LOCUS       NM_022830               2705 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens terminal uridylyl transferase 1, U6 snRNA-specific
            (TUT1), transcript variant 1, mRNA.
ACCESSION   NM_022830
VERSION     NM_022830.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2705)
  AUTHORS   Mohanan,N.K., Shaji,F., Sudheesh,A.P., Bangalore Prabhashankar,A.,
            Sundaresan,N.R. and Laishram,R.S.
  TITLE     Star-PAP controls oncogene expression through primary miRNA 3'-end
            formation to regulate cellular proliferation and tumour formation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167080 (2024)
   PUBMED   38364942
  REMARK    GeneRIF: Star-PAP controls oncogene expression through primary
            miRNA 3'-end formation to regulate cellular proliferation and
            tumour formation.
REFERENCE   2  (bases 1 to 2705)
  AUTHORS   Yamashita,S. and Tomita,K.
  TITLE     Mechanism of U6 snRNA oligouridylation by human TUT1
  JOURNAL   Nat Commun 14 (1), 4686 (2023)
   PUBMED   37563152
  REMARK    GeneRIF: Mechanism of U6 snRNA oligouridylation by human TUT1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2705)
  AUTHORS   Koshre,G.R., Shaji,F., Mohanan,N.K., Mohan,N., Ali,J. and
            Laishram,R.S.
  TITLE     Star-PAP RNA Binding Landscape Reveals Novel Role of Star-PAP in
            mRNA Metabolism That Requires RBM10-RNA Association
  JOURNAL   Int J Mol Sci 22 (18), 9980 (2021)
   PUBMED   34576144
  REMARK    GeneRIF: Star-PAP RNA Binding Landscape Reveals Novel Role of
            Star-PAP in mRNA Metabolism That Requires RBM10-RNA Association.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2705)
  AUTHORS   Kim,J., Nakamura,J., Hamada,C., Taketomi,T., Yano,S., Okajima,T.,
            Kashiwabara,S.I., Baba,T., Sato,B., Chiba,T. and Tsuruta,F.
  TITLE     USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and
            Maintains Cerebellar Homeostasis
  JOURNAL   Mol Cell Biol 40 (21), e00098-20 (2020)
   PUBMED   32839293
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2705)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2705)
  AUTHORS   Martin,G. and Keller,W.
  TITLE     RNA-specific ribonucleotidyl transferases
  JOURNAL   RNA 13 (11), 1834-1849 (2007)
   PUBMED   17872511
  REMARK    Review article
REFERENCE   7  (bases 1 to 2705)
  AUTHORS   Trippe,R., Guschina,E., Hossbach,M., Urlaub,H., Luhrmann,R. and
            Benecke,B.J.
  TITLE     Identification, cloning, and functional analysis of the human U6
            snRNA-specific terminal uridylyl transferase
  JOURNAL   RNA 12 (8), 1494-1504 (2006)
   PUBMED   16790842
REFERENCE   8  (bases 1 to 2705)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (bases 1 to 2705)
  AUTHORS   Trippe,R., Richly,H. and Benecke,B.J.
  TITLE     Biochemical characterization of a U6 small nuclear RNA-specific
            terminal uridylyltransferase
  JOURNAL   Eur J Biochem 270 (5), 971-980 (2003)
   PUBMED   12603330
REFERENCE   10 (bases 1 to 2705)
  AUTHORS   Trippe,R., Sandrock,B. and Benecke,B.J.
  TITLE     A highly specific terminal uridylyl transferase modifies the 3'-end
            of U6 small nuclear RNA
  JOURNAL   Nucleic Acids Res 26 (13), 3119-3126 (1998)
   PUBMED   9628908
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002990.2.
            
            On Dec 27, 2018 this sequence version replaced NM_022830.2.
            
            Summary: This gene encodes a nucleotidyl transferase that functions
            as both a terminal uridylyltransferase and a nuclear poly(A)
            polymerase. The encoded enzyme specifically adds and removes
            nucleotides from the 3' end of small nuclear RNAs and select mRNAs
            and may function in controlling gene expression and cell
            proliferation.[provided by RefSeq, Apr 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110910.1, AB101208.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2149178
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000476907.6/ ENSP00000419607.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AP002990.2         49781-49900         c
            121-311             AP002990.2         47408-47598         c
            312-627             AP002990.2         39763-40078         c
            628-728             AP002990.2         39483-39583         c
            729-1198            AP002990.2         36938-37407         c
            1199-1308           AP002990.2         35559-35668         c
            1309-1419           AP002990.2         35284-35394         c
            1420-1512           AP002990.2         35034-35126         c
            1513-2705           AP002990.2         33429-34621         c
FEATURES             Location/Qualifiers
     source          1..2705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..2705
                     /gene="TUT1"
                     /gene_synonym="PAPD2; RBM21; STARPAP; TENT1; TUTase;
                     URLC6"
                     /note="terminal uridylyl transferase 1, U6 snRNA-specific"
                     /db_xref="GeneID:64852"
                     /db_xref="HGNC:HGNC:26184"
                     /db_xref="MIM:610641"
     exon            1..120
                     /gene="TUT1"
                     /gene_synonym="PAPD2; RBM21; STARPAP; TENT1; TUTase;
                     URLC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2663
                     /gene="TUT1"
                     /gene_synonym="PAPD2; RBM21; STARPAP; TENT1; TUTase;
                     URLC6"
                     /EC_number="2.7.7.19"
                     /EC_number="2.7.7.52"
                     /note="isoform 1 is encoded by transcript variant 1; RNA
                     uridylyltransferase; poly(A) polymerase associated domain
                     containing 2; TUTase 6; up-regulated in lung cancer 6;
                     nuclear speckle targeted phosphatidylinositol 4-phosphate
                     5-kinase type I-alpha regulated-poly(A) polymerase;
                     U6-TUTase; nuclear speckle-targeted
                     PIPK1A-regulated-poly(A) polymerase; PAP-associated
                     domain-containing 2; U6 snRNA-specific terminal
                     uridylyltransferase 1; speckle targeted PIP5K1A-regulated
                     poly(A) polymerase; RNA-binding protein 21; RNA-binding
                     motif protein 21; star-PAP"
                     /codon_start=1
                     /product="speckle targeted PIP5K1A-regulated poly(A)
                     polymerase isoform 1"
                     /protein_id="NP_073741.3"
                     /db_xref="CCDS:CCDS8021.3"
                     /db_xref="GeneID:64852"
                     /db_xref="HGNC:HGNC:26184"
                     /db_xref="MIM:610641"
                     /translation="MAAVDSDVESLPRGGFRCCLCHVTTANRPSLDAHLGGRKHRHLV
                     ELRAARKAQGLRSVFVSGFPRDVDSAQLSEYFLAFGPVASVVMDKDKGVFAIVEMGDV
                     GAREAVLSQSQHSLGGHRLRVRPREQKEFQSPASKSPKGAAPDSHQLAKALAEAADVG
                     AQMIKLVGLRELSEAERQLRSLVVALMQEVFTEFFPGCVVHPFGSSINSFDVHGCDLD
                     LFLDLGDLEEPQPVPKAPESPSLDSALASPLDPQALACTPASPPDSQPPASPQDSEAL
                     DFETPSSSLAPQTPDSALASETLASPQSLPPASPLLEDREEGDLGKASELAETPKEEK
                     AEGAAMLELVGSILRGCVPGVYRVQTVPSARRPVVKFCHRPSGLHGDVSLSNRLALHN
                     SRFLSLCSELDGRVRPLVYTLRCWAQGRGLSGSGPLLSNYALTLLVIYFLQTRDPPVL
                     PTVSQLTQKAGEGEQVEVDGWDCSFPRDASRLEPSINVEPLSSLLAQFFSCVSCWDLR
                     GSLLSLREGQALPVAGGLPSNLWEGLRLGPLNLQDPFDLSHNVAANVTSRVAGRLQNC
                     CRAAANYCRSLQYQRRSSRGRDWGLLPLLQPSSPSSLLSATPIPLPLAPFTQLTAALV
                     QVFREALGCHIEQATKRTRSEGGGTGESSQGGTSKRLKVDGQKNCCEEGKEEQQGCAG
                     DGGEDRVEEMVIEVGEMVQDWAMQSPGQPGDLPLTTGKHGAPGEEGQPSHAALAERGP
                     KGHEAAQEWSQGEAGKGASLPSSASWRCALWHRVWQGRRRARRRLQQQTKEGAGGGAG
                     TRAGWLATEAQVTQELKGLSGGEERPETEPLLSFVASVSPADRMLTVTPLQDPQGLFP
                     DLHHFLQVFLPQAIRHLK"
     exon            121..311
                     /gene="TUT1"
                     /gene_synonym="PAPD2; RBM21; STARPAP; TENT1; TUTase;
                     URLC6"
                     /inference="alignment:Splign:2.1.0"
     exon            312..627
                     /gene="TUT1"
                     /gene_synonym="PAPD2; RBM21; STARPAP; TENT1; TUTase;
                     URLC6"
                     /inference="alignment:Splign:2.1.0"
     exon            628..728
                     /gene="TUT1"
                     /gene_synonym="PAPD2; RBM21; STARPAP; TENT1; TUTase;
                     URLC6"
                     /inference="alignment:Splign:2.1.0"
     exon            729..1198
                     /gene="TUT1"
                     /gene_synonym="PAPD2; RBM21; STARPAP; TENT1; TUTase;
                     URLC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1308
                     /gene="TUT1"
                     /gene_synonym="PAPD2; RBM21; STARPAP; TENT1; TUTase;
                     URLC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1419
                     /gene="TUT1"
                     /gene_synonym="PAPD2; RBM21; STARPAP; TENT1; TUTase;
                     URLC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1512
                     /gene="TUT1"
                     /gene_synonym="PAPD2; RBM21; STARPAP; TENT1; TUTase;
                     URLC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..2705
                     /gene="TUT1"
                     /gene_synonym="PAPD2; RBM21; STARPAP; TENT1; TUTase;
                     URLC6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2684..2689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUT1"
                     /gene_synonym="PAPD2; RBM21; STARPAP; TENT1; TUTase;
                     URLC6"
                     /note="hexamer: AATAAA"
     polyA_site      2705
                     /gene="TUT1"
                     /gene_synonym="PAPD2; RBM21; STARPAP; TENT1; TUTase;
                     URLC6"
                     /note="major polyA site"
ORIGIN      
        1 agaggtgctt gtgtttttgt cggtacagga gagtcgctat ggcggcggtg gattcggatg
       61 tcgaatcgct gccgcgtggg gggttccgct gctgcctctg ccacgttact acagccaacc
      121 gacccagcct tgatgcccac ttgggaggca gaaagcaccg gcacctggta gaactacgag
      181 ctgcgagaaa ggcccaggga cttcgaagtg tgtttgtcag tggctttccc agggatgtgg
      241 attctgctca gctctctgag tacttcctag catttggacc tgtggccagt gttgtcatgg
      301 acaaggacaa gggagtgttt gccattgtgg agatggggga cgtgggtgct cgagaggctg
      361 tcttgtcaca gtcccagcac agcctgggag gacatcgcct gcgtgtccgc ccacgggagc
      421 agaaggagtt ccagagcccg gcctccaaat cccccaaagg agcggccccc gacagtcacc
      481 agctggccaa agcgctagct gaggctgcag acgtgggggc acaaatgata aagcttgtgg
      541 ggctgaggga gttgtccgag gccgagcggc agcttcgcag cctagtggtg gccctgatgc
      601 aggaggtctt cacagagttc ttccctggct gtgtggtcca cccttttggc tcttccataa
      661 atagcttcga tgtccatggc tgtgatcttg acctcttctt ggatctgggt gacttggaag
      721 agccccagcc agtcccaaag gctccagaat ctccatcgct ggactcggcc ctggcttccc
      781 cactggaccc tcaagccctg gcctgcaccc cagcttcccc tccagattca caacctcctg
      841 cttctcccca ggattctgaa gccctggact ttgaaacccc ttcctcctcc ctggcgcccc
      901 aaactccgga ctctgccttg gcctccgaga cccttgcttc tccccagtct ctgcctccag
      961 cttcaccact gctagaggac agggaagagg gggacctggg gaaggcctcg gaactagcag
     1021 agaccccaaa ggaggagaaa gcagaggggg cagcaatgct ggagctggtg ggatccattc
     1081 tccggggctg tgtccctggg gtgtatcgag tccaaactgt gccctctgcc cggcgccctg
     1141 tggtcaagtt ctgtcatcgg ccttcaggtc tccacggtga tgtctccctc agtaaccggc
     1201 tggccctgca taactcccgt ttcctgagtc tctgctctga gctggatggt cgagtccggc
     1261 ccctcgtgta caccctccgc tgctgggctc agggtcgggg gctgtcaggg agtggccccc
     1321 ttctcagtaa ctacgccctg accttgctgg tgatctattt tcttcagacc agggaccctc
     1381 ctgtgttgcc cactgtgtcc cagctcaccc agaaagcagg agagggggaa caggtggaag
     1441 tcgatggctg ggactgcagt ttccccaggg atgcctcaag actggagccc agcataaatg
     1501 tggagcccct cagttccctg ctagcccagt tcttctcctg tgtatcttgt tgggatcttc
     1561 gtggctccct gctgtccctg cgggagggtc aggcactgcc tgtggcaggg ggcctgcctt
     1621 ctaatctctg ggagggtctg cgccttggcc ccctgaatct ccaggaccct tttgacctga
     1681 gtcacaatgt cgcagccaat gtgaccagcc gggtggctgg gcgcctacag aactgctgcc
     1741 gagcagcagc caattactgc cgaagcctcc agtaccagcg ccgttcctcc cggggtcggg
     1801 actgggggct gctccctctt ctgcagccca gctcccccag ctccctgctc tctgctacgc
     1861 cgatcccttt accccttgca cccttcaccc agctcactgc tgccctggtg caggtattca
     1921 gggaagcact ggggtgccat atagaacagg caaccaagag aacgcggtca gaaggaggtg
     1981 gaactgggga gtcctctcag ggagggacaa gcaaaagact caaagtagat ggacagaaaa
     2041 actgctgtga ggaggggaaa gaggagcagc agggatgtgc aggggacggt ggggaagaca
     2101 gggtagaaga gatggttata gaggttggag agatggtgca ggactgggcc atgcagagcc
     2161 ctgggcagcc aggggacctg cccctgacca ctggaaagca tggagcccct ggagaagagg
     2221 ggcagcccag ccacgcagcc ctggcagagc gggggcccaa gggacatgag gcagcccaag
     2281 aatggtctca gggtgaggca gggaaggggg catccctgcc ctcctcagcg agctggcgct
     2341 gtgccttgtg gcaccgagtg tggcaagggc ggcggcgagc ccgtagacgc ttgcagcagc
     2401 aaaccaagga gggagctgga ggtggcgctg gcacaagagc agggtggctg gcgactgagg
     2461 ctcaggtcac ccaggagctg aaaggactga gtggtggcga agagaggcca gaaactgagc
     2521 ccctgctgag ctttgtggcg tctgtctccc cggctgaccg aatgctcact gtgaccccgc
     2581 tccaggatcc ccaaggcctg ttccctgatc tccatcattt cttacaggtt ttcctccctc
     2641 aagcaattcg acatctcaag tgaagacatg gcccctgaag ggcaataaag ctgctagttt
     2701 attaa
//
