LOCUS       NM_153235               4612 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens taxilin beta (TXLNB), mRNA.
ACCESSION   NM_153235 NM_138816 XM_371849
VERSION     NM_153235.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4612)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4612)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4612)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4612)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 4612)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 4612)
  AUTHORS   Li,S., Wang,L., Berman,M., Kong,Y.Y. and Dorf,M.E.
  TITLE     Mapping a dynamic innate immunity protein interaction network
            regulating type I interferon production
  JOURNAL   Immunity 35 (3), 426-440 (2011)
   PUBMED   21903422
  REMARK    Erratum:[Immunity. 2011 Oct 28;35(4):647-8]
REFERENCE   7  (bases 1 to 4612)
  AUTHORS   Nogami,S., Satoh,S., Tanaka-Nakadate,S., Yoshida,K., Nakano,M.,
            Terano,A. and Shirataki,H.
  TITLE     Identification and characterization of taxilin isoforms
  JOURNAL   Biochem Biophys Res Commun 319 (3), 936-943 (2004)
   PUBMED   15184072
  REMARK    GeneRIF: identification of isoforms of taxilin; interaction with
            syntaxin; tissue distribution [beta-taxilin, gamma-taxilin].
REFERENCE   8  (bases 1 to 4612)
  AUTHORS   Itoh,S., Uyeda,A., Hukuoka,Y., Fujimori,K.E., Matsuda,A.,
            Ichinose,S., Kobayashi,H., Shinomiya,K., Tanaka,J. and Taguchi,T.
  TITLE     Muscle-specific protein MDP77 specifically promotes motor nerve
            regeneration in rats
  JOURNAL   Neurosci Lett 360 (3), 175-177 (2004)
   PUBMED   15082161
REFERENCE   9  (bases 1 to 4612)
  AUTHORS   Fujimori,K.E., Uyeda,A. and Taguchi,T.
  TITLE     Regulatory expression of MDP77 protein in the skeletal and cardiac
            muscles
  JOURNAL   FEBS Lett 529 (2-3), 303-308 (2002)
   PUBMED   12372618
REFERENCE   10 (bases 1 to 4612)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB085905.1 and AL158850.8.
            
            On Nov 23, 2018 this sequence version replaced NM_153235.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL831988.1, BX647477.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358430.8/ ENSP00000351206.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2635              AB085905.1         74-2708
            2636-4612           AL158850.8         47551-49527         c
FEATURES             Location/Qualifiers
     source          1..4612
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.1"
     gene            1..4612
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /note="taxilin beta"
                     /db_xref="GeneID:167838"
                     /db_xref="HGNC:HGNC:21617"
                     /db_xref="MIM:611438"
     exon            1..78
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /inference="alignment:Splign:2.1.0"
     exon            79..516
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2147
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /note="muscle-derived protein 77"
                     /codon_start=1
                     /product="beta-taxilin"
                     /protein_id="NP_694967.3"
                     /db_xref="CCDS:CCDS34545.1"
                     /db_xref="GeneID:167838"
                     /db_xref="HGNC:HGNC:21617"
                     /db_xref="MIM:611438"
                     /translation="MEANHSEQLSAERQSTPPGDSSSLPSHNGLEKEDGQDSPTPVQP
                     PEKEASVHPDISEELNRQLEDIINTYGSAASTAGKEGSARASEQPENAESPDNEDGDC
                     EETTEEAGREPVASGEPPTVKEPVSNKEQKLEKKILKGLGKEANLLMQNLNKLQTPEE
                     KFDFLFKKYAELLDEHRTEQKKLKLLQKKQVQIQKEKDQLQGEHSRAILARSKLESLC
                     RELQRHNKTLKEEALQRAREEEEKRKEITSHFQSTLTDIQGQIEQQSERNMKLCQENT
                     ELAEKLKSIIDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHKREKEY
                     LLNQAAEWKLQAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTT
                     KKMKKLEKDTATWKARFENCNKALLDMIEEKALRAKEYECFVMKIGRLENLCRALQEE
                     RNELHKKIRDAEISEKDDQSQHNSDEEPESNVSVDQEIDAEEVNSVQTAVKNLATAFM
                     IIHHPESTPHQSKETQPEIGSSQESADAALKEPEQPPLIPSRDSESPLPPLTPQAEAE
                     GGSDAEPPSKASNSPAGLGAETQCEGLPVGAQADQASWKPEAEASGQAPQAPTEASLQ
                     KMEADVPAPACAAEEHVAAMVPACEPSRQPPRAAAEELPVGASAGPQPRNVADTNLEG
                     VD"
     exon            517..608
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /inference="alignment:Splign:2.1.0"
     exon            609..779
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /inference="alignment:Splign:2.1.0"
     exon            780..974
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1094
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1169
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1262
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1358
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..4612
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4587..4592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /note="hexamer: ATTAAA"
     polyA_site      4612
                     /gene="TXLNB"
                     /gene_synonym="C6orf198; dJ522B19.2; LST001; MDP77"
                     /note="major polyA site"
ORIGIN      
        1 gctgttgctg cagctctgac ttgctttttc ctgcctcctt cctctcctct ctcttcttgc
       61 ttagcttctt gccttctgat actactccca agatggaggc taatcactct gaacagctct
      121 cagcggaacg acagtcaaca cctccaggtg acagttcatc attacccagt cacaatggcc
      181 tggagaagga agatggccag gattctccaa ccccagtcca accaccagag aaagaggcaa
      241 gtgtgcaccc cgatatctct gaagagctga atcgacagct ggaagacatc attaacactt
      301 atgggtctgc tgccagcaca gcagggaaag agggctctgc cagggccagt gagcagcctg
      361 agaatgcaga atcacctgac aacgaggatg gggactgtga ggaaacaact gaagaggctg
      421 gaagagaacc cgttgcttct ggagagccac ccactgtcaa agagcccgtc agcaataagg
      481 agcaaaaatt ggaaaagaaa atcctaaaag gattaggcaa agaagccaac ctgctaatgc
      541 aaaatctgaa caagttgcaa acaccggaag aaaagtttga ttttttattc aagaagtatg
      601 ctgaattgct ggatgaacat cgtactgagc aaaagaagtt aaagctcctc caaaagaaac
      661 aggtacaaat tcaaaaagaa aaggaccagt tacaaggtga acacagcaga gctatcctcg
      721 ctcgaagcaa attggagagt ctgtgccggg agctgcagag acacaacaag actctgaagg
      781 aagaggcgct tcagcgggca cgtgaggaag aagagaaaag gaaggaaatc acaagccatt
      841 tccagagtac cctcacggac atccagggcc agatcgagca gcagagtgag cgaaatatga
      901 agctctgtca ggagaacaca gagcttgcag aaaagctgaa aagcatcatc gatcagtatg
      961 agctcagaga ggagcatctg gacaaaatat ttaaacacag agaactgcag cagaagctgg
     1021 tggatgcaaa gcttgagcag gcccaagaaa tgatgaagga agcggaggag cgacacaaac
     1081 gagaaaagga atatttgctg aaccaggcag cagagtggaa acttcaggcg aaagtgctga
     1141 aggagcaaga gacagtcctg caggctcagc tcactctcta ctcaggaagg tttgaagaat
     1201 tccagagcac actaactaaa agcaacgagg tgtttgccac gttcaaacag gaaatggaca
     1261 aaacaactaa gaaaatgaag aagctggaaa aggacacagc cacatggaaa gcccgatttg
     1321 agaactgtaa caaagctctg ttggacatga ttgaagagaa agcactgaga gctaaagaat
     1381 atgagtgctt tgtgatgaaa atcgggaggc tagagaacct ctgccgtgct ttacaagaag
     1441 agagaaacga actccacaaa aaaatcagag acgcagaaat atctgaaaag gatgaccaaa
     1501 gtcagcacaa ctccgatgaa gagccagagt caaacgtctc tgtggatcaa gagattgacg
     1561 cagaggaggt taatagtgtc caaaccgccg tgaaaaatct ggccacagcc ttcatgataa
     1621 ttcatcatcc agagtcaacc ccgcaccagt ccaaagaaac ccaacccgaa ataggcagtt
     1681 ctcaggagag tgctgacgcc gctctcaagg agccagagca accccctctg atcccttcac
     1741 gggattcaga gagtcccctg cctcccctaa ctcctcaggc tgaagccgaa ggaggcagtg
     1801 atgctgaacc tccctccaag gccagtaatt ctcctgccgg gttgggagca gaaacccaat
     1861 gcgagggtct ccctgttgga gcacaggctg atcaggcgtc ctggaagcca gaggcagaag
     1921 cttccggtca ggccccacag gctcccaccg aggcctccct acagaagatg gaggcagatg
     1981 tgcctgctcc agcatgcgca gcagaagagc acgttgcagc catggtgcct gcatgcgagc
     2041 ccagtaggca gcccccacga gcagcagcag aggagctgcc agtaggggcc tcagctgggc
     2101 cccagccgcg caacgtggct gacaccaatc tggaaggcgt cgactaagcc tcaccgtgcc
     2161 ttcagaggct tcttcctgcc tctttgcata ttcagcataa cagcttgtct tccgaaaaag
     2221 gcattaaggg ctagagatgt caaatggaag agacttagga tcaagacatt ttttaatgtt
     2281 aggcagaaca cattcattca gactttgcta tttgttgtca atttatagct gatttgaagg
     2341 ttttctattt aacactggtt gacagtataa ttttcccaaa gggcaacaaa acatacagat
     2401 agcaaattta tattcctttt ctgttaagat aatacttaaa tttgttaatc accagtaaga
     2461 tttgatgttt aaagacttcc actgcaatat ataaatactg aaaatgtgat gttctgctta
     2521 tttggatata tagtttaaca agttccatag taatttatgg atgcccaggt tacatttaaa
     2581 ctatacatat acataatata tacatacgtg tgtacttatt atatgtatat atacacgtat
     2641 gtatagatgt gtgaatattt gtttatatac atatatgcac gtatctatat gtatatataa
     2701 atgcattatt acacatacat ttctctcacc ccttaatgca tttttctcaa tgcagaatat
     2761 ttagatgcta atcaaaaaaa tgatctctta cttgcacttg agactatggt tgactaatgc
     2821 tctataaatc cgaagagagt tcggactata agtatttagg ctatcattat gttgggcaaa
     2881 aataagtaac ccaatggtag ataaatgaat tcaaccagtt gatcaaatgg cagaaaagca
     2941 gttagactac aatctgtgca gacagcatgg acacaaagat gaccacaagg ggcccaaaac
     3001 agaaaagaga aacacaagct cacctcttgg agctgcttct cctacacttc tcagcccatt
     3061 gctttgccac cccctcatgt gccagggcat cccattccag gcttcctgca aggaaacggt
     3121 tggaagtggg aaaggggagc tagggattga ggggttaagg gacctcacac taagaagggg
     3181 ctgtgctttg atcccctgcc tcttgcacta ccaatgtctc aagacataat attcatctct
     3241 tgctgtcaga cccattctat attctaaaag cttctgctcc ttccttccca atttctcctt
     3301 tgtagcagga aattacaccc agccctcatc tcaattaatg ctaaataaag ctattgtttt
     3361 tccaaaacac aaatctacac tgggtctcaa tatcagtgat gaggcttaca aaccaacacg
     3421 ttttctgcca tgaggatttc tctttaggcc agaagtacaa aacaaaaaaa ccaatggatt
     3481 ttaaccaaaa tgatttgaaa tataggtgag gattcaggag aaggcaaaag ctagaaacac
     3541 ttggggttgt caacatgagt attacattaa cattgcttga tgagaacctc taatgatact
     3601 gacaacataa attacctagg gtaaaggata gctgcaacaa tgaaacagga aagaagagag
     3661 ggagagagag gaaagggaag gaagaaagga aggagggaga agggaagaaa gaaacaatgt
     3721 ctaacccaac cctatcttga aagttgaact caagtagaaa aatggataga aacaaaattc
     3781 tctagtactc atccaggaaa ccattcttca atgttgcatg tggctgtttg ccaaggcaca
     3841 caaagtgctt gtaggcagca accatatgct acaagaattg taaactgcat acagtttgtt
     3901 tgaagtagac agtgaggata ataacaaagt tgctaggcag gaaaaaaaat caggaaaaaa
     3961 gcttgtcgct atttgagaat ctgtatattt ttaaaggctt aaaatattat aaccacaggg
     4021 tatccagcca aattcaacat tactgcaagt cttagagatt taaacattca tttgattcag
     4081 agctaaatat tcaccataat ccaggagggt ctccttcccc actgcagagg cagaacgtcc
     4141 aagaatggag taagattagt catagtaaag tctcagtctg aatatttagc aagagaaaca
     4201 ggcagcagag gaacccaaag gcagtaaatc aaatattcta aaacccaaag ttcattattt
     4261 tcatccaaaa gactttcaca gaaacacatt actcacagcc atgtatatct tggacagagt
     4321 ttcagatgga atgacttgtc tgaaatttgt aaagcttaat ataggttttg ggggaattat
     4381 tttaatattc aaagaatgtt ttattatagt cctttgtgtt aaaatttagc cttactaatt
     4441 ataacaataa ctcataaagt tctaaattca gaaggaatgt ctgttcttta tcaagtgtat
     4501 gtaactattt tttagaaatg ccatctactt tctagaaaca ctaaagttat tgttttctaa
     4561 gttaaataac tataatttat atatctatta aaaaggtact tctcttccca aa
//
