LOCUS       NM_007284               1614 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens twinfilin actin binding protein 2 (TWF2), mRNA.
ACCESSION   NM_007284
VERSION     NM_007284.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1614)
  AUTHORS   Walker,C.K., Greathouse,K.M., Tuscher,J.J., Dammer,E.B.,
            Weber,A.J., Liu,E., Curtis,K.A., Boros,B.D., Freeman,C.D.,
            Seo,J.V., Ramdas,R., Hurst,C., Duong,D.M., Gearing,M.,
            Murchison,C.F., Day,J.J., Seyfried,N.T. and Herskowitz,J.H.
  TITLE     Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex
            Identifies TWF2 as a Modulator of Dendritic Spine Length
  JOURNAL   J Neurosci 43 (20), 3764-3785 (2023)
   PUBMED   37055180
  REMARK    GeneRIF: Cross-Platform Synaptic Network Analysis of Human
            Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine
            Length.
REFERENCE   2  (bases 1 to 1614)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1614)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   4  (bases 1 to 1614)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 1614)
  CONSRTM   Psychiatric GWAS Consortium Bipolar Disorder Working Group
  TITLE     Large-scale genome-wide association analysis of bipolar disorder
            identifies a new susceptibility locus near ODZ4
  JOURNAL   Nat Genet 43 (10), 977-983 (2011)
   PUBMED   21926972
  REMARK    Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
            [added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
            [corrected to Meng, Fan]]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1614)
  AUTHORS   Nevalainen,E.M., Skwarek-Maruszewska,A., Braun,A., Moser,M. and
            Lappalainen,P.
  TITLE     Two biochemically distinct and tissue-specific twinfilin isoforms
            are generated from the mouse Twf2 gene by alternative promoter
            usage
  JOURNAL   Biochem J 417 (2), 593-600 (2009)
   PUBMED   18837697
REFERENCE   7  (bases 1 to 1614)
  AUTHORS   Yamada,S., Uchimura,E., Ueda,T., Nomura,T., Fujita,S.,
            Matsumoto,K., Funeriu,D.P., Miyake,M. and Miyake,J.
  TITLE     Identification of twinfilin-2 as a factor involved in neurite
            outgrowth by RNAi-based screen
  JOURNAL   Biochem Biophys Res Commun 363 (4), 926-930 (2007)
   PUBMED   17910947
  REMARK    GeneRIF: twinfilin-2 is a protein that is involved in neurite
            outgrowth
REFERENCE   8  (bases 1 to 1614)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   9  (bases 1 to 1614)
  AUTHORS   Vartiainen,M.K., Sarkkinen,E.M., Matilainen,T., Salminen,M. and
            Lappalainen,P.
  TITLE     Mammals have two twinfilin isoforms whose subcellular localizations
            and tissue distributions are differentially regulated
  JOURNAL   J Biol Chem 278 (36), 34347-34355 (2003)
   PUBMED   12807912
REFERENCE   10 (bases 1 to 1614)
  AUTHORS   Rohwer,A., Kittstein,W., Marks,F. and Gschwendt,M.
  TITLE     Cloning, expression and characterization of an A6-related protein
  JOURNAL   Eur J Biochem 263 (2), 518-525 (1999)
   PUBMED   10406962
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI551353.1, AL136773.1 and
            BC003161.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007284.3.
            
            Summary: The protein encoded by this gene was identified by its
            interaction with the catalytic domain of protein kinase C-zeta. The
            encoded protein contains an actin-binding site and an ATP-binding
            site. It is most closely related to twinfilin (PTK9), a conserved
            actin monomer-binding protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.160093.1,
                                           SRR3476690.791267.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305533.10/ ENSP00000303908.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BI551353.1         108-131
            25-74               AL136773.1         1-50
            75-1614             BC003161.1         1-1540
FEATURES             Location/Qualifiers
     source          1..1614
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..1614
                     /gene="TWF2"
                     /gene_synonym="A6r; A6RP; MSTP011; PTK9L"
                     /note="twinfilin actin binding protein 2"
                     /db_xref="GeneID:11344"
                     /db_xref="HGNC:HGNC:9621"
                     /db_xref="MIM:607433"
     exon            1..167
                     /gene="TWF2"
                     /gene_synonym="A6r; A6RP; MSTP011; PTK9L"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1192
                     /gene="TWF2"
                     /gene_synonym="A6r; A6RP; MSTP011; PTK9L"
                     /note="protein tyrosine kinase 9-like (A6-related
                     protein); PTK9L protein tyrosine kinase 9-like (A6-related
                     protein); twinfilin-1-like protein; twinfilin,
                     actin-binding protein, homolog 2"
                     /codon_start=1
                     /product="twinfilin-2"
                     /protein_id="NP_009215.1"
                     /db_xref="CCDS:CCDS2849.1"
                     /db_xref="GeneID:11344"
                     /db_xref="HGNC:HGNC:9621"
                     /db_xref="MIM:607433"
                     /translation="MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQE
                     PVGRWDQDYDRAVLPLLDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYA
                     ATRATVKKEFGGGHIKDELFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRIN
                     EVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTE
                     PTDVAQLPSRVPRDAARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCK
                     SRLLDSVEQDFHLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRG
                     HKRLIRGPGENGDDS"
     exon            168..245
                     /gene="TWF2"
                     /gene_synonym="A6r; A6RP; MSTP011; PTK9L"
                     /inference="alignment:Splign:2.1.0"
     exon            246..424
                     /gene="TWF2"
                     /gene_synonym="A6r; A6RP; MSTP011; PTK9L"
                     /inference="alignment:Splign:2.1.0"
     exon            425..520
                     /gene="TWF2"
                     /gene_synonym="A6r; A6RP; MSTP011; PTK9L"
                     /inference="alignment:Splign:2.1.0"
     exon            521..625
                     /gene="TWF2"
                     /gene_synonym="A6r; A6RP; MSTP011; PTK9L"
                     /inference="alignment:Splign:2.1.0"
     exon            626..751
                     /gene="TWF2"
                     /gene_synonym="A6r; A6RP; MSTP011; PTK9L"
                     /inference="alignment:Splign:2.1.0"
     exon            752..902
                     /gene="TWF2"
                     /gene_synonym="A6r; A6RP; MSTP011; PTK9L"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1024
                     /gene="TWF2"
                     /gene_synonym="A6r; A6RP; MSTP011; PTK9L"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1614
                     /gene="TWF2"
                     /gene_synonym="A6r; A6RP; MSTP011; PTK9L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1594..1599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TWF2"
                     /gene_synonym="A6r; A6RP; MSTP011; PTK9L"
                     /note="hexamer: AATAAA"
     polyA_site      1614
                     /gene="TWF2"
                     /gene_synonym="A6r; A6RP; MSTP011; PTK9L"
                     /note="major polyA site"
ORIGIN      
        1 gggtcctgcg gcaccgcccg ggaagctgcg cgagggtcga cagcctccgc cacatcctcc
       61 acctctcttg gtccagcgag cgttgccggg ccagggtcaa gcggagggct ccgacggcgc
      121 ggacggagcg aagcgccgag ccatggcgca ccaaacgggc atccacgcca cggaagagct
      181 gaaggaattc tttgccaagg cacgggctgg ctctgtgcgg ctcatcaagg ttgtgattga
      241 ggacgagcag ctcgtgctgg gtgcctcgca ggagccagta ggccgctggg atcaggacta
      301 tgacagggcc gtgctgccac tgctggacgc ccagcagccc tgctacctgc tctaccgcct
      361 cgactcacag aatgctcagg gcttcgaatg gctcttcctc gcctggtcgc ctgataactc
      421 ccccgtgcgg ctgaagatgc tgtacgcggc cacgcgggcc acagtgaaaa aggagtttgg
      481 aggtggccac atcaaggatg agctcttcgg gactgtgaag gatgacctct cttttgctgg
      541 gtaccagaaa cacctgtcgt cctgtgcggc acctgccccg ctgacctcgg ctgagagaga
      601 gctccagcag atccgcatta acgaggtgaa gacagagatc agtgtggaaa gcaagcacca
      661 gaccctgcag ggcctcgcct tccccctgca gcctgaggcc cagcgggcac tccagcagct
      721 caagcagaaa atggtcaact acatccagat gaagctggac ctagagcggg aaaccattga
      781 gctggtgcac acagagccca cggatgtggc ccagctgccc tcccgggtgc cccgagatgc
      841 tgcccgctac cacttcttcc tctacaagca cacccatgag ggcgaccccc ttgagtctgt
      901 agtgttcatc tactccatgc cggggtacaa gtgcagcatc aaggagcgaa tgctctactc
      961 cagctgcaag agccgcctcc tcgactccgt ggagcaggac ttccatctgg agatcgccaa
     1021 gaaaattgag attggcgatg gggcagagct gacggcagag ttcctctacg acgaggtgca
     1081 ccccaagcaa cacgccttca agcaggcctt cgccaagccc aagggcccag ggggcaagcg
     1141 gggccataag cgcctcatcc gcggcccggg tgaaaatggg gatgacagct aggaggctgg
     1201 agcagggccg gccacgtgtg gactgtgggg ctgcccacct tccgctccct gccaccatcc
     1261 tccttcctgg gctccaggaa agtgtttctg ggaggtcagg agggctggca gctgaacgca
     1321 cttgcagcgt ccgagggcca ccgggctggc attttgtgac ccttccctgt tgctgtccct
     1381 gcatctcgtc tgtgtgccca gggtgtccgg ggaccctgcc tggctggctt aagggggctg
     1441 ggtcaggggc ctggcatgaa cctggcctcc cggggagctg agactagggt cccagcacag
     1501 cccagaaacc tttggccaca agaagtgggg tcagtcaggg ctggggcagg ggtcactgca
     1561 gtttgggatg gttgaatgct gtattttcta aagaataaaa tatttttaaa tcaa
//
