LOCUS       NM_001079512            3370 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens trans-golgi network vesicle protein 23 homolog A
            (TVP23A), transcript variant 1, mRNA.
ACCESSION   NM_001079512
VERSION     NM_001079512.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3370)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA248626.1, AK294418.1,
            AC074136.4 and AL833564.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001079512.3.
            
            Summary: This gene encodes a membrane protein associated with the
            Golgi apparatus, which plays a crucial role in intracellular
            vesicular transport. The encoded protein is likely associated with
            the late (trans) Golgi compartments, which are involved in the
            delivery of secretory and membrane proteins to the endosome,
            lysosome or the plasma membrane. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.127198.1,
                                           SRR1803614.237197.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299866.13/ ENSP00000299866.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DA248626.1         1-9
            10-1507             AK294418.1         1-1498
            1508-3323           AC074136.4         59566-61381
            3324-3369           AL833564.1         3210-3255
            3370-3370           AC074136.4         61428-61428
FEATURES             Location/Qualifiers
     source          1..3370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.13"
     gene            1..3370
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /note="trans-golgi network vesicle protein 23 homolog A"
                     /db_xref="GeneID:780776"
                     /db_xref="HGNC:HGNC:20398"
     exon            1..310
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..943
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM18A; family with sequence similarity 18, member
                     A; Golgi apparatus membrane protein TVP23 homolog A"
                     /codon_start=1
                     /product="Golgi apparatus membrane protein TVP23 homolog A
                     isoform 1"
                     /protein_id="NP_001072980.1"
                     /db_xref="CCDS:CCDS45408.1"
                     /db_xref="GeneID:780776"
                     /db_xref="HGNC:HGNC:20398"
                     /translation="MKQALVDDTEDVSLDFGNEEELAFRKAKIRHPLATFFHLFFRVS
                     AIVTYVSCDWFSKSFVGCFVMVLLLLSLDFWSVKNVTGRLLVGLRWWNQIDEDGKSHW
                     IFEARKVSPNSIAATEAEARIFWLGLIICPMIWIVFFFSTLFSLKLKWLALVVAGISL
                     QAANLYGYILCKMGGNSDIGKVTASFLSQTVFQTACPGDFQKPGLEGLEIHQH"
     exon            311..390
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     exon            391..535
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     exon            536..625
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     exon            626..754
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     exon            755..883
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     exon            884..943
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     exon            944..3370
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1113..1118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /note="hexamer: CATAAA"
     polyA_site      1135
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /note="major polyA site"
     regulatory      3345..3350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /note="hexamer: AATAAA"
     polyA_site      3370
                     /gene="TVP23A"
                     /gene_synonym="FAM18A; YDR084C"
                     /note="major polyA site"
ORIGIN      
        1 attcctccca ctatctctgt ccgcagttcc ccaggccgtt gcctccctgc cgccgctttc
       61 tctcctgggc gcgtccccgg cgagccgagc cccctcccca gcctgcgact gcgccttagg
      121 ccccgagcgc cccgccccac ccgagaagct gcgctgaggc tgccccacag ggcgcaggcc
      181 ccgaccctca gcgtccaccg tctgctgcct acatccgccc gcccggcgtc cgaccccttc
      241 agcggcgacg ggcggagctg gagccccggg cctgggcgcc aggtgggctc ctgggagggt
      301 gatgaagcag gccctggtgg acgataccga ggatgtgtcc ctggactttg gaaacgagga
      361 ggagctggcc tttaggaaag ccaagatcag acaccccttg gccacctttt tccacctgtt
      421 tttccgagtg agtgccatcg tcacctacgt gagctgcgac tggttcagca agagctttgt
      481 gggctgtttt gtcatggtgc tgctcctcct gtccctggac ttctggtctg tgaagaatgt
      541 aaccggaaga ctcctggtgg gccttcgatg gtggaaccag atagatgaag atgggaagag
      601 ccactggatc tttgaagcca ggaaggtctc tccgaatagc attgctgcca cagaagctga
      661 agcacgaatc ttctggctgg gcctcataat ctgccccatg atatggattg tgtttttttt
      721 tagcacctta ttttccttga agctaaagtg gctggctctg gtggttgctg ggatctctct
      781 ccaagctgca aacctgtatg gctacatcct ttgtaagatg ggaggcaaca gtgacattgg
      841 caaggtcaca gccagtttcc tgtcccagac agtgttccag acggcctgcc caggtgactt
      901 tcagaagcct ggcctcgagg ggctggagat tcaccagcat taggaactga tgaggttctc
      961 ttcttttgac tgatggagat tacaaaactc ttggattcct ggaaaacaag acgacaggca
     1021 tagagtgcta atggcttgtc taccccttga cagccctgtc ctgtgctggg gagggctgtg
     1081 ttttgacagg ggtggaatcc tctggctagt tccataaaaa gacctgtgtc tgtgatgccc
     1141 tgagtctttg aaagtgaccg gaatacctca cactacccat cttgctcata accagtggct
     1201 gcggccttcc tcggaccatc tatagatgga ggattctggg aatgctgttt ccttaccctt
     1261 gacatcattc ttctaggcaa gtaaaaccca gccacaaact cagagaccac agctttaaca
     1321 aacactgaca cctctgccct aactctgggg cctctgatgg ctgccactgg ctgaatgtgg
     1381 cctgcacgtg ggtttggtct ggctcaacaa agtttttatt tttatttttt atttttttga
     1441 gacacggtct cacgctgttg cccaggctgg agtgcagtgg cgcgatctcg ccttactgca
     1501 gcctccgcct cccaggttca agcgattctc ctgcctcagc ctcctgagta gctgggacta
     1561 caggcatgcg ccaccacacc cggctaattt tcatattttt agtagagaca gtgtttctcc
     1621 atgttagcca ggctggtctt gaactcctga ccagcctcaa gtgatctgcc tgcctccttc
     1681 acccaaagtg ctgggattcc aggtgtgagc cactgcacct ggcctttttt ttttttatca
     1741 gttactttta aaaatgaatt actttatccc tttattggga tgtatttcct aagccataaa
     1801 tttcaccctc accatgtttt ttaaactatg aattaattca caatactcac acattgagag
     1861 atttctcatg gactcctggc ttcctcggct atgggggcca ctctgtggtc atcacagacc
     1921 ccaccaccca cctgtccttc cacacccctg gctcctttat gttgcttcct gccccacagg
     1981 catctgcatt tagtactcat ggaaatactt actctgaatt atacttctgt aggctaacgt
     2041 ggctggggaa tctggggcgt caatgaaaaa agactggcct ttgtcacaat tcttacctta
     2101 aaaaagaaac aaacggaaga caattcagtc caagaggaaa acagaatggc cacaagatct
     2161 tggggctctt tccgtgctgg tgacaatggg aagatcttga gcccgcttca ctcgtaatga
     2221 agaacaaagt agaaaagacc agtggggtct cagggacctt ccttccagca gggtccccag
     2281 ccagcatttc agcgtggcta aataatcagg tggtgtacag aaaatgcagg ttccagggcc
     2341 ctacagagaa ctgattcagc agcttccaca tgggcccagg agtctgcatt ttaagagatt
     2401 agcttttgag tgaaaggatc atgaatgcac atggttaaaa aaagtacaga atgcaaaagg
     2461 atatggcata aaaggccaag tccgaaaagg gctactagtg ttctaggtgt ctttccagaa
     2521 agattatgcg catataaatg tgcacacttg catgtgtgcg cacacacata cacacactct
     2581 catataccta aaatacgaat gggagcacat gacacacaca ttctgcctgc tgctttgtct
     2641 gtgtataatt ttatcttcca ggtcatctgt gctggtgtct atcagtctgc tagtctttcc
     2701 ccgccatgtg gccattgttc cagtcccctc ctatgcacac ccaggtttct ctaggaccat
     2761 gttatcccag agccaggtgg acaggacaca aggggctagg ggtcaatggg ggtgttctcg
     2821 cctccagtct gccctgccag cccccagtcg tgggtggacc tgccatcagc ttgctctgcc
     2881 cactccccag gcctgagctg ctggcgaaac aggcaagtga ctgcactgcc catggccggt
     2941 caccagcctc aggtgaaccc caggaggggt tcctacctag cactcatcat ttcctcaact
     3001 tcactactgt gtcgccctgt gggacaggga agtccaagtc ggggaagaag cctgtgggga
     3061 ggggttggtg ggagatgggg agcccatatg gcccagtgag tcaggaaaat agggtccaga
     3121 ggcagggaac ataaggccaa ttcgcacttg agccataaca ggaaatgtcc tctccatagg
     3181 acgtatgccg taaatgactt tgtaacttta cttcatcctt ttcgtttata tagggcgtac
     3241 ctcaagtaga gggtatttaa acacaaaaac tctgtaatgg ggcctttgag cccctattct
     3301 caggcccgtt ctcctcccac accgtggagt tgactttcat tttcaataaa tcccttcctt
     3361 ccttcctttc
//
