1; ERP16; ERP18; ERP19; hAG-1;
                     hTLP19; PDIA16; TLP19"
                     /note="major polyA site"
ORIGIN      
        1 gttgtgctga gcggcgctcg gcgaactgtg tggaccgtct gctgggactc cggccctgcg
       61 tccgctcagc cccgtggccc cgcgcaccta ctgccatgga gacgcggcct cgtctcgggg
      121 ccacctgttt gctgggcttc agtttcctgc tcctcgtcat ctcttctgat ggacataatg
      181 ggcttggaaa gggttttgga gatcatattc attggaggac actggaagat gggaagaaag
      241 aagcagctgc cagtggactg cccctgatgg tgattattca taaatcctgg tgtggagctt
      301 gcaaagctct aaagcccaaa tttgcagaat ctacggaaat ttcagaactc tcccataatt
      361 ttgttatggt aaatcttgag gatgaagagg aacccaaaga tgaagatttc agccctgacg
      421 ggggttatat tccacgaatc ctttttctgg atcccagtgg caaggtgcat cctgaaatca
      481 tcaatgagaa tggaaacccc agctacaagt atttttatgt cagtgccgag caagttgttc
      541 aggggatgaa ggaagctcag gaaaggctga cgggtgatgc cttcagaaag aaacatcttg
      601 aagatgaatt gtaacatgaa tgtgcccctt ctttcatcag agttagtgtt ctggaaggaa
      661 agcagcaggg aagggaatat tgaggaatca tctagaacaa ttaagccgac caggaaacct
      721 cattcctacc tacactggaa ggagcgctct cactgtggaa gagttctgct aacagaagct
      781 ggtctgcatg tttgtggatc cagcggagag tggcagactt tcttctcctt ttccctctca
      841 cctaaatgtc aacttgtcat tgaatgtaaa gaatgaaacc ttctgacaca aaacttgagc
      901 cacttggatg tttactcctc gcacttaagt atttgagtct tttcccattt cctcccactt
      961 tactcacctt agtggtgaaa ggagactagt agcatctttt ctacaacgtt aaaattgcag
     1021 aagtagctta tcattaaaaa acaacaacaa caacaataac aataaatcct aagtgtaaat
     1081 cagttattct accccctacc aaggatatca gcctgttttt tccctttttt ctcctgggaa
     1141 taattgtggg cttcttccca aatttctaca gcctctttcc tcttctcatg cttgagcttc
     1201 cctgtttgca cgcatgcgtg tgcaggactg gctgtgtgct tggactcggc tccaggtgga
     1261 agcatgcttt cccttgttac tgttggagaa actcaaacct tcaagcccta ggtgtagcca
     1321 ttttgtcaag tcatcaactg tatttttgta ctggcattaa caaaaaaaga gataaaatat
     1381 tgtaccatta aactttaata aaactttaaa aggaaa
//
