LOCUS       NM_015914               3116 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens thioredoxin domain containing 11 (TXNDC11), transcript
            variant 2, mRNA.
ACCESSION   NM_015914
VERSION     NM_015914.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3116)
  AUTHORS   Chen,Y.T., Chung,C.L., Cheng,Y.W., Lin,C.J., Tseng,T.T., Hsu,S.S.,
            Tsai,H.P. and Kwan,A.L.
  TITLE     High Thioredoxin Domain-Containing Protein 11 Expression Is
            Associated with Tumour Progression in Glioma
  JOURNAL   Int J Mol Sci 24 (17), 13367 (2023)
   PUBMED   37686174
  REMARK    GeneRIF: High Thioredoxin Domain-Containing Protein 11 Expression
            Is Associated with Tumour Progression in Glioma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3116)
  AUTHORS   Murase,R., Yamamoto,A., Hirata,Y. and Oh-Hashi,K.
  TITLE     Expression analysis and functional characterization of thioredoxin
            domain-containing protein 11
  JOURNAL   Mol Biol Rep 49 (11), 10541-10556 (2022)
   PUBMED   36152228
  REMARK    GeneRIF: Expression analysis and functional characterization of
            thioredoxin domain-containing protein 11.
REFERENCE   3  (bases 1 to 3116)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3116)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3116)
  AUTHORS   George,G., Ninagawa,S., Yagi,H., Saito,T., Ishikawa,T., Sakuma,T.,
            Yamamoto,T., Imami,K., Ishihama,Y., Kato,K., Okada,T. and Mori,K.
  TITLE     EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first
            mannose trimming step in mammalian glycoprotein ERAD
  JOURNAL   Elife 9, e53455 (2020)
   PUBMED   32065582
  REMARK    GeneRIF: EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the
            first mannose trimming step in mammalian glycoprotein ERAD.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3116)
  AUTHORS   Okada,Y., Wu,D., Trynka,G., Raj,T., Terao,C., Ikari,K., Kochi,Y.,
            Ohmura,K., Suzuki,A., Yoshida,S., Graham,R.R., Manoharan,A.,
            Ortmann,W., Bhangale,T., Denny,J.C., Carroll,R.J., Eyler,A.E.,
            Greenberg,J.D., Kremer,J.M., Pappas,D.A., Jiang,L., Yin,J., Ye,L.,
            Su,D.F., Yang,J., Xie,G., Keystone,E., Westra,H.J., Esko,T.,
            Metspalu,A., Zhou,X., Gupta,N., Mirel,D., Stahl,E.A., Diogo,D.,
            Cui,J., Liao,K., Guo,M.H., Myouzen,K., Kawaguchi,T., Coenen,M.J.,
            van Riel,P.L., van de Laar,M.A., Guchelaar,H.J., Huizinga,T.W.,
            Dieude,P., Mariette,X., Bridges,S.L. Jr., Zhernakova,A., Toes,R.E.,
            Tak,P.P., Miceli-Richard,C., Bang,S.Y., Lee,H.S., Martin,J.,
            Gonzalez-Gay,M.A., Rodriguez-Rodriguez,L., Rantapaa-Dahlqvist,S.,
            Arlestig,L., Choi,H.K., Kamatani,Y., Galan,P., Lathrop,M., Eyre,S.,
            Bowes,J., Barton,A., de Vries,N., Moreland,L.W., Criswell,L.A.,
            Karlson,E.W., Taniguchi,A., Yamada,R., Kubo,M., Liu,J.S., Bae,S.C.,
            Worthington,J., Padyukov,L., Klareskog,L., Gregersen,P.K.,
            Raychaudhuri,S., Stranger,B.E., De Jager,P.L., Franke,L.,
            Visscher,P.M., Brown,M.A., Yamanaka,H., Mimori,T., Takahashi,A.,
            Xu,H., Behrens,T.W., Siminovitch,K.A., Momohara,S., Matsuda,F.,
            Yamamoto,K. and Plenge,R.M.
  CONSRTM   RACI consortium; GARNET consortium
  TITLE     Genetics of rheumatoid arthritis contributes to biology and drug
            discovery
  JOURNAL   Nature 506 (7488), 376-381 (2014)
   PUBMED   24390342
REFERENCE   7  (bases 1 to 3116)
  AUTHORS   de Chassey,B., Navratil,V., Tafforeau,L., Hiet,M.S., Aublin-Gex,A.,
            Agaugue,S., Meiffren,G., Pradezynski,F., Faria,B.F., Chantier,T.,
            Le Breton,M., Pellet,J., Davoust,N., Mangeot,P.E., Chaboud,A.,
            Penin,F., Jacob,Y., Vidalain,P.O., Vidal,M., Andre,P.,
            Rabourdin-Combe,C. and Lotteau,V.
  TITLE     Hepatitis C virus infection protein network
  JOURNAL   Mol Syst Biol 4, 230 (2008)
   PUBMED   18985028
REFERENCE   8  (bases 1 to 3116)
  AUTHORS   Kaltenbach,L.S., Romero,E., Becklin,R.R., Chettier,R., Bell,R.,
            Phansalkar,A., Strand,A., Torcassi,C., Savage,J., Hurlburt,A.,
            Cha,G.H., Ukani,L., Chepanoske,C.L., Zhen,Y., Sahasrabudhe,S.,
            Olson,J., Kurschner,C., Ellerby,L.M., Peltier,J.M., Botas,J. and
            Hughes,R.E.
  TITLE     Huntingtin interacting proteins are genetic modifiers of
            neurodegeneration
  JOURNAL   PLoS Genet 3 (5), e82 (2007)
   PUBMED   17500595
REFERENCE   9  (bases 1 to 3116)
  AUTHORS   Wang,D., De Deken,X., Milenkovic,M., Song,Y., Pirson,I.,
            Dumont,J.E. and Miot,F.
  TITLE     Identification of a novel partner of duox: EFP1, a
            thioredoxin-related protein
  JOURNAL   J Biol Chem 280 (4), 3096-3103 (2005)
   PUBMED   15561711
  REMARK    GeneRIF: EFP1 is a thioredoxin-related protein and partner of duox
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN347909.1, AK027646.1 and AF131780.1.
            
            On Jun 2, 2019 this sequence version replaced NM_015914.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1120108.1, AK027646.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283033.10/ ENSP00000283033.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               CN347909.1         22-337
            317-3112            AK027646.1         252-3047
            3113-3116           AF131780.1         1502-1505
FEATURES             Location/Qualifiers
     source          1..3116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..3116
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /note="thioredoxin domain containing 11"
                     /db_xref="GeneID:51061"
                     /db_xref="HGNC:HGNC:28030"
                     /db_xref="MIM:617792"
     exon            1..381
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..3004
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     EF-hand binding protein 1; thioredoxin domain-containing
                     protein 11"
                     /codon_start=1
                     /product="thioredoxin domain-containing protein 11 isoform
                     2"
                     /protein_id="NP_056998.4"
                     /db_xref="CCDS:CCDS32387.1"
                     /db_xref="GeneID:51061"
                     /db_xref="HGNC:HGNC:28030"
                     /db_xref="MIM:617792"
                     /translation="MSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASS
                     AGRLRRGLRGAFLMARQRPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFS
                     LRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAASRLSDQVLF
                     VAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLY
                     IPSQSELLDFLSNYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKKDYLGTVRFGVIT
                     NKHLAKLVSLVHSGSVYLHRHFNTSLVFPREVLNYTAENICKWALENQETLFRWLRPH
                     GGKSLLLNNELKKGPALFLFIPFNPLAESHPLIDEITEVALEYNNCHGDQVVERLLQH
                     LRRVDAPVLESLALEVPAQLPDPPTITASPCCNTVVLPQWHSFSRTHNVCELCVNQTS
                     GGMKPSSVSVPQCSFFEMAAALDSFYLKEQTFYHVASDSIECSNFLTSYSPFSYYTAC
                     CRTISRGVSGFIDSEQGVFEAPTVAFSSLEKKCEVDAPSSVPHIEENRYLFPEVDMTS
                     TNFTGLSCRTNKTLNIYLLDSNLFWLYAERLGAPSSTQVKEFAAIVDVKEESHYILDP
                     KQALMKLTLESFIQNFSVLYSPLKRHLIGSGSAQFPSQHLITEVTTDTFWEVVLQKQD
                     VLLLYYAPWCGFCPSLNHIFIQLARNLPMDTFTVARIDVSQNDLPWEFMVDRLPTVLF
                     FPCNRKDLSVKYPEDVPITLPNLLRFILHHSDPASSPQNVANSPTKECLQSEAVLQRG
                     HISHLEREIQKLRAEISSLQRAQVQVESQLSSARRDEHRLRQQQRALEEQHSLLHAHS
                     EQLQALYEQKTRELQELARKLQELADASENLLTENTWLKILVATMERKLEGRDGAESL
                     AAQREVHPKQPEPSATPQLPGSSPPPANVSATLVSERNKENRTD"
     exon            382..598
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..696
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..826
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..920
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1033
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1234
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..2027
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2170
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2280
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2361
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..3116
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3088..3093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /note="hexamer: AATAAA"
     polyA_site      3116
                     /gene="TXNDC11"
                     /gene_synonym="EFP1"
                     /note="major polyA site"
ORIGIN      
        1 gcggctgacg tggagcgtcc gggttagcgg gtgcggcgag ctgcgggatt ggggagcaac
       61 gggccgggcc gggccttcgg gcccgaggcg gcggcggcgg tataaagccg gcgactggga
      121 gcatgtaatg tcggaatgcg gaggccgcgg cggcggcagc agcagcagcg aggacgccga
      181 ggacgaggga gggggcggcg gcggccccgc gggctcagac tgcctcagct cgagcccgac
      241 cctggccaca gcgtcctcgg cgggccggct ccgtcgcggg ctgcgtggcg ccttcctcat
      301 ggcgcgccag cggccggagc tgctctgcgg ggccgtggcg ctcggctgcg cgctgctcct
      361 cgccctcaag ttcacctgca gtcgagcaaa agatgtgata ataccagcaa agccacctgt
      421 cagctttttc tccttgaggt ctccagtcct tgacctcttc caggggcagc tggattatgc
      481 agagtacgtt cgacgggatt cagaggtggt actgctcttc ttctatgccc cttggtgtgg
      541 acagtccatc gctgccaggg cagaaattga gcaagcagca agtcggcttt cagatcaggt
      601 gttgtttgtg gcaattaact gttggtggaa ccaggggaaa tgcagaaaac agaaacactt
      661 cttttatttt cctgtaatat atctgtatca tcggagtttt ggaccaatcg aatacaaagg
      721 ccccatgagt gctgtttaca ttgagaagtt tgtccgccgg gtgatgaaac cacttctcta
      781 catcccatct caatcagaat tactagattt tctctcaaac tacgagcctg gagtactcgg
      841 gtactttgag ttcagtggct caccccagcc tcctggttat ttgaccttct tcacctcagc
      901 attacattca ttaaagaaag attacctagg aacagtacga tttggggtta tcacaaataa
      961 acatcttgcg aaactggtat ccttagtaca ctctggaagt gtgtatttac atagacattt
     1021 caacacatca cttgtcttcc ccagggaggt cctgaactac acagctgaga acatctgtaa
     1081 gtgggcctta gaaaaccagg agacgctctt tcggtggctg cggccacacg gaggcaagag
     1141 tctcctgctg aataacgagc tgaagaaagg accagcgctg tttctgttca taccttttaa
     1201 tcccctggcc gaaagtcatc ctttaataga cgagatcacc gaagtggcct tggagtacaa
     1261 caactgtcat ggggaccagg tggtggagcg tctccttcag cacctgcggc gggtggatgc
     1321 tccagtgctg gagtccctgg ccctggaagt gccggcacag ctgccagacc cgccaacgat
     1381 cacagcgtcc ccctgctgca acactgtggt gctgccccag tggcactcct tctccaggac
     1441 ccacaacgtc tgtgaactct gtgtcaacca gacctccggg ggcatgaagc cgagctcggt
     1501 cagcgtgcca cagtgcagct tttttgaaat ggcagcagct ctggattctt tctacctcaa
     1561 ggagcagacc ttttatcatg tggcatcaga cagcatagaa tgcagcaatt ttttaacttc
     1621 ctatagcccc ttcagctact acactgcatg ttgcaggacc ataagcaggg gtgtgtcagg
     1681 cttcatcgac tctgaacaag gtgtctttga agcccctact gttgcatttt cttcccttga
     1741 gaagaaatgt gaggttgatg ccccaagctc cgttcctcac attgaggaga acaggtatct
     1801 ctttccagaa gtggacatga ctagcacaaa cttcacaggc ctgagctgca gaaccaacaa
     1861 gactctcaac atctaccttt tggattcaaa tttgttttgg ttatatgcag agagactggg
     1921 tgctccgagc tccactcagg tgaaagaatt tgcggcaatt gttgacgtga aagaagaatc
     1981 tcattacatc ttggatccaa agcaagcact gatgaagctc accctagagt cttttattca
     2041 aaacttcagc gttctctata gtcccttgaa aaggcatctc attggaagtg gctctgccca
     2101 gttcccgtct cagcatttaa tcactgaagt gacaactgat accttttggg aagtagtcct
     2161 tcaaaaacag gacgttctcc tgctctatta cgctccgtgg tgcggcttct gtccatccct
     2221 caatcacatc ttcatccagc tagctcggaa cctgcccatg gacacattca ctgtggcaag
     2281 gattgacgtg tctcagaatg accttccttg ggaatttatg gtcgatcgtc ttcctactgt
     2341 cttgtttttt ccctgcaaca gaaaggacct aagtgtgaaa taccccgaag acgtccccat
     2401 cacccttcca aacctgttga ggttcatttt gcatcactca gaccctgctt ccagccccca
     2461 gaatgtggct aactctccta ccaaggagtg tcttcagagc gaggcagtct tacagcgggg
     2521 gcacatctcc cacttggaga gagagatcca gaaactgaga gcagaaataa gcagcctcca
     2581 gcgagcacaa gtgcaggtgg agtcccagct ctccagtgcc cgcagagatg agcaccggct
     2641 gcggcagcag cagcgggccc tggaagagca gcacagcctg ctccacgcac acagtgagca
     2701 gctgcaggcc ctctatgagc agaagacacg tgagctgcag gagctggccc gcaagctgca
     2761 ggagctggcc gatgcctcag aaaacctcct taccgagaac acgtggctca agatcctggt
     2821 ggcgaccatg gagaggaaac tggagggcag ggatggagct gaaagcctgg cggcccagag
     2881 agaggtccac cccaagcagc ctgagccctc agccaccccc cagctccctg gcagctcccc
     2941 tccacctgcc aatgtcagcg ccacactggt gtctgaaagg aataaggaga acaggacaga
     3001 ctaacttttt aaatgatatg aagaaatcag aggtgaaaat tgtacattgg gaatatattt
     3061 atgcaaattt tattgaaatt tattgtaaat aaagattttc tcagtggtct agaaaa
//
