LOCUS       NM_016078               1876 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens trans-golgi network vesicle protein 23 homolog B
            (TVP23B), transcript variant 1, mRNA.
ACCESSION   NM_016078 XM_939496
VERSION     NM_016078.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1876)
  AUTHORS   Wang,A.L., Rao,V.R., Chen,J.J., Lussier,Y.A., Rehman,J., Huang,Y.,
            Jager,R.D. and Grassi,M.A.
  TITLE     Role of FAM18B in diabetic retinopathy
  JOURNAL   Mol Vis 20, 1146-1159 (2014)
   PUBMED   25221423
  REMARK    GeneRIF: The role of FAM18B in regulating retinal microvascular
            endothelial cell viability, migration, and endothelial tube
            formation was determined following RNAi-mediated knockdown of
            FAM18B.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB143840.1, AC107982.6 and BC008430.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016078.5.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF151906.1, SRR3476690.989139.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307767.13/ ENSP00000305654.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DB143840.1         157-187
            32-32               AC107982.6         92455-92455         c
            33-86               DB143840.1         189-242
            87-1875             BC008430.1         1-1789
            1876-1876           AC107982.6         66955-66955         c
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..1876
                     /gene="TVP23B"
                     /gene_synonym="CGI-148; FAM18B; FAM18B1; NPD008; YDR084C"
                     /note="trans-golgi network vesicle protein 23 homolog B"
                     /db_xref="GeneID:51030"
                     /db_xref="HGNC:HGNC:20399"
     exon            1..123
                     /gene="TVP23B"
                     /gene_synonym="CGI-148; FAM18B; FAM18B1; NPD008; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..729
                     /gene="TVP23B"
                     /gene_synonym="CGI-148; FAM18B; FAM18B1; NPD008; YDR084C"
                     /note="isoform a is encoded by transcript variant 1;
                     family with sequence similarity 18, member B; protein
                     FAM18B1; family with sequence similarity 18, member B1;
                     Golgi apparatus membrane protein TVP23 homolog B"
                     /codon_start=1
                     /product="Golgi apparatus membrane protein TVP23 homolog B
                     isoform a"
                     /protein_id="NP_057162.4"
                     /db_xref="CCDS:CCDS42274.1"
                     /db_xref="GeneID:51030"
                     /db_xref="HGNC:HGNC:20399"
                     /translation="MLQQDSNDDTEDVSLFDAEEETTNRPRKAKIRHPVASFFHLFFR
                     VSAIIVYLLCGLLSSSFITCMVTIILLLSCDFWAVKNVTGRLMVGLRWWNHIDEDGKS
                     HWVFESRKESSQENKTVSEAESRIFWLGLIACPVLWVIFAFSALFSFRVKWLAVVIMG
                     VVLQGANLYGYIRCKVRSRKHLTSMATSYFGKQFLRQNTGDDQTS"
     exon            124..206
                     /gene="TVP23B"
                     /gene_synonym="CGI-148; FAM18B; FAM18B1; NPD008; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     exon            207..351
                     /gene="TVP23B"
                     /gene_synonym="CGI-148; FAM18B; FAM18B1; NPD008; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     exon            352..441
                     /gene="TVP23B"
                     /gene_synonym="CGI-148; FAM18B; FAM18B1; NPD008; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     exon            442..573
                     /gene="TVP23B"
                     /gene_synonym="CGI-148; FAM18B; FAM18B1; NPD008; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     exon            574..702
                     /gene="TVP23B"
                     /gene_synonym="CGI-148; FAM18B; FAM18B1; NPD008; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     exon            703..1876
                     /gene="TVP23B"
                     /gene_synonym="CGI-148; FAM18B; FAM18B1; NPD008; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1851..1856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TVP23B"
                     /gene_synonym="CGI-148; FAM18B; FAM18B1; NPD008; YDR084C"
                     /note="hexamer: TATAAA"
     polyA_site      1876
                     /gene="TVP23B"
                     /gene_synonym="CGI-148; FAM18B; FAM18B1; NPD008; YDR084C"
                     /note="major polyA site"
ORIGIN      
        1 cttacagtgg tccctgctgg cccttggtga cgggtcgcct cagttccgac ccggacccgt
       61 acgctgctgc gctgacgtgg ctcccggaag tagggctggc gtagggccgc catgttgcag
      121 caggatagta atgatgacac tgaagatgtt tcactgtttg atgcggaaga ggagacgact
      181 aatagaccaa gaaaagccaa aatcagacat ccagtagcat cgtttttcca cttattcttt
      241 cgagtcagtg caatcatcgt ctatcttctc tgtgggttgc tcagcagcag ctttattacc
      301 tgtatggtga caattatctt gttgttgtcg tgtgactttt gggcagtgaa gaatgtcaca
      361 ggtagactaa tggttggcct acgttggtgg aatcacattg atgaagatgg aaagagccat
      421 tgggtgtttg aatctagaaa ggagtcctct caagagaata aaactgtgtc agaggctgaa
      481 tcaagaatct tttggttggg acttattgcc tgtccagtac tgtgggtgat atttgctttt
      541 agtgcactct tctccttcag agtaaagtgg ttggcggtgg ttatcatggg tgtggtgcta
      601 caaggtgcca acctgtatgg ttacatcagg tgtaaggtgc gcagcagaaa gcatttaacc
      661 agcatggcta cttcatattt tggaaagcag tttttaagac aaaacactgg agatgatcag
      721 acttcctgaa tagagaaagc ttatgtgctt tgttacattg gggaacaact gaagagattc
      781 ttgactcaac cttttagagc ttagtccatg ttgcaacgag gagtgttggc tttgtttttc
      841 cacttaaaaa ctttatttat aaaaaggaaa agtagttttc atattaagtt tttatttcct
      901 ttccagcagt tggggctaga aagtatgtgt tggcactaga aacattgtca agatttgttc
      961 tgtggtgtag gtatgcacat tccataggta tgcacacggc catgtaatat cagtatatcc
     1021 caagttaatg aaagtgttca tttacatagg taatggagac ctttgcattt tgatccatag
     1081 aacataggag gatgttctta gtctgtctca aagctctata tgtttacata ttatttctgt
     1141 agattgtttt caggagaaag ttttgcttct atggtaagag tgagcacttt ggcttatgta
     1201 taagttagaa ataattgtta gtttttaata tgcacttcgt ggggaaattt cttagacgta
     1261 tgcaagcaag tgaaaacaat tagggccagt ggtattaact actttataaa attttatttt
     1321 tgtttgtaag aagtcatcta tttaaggccc agttaatata agtggaatca tcatagttta
     1381 aggaataccc agagattgct gctgttctat ttattttaca gaaaggatag ctagattgaa
     1441 agctcttcag tggaccttga gctaatagat cttttaccac taaaagagca ttattctcat
     1501 gtcataatga gaataataat ttacatactt ggcataataa atgcctaaaa gacattttat
     1561 tttctgaatc tatttttttc ttgctataat ggggatattg taaattatgc atttgtatta
     1621 atggtatttc ttaaagcaat ctatgtaact gtaaattaaa ccaatctaca aactattgta
     1681 ggcatctgta aattctgttg taggtattat aaactttgtt gaagtcttaa tcagcagatt
     1741 atgttgtgaa tatatttgta cattgttaaa atagttttta agattatttg tttaattgaa
     1801 taagtgtctt attggagtga tagctttgaa ggtgcaaaac tttatatttg tataaaattc
     1861 tactatttac aaggca
//
