LOCUS       NM_018360               4362 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens taxilin gamma (TXLNG), transcript variant 1, mRNA.
ACCESSION   NM_018360
VERSION     NM_018360.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4362)
  AUTHORS   Tao,J., Gu,P., Lai,H., Peng,H., Guo,Z., Yuan,Y., Yu,X., Shen,X.,
            Liu,J., Xier,Z., Li,G. and Yang,Y.
  TITLE     TXLNG improves insulin resistance in obese subjects in vitro and in
            vivo by inhibiting ATF4 transcriptional activity
  JOURNAL   Mol Cell Endocrinol 568-569, 111928 (2023)
   PUBMED   37028586
  REMARK    GeneRIF: TXLNG improves insulin resistance in obese subjects in
            vitro and in vivo by inhibiting ATF4 transcriptional activity.
REFERENCE   2  (bases 1 to 4362)
  AUTHORS   Ma,D., Wang,F., Wang,R., Hu,Y., Chen,Z., Huang,N., Tian,Y., Xia,Y.,
            Teng,J. and Chen,J.
  TITLE     alpha-/gamma-Taxilin are required for centriolar subdistal
            appendage assembly and microtubule organization
  JOURNAL   Elife 11, e73252 (2022)
   PUBMED   35119360
  REMARK    GeneRIF: alpha-/gamma-Taxilin are required for centriolar subdistal
            appendage assembly and microtubule organization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4362)
  AUTHORS   Makiyama,T., Higashi,S., Sakane,H., Nogami,S. and Shirataki,H.
  TITLE     gamma-Taxilin temporally regulates centrosome disjunction in a
            Nek2A-dependent manner
  JOURNAL   Exp Cell Res 362 (2), 412-423 (2018)
   PUBMED   29225051
  REMARK    GeneRIF: Taken together with the result that gamma-taxilin protein
            expression levels were decreased at the onset of mitosis, we
            propose that gamma-taxilin participates in Nek2A-mediated
            centrosome disjunction as a negative regulator through its
            interaction with Nek2A.
REFERENCE   4  (bases 1 to 4362)
  AUTHORS   St-Arnaud,R. and Hekmatnejad,B.
  TITLE     Combinatorial control of ATF4-dependent gene transcription in
            osteoblasts
  JOURNAL   Ann N Y Acad Sci 1237, 11-18 (2011)
   PUBMED   22082360
  REMARK    GeneRIF: [review] First evidence of a functional interaction
            between ATF4, FIAT (factor-inhibiting ATF4-mediated transcription)
            and alphaNAC (nascent polypeptide-associated complex and
            coactivator alpha).
            Review article
REFERENCE   5  (bases 1 to 4362)
  AUTHORS   Du,K., Chai,Y., Hou,L., Chang,W., Chen,S., Luo,W., Cai,T.,
            Zhang,X., Chen,N., Chen,Y. and Chen,J.
  TITLE     Over-expression and siRNA of a novel environmental
            lipopolysaccharide-responding gene on the cell cycle of the human
            hepatoma-derived cell line HepG2
  JOURNAL   Toxicology 243 (3), 303-310 (2008)
   PUBMED   18068885
  REMARK    GeneRIF: evaluation of the effects of a novel environmental
            lipopolysaccharide-responding (Elrg) gene on the regulation of
            proliferation and cell cycle of the hepatoma-derived cell line,
            HepG2
REFERENCE   6  (bases 1 to 4362)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   7  (bases 1 to 4362)
  AUTHORS   Yu,V.W., Gauthier,C. and St-Arnaud,R.
  TITLE     Inhibition of ATF4 transcriptional activity by FIAT/gamma-taxilin
            modulates bone mass accrual
  JOURNAL   Ann N Y Acad Sci 1068, 131-142 (2006)
   PUBMED   16831913
REFERENCE   8  (bases 1 to 4362)
  AUTHORS   Yu,V.W., Ambartsoumian,G., Verlinden,L., Moir,J.M., Prud'homme,J.,
            Gauthier,C., Roughley,P.J. and St-Arnaud,R.
  TITLE     FIAT represses ATF4-mediated transcription to regulate bone mass in
            transgenic mice
  JOURNAL   J Cell Biol 169 (4), 591-601 (2005)
   PUBMED   15911876
REFERENCE   9  (bases 1 to 4362)
  AUTHORS   Nogami,S., Satoh,S., Tanaka-Nakadate,S., Yoshida,K., Nakano,M.,
            Terano,A. and Shirataki,H.
  TITLE     Identification and characterization of taxilin isoforms
  JOURNAL   Biochem Biophys Res Commun 319 (3), 936-943 (2004)
   PUBMED   15184072
  REMARK    GeneRIF: identification of isoforms of taxilin; interaction with
            syntaxin; tissue distribution [beta-taxilin, gamma-taxilin].
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC101576.1, AF143740.2,
            DA516680.1, AK123142.1, AW197225.1 and AA731379.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018360.2.
            
            Summary: This gene encodes a member of the taxilin family. The
            encoded protein binds to the C-terminal coiled-coil region of
            syntaxin family members 1A, 3A and 4A, and may play a role in
            intracellular vesicle trafficking. This gene is up-regulated by
            lipopolysaccharide and the gene product may be involved in cell
            cycle regulation. The related mouse protein was also shown to
            inhibit activating transcription factor 4-mediated transcription
            and thus regulate bone mass accrual. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.131237.1,
                                           SRR1660805.89071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380122.10/ ENSP00000369465.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1637              BC101576.1         2-1638
            1638-2023           AF143740.2         592-977
            2024-2325           DA516680.1         244-545
            2326-2584           AK123142.1         294-552
            2585-3066           AW197225.1         1-482               c
            3067-4360           AK123142.1         1035-2328
            4361-4362           AA731379.1         23-24               c
FEATURES             Location/Qualifiers
     source          1..4362
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..4362
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /note="taxilin gamma"
                     /db_xref="GeneID:55787"
                     /db_xref="HGNC:HGNC:18578"
                     /db_xref="MIM:300677"
     exon            1..124
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1609
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lipopolysaccharide specific response-5 protein;
                     gamma-taxilin; factor inhibiting activating transcription
                     factor 4 (ATF4)-mediated transcription; environmental
                     LPS-responding; lipopolysaccharide-specific response
                     protein 5; factor inhibiting ATF4-mediated transcription;
                     environmental lipopolysaccharide-responding gene protein"
                     /codon_start=1
                     /product="gamma-taxilin isoform 1"
                     /protein_id="NP_060830.2"
                     /db_xref="CCDS:CCDS14178.1"
                     /db_xref="GeneID:55787"
                     /db_xref="HGNC:HGNC:18578"
                     /db_xref="MIM:300677"
                     /translation="MATRVEEAARGRGGGAEEATEAGRGGRRRSPRQKFEIGTMEEAG
                     ICGLGVKADMLCNSQSNDILQHQGSNCGGTSNKHSLEEDEGSDFITENRNLVSPAYCT
                     QESREEIPGGEARTDPPDGQQDSECNRNKEKTLGKEVLLLMQALNTLSTPEEKLAALC
                     KKYADLLEESRSVQKQMKILQKKQAQIVKEKVHLQSEHSKAILARSKLESLCRELQRH
                     NKTLKEENMQQAREEEERRKEATAHFQITLNEIQAQLEQHDIHNAKLRQENIELGEKL
                     KKLIEQYALREEHIDKVFKHKELQQQLVDAKLQQTTQLIKEADEKHQREREFLLKEAT
                     ESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFRQEMEKMTKKIKKL
                     EKETIIWRTKWENNNKALLQMAEEKTVRDKEYKALQIKLERLEKLCRALQTERNELNE
                     KVEVLKEQVSIKAAIKAANRDLATPVMQPCTALDSHKELNTSSKRALGAHLEAEPKSQ
                     RSAVQKPPSTGSAPAIESVD"
     exon            125..428
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /inference="alignment:Splign:2.1.0"
     exon            429..520
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /inference="alignment:Splign:2.1.0"
     exon            521..691
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /inference="alignment:Splign:2.1.0"
     exon            692..886
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1006
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1081
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1174
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1270
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..4362
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3042..3047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /note="hexamer: AATAAA"
     polyA_site      3068
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
     regulatory      4339..4344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /note="hexamer: AGTAAA"
     polyA_site      4362
                     /gene="TXLNG"
                     /gene_synonym="CXorf15; ELRG; FIAT; LSR5; TXLNGX"
                     /note="major polyA site"
ORIGIN      
        1 gtttggctgc tgccgtcacc tcatggcgac gcgggtagag gaggcagcgc ggggaagagg
       61 cggcggcgcc gaagaggcga ctgaggccgg acggggcgga cggcgacgca gcccgcggca
      121 gaagtttgaa attggcacaa tggaagaagc tggaatttgt gggctagggg tgaaagcaga
      181 tatgttgtgt aactctcaat caaatgatat tcttcaacat caaggctcaa attgtggtgg
      241 cacaagtaac aagcattcat tggaagagga tgaaggcagt gactttataa cagagaacag
      301 gaatttggtg agcccagcat actgcacgca agaatcaaga gaggaaatcc ctgggggaga
      361 agctcgaaca gatccccctg atggtcagca agattcagag tgcaacagga acaaagaaaa
      421 aactttagga aaagaagttt tattactgat gcaagcccta aacacccttt caaccccaga
      481 ggagaagctg gcagctctct gtaagaaata tgctgatctt ctggaggaga gcaggagtgt
      541 tcagaagcaa atgaagatcc tgcagaagaa gcaagcccag attgtgaaag agaaagttca
      601 cttgcagagt gaacatagca aggctatctt ggcaagaagc aagctagaat ctctttgcag
      661 agaacttcag cgtcacaata agacgttaaa ggaggaaaat atgcagcagg cacgagagga
      721 agaagaacga cgtaaagaag caactgcaca tttccagatt accttaaatg aaattcaagc
      781 ccagctggag cagcatgaca tccacaacgc caaactccga caggaaaaca ttgagctggg
      841 ggagaagcta aagaagctca tcgaacagta cgcactgagg gaagagcaca ttgataaggt
      901 gttcaaacat aaggaactgc aacagcagct cgtggatgcc aaactgcagc aaacgacaca
      961 actgataaaa gaagctgatg aaaaacatca gagagagaga gagtttttat taaaagaagc
     1021 gacagaatcg aggcacaaat acgaacaaat gaaacagcaa gaagtacaac taaaacagca
     1081 gctttctctt tatatggata agtttgaaga attccagact accatggcaa aaagcaatga
     1141 actgtttaca accttcagac aggaaatgga aaagatgaca aagaaaatta aaaaactgga
     1201 aaaagaaaca ataatttggc gtaccaaatg ggaaaacaat aataaagcac ttctgcaaat
     1261 ggctgaagag aaaacagtcc gtgataaaga gtacaaggcc cttcaaataa aactggaacg
     1321 gttagagaag ctgtgcaggg ctcttcagac agaaaggaat gagctcaatg agaaggtgga
     1381 agtcctgaaa gagcaggtat ccatcaaagc ggccatcaaa gcggcgaaca gggatttagc
     1441 aacacctgtg atgcagccct gtactgccct ggattctcac aaggagctga acacttcctc
     1501 gaaaagagcc ctgggagcgc acctggaggc tgagcccaag agtcagagaa gcgctgtgca
     1561 aaagcccccg tccacaggct ctgctccggc catcgagtcg gttgactaag atgaggtgtg
     1621 atcactgtat tgagagatat attttgtgta taactttctc tgttagtagt taactattgg
     1681 ttttgtggtg aaaattttct tactttttct accatatctg tattttctta gaactactgg
     1741 acttatgtgg tacaggaggc tgcttagcag ttttgaatag tttaatctat aaattttcct
     1801 cagctgtgtt gcacatcagc ctcgttctcc ctccactgga atgcatgtgt tcattgcctt
     1861 gtcctttctc tccctgctcc ttgcacatta tcatcctaat gaaaatttca ctgacagggc
     1921 cgaccattac aagggaactt tgttctgacg atggttcctt gatgtgaaaa caatattaat
     1981 ttaaacgtct tagccccccc ccccataata ttattcagaa aaacaaaata ccaaggcgat
     2041 tagttttgtc taataaccca tttaaatgcc aagtaaaaat aaaactccta gtgttgggtc
     2101 agaagcatat ttgattgaaa ttagcttttt gaaaacattt atatctcggg acaaattgag
     2161 atggccacat gcctagaatc ctaagtttcg gcagaatatg tatataaaga tgtcacttgt
     2221 ggacaaaata gtacatagag gcaaatcact agacaaataa gcttagtgtt tacgtgactg
     2281 aacagtcatc ctgctttggt ttcaggtgtg ggatttggac catgaggggc tcccgtagag
     2341 gatggcggtt tgtgtttgat tctgatttgg gatttcagta catattctcc acttcccata
     2401 gaaggccact tattctttga aaactggtgt tcatgtttgc cgttcaatga agtcccttgt
     2461 caaagacaag gacggtcaat tcacgtgtca ctttcactag gcagaagttt ctccaatacc
     2521 ttctggctac ttgaaagtta ctacaaaaat tccaccagca aagtactcca ggtttttcaa
     2581 aagggaattt tcattatgga tcagtaccaa ccgaaattga ttttcatttc caaaacaaac
     2641 actggcacca acatttttac tttgggaaga cttggcagag tgttagtcat gatctgttac
     2701 ttacgtgttc agtctgtttt ctcaccccct tcttagttac catctctttt ttaagaagaa
     2761 aaaagaaaag ccacagtatt atcaaggtct ctacacttgg actgggggaa aatttgaaat
     2821 taagcacata acttttgaat tagttctttg tttcaatgtt gaatgtggcg cagttatgca
     2881 gatgattaat caggctgcac tgatggaagt tttgactttg tccctggtat aatttgcatt
     2941 gaaatgcttt atgaaataaa aggttctact agaactgatg ttagcacatt ccactgagca
     3001 aaactatcag actgacactt gttaaattgc ttactggact gaataaactc tgttttgtcc
     3061 agttaaaagg gttttctctt tgttacaagt gttatttgta aagtcctgtc acattcatgg
     3121 tcgaaactgg gttgaaagaa ttgaaaattg tccaacagat agatagatag gaaaccgcct
     3181 ggagtggagg agggttgtat ctaagcctcc actatcagtc atgttaattc aaggggccac
     3241 agtggaggaa aataaatcca caaagtagat tatctaatta ccatcaaaat gagtcagaag
     3301 caaaaaacac caccctccaa cagcctctta ggagtacacc ctgttctgct actaaaatac
     3361 tagactcatt tccctggtgg tgggggggaa tgcaggtata gatcagaaat ataatccacc
     3421 ttaaaattag tactaatgat cacattattt cacaagaact ctgctggatg tacagctctt
     3481 aacattttat taagccattt gtgtagccca ccacgtttct ttgtggtgct tgtcctgtgt
     3541 ggaagattgt aaatcttggg cctgttgcat acttccaagg gctttaaagc aatgtgatta
     3601 acagtacttg gcctgctgct tttggcttac tttgtatttt tagctagatg ctattatagt
     3661 gttgaaagga tatggattct gtctgggatg catttgttgt cctttcagaa cccttcctcc
     3721 cattaccctg tgaataaaaa caaatgggac cccctgagaa ggacatcttc ctacagtgat
     3781 cacctcacca gcccagtgtt gtggctttgt agcgcacccc gtatctacca tattctagaa
     3841 cactgtaatg ctactaggct ggcccagaaa aggtttaaat gttgaattca cttaaattgc
     3901 aattgttgca ccatcatgga atcgtgatgt gtattattta tattggcggt ggactccaag
     3961 gtgtagagaa aacttgggtc ttgggtaata tggaccattt catcctcaga cttgttagga
     4021 gtacatttct tggtcttgag accagtattt ttcagttatg tatgcaactg cctttattac
     4081 acctggttat cacaattcaa ttctcaggtg ttgcagaaaa atctacctct ttcagactgt
     4141 agatggaaat aactgtgaaa aaaatgatgc agatatcttc tagtttgtgc taaacacact
     4201 gctttatttt tacagcccac gtctttcatg aggatacgaa ttgttaagag gcagtctcgt
     4261 tttgcttttc aaagacattt tgtagagatt tttcactaat gtgaatctga ttttatctac
     4321 ttgattctgt atagattaag taaatatgta tgataaactt aa
//
