LOCUS       NM_001204478            2761 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens TVP23C-CDRT4 readthrough (TVP23C-CDRT4), transcript
            variant 1, mRNA.
ACCESSION   NM_001204478
VERSION     NM_001204478.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2761)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB074181.1, AC005838.2 and CB850543.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001204478.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring TVP23C (trans-golgi network
            vesicle protein 23 homolog) and CDRT4 (CMT1A duplicated region
            transcript 4) genes on chromosome 17. Alternative splicing results
            in multiple transcript variants, one of which encodes a protein
            that shares sequence identity with the upstream gene product, but
            its C-terminus is distinct due to frameshifts relative to the
            downstream gene. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is protein-coding.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB074181.1, SRR14038194.2293144.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 201158, 284040
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AB074181.1         79-416
            339-339             AC005838.2         44407-44407
            340-2755            AB074181.1         418-2833
            2756-2761           CB850543.1         18-23               c
FEATURES             Location/Qualifiers
     source          1..2761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..2761
                     /gene="TVP23C-CDRT4"
                     /gene_synonym="FAM18B2; FAM18B2-CDRT4; TVP23C"
                     /note="TVP23C-CDRT4 readthrough"
                     /db_xref="GeneID:100533496"
                     /db_xref="HGNC:HGNC:42961"
     exon            1..47
                     /gene="TVP23C-CDRT4"
                     /gene_synonym="FAM18B2; FAM18B2-CDRT4; TVP23C"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..530
                     /gene="TVP23C-CDRT4"
                     /gene_synonym="FAM18B2; FAM18B2-CDRT4; TVP23C"
                     /note="FAM18B2-CDRT4 readthrough; Golgi apparatus membrane
                     protein TVP23 homolog C"
                     /codon_start=1
                     /product="uncharacterized protein LOC100533496"
                     /protein_id="NP_001191407.1"
                     /db_xref="GeneID:100533496"
                     /db_xref="HGNC:HGNC:42961"
                     /translation="MLQQDSNDDTEDVSLFDAEEETTNRPRKAKIRHPVASFFHLFFR
                     VSAIIVCLLCELLSSSFITCMVTIILLLSCDFWAVKNVTGRLMVGLRWWNHIDEDGKS
                     HWVFESRKESSQENKTVSEAESRIFWLGLIACSVLWVIFAFSALFSFTVKWLESEPVM
                     LRNQ"
     exon            48..130
                     /gene="TVP23C-CDRT4"
                     /gene_synonym="FAM18B2; FAM18B2-CDRT4; TVP23C"
                     /inference="alignment:Splign:2.1.0"
     exon            131..275
                     /gene="TVP23C-CDRT4"
                     /gene_synonym="FAM18B2; FAM18B2-CDRT4; TVP23C"
                     /inference="alignment:Splign:2.1.0"
     exon            276..365
                     /gene="TVP23C-CDRT4"
                     /gene_synonym="FAM18B2; FAM18B2-CDRT4; TVP23C"
                     /inference="alignment:Splign:2.1.0"
     exon            366..497
                     /gene="TVP23C-CDRT4"
                     /gene_synonym="FAM18B2; FAM18B2-CDRT4; TVP23C"
                     /inference="alignment:Splign:2.1.0"
     exon            498..575
                     /gene="TVP23C-CDRT4"
                     /gene_synonym="FAM18B2; FAM18B2-CDRT4; TVP23C"
                     /inference="alignment:Splign:2.1.0"
     exon            576..2761
                     /gene="TVP23C-CDRT4"
                     /gene_synonym="FAM18B2; FAM18B2-CDRT4; TVP23C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2736..2741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TVP23C-CDRT4"
                     /gene_synonym="FAM18B2; FAM18B2-CDRT4; TVP23C"
                     /note="hexamer: AATAAA"
     polyA_site      2761
                     /gene="TVP23C-CDRT4"
                     /gene_synonym="FAM18B2; FAM18B2-CDRT4; TVP23C"
                     /note="major polyA site"
ORIGIN      
        1 gtggctcctg gaagcagggc tggcgtaggg ccgccatgtt gcagcaggat agtaatgatg
       61 acactgaaga tgtttcactg tttgatgcgg aagaggagac gactaataga ccaagaaaag
      121 ccaaaatcag acatccagta gcatcgtttt tccacttatt ctttcgagtc agtgcaatca
      181 tcgtctgtct tctctgtgag ttgctcagca gcagctttat tacctgtatg gttacaatta
      241 tcttgttgtt gtcgtgtgac ttttgggcag tgaagaatgt cacaggtaga ctaatggttg
      301 gcctacgttg gtggaatcac attgatgaag atggaaagag ccattgggtg tttgaatcta
      361 gaaaggagtc ctctcaagag aataaaactg tgtcagaggc tgaatcaaga atcttttggt
      421 tgggacttat tgcctgttca gtactgtggg tgatatttgc ctttagtgca ctcttctcct
      481 tcacagtaaa gtggctggaa tctgaacctg tgatgttaag aaatcagtaa atattaaaaa
      541 gaagatggat gcaagaagga tgaagaaaga agaaggactc acagaaaaca ctggacttcc
      601 ccggaagcta cttgaaaaac atgacccctg gccggcctat gtcacctata cctctcagac
      661 agtgaaaaga ctcattgaga aaagcaaaac tagagaactg gaatgcatgc gtgccctcga
      721 ggaaagaccc tgggcatcaa ggcagaataa accttccagc gtcattcagc cgaaaaggag
      781 gaagtcttcc aagtcttctg gcaaagctgt gttcagggac acgctgtcag aatccacgtt
      841 atcaatgtgg ggcgcttatt cggtattggc catggctcct accatgatcc cagaacccac
      901 acacttacat gcggattcca gagactgtcc aactgaaaac tataacaaga tcatctttgc
      961 ccgcaagcct atgatgagga tgctccctac agttcgctac tgaccaacaa ggagaaacat
     1021 gcaaatgttt tagccagggg tccctgcagc cattccccaa gaacgtacaa aagttaagct
     1081 ccatttacca ctcacttgac agtgtccttt aaatctgaac ttgctcttgc tcatgcggag
     1141 cttggctaag agaaaccaga tcagaatgca agctgtaggt gggtgggtga gtgtgtcccc
     1201 tcccacactg ctctctggtg ggtttgggca gtccctggct ctagtctctg ctgcagattc
     1261 tcaggaccaa aatgtgggtg atttgtctgg gtccaggcag gagacagaaa tcacacaagc
     1321 tcttttatta gagataatat aaagaatgat taaccaggtg acagtaaagg gcaggaaggg
     1381 aatacaaagg tatccatgga ggtagcacca caggaagcag gcatcacact tgaggcttgg
     1441 gaacaagggg aagatgctgg actcattgaa aggtggttgc ttggagaagg gacatggggc
     1501 tgaatctcag acttctgagg tgggggagtg gggatgccac tcaatgcagc tggtatctct
     1561 gagctctgag gagagtcctg tggggatggt gccccctcct ctgaataggg gagatgtttt
     1621 gttggtgtct ctgaggggac ccccatgagg ctgcttttgt gagtgttgga aaaaccaaaa
     1681 actgcattga aatgtttctg ggaggagttg ccactgcctg ggtgaagaaa aagcactgct
     1741 agggttagca acctgtctgg caagggacag gaagctgata gaaagtgaac aggaagcaaa
     1801 caggaagtga gcaaggggcc acttcctact tcctccttta gcctagcaga ttccttctag
     1861 ctccccctgg gggctgagcc tatcagggca caaagccaga atgtggtttg tagaatccca
     1921 gccccagcat ctccaagcat aggatggatt ttgaagccaa gagggaatta gctctcggcc
     1981 gggttctgag tgatcccatc cagctgctcc tggacctggt attgagaggt ttttcccttg
     2041 gagggcaaac aaagtggcag tggggaccag ggtgtcccct gctgagaaat ggagagctct
     2101 tttcccctgt acttctctgg ggtttgcctt gtggaaccaa gtgcttgggg gaggagctcc
     2161 tggcaggact ccagctgtta tttgtcagag gacagctagg attggttcac ccttgctctg
     2221 agttggcccc aaagcgagct atgctgaact cttctccatc tccaagcaga caacctttgt
     2281 ctttacatgc aagagggatc caattatgac aggctgaccc agctggtttc atgtttgggg
     2341 tttatctact gagtaaggct gaccttacct gagtttctgt atgtgtattt gcaagacagt
     2401 taatactaat ccatcatccc tcacagagat gtagaggatg agatgtagta acttatagca
     2461 gtgtcatttg gaaaagttga atttgcccta caaggcatgt tctccattca agggtcttgt
     2521 gtaaacgttt gcagacacag gtgcagcttt ggagaactca cctctggctc ttgtgctttt
     2581 atgttgggac agctgcctaa attaggagct ctagacctgt tattggttcc caactgttgg
     2641 ccagaatgaa ttcttcgaaa aatataggtg gtttccaggg aatttgaatg attgtatttt
     2701 gtgtccatgg aacgtttata gacatggagg caggcaataa attcctccaa taattttttt
     2761 a
//
