LOCUS       NM_020648               3750 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens twisted gastrulation BMP signaling modulator 1
            (TWSG1), mRNA.
ACCESSION   NM_020648
VERSION     NM_020648.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3750)
  AUTHORS   Suzuki,E. and Fukuda,T.
  TITLE     Multifaceted Functions of TWSG1: From Embryogenesis to Cancer
            Development
  JOURNAL   Int J Mol Sci 23 (21), 12755 (2022)
   PUBMED   36361543
  REMARK    GeneRIF: Multifaceted Functions of TWSG1: From Embryogenesis to
            Cancer Development.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3750)
  AUTHORS   Liu,Z. and Li,H.
  TITLE     Twisted gastrulation signaling modulator 1 promotes the ability of
            glioma cell through activating Akt pathway
  JOURNAL   Neuroreport 32 (3), 198-205 (2021)
   PUBMED   33534374
  REMARK    GeneRIF: Twisted gastrulation signaling modulator 1 promotes the
            ability of glioma cell through activating Akt pathway.
REFERENCE   3  (bases 1 to 3750)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3750)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3750)
  AUTHORS   Lockhart-Cairns,M.P., Lim,K.T.W., Zuk,A., Godwin,A.R.F., Cain,S.A.,
            Sengle,G. and Baldock,C.
  TITLE     Internal cleavage and synergy with twisted gastrulation enhance BMP
            inhibition by BMPER
  JOURNAL   Matrix Biol 77, 73-86 (2019)
   PUBMED   30125619
  REMARK    GeneRIF: Internal cleavage and synergy with TWSG1 enhance BMP-4
            inhibition by BMPER.
REFERENCE   6  (bases 1 to 3750)
  AUTHORS   Zakin,L. and De Robertis,E.M.
  TITLE     Inactivation of mouse Twisted gastrulation reveals its role in
            promoting Bmp4 activity during forebrain development
  JOURNAL   Development 131 (2), 413-424 (2004)
   PUBMED   14681194
REFERENCE   7  (bases 1 to 3750)
  AUTHORS   Graf,D., Nethisinghe,S., Palmer,D.B., Fisher,A.G. and
            Merkenschlager,M.
  TITLE     The developmentally regulated expression of Twisted gastrulation
            reveals a role for bone morphogenetic proteins in the control of T
            cell development
  JOURNAL   J Exp Med 196 (2), 163-171 (2002)
   PUBMED   12119341
REFERENCE   8  (bases 1 to 3750)
  AUTHORS   Graf,D., Timmons,P.M., Hitchins,M., Episkopou,V., Moore,G., Ito,T.,
            Fujiyama,A., Fisher,A.G. and Merkenschlager,M.
  TITLE     Evolutionary conservation, developmental expression, and genomic
            mapping of mammalian Twisted gastrulation
  JOURNAL   Mamm Genome 12 (7), 554-560 (2001)
   PUBMED   11420619
REFERENCE   9  (bases 1 to 3750)
  AUTHORS   Scott,I.C., Blitz,I.L., Pappano,W.N., Maas,S.A., Cho,K.W. and
            Greenspan,D.S.
  TITLE     Homologues of Twisted gastrulation are extracellular cofactors in
            antagonism of BMP signalling
  JOURNAL   Nature 410 (6827), 475-478 (2001)
   PUBMED   11260715
  REMARK    Erratum:[Nature 2001 Jun 7;411(6838):720]
REFERENCE   10 (bases 1 to 3750)
  AUTHORS   Oelgeschlager,M., Larrain,J., Geissert,D. and De Robertis,E.M.
  TITLE     The evolutionarily conserved BMP-binding protein Twisted
            gastrulation promotes BMP signalling
  JOURNAL   Nature 405 (6788), 757-763 (2000)
   PUBMED   10866189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001033.6.
            
            On Nov 23, 2018 this sequence version replaced NM_020648.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020490.1, SRR1660807.133812.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262120.10/ ENSP00000262120.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AP001033.6         131209-131356
            149-308             AP001033.6         133629-133788
            309-408             AP001033.6         156408-156507
            409-675             AP001033.6         192716-192982
            676-3750            AP001033.6         195782-198856
FEATURES             Location/Qualifiers
     source          1..3750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.22"
     gene            1..3750
                     /gene="TWSG1"
                     /gene_synonym="TSG"
                     /note="twisted gastrulation BMP signaling modulator 1"
                     /db_xref="GeneID:57045"
                     /db_xref="HGNC:HGNC:12429"
                     /db_xref="MIM:605049"
     exon            1..148
                     /gene="TWSG1"
                     /gene_synonym="TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            149..308
                     /gene="TWSG1"
                     /gene_synonym="TSG"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..857
                     /gene="TWSG1"
                     /gene_synonym="TSG"
                     /note="twisted gastrulation protein homolog 1; twisted
                     gastrulation homolog 1"
                     /codon_start=1
                     /product="twisted gastrulation protein homolog 1
                     precursor"
                     /protein_id="NP_065699.1"
                     /db_xref="CCDS:CCDS11844.1"
                     /db_xref="GeneID:57045"
                     /db_xref="HGNC:HGNC:12429"
                     /db_xref="MIM:605049"
                     /translation="MKLHYVAVLTLAILMFLTWLPESLSCNKALCASDVSKCLIQELC
                     QCRPGEGNCSCCKECMLCLGALWDECCDCVGMCNPRNYSDTPPTSKSTVEELHEPIPS
                     LFRALTEGDTQLNWNIVSFPVAEELSHHENLVSFLETVNQPHHQNVSVPSNNVHAPYS
                     SDKEHMCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECIGPECIDYGSKTVKC
                     MNCMF"
     exon            309..408
                     /gene="TWSG1"
                     /gene_synonym="TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            409..675
                     /gene="TWSG1"
                     /gene_synonym="TSG"
                     /inference="alignment:Splign:2.1.0"
     exon            676..3750
                     /gene="TWSG1"
                     /gene_synonym="TSG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3733..3738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TWSG1"
                     /gene_synonym="TSG"
                     /note="hexamer: AATAAA"
     polyA_site      3750
                     /gene="TWSG1"
                     /gene_synonym="TSG"
                     /note="major polyA site"
ORIGIN      
        1 aaggtgcccg aggctcgcgg gcgctgcgct gaggggacgg cgggaggcgc ggcctggcct
       61 cgcactcaaa gccgccgcag cgcgccccgg gctcggccga cccggcgggg atctaggggt
      121 gggcgacttc gcgggaccgt ggcgcatgtt tcctgggagt tactgatcat cttctttgaa
      181 gaaacatgaa gttacactat gttgctgtgc ttactctagc catcctgatg ttcctgacat
      241 ggcttccaga atcactgagc tgtaacaaag cactctgtgc tagtgatgtg agcaaatgcc
      301 tcattcagga gctctgccag tgccggccgg gagaaggcaa ttgctcctgc tgtaaggagt
      361 gcatgctgtg tcttggggcc ctttgggacg agtgctgtga ctgtgttggt atgtgtaatc
      421 ctcgaaatta tagtgacaca cctccaactt caaagagcac agtggaggag ctgcatgaac
      481 cgatcccttc tctcttccgg gcactcacag aaggagatac tcagttgaat tggaacatcg
      541 tttctttccc tgttgcagaa gaactttcac atcatgagaa tctggtttca tttttagaaa
      601 ctgtgaacca gccacaccac cagaatgtgt ctgtccccag caataatgtt cacgcgcctt
      661 attccagtga caaagaacac atgtgtactg tggtttattt tgatgactgc atgtccatac
      721 atcagtgtaa aatatcctgt gagtccatgg gagcatccaa atatcgctgg tttcataatg
      781 cctgctgcga gtgcattggt ccagaatgta ttgactatgg tagtaaaact gtcaaatgta
      841 tgaactgcat gttttaaaga agacaaatgc aaaccaaagc aacttagtaa aataataggt
      901 ataaaaagtt attctgtaag tctgttggtt gtatcttgta tcagaatccc agtaagttaa
      961 gttgtaaaga ctttggaata agtttctttt aaaaatatga catagccagt gatgtgttta
     1021 attatataac tgttcttact gattttattg ccccctagca ataagccctt tcctttgaat
     1081 acatgtacaa ctttggtcat atgagaagca ggtgcgcaga gaattccttg aaagatctga
     1141 ggtttttaac atgaagtctg acgtggtttt cctctagcat tccaaaaggt ttttgctttg
     1201 aaagtgttag cagaagcatg ttgatgtgaa ttatgatttc ttcatgtgct actgttagca
     1261 cactgagttt ttatagttgc acatcattcc tcattgtgcc ttgttttatc cattttataa
     1321 atagagtaga tatttgatat accactctga taactcatat aaaaatatca tcataaaaag
     1381 cttaatttca tcccttttat gttggtttta aaaggtaaat gcttaccata ttttataatt
     1441 gagaactctt acatagtaga atccattcta taatacatgt gttgacaaag ctttagagaa
     1501 agtttcctat tctcttccat ttcccctgcc caaagtgctg acataggcag tgatgaagaa
     1561 tctttaccaa gattttcagg gtgtacctat gaaattgctt taaatgcact gctggtgtaa
     1621 ataattagca agcaaagcgt ttctgtgact tcaggtacca gcttaaagag cactagggat
     1681 ggggaacgaa tgccaaatca gactccacct agagcaccag gaaacagctt gtaccctggt
     1741 agggaaatgg tgttgctgaa aggggaggct gagccagtgc gagactgaac ttgtgcagcc
     1801 ttagccaaga caaagcagtg tttttcagca gacggctgat gggacaggaa ttgaagaaga
     1861 gaattgactc gtatgaacag gacagggtga aaatgctggg aattattatg ggaaacaaaa
     1921 ctatctatgt tcatattttg taatatttca tttgttaagt ttatatctgg atataatgtt
     1981 ctttttaaac aagtataatc atatcgtcgg aggttaagat tatgaaattt tagaatctct
     2041 attcaagatg atgttcactc caaatacact acagaattta gtcaacattt tatataatgt
     2101 ttcaataaat gtttctttca ataaagatac tatgtgccct tcatagtaat aaaatctcaa
     2161 tcttaaagca tgaatctaaa acataaatat ttatattaca gactcaattt tacaaaatta
     2221 ctaattgctc tagtgcatat ttgaactaca agcaactttt taggaatacc tctttatacg
     2281 tctacatatt ttagtatata aaaatagata atgctcttgg acacattttg tattattcat
     2341 gatctgaata gtagttagtt aaaagatcat ttgtaatatt atgatcaact gttataaatt
     2401 aaggtcttaa taccttttct gctctttcaa ataactctaa tgaatattca agatatttta
     2461 gccttttaaa aagttgagat ttagctcatg gatatatttt ttggtaggga aacattaggg
     2521 tctccttttc ttccttttac ctagaatgcc tcatttaaaa gtgccttgaa aacatttagc
     2581 tccccttctt catgagcatc tgtagagctg aaagtattct ggaactttag acagaaagct
     2641 gaaaggaatc tgcagtctcc tgctgcagtt caactctgct gtttttcagt catttcctac
     2701 tgtgagtgga gtgatgtttg tgtgtgtgtt ggcaacatgc ctaatgtttt cttaatgatg
     2761 acaacaaata ttttaaaact gcatttatca ttttttaggt cttcattaaa ttttaaaatg
     2821 taatatctgt ttcccacccc ctacattagg aggataattt cttaaaccac attgttttaa
     2881 ttgatttttc ttatcttgat ttctttcatt agaaactatc cctaaatgta aagatctttt
     2941 gccttcaaat ttggcttatt ttttctgatt tatgagggtt tgaaagaaag aattcaccta
     3001 aaagattcca tttccagttt tataatgtat ttcaggttct gaataacaat atttttccaa
     3061 attgaaagta aatattccag aagttgatag cctggttaaa agttagatcc tctattacca
     3121 ttctaagcac attcacttct atattgaagt tttggtaaaa attctttttt cttttttaat
     3181 aaaaaattag gttattactt tttttataac cagattttta aagcactagg ttttaaatca
     3241 gtgggtatca taaaagccat atataaaaga tcctttctta tagtaagact tgtgcttgtt
     3301 agcaggtttt tctgttagtt tttcccccat aacatttaat tattactaaa attgtattta
     3361 caatagtggt gccaaatcaa atggtaattt aaataaaatc tattctgtgt ttatgtaggg
     3421 tggtataaaa aagaggtctt catttagaca tgtgatttct aaaattccag aaagcaaaat
     3481 tgataagatg ttagaaattt ggaccattat ttataatcag ggtagcatta aaatggagaa
     3541 aagaaagttt tctgaaaaaa tgcagtaaat ataagccaca tttctaaagt ttatttttat
     3601 gaaagcttct tttaagattt tgaaatctat tctgcattcc caagagttta tgtttattgt
     3661 attttatatg atctacaaca tataaaattg tgtatttttc tttggttgtc cctattaaca
     3721 aaaaagtatt ttaataaaaa attgaaatga
//
