LOCUS       NM_024617               5603 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens terminal uridylyl transferase 7 (TUT7), transcript
            variant 1, mRNA.
ACCESSION   NM_024617 XM_372124
VERSION     NM_024617.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5603)
  AUTHORS   Zhang,P., Frederick,M.I. and Heinemann,I.U.
  TITLE     Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA
            Homeostasis
  JOURNAL   Cells 11 (23), 3742 (2022)
   PUBMED   36497000
  REMARK    GeneRIF: Terminal Uridylyltransferases TUT4/7 Regulate microRNA and
            mRNA Homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5603)
  AUTHORS   Yang,A., Bofill-De Ros,X., Stanton,R., Shao,T.J., Villanueva,P. and
            Gu,S.
  TITLE     TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and
            abundance
  JOURNAL   Nat Commun 13 (1), 5260 (2022)
   PUBMED   36071058
  REMARK    GeneRIF: TENT2, TUT4, and TUT7 selectively regulate miRNA sequence
            and abundance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5603)
  AUTHORS   Medhi,R., Price,J., Furlan,G., Gorges,B., Sapetschnig,A. and
            Miska,E.A.
  TITLE     RNA uridyl transferases TUT4/7 differentially regulate miRNA
            variants depending on the cancer cell type
  JOURNAL   RNA 28 (3), 353-370 (2022)
   PUBMED   34949722
  REMARK    GeneRIF: RNA uridyl transferases TUT4/7 differentially regulate
            miRNA variants depending on the cancer cell type.
REFERENCE   4  (bases 1 to 5603)
  AUTHORS   Arayataweegool,A., Srisuttee,R., Bin-Alee,F., Mahattanasakul,P.,
            Tangjaturonrasme,N., Kerekhanjanarong,V., Mutirangura,A. and
            Kitkumthorn,N.
  TITLE     Induction of ZCCHC6 expression in peripheral blood mononuclear
            cells by HNSCC secretions
  JOURNAL   Gene 754, 144880 (2020)
   PUBMED   32526260
  REMARK    GeneRIF: High ZCCHC6 expression is associated with head and neck
            squamous cell carcinoma.
REFERENCE   5  (bases 1 to 5603)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5603)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 5603)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 5603)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   9  (bases 1 to 5603)
  AUTHORS   Mullen,T.E. and Marzluff,W.F.
  TITLE     Degradation of histone mRNA requires oligouridylation followed by
            decapping and simultaneous degradation of the mRNA both 5' to 3'
            and 3' to 5'
  JOURNAL   Genes Dev 22 (1), 50-65 (2008)
   PUBMED   18172165
REFERENCE   10 (bases 1 to 5603)
  AUTHORS   Rissland,O.S., Mikulasova,A. and Norbury,C.J.
  TITLE     Efficient RNA polyuridylation by noncanonical poly(A) polymerases
  JOURNAL   Mol Cell Biol 27 (10), 3612-3624 (2007)
   PUBMED   17353264
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC377509.1, BC016387.1, AK055546.1, BC015897.1, CA773862.1 and
            BU734789.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024617.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longer protein (isoform 1). Variants
            1 and 2 encode the same protein isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.282314.1,
                                           SRR1803616.229278.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375963.8/ ENSP00000365130.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               DC377509.1         78-543
            467-730             BC016387.1         198-461
            731-2422            AK055546.1         733-2424
            2423-4883           BC015897.1         337-2797
            4884-5228           CA773862.1         236-580
            5229-5603           BU734789.1         17-391              c
FEATURES             Location/Qualifiers
     source          1..5603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..5603
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /note="terminal uridylyl transferase 7"
                     /db_xref="GeneID:79670"
                     /db_xref="HGNC:HGNC:25817"
                     /db_xref="MIM:613467"
     exon            1..140
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            141..691
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..4659
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /EC_number="2.7.7.52"
                     /note="isoform 1 is encoded by transcript variant 1; PAP
                     associated domain containing 6; terminal
                     uridylyltransferase 7; TUTase 7; zinc finger CCHC
                     domain-containing protein 6; zinc finger, CCHC domain
                     containing 6; zinc finger CCHC-type containing 6"
                     /codon_start=1
                     /product="terminal uridylyltransferase 7 isoform 1"
                     /protein_id="NP_078893.2"
                     /db_xref="CCDS:CCDS35057.1"
                     /db_xref="GeneID:79670"
                     /db_xref="HGNC:HGNC:25817"
                     /db_xref="MIM:613467"
                     /translation="MGDTAKPYFVKRTKDRGTMDDDDFRRGHPQQDYLIIDDHAKGHG
                     SKMEKGLQKKKITPGNYGNTPRKGPCAVSSNPYAFKNPIYSQPAWMNDSHKDQSKRWL
                     SDEHTGNSDNWREFKPGPRIPVINRQRKDSFQENEDGYRWQDTRGCRTVRRLFHKDLT
                     SLETTSEMEAGSPENKKQRSRPRKPRKTRNEENEQDGDLEGPVIDESVLSTKELLGLQ
                     QAEERLKRDCIDRLKRRPRNYPTAKYTCRLCDVLIESIAFAHKHIKEKRHKKNIKEKQ
                     EEELLTTLPPPTPSQINAVGIAIDKVVQEFGLHNENLEQRLEIKRIMENVFQHKLPDC
                     SLRLYGSSCSRLGFKNSDVNIDIQFPAIMSQPDVLLLVQECLKNSDSFIDVDADFHAR
                     VPVVVCREKQSGLLCKVSAGNENACLTTKHLTALGKLEPKLVPLVIAFRYWAKLCSID
                     RPEEGGLPPYVFALMAIFFLQQRKEPLLPVYLGSWIEGFSLSKLGNFNLQDIEKDVVI
                     WEHTDSAAGDTGITKEEAPRETPIKRGQVSLILDVKHQPSVPVGQLWVELLRFYALEF
                     NLADLVISIRVKELVSRELKDWPKKRIAIEDPYSVKRNVARTLNSQPVFEYILHCLRT
                     TYKYFALPHKITKSSLLKPLNAITCISEHSKEVINHHPDVQTKDDKLKNSVLAQGPGA
                     TSSAANTCKVQPLTLKETAESFGSPPKEEMGNEHISVHPENSDCIQADVNSDDYKGDK
                     VYHPETGRKNEKEKVGRKGKHLLTVDQKRGEHVVCGSTRNNESESTLDLEGFQNPTAK
                     ECEGLATLDNKADLDGESTEGTEELEDSLNHFTHSVQGQTSEMIPSDEEEEDDEEEEE
                     EEEPRLTINQREDEDGMANEDELDNTYTGSGDEDALSEEDDELGEAAKYEDVKECGKH
                     VERALLVELNKISLKEENVCEEKNSPVDQSDFFYEFSKLIFTKGKSPTVVCSLCKREG
                     HLKKDCPEDFKRIQLEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLE
                     SFIRQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLETAEGLDCVRTIEELARVLR
                     KHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSAYSAIDPRVKY
                     LCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNPPVIPVLQEIYKGEKKPEI
                     FVDGWNIYFFDQIDELPTYWSECGKNTESVGQLWLGLLRFYTEEFDFKEHVISIRRKS
                     LLTTFKKQWTSKYIVIEDPFDLNHNLGAGLSRKMTNFIMKAFINGRRVFGIPVKGFPK
                     DYPSKMEYFFDPDVLTEGELAPNDRCCRICGKIGHFMKDCPMRRKVRRRRDQEDALNQ
                     RYPENKEKRSKEDKEIHNKYTEREVSTKEDKPIQCTPQKAKPMRAAADLGREKILRPP
                     VEKWKRQDDKDLREKRCFICGREGHIKKECPQFKGSSGSLSSKYMTQGKASAKRTQQE
                     S"
     exon            692..873
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            874..990
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1168
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1257
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1309
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1379
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1506
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1626
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1779
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1960
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..3048
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3199
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3286
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..3387
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3445
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3549
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3639
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..3753
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3831
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..4009
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            4010..4057
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            4058..4149
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..4265
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            4266..4591
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     exon            4592..5603
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5578..5583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /note="hexamer: AATAAA"
     polyA_site      5603
                     /gene="TUT7"
                     /gene_synonym="PAPD6; TENT3B; ZCCHC6"
                     /note="major polyA site"
ORIGIN      
        1 aggaagaggc tggggaccgc ggcgaaggtg gtgagtgctc ttgggcgcct tctcccaacg
       61 tccctgccag actcgcctcc gggctgattc tccagttggt ttcctggact ccagagtagc
      121 tgtccggcct ggccccggag gtgcaaagta agaaaattga agtcaaagac catgggagat
      181 acagcaaaac cttatttcgt gaagcgcact aaagaccggg ggactatgga tgatgatgac
      241 ttcagaaggg gtcaccccca acaagattat ttaataatag atgaccatgc taaaggccat
      301 ggcagtaaaa tggaaaaggg ccttcaaaaa aagaagataa caccagggaa ctatgggaat
      361 acccccagaa aaggaccatg tgctgtttcc agcaatccat atgcatttaa aaacccaatc
      421 tacagtcaac ccgcttggat gaatgacagc cacaaagatc agagtaagag atggctgtct
      481 gatgaacata ctggtaattc agacaactgg agagaattca aacctggacc tagaattcct
      541 gttataaacc gacaaagaaa agactccttt caagaaaatg aagatggtta taggtggcaa
      601 gacacaagag gctgcagaac tgtaagacga ctgtttcata aagacctaac aagcctagaa
      661 accacgtcag aaatggaagc aggaagtcct gaaaacaaga agcagaggtc cagacctagg
      721 aagccacgga agactagaaa tgaggaaaat gagcaggatg gagacttgga aggccctgtg
      781 atcgatgagt ctgtactttc aacgaaggag ctgctaggct tacagcaggc tgaggagaga
      841 ctgaagagag actgcattga caggctaaaa aggcgaccac gaaactaccc tacagcaaag
      901 tacacctgca gactctgtga tgttttaatt gaatccattg catttgccca taagcatatc
      961 aaggaaaaga ggcacaagaa aaacattaag gagaagcaag aggaagagtt gctcactacg
     1021 ttacccccac caacaccctc ccagataaat gcagttggca ttgccattga caaagtggta
     1081 caggaatttg gcttacacaa tgagaacttg gaacagaggc tggaaattaa acgtatcatg
     1141 gaaaatgtgt tccaacacaa gttaccagat tgttccctaa gattatatgg gtcatcctgt
     1201 agcagattgg gtttcaaaaa ttcggatgta aacattgaca tccagtttcc agccattatg
     1261 tctcagccag atgtcctctt acttgttcaa gaatgtttaa agaacagtga ctcctttatt
     1321 gatgttgatg cagacttcca tgctagggtg ccagtggtgg tgtgcagaga aaagcaaagt
     1381 ggtcttctgt gtaaagtgag cgcaggaaat gaaaatgctt gtctgacaac aaagcattta
     1441 actgcccttg gaaaactaga accaaagctg gttcctttgg tgattgcatt taggtactgg
     1501 gcaaagcttt gcagtataga tcgccctgaa gaaggaggtc tgccacctta tgtgtttgcc
     1561 ctgatggcca ttttctttct tcagcagagg aaagaacccc ttttgcctgt atatctagga
     1621 tcatggattg aaggattctc attaagcaaa ctagggaatt tcaaccttca agacattgaa
     1681 aaagatgttg tgatctggga acatactgac agtgctgcag gggacacagg cataacaaaa
     1741 gaagaggcac caagagaaac gccgattaaa aggggacagg tgtcattaat attggatgtg
     1801 aaacaccagc cttcagtacc agttgggcag ctctgggtgg aattgctgcg gttctatgct
     1861 ttagaattta atttggctga tttagtgata agtattcgtg tcaaagaatt ggtatctcgg
     1921 gaattgaagg attggcccaa aaagcgcatt gccattgaag atccctactc tgttaaaaga
     1981 aatgtggcaa gaaccctaaa tagtcaacct gtgtttgaat atatacttca ttgtttaagg
     2041 acaacataca agtattttgc tcttccacac aaaattacaa aatccagcct tctaaagcct
     2101 ctgaatgcaa ttacatgtat ttcagaacat tctaaagaag taataaatca tcatccagat
     2161 gtacaaacaa aagatgataa gctcaaaaac tcagttttgg cccaaggtcc tggtgctacc
     2221 agttcagctg caaatacctg taaggtacag ccacttactc ttaaagagac tgctgaaagt
     2281 tttggaagcc caccaaaaga agaaatggga aatgaacaca tcagtgtcca ccctgaaaac
     2341 tcagactgta tccaagcaga tgttaactct gatgattaca agggtgataa agtataccat
     2401 ccagaaacag gaaggaaaaa cgagaaagag aaagttggaa ggaagggcaa gcatctgttg
     2461 actgttgatc agaaacgtgg agagcatgtt gtctgtggca gcacacgtaa taatgagtca
     2521 gagagcactt tggatttaga aggcttccaa aatcccacag ctaaagagtg tgagggactt
     2581 gccactttag ataacaaggc tgatcttgat ggagaaagta cagaaggtac tgaggaacta
     2641 gaagactctc taaaccactt tacccactca gtacagggcc agacatcaga aatgattccc
     2701 tctgatgaag aggaggagga cgacgaagaa gaggaggagg aagaagaacc taggctcacc
     2761 attaaccaaa gggaagatga agatggcatg gctaatgaag atgagttaga caacacctac
     2821 actgggtcag gggatgagga cgccctatct gaagaggatg atgagttagg cgaagctgct
     2881 aagtatgaag acgtgaaaga atgtggaaaa catgtagaaa gagctctcct agtggaactt
     2941 aataaaataa gtctcaagga agaaaatgta tgtgaagaaa aaaattcacc tgtggatcag
     3001 tctgattttt tttatgaatt cagtaaactt atcttcacca aaggcaagtc tcctacggta
     3061 gtgtgcagct tatgcaaacg agagggtcat ctaaagaagg actgtcctga agacttcaaa
     3121 agaatccagc tagaacctct gccaccatta acacccaagt ttttaaatat cttagatcaa
     3181 gtctgtatcc agtgttataa ggatttttct ccaacaatta tagaagatca ggctcgtgaa
     3241 catattcggc aaaacctaga aagtttcata agacaggact ttccaggaac taaattgagc
     3301 ctgtttggct cctccaaaaa tggatttggg ttcaaacaga gtgaccttga cgtctgtatg
     3361 acaattaatg gacttgaaac tgctgaggga ttggactgtg tcagaactat tgaagaatta
     3421 gcaagagtcc tcagaaaaca ttcaggtctg agaaacatct tacctattac aacagcaaag
     3481 gtgccaattg tgaagttctt ccatttgaga agtggtctgg aagtagatat cagtttgtat
     3541 aacacattgg cccttcataa cacaaggctt ttatctgctt attccgccat tgatcccaga
     3601 gtgaagtatt tgtgctatac catgaaagta tttacaaaga tgtgtgatat tggtgatgca
     3661 tctagaggca gcttatcatc gtatgcatat actcttatgg tgctatattt tctccagcag
     3721 aggaatccac cagtcattcc tgtccttcaa gagatataca aaggtgaaaa gaaacctgaa
     3781 atatttgttg atggctggaa tatttatttt tttgatcaaa tagatgaact gcctacctat
     3841 tggtcagaat gtggaaaaaa tacagaatct gttgggcagt tatggttggg ccttcttcgt
     3901 ttctacacag aggaatttga ttttaaagaa catgttatta gcatcaggag aaaaagtctg
     3961 cttacaactt ttaagaaaca gtggacctca aaatacattg ttattgaaga tccctttgat
     4021 ttgaatcata atcttggagc tggattatca aggaaaatga caaattttat aatgaaggct
     4081 tttatcaatg gtagaagagt atttggtatt cctgtcaagg gatttccaaa ggactacccc
     4141 tcaaaaatgg aatacttttt tgatccagat gtgttaactg aaggagagct ggccccaaat
     4201 gatagatgtt gtcgaatttg tggaaaaatc ggacacttca tgaaggactg tcctatgagg
     4261 agaaaagtaa gacggcggcg agatcaggaa gatgccctga accaaagata ccctgagaac
     4321 aaggaaaaaa gaagcaaaga ggacaaagaa attcacaaca agtacacaga aagggaggtg
     4381 tcaacaaaag aagataagcc catacagtgc acacctcaga aagccaagcc aatgcgggca
     4441 gctgctgacc tggggaggga gaagatcctc aggccaccag tagaaaaatg gaagagacag
     4501 gatgacaaag acttaagaga aaaacgttgt tttatttgtg gaagagaagg gcacattaaa
     4561 aaggaatgcc cacagtttaa aggctcttca ggtagccttt ccagtaaata tatgactcag
     4621 ggaaaagcct cagcgaagag gacccagcag gaatcatgag ggaaggaaaa tgcagcactc
     4681 taaatggcca ctcaggcgtt cctattcact cggaaaatta ggttcatttc acaggacaca
     4741 gcagtgtaga tcaggcttca acttaacatt taagggaaat gtcagatttt tttttaattt
     4801 aatgaaattg ttaatgagga aaaattttta atatagtctt atctaccaca catccccata
     4861 gatttaagga ttttaataga aagacatgat gtatgtattt aagccacgtt aaaagaaaaa
     4921 atataactat ggaccggtat tcagtgaata cagtttcatg gtttttaatt ctttcaaagc
     4981 acattaaaaa tggtgtgctg ataaacccca agtaaattaa ccctttttcc gtataaatcc
     5041 attttttgtt ttgaagaggg gaaattatat ttattgttgt ttactgaatc ctggtgtgaa
     5101 agcatatcag atatgtatga actgctactg ctgtacttcc gatttacgga catcatttta
     5161 ttgctatttg tagacgtgat aacatgaaca tgagtaccta tttatgtggg ccttcagtgg
     5221 atgggcagtg ccactcaggt ctctggggtt tccctctcta attttaagta aattgacata
     5281 taactactat gcttataaaa atgaagtaag gaaaacaagt agtcctgttt gccactaaaa
     5341 acattttcaa aggaaaaata aaatgaaagt actttttact ttttatgata ctcagaaatt
     5401 aggatgaaga acttttaaaa ttgctgaaga tcaaagaggt tatctctgcc agtcacaagt
     5461 gtggctggtg tcattctggg tctgactgga gccctcctgg actgtttctt taatttcaaa
     5521 agccctgcag acatagtacc tggtcagaac tatgcctcgg tttatttatc attttgaaat
     5581 aaaatcagaa tttcaacctg taa
//
