LOCUS       NM_175852               4865 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens taxilin alpha (TXLNA), transcript variant 1, mRNA.
ACCESSION   NM_175852
VERSION     NM_175852.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4865)
  AUTHORS   Ma,D., Wang,F., Wang,R., Hu,Y., Chen,Z., Huang,N., Tian,Y., Xia,Y.,
            Teng,J. and Chen,J.
  TITLE     alpha-/gamma-Taxilin are required for centriolar subdistal
            appendage assembly and microtubule organization
  JOURNAL   Elife 11, e73252 (2022)
   PUBMED   35119360
  REMARK    GeneRIF: alpha-/gamma-Taxilin are required for centriolar subdistal
            appendage assembly and microtubule organization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4865)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4865)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 4865)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4865)
  AUTHORS   Lv,S., Zhang,G., Xie,L., Yan,Z., Wang,Q., Li,Y., Zhang,L., Han,Y.,
            Li,H., Du,Y., Yang,Y. and Guo,X.
  TITLE     High TXLNA Expression Predicts Favourable Outcome for Pancreatic
            Adenocarcinoma Patients
  JOURNAL   Biomed Res Int 2020, 2585862 (2020)
   PUBMED   32185195
  REMARK    GeneRIF: High TXLNA Expression Predicts Favourable Outcome for
            Pancreatic Adenocarcinoma Patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4865)
  AUTHORS   Nogami,S., Satoh,S., Nakano,M., Terano,A. and Shirataki,H.
  TITLE     Interaction of taxilin with syntaxin which does not form the SNARE
            complex
  JOURNAL   Biochem Biophys Res Commun 311 (4), 797-802 (2003)
   PUBMED   14623251
REFERENCE   7  (bases 1 to 4865)
  AUTHORS   Nogami,S., Satoh,S., Nakano,M., Shimizu,H., Fukushima,H.,
            Maruyama,A., Terano,A. and Shirataki,H.
  TITLE     Taxilin; a novel syntaxin-binding protein that is involved in
            Ca2+-dependent exocytosis in neuroendocrine cells
  JOURNAL   Genes Cells 8 (1), 17-28 (2003)
   PUBMED   12558796
REFERENCE   8  (bases 1 to 4865)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 4865)
  AUTHORS   Ambrus,J.L. Jr., Pippin,J., Joseph,A., Xu,C., Blumenthal,D.,
            Tamayo,A., Claypool,K., McCourt,D., Srikiatchatochorn,A. and
            Ford,R.
  TITLE     Identification of a cDNA for a human high molecular-weight B-cell
            growth factor
  JOURNAL   Proc Natl Acad Sci U S A 93 (15), 8154 (1996)
   PUBMED   8755619
  REMARK    Correction to:[Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6330-4.
            doi: 10.1073/pnas.90.13.6330.. PMID: 8327514]
REFERENCE   10 (bases 1 to 4865)
  AUTHORS   Ambrus,J.L. Jr., Pippin,J., Joseph,A., Xu,C., Blumenthal,D.,
            Tamayo,A., Claypool,K., McCourt,D., Srikiatchatochorn,A. and
            Ford,R.J.
  TITLE     Identification of a cDNA for a human high-molecular-weight B-cell
            growth factor
  JOURNAL   Proc Natl Acad Sci U S A 90 (13), 6330-6334 (1993)
   PUBMED   8327514
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):8154. doi:
            10.1073/pnas.93.15.8154-b.. PMID: 8755619]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049795.21, AL832338.1, BC046565.1 and BC029686.1.
            
            On Nov 23, 2018 this sequence version replaced NM_175852.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832636.2, SRR1660803.162601.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373610.8/ ENSP00000362712.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AL049795.21        69003-69071
            70-1721             AL832338.1         38-1689
            1722-4393           BC046565.1         365-3036
            4394-4865           BC029686.1         3010-3481
FEATURES             Location/Qualifiers
     source          1..4865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..4865
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /note="taxilin alpha"
                     /db_xref="GeneID:200081"
                     /db_xref="HGNC:HGNC:30685"
                     /db_xref="MIM:608676"
     exon            1..102
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /inference="alignment:Splign:2.1.0"
     exon            103..303
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1775
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-taxilin; interleukin 14"
                     /codon_start=1
                     /product="alpha-taxilin isoform 1"
                     /protein_id="NP_787048.1"
                     /db_xref="CCDS:CCDS353.1"
                     /db_xref="GeneID:200081"
                     /db_xref="HGNC:HGNC:30685"
                     /db_xref="MIM:608676"
                     /translation="MKNQDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAE
                     GPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQG
                     EPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQ
                     EKKKAKGLGKEITLLMQTLNTLSTPEEKLAALCKKYAELLEEHRNSQKQMKLLQKKQS
                     QLVQEKDHLRGEHSKAVLARSKLESLCRELQRHNRSLKEEGVQRAREEEEKRKEVTSH
                     FQVTLNDIQLQMEQHNERNSKLRQENMELAERLKKLIEQYELREEHIDKVFKHKDLQQ
                     QLVDAKLQQAQEMLKEAEERHQREKDFLLKEAVESQRMCELMKQQETHLKQQLALYTE
                     KFEEFQNTLSKSSEVFTTFKQEMEKMTKKIKKLEKETTMYRSRWESSNKALLEMAEEK
                     TVRDKELEGLQVKIQRLEKLCRALQTERNDLNKRVQDLSAGGQGSLTDSGPERRPEGP
                     GAQAPSSPRVTEAPCYPGAPSTEASGQTGPQEPTSARA"
     exon            304..639
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /inference="alignment:Splign:2.1.0"
     exon            640..731
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /inference="alignment:Splign:2.1.0"
     exon            732..902
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1097
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1217
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1292
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1385
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1481
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..4865
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4845..4850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /note="hexamer: AATAAA"
     polyA_site      4865
                     /gene="TXLNA"
                     /gene_synonym="IL-14; IL14; TXLN"
                     /note="major polyA site"
ORIGIN      
        1 attgattggc tgaggcggga gcaggcggct ggccggcagc agttactcgg ggtttccggt
       61 gcgaggccag aggtggggaa gccatcggac gtcggcggtg aggatcttct cctgacccag
      121 catcgctcat cacaatgaag aaccaagaca aaaagaacgg ggctgccaaa caatccaatc
      181 caaaaagcag cccaggacaa ccggaagcag gacccgaggg agcccaggag cggcccagcc
      241 aggcggctcc tgcagtagaa gcagaaggtc ccggcagcag ccaggctcct cggaagccgg
      301 agggggctca agccagaacg gctcagtctg gggcccttcg tgatgtctct gaggagctga
      361 gccgccaact ggaagacata ctgagcacat actgtgtgga caataaccag gggggccccg
      421 gcgaggatgg ggcacagggt gagccggctg aacccgaaga tgcagagaag tcccggacct
      481 atgtggcaag gaatggggag cctgaaccaa ctccagtagt caatggagag aaggaaccct
      541 ccaaggggga tccaaacaca gaagagatcc ggcagagtga cgaggtcgga gaccgagacc
      601 atcgaaggcc acaggagaag aaaaaagcca agggtttggg gaaggagatc acgttgctga
      661 tgcagacatt gaatactctg agtaccccag aggagaagct ggctgctctg tgcaagaagt
      721 atgctgaact gctggaggag caccggaatt cacagaagca gatgaagctc ctacagaaaa
      781 agcagagcca gctggtgcaa gagaaggacc acctgcgcgg tgagcacagc aaggccgtcc
      841 tggcccgcag caagcttgag agcctatgcc gtgagctgca gcggcacaac cgctccctca
      901 aggaagaagg tgtgcagcgg gcccgggagg aggaggagaa gcgcaaggag gtgacctcgc
      961 acttccaggt gacactgaat gacattcagc tgcagatgga acagcacaat gagcgcaact
     1021 ccaagctgcg ccaagagaac atggagctgg ctgagaggct caagaagctg attgagcagt
     1081 atgagctgcg cgaggagcat atcgacaaag tcttcaaaca caaggaccta caacagcagc
     1141 tggtggatgc caagctccag caggcccagg agatgctaaa ggaggcagaa gagcggcacc
     1201 agcgggagaa ggattttctc ctgaaagagg cagtagagtc ccagaggatg tgtgagctga
     1261 tgaagcagca agagacccac ctgaagcaac agcttgccct atacacagag aagtttgagg
     1321 agttccagaa cacactttcc aaaagcagcg aggtattcac cacattcaag caggagatgg
     1381 aaaagatgac taagaagatc aagaagctgg agaaagaaac caccatgtac cggtcccggt
     1441 gggagagcag caacaaggcc ctgcttgaga tggctgagga gaaaacagtc cgggataaag
     1501 aactggaggg cctgcaggta aaaatccaac ggctggagaa gctgtgccgg gcactgcaga
     1561 cagagcgcaa tgacctgaac aagagggtac aggacctgag tgctggtggc cagggctccc
     1621 tcactgacag tggccctgag aggaggccag aggggcctgg ggctcaagca cccagctccc
     1681 ccagggtcac agaagcgcct tgctacccag gagcaccgag cacagaagca tcaggccaga
     1741 ctgggcctca agagcccacc tccgccaggg cctagagagc ctggtgttgg gtcatgctgg
     1801 gaagggagcg gcagcccagc caggcctggc ccataaaagg ctcccatgct gagcagccca
     1861 ttgctgaagc caggatgttc tgacctggct ggcatctggc acttgcaatt ttggattttg
     1921 tgggtcagtt ttacgtacat agggcatttt gcaaggcctt gcaaatgcat ttatacctgt
     1981 aagtgtacag tgggcttgca ttggggatgg gggtgtgtac agatgaagtc agtggcttgt
     2041 ctgtgagctg aagagtcttg agaggggctg tcatctgtag ctgccatcac agtgagttgg
     2101 cagaagtgac ttgagcattt ctctgtctga tttgaggctc agacccctcc ctgcccttca
     2161 gagctcaaga caagtaatac acccaggtct tgactgcatt tgtcttgtga gcagggcttg
     2221 cttggtcagc tcaggccctc ctagctgctc tggaggctcc tttgattctc tagacctgga
     2281 aaaggtgtcc ctaggcagag ccctggcagg gcgctcagag ctggggattt cctgcctgga
     2341 acaagggacc tggagaatgt ttttgcgtgg gatgatgtgc tggtcaggag ccccttgggc
     2401 atcgcttccc ctgccctttg gtagtgccag gaccaggcca atgatgcttc tcagtagcct
     2461 tatcattcac aggtgcctct ctagcctgca caaatgattg acaagagatc acccaaagga
     2521 ttatttctga aggtgttttt ttctttattt ctttttcttt tttttttttt ttctttttct
     2581 tttttttttg cacatgacag tgtttgtatt gaggaccttc caaggaagag ggatgctgta
     2641 gcagtggtgc ctgggtgcct ggcctccagt gtcccacctc cttcaccacc ccacttggct
     2701 cctttgccat cttgatgctg aggtttcctg tttggtgaga tcaggttgtt tgtggtaaaa
     2761 gaaaggaaag ggcttctgat ggctttgcca caagcttacc tgtgggtttc agtcctgaga
     2821 ggccaccacc agttcccatc agcactgtct ccatgcagca gttgctgggt cccatgtcca
     2881 gctgcctctt tggcttcatg ggtttttctg cttcctgccc ccacccccac atgtgcaatc
     2941 ctcaagattt gtcctgattc tatttcctgg cacctccctg cctgtccttg gggattctac
     3001 ttcttcctgt gtgggagccc atagctgttg tctaacaggt aagaaatgaa attgaactat
     3061 tgactgggcc ccagaaatcc ataaaatggc tgcagacagt tgtttctgtg tcctgttcta
     3121 cccccactcc agtacataac tactatgtac tgtgtagagc cattctatat gctgaatgtt
     3181 ctgctgttgc aaacttgcca gggtattagc cagtgtttgt gccaagcagt tttctgggac
     3241 aacagaatga ctcagaccaa gatggatagg atggttaggg ctttgcttct tgctgttttt
     3301 ctttgaagct agttcattgt cctgcaggtc ccttcatctt ccatacctag cccactcttt
     3361 tagcccttac cttaaatctc tcagataagt tggttcacaa agaatgttaa gtactgaatc
     3421 atgtgtgact gagaccagag atggcaaatg aatggcacac catttctcct tctcctgccc
     3481 cagggcaggt accactgatc tgcatcagag ttgcctgcta ttctctggtg tatccttcac
     3541 atctaggtgc cctcaagcag ctgtgtgagt gttgagatct ctgccatctc tggctgagat
     3601 actgctgtcc tgtgaagtgt ttcccatgac ctttttcttc ccctttgaat ccctctgtct
     3661 ggagtagtcc ttgcctcttc ctgctccagt agggcctttt ccctacccca gcccctgtgc
     3721 caggctaagc tggtacaaga gctgccaacc tcacagagtg tttgctaggc gagagaggtg
     3781 cagggaagag gcagaggtat gcaccttccc ccttgaagag aggggaaagg cctacagtgg
     3841 cccacataat tgcctgactc acacttcagc tacctcttaa tgcctgtgga gggactggag
     3901 ctgctggatc ccagtgtggt ggtgtaggag gccacagtga gcaggtggcc ccagctgggt
     3961 ttcccaggtc aggaatgtgg gccccaggca aggtgcagcc tttgctcaca gctccatcca
     4021 tgtctagacc ttcaggccag tctgcagatg aggttcccta cctttttctt ctcttcattg
     4081 accaaatcaa ccaatcacta cagctgctct gcttctgctt tccaaagtag cccaggtcct
     4141 gggccagatg caggggaggt gcctatccat gagtgaaggc cagtgtcttc ctcacctggg
     4201 tgggtcccac acttgtgacc tcagttttag gaccaagatc tgtgttggtt tcttagattg
     4261 ctagcttttc ctccagggga ccacagcagg tgaagctcaa gagcgcatgg ctctgctaat
     4321 agtaaattgt tttcagggcc ttgtccagct gagagcttca tgtccaccag attctgagag
     4381 gtgtcagcag cacttttttt ttttatttgt tgtttgtttt ccatgaggtt atcggaccat
     4441 gggctgagct caggcacttt ctgtaggaga ctgttatttc tgtaaagatg gttatttaac
     4501 cctcctccac cccatcacgg tggccctgag ggctgacccg gaggccagtg gagctgcctg
     4561 gtgtccacgg gggagggcca aggcctgctg agctgattct ccagctgctg ccccagcctt
     4621 tccgccttgc acagcacaga ggtggtcacc ccagggacag ccaggcacct gctcctcttg
     4681 cccttcctgg gggaagggag ctgccttctg tccctgtaac tgctttcctt atggcccagc
     4741 ccggccactc agacttgttt gaagctgcac tggcagcttt tttgtctcct ttgggtattc
     4801 acaacagcca gggacttgat tttgatgtat tttaaaccac attaaataaa gagtctgttg
     4861 cctta
//
