LOCUS       NM_001135036            4079 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens trans-golgi network vesicle protein 23 homolog C
            (TVP23C), transcript variant 2, mRNA.
ACCESSION   NM_001135036
VERSION     NM_001135036.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4079)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK310363.1, AC005838.2 and BU754306.1.
            
            On May 21, 2020 this sequence version replaced NM_001135036.1.
            
            Transcript Variant: This variant (2) uses an alternate terminal
            exon and thus differs in the 3' coding region and 3' UTR, compared
            to variant 1. The encoded isoform (2) has a distinct and shorter
            C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2796588.1,
                                           SRR14038194.3531530.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518321.6/ ENSP00000464052.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-630               AK310363.1         108-737
            631-3679            AC005838.2         51064-54112
            3680-4079           BU754306.1         18-417              c
FEATURES             Location/Qualifiers
     source          1..4079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..4079
                     /gene="TVP23C"
                     /gene_synonym="FAM18B2"
                     /note="trans-golgi network vesicle protein 23 homolog C"
                     /db_xref="GeneID:201158"
                     /db_xref="HGNC:HGNC:30453"
     exon            1..47
                     /gene="TVP23C"
                     /gene_synonym="FAM18B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..647
                     /gene="TVP23C"
                     /gene_synonym="FAM18B2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein FAM18B2; family with sequence similarity 18,
                     member B2; Golgi apparatus membrane protein TVP23 homolog
                     C"
                     /codon_start=1
                     /product="Golgi apparatus membrane protein TVP23 homolog C
                     isoform 2"
                     /protein_id="NP_001128508.1"
                     /db_xref="CCDS:CCDS45617.1"
                     /db_xref="GeneID:201158"
                     /db_xref="HGNC:HGNC:30453"
                     /translation="MLQQDSNDDTEDVSLFDAEEETTNRPRKAKIRHPVASFFHLFFR
                     VSAIIVCLLCELLSSSFITCMVTIILLLSCDFWAVKNVTGRLMVGLRWWNHIDEDGKS
                     HWVFESRKESSQENKTVSEAESRIFWLGLIACSVLWVIFAFSALFSFTVKWLAVVIMG
                     VVLQGANLYGYIRCKVRSRKHLTSMATSYFGKQFLRQVSVFWM"
     exon            48..130
                     /gene="TVP23C"
                     /gene_synonym="FAM18B2"
                     /inference="alignment:Splign:2.1.0"
     exon            131..275
                     /gene="TVP23C"
                     /gene_synonym="FAM18B2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..365
                     /gene="TVP23C"
                     /gene_synonym="FAM18B2"
                     /inference="alignment:Splign:2.1.0"
     exon            366..497
                     /gene="TVP23C"
                     /gene_synonym="FAM18B2"
                     /inference="alignment:Splign:2.1.0"
     exon            498..4079
                     /gene="TVP23C"
                     /gene_synonym="FAM18B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4054..4059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TVP23C"
                     /gene_synonym="FAM18B2"
                     /note="hexamer: TATAAA"
     polyA_site      4079
                     /gene="TVP23C"
                     /gene_synonym="FAM18B2"
                     /note="major polyA site"
ORIGIN      
        1 gtggctcctg gaagcagggc tggcgtaggg ccgccatgtt gcagcaggat agtaatgatg
       61 acactgaaga tgtttcactg tttgatgcgg aagaggagac gactaataga ccaagaaaag
      121 ccaaaatcag acatccagta gcatcgtttt tccacttatt ctttcgagtc agtgcaatca
      181 tcgtctgtct tctctgtgag ttgctcagca gcagctttat tacctgtatg gttacaatta
      241 tcttgttgtt gtcgtgtgac ttttgggcag tgaagaatgt cacaggtaga ctaatggttg
      301 gcctacgttg gtggaatcac attgatgaag atggaaagag ccattgggtg tttgaatcta
      361 gaaaggagtc ctctcaagag aataaaactg tgtcagaggc tgaatcaaga atcttttggt
      421 tgggacttat tgcctgttca gtactgtggg tgatatttgc ctttagtgca ctcttctcct
      481 tcacagtaaa gtggctggcg gtggttatta tgggtgtggt gctacaaggt gccaacctgt
      541 atggttacat caggtgtaag gtgcgcagca gaaagcattt aaccagcatg gctacttcat
      601 attttggaaa gcagttttta agacaagtaa gtgttttctg gatgtgatca gtgactaatg
      661 caattatttc taactttcat agtttaattt ttatgaaacg ctcctgaaca gaagttttaa
      721 aggcatatag ttgtataaat ataatgataa agatgttgta attgctcttt gggggtgttc
      781 aagacagtct ggaagtgtat tgtcagtatc ctaaaattat tttaaagcca ggaaggataa
      841 actatcattg ataataactt attttttaaa aattactttt aagttcagtt gtttttcatc
      901 aattatggga gctttaagtg aatgcccttg cagaatgtat gttgtatgtt tttattttta
      961 ttttttgaga cagagttttg ctctgtcgcc caggctggag tgcagtggtg caatctcggc
     1021 tcactgcaac ctctgccccc cgggttcatg tgattctcct gcctcagcct tatgagtagc
     1081 tgggattaca ggcgcatgcc accacgccca gctaattttt tgtattttca gtagagatgg
     1141 gatttcatca tgttagccag gatggtctcc atctcatgac cttgtgatct gcccacctca
     1201 gcctcccaaa gtgctgggat tacaggcgtg agccaccgtg cccagcctgt atgttgtatg
     1261 gttttaggga gaacagttga atcacaagaa gaccataaca tttgtactca gatgtttttt
     1321 tccccctaga acataaggat tttactataa tacctcaaca tcagggtttt cagcaggatg
     1381 agtagtagtc ataggtaaat aattattggt taaatctctt gggaaaagtg actaggtctt
     1441 tttttttttt tttcttgaga tggagtcttg ctctgtcgcc caggctggag tgcagtggcg
     1501 tgatctcggc ttactgcaag ctccgcctcc cgggttcacg ccattctcct gcatcagcct
     1561 cccgagtagc tgggactaca ggcgccgcca ccacgcctgg cttttttgta tttttagtag
     1621 agacggggtt tcaccgtgtt agccaggatg gtctcgatct cctgacctcg tgatccgcct
     1681 gcctccgcct cccaaagtgc tgggattaca ggcgtgagcc acggcgcctg gccgtgacta
     1741 ggtctttata tgagtaatac cttgcatttg gttagtacag taggttgggc aagtgatatt
     1801 atgtaggaca gggattctta aactcgaaca tacatgagaa tcacctagag ggcacaagat
     1861 tgctgggttc cacctccaga ctccttattc agtagatctg ggggtggagt ctcataattt
     1921 gcatttctcc caagtttctg ggtggtactg agggcactgg tccagggatt acattttaga
     1981 taactaaagc cccgagaaat taaattattt acttaagatt atacagctaa tagtggtaca
     2041 aagctagatc ttaaacccag ccctctgtac tcaaaattta ttgttctttt tattctactg
     2101 tacagtttct ctcacagaag atgaaaagta gagaaaatga atattcatgt agggacatga
     2161 tcatctcatt ctgaaggatt tttgcatggc tccaatatac ctttactgtg gtccacctta
     2221 gggtaacttt catgtatgtg cttattaggt ttttttcgtt agaattttca gtgtttctga
     2281 aggtggggag gaacatggaa tacaggtgaa attaaacctt aaacctggca taacatggat
     2341 agggttagtg tcttacatgg tatccggcgt ctgctcaaat gagacaaact ggacagctgg
     2401 gtggatgatg gtatccatgg atttacttca ttagcgcatg tctacttttt tatttattta
     2461 ttttttttga gacagagtct cactctgttt gcccaggctg gagtgcagtg gcgcgatctc
     2521 ggctcactgc aaactccacc tcccgggttc atactattct tctgcctcag cctcccgagt
     2581 agctgggatt gcaggcgccc gccaccacgc ctggctaatt ttttgtattt ttagtagaga
     2641 cggggtttca ctgtgttagc caggagggtc tcgatctcct gacctcatga tccaccctcc
     2701 tcggcctccc aaagtgctgg gattacaggt gtaagccacg gcgcccagcc tagcatgtct
     2761 actttttaat gtgattgggc cattgtatgt aaggtaatgc tctgcttaga aatatagaat
     2821 gttttcctag gcctaggccc caagtccatg gtgtgtgaag tgaaataact ttgatgttaa
     2881 ggagttcttt ttttgtcttt tgcggaacac tggagatgat cagacttcct gaatagagaa
     2941 agcttatgtg ctttgttaca ttggggaaca actgaagaga ttcttgactc aaccttttag
     3001 agcttagtcc atgttgcaac gaggagtgtt ggctttgttt ttccacttaa aaactttatt
     3061 tataaaaagg aaaagtagtt ttcatattaa gtttttattt cctttccagc agttggggct
     3121 agaaagtata tgttggcact agaaacattg ttaagatttg ttctgtggtg taggtatgca
     3181 cattccatag gtatgcacac ggccatgtaa tacctgtata tcccaagtta atgaaagtgt
     3241 tcatttacac agataatgga gacctttgca ttttgatcca tagaacatag gaggatgttc
     3301 ttagtctgtc tcaaagctct atatgtttac atattatttc tgtagattgt tttcaggaga
     3361 aagttttgct tctatggtaa gagtgagcac tttggcttat gtataagtta gaaataattg
     3421 ttagttttta atatgtactt catggggaaa tttcttagac gtatgcaagc aagtgaaaac
     3481 aattagggcc agtggtatta actactttat aaaattttat ttttgtttgt aagaagttat
     3541 ctacttaagg cccagttaat ataagtggaa tcatcatagt ttaaggaata cccagagatt
     3601 gctgctattc tatttatttt acagaaagga tagctagatt gaaagttctt cagtggacct
     3661 tgagctaata gatcttttac cactaaaaga gcattattct catgtcataa tgagaataat
     3721 aatttacata cttggcataa taaatgccta aaagacattt tattttctga atctattttt
     3781 ttcttgctat aatggggata ttgtaaatta tgcatttgta ttaatggtat ttcttaaagc
     3841 aatctatgta actgtaaatt aaaccaatct acaaactatt gtaggcatct gtaaattctg
     3901 ttgtaggtat tataaacttt gttgaagtct taatcagcag attatgttgt gaatatattt
     3961 gtacattgtt aaaatagttt ttaagattat ttgtttaatt gaataagtgt cttattggag
     4021 tgatagcttt gaaggtgcaa aactttatat ttgtataaaa ttctactatt tacaaggca
//
