LOCUS       NM_001413677            4428 bp    mRNA    linear   PRI 15-MAR-2025
DEFINITION  Homo sapiens tumor suppressor candidate 3 (TUSC3), transcript
            variant 13, mRNA.
ACCESSION   NM_001413677
VERSION     NM_001413677.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4428)
  AUTHORS   Deng,R., Lu,X., Hong,C., Cai,R., Wang,P., Xiong,L., Wang,X.,
            Chen,Q. and Lin,J.
  TITLE     Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma
            progression through LIPC/AKT axis
  JOURNAL   J Transl Med 20 (1), 485 (2022)
   PUBMED   36274132
  REMARK    GeneRIF: Downregulation of TUSC3 promotes EMT and hepatocellular
            carcinoma progression through LIPC/AKT axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4428)
  AUTHORS   Sun,F., Jie,Q., Li,Q., Wei,Y., Li,H., Yue,X. and Ma,Y.
  TITLE     TUSC3 inhibits cell proliferation and invasion in cervical squamous
            cell carcinoma via suppression of the AKT signalling pathway
  JOURNAL   J Cell Mol Med 26 (5), 1629-1642 (2022)
   PUBMED   35137520
  REMARK    GeneRIF: TUSC3 inhibits cell proliferation and invasion in cervical
            squamous cell carcinoma via suppression of the AKT signalling
            pathway.
REFERENCE   3  (bases 1 to 4428)
  AUTHORS   Ren,Y., Deng,R., Cai,R., Lu,X., Luo,Y., Wang,Z., Zhu,Y., Yin,M.,
            Ding,Y. and Lin,J.
  TITLE     TUSC3 induces drug resistance and cellular stemness via Hedgehog
            signaling pathway in colorectal cancer
  JOURNAL   Carcinogenesis 41 (12), 1755-1766 (2020)
   PUBMED   32338281
  REMARK    GeneRIF: TUSC3 induces drug resistance and cellular stemness via
            Hedgehog signaling pathway in colorectal cancer.
REFERENCE   4  (bases 1 to 4428)
  AUTHORS   Ouidir,M., Mendola,P., Buck Louis,G.M., Kannan,K., Zhang,C. and
            Tekola-Ayele,F.
  TITLE     Concentrations of persistent organic pollutants in maternal plasma
            and epigenome-wide placental DNA methylation
  JOURNAL   Clin Epigenetics 12 (1), 103 (2020)
   PUBMED   32653021
  REMARK    GeneRIF: Concentrations of persistent organic pollutants in
            maternal plasma and epigenome-wide placental DNA methylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4428)
  AUTHORS   Wang,S. and Zhu,W.
  TITLE     Tumour suppressor candidate 3 inhibits biological function and
            increases endoplasmic reticulum stress of melanoma cells WM451 by
            regulating AKT/GSK3-beta/beta-catenin pathway
  JOURNAL   Cell Biochem Funct 38 (5), 604-612 (2020)
   PUBMED   32090352
  REMARK    GeneRIF: Tumour suppressor candidate 3 inhibits biological function
            and increases endoplasmic reticulum stress of melanoma cells WM451
            by regulating AKT/GSK3-beta/beta-catenin pathway.
REFERENCE   6  (bases 1 to 4428)
  AUTHORS   Kelleher,D.J., Karaoglu,D., Mandon,E.C. and Gilmore,R.
  TITLE     Oligosaccharyltransferase isoforms that contain different catalytic
            STT3 subunits have distinct enzymatic properties
  JOURNAL   Mol Cell 12 (1), 101-111 (2003)
   PUBMED   12887896
REFERENCE   7  (bases 1 to 4428)
  AUTHORS   Ishii,H., Baffa,R., Numata,S.I., Murakumo,Y., Rattan,S., Inoue,H.,
            Mori,M., Fidanza,V., Alder,H. and Croce,C.M.
  TITLE     The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein,
            and its expression is altered in multiple human tumors
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3928-3933 (1999)
   PUBMED   10097140
REFERENCE   8  (bases 1 to 4428)
  AUTHORS   Pak,B.J., Park,H., Chang,E.R., Pang,S.C. and Graham,C.H.
  TITLE     Differential display analysis of oxygen-mediated changes in gene
            expression in first trimester human trophoblast cells
  JOURNAL   Placenta 19 (7), 483-488 (1998)
   PUBMED   9778121
REFERENCE   9  (bases 1 to 4428)
  AUTHORS   MacGrogan,D., Levy,A., Bova,G.S., Isaacs,W.B. and Bookstein,R.
  TITLE     Structure and methylation-associated silencing of a gene within a
            homozygously deleted region of human chromosome band 8p22
  JOURNAL   Genomics 35 (1), 55-65 (1996)
   PUBMED   8661104
REFERENCE   10 (bases 1 to 4428)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091559.7, AC010656.7 and
            AC019292.10.
            
            Summary: This gene encodes a protein that has been associated with
            several biological functions including cellular magnesium uptake,
            protein glycosylation and embryonic development. This protein
            localizes to the endoplasmic reticulum and acts as a component of
            the oligosaccharyl transferase complex which is responsible for
            N-linked protein glycosylation. This gene is a candidate tumor
            suppressor gene. Homozygous mutations in this gene are associated
            with autosomal recessive nonsyndromic mental retardation-7 and in
            the proliferation and invasiveness of several cancers including
            metastatic pancreatic cancer, ovarian cancer and glioblastoma
            multiform. [provided by RefSeq, Oct 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.2974711.1,
                                           SRR14038192.1979619.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC091559.7         162788-163093
            307-476             AC010656.7         58176-58345         c
            477-617             AC010656.7         21778-21918         c
            618-758             AC010656.7         19129-19269         c
            759-848             AC010656.7         7589-7678           c
            849-912             AC019292.10        10844-10907
            913-987             AC019292.10        23716-23790
            988-1078            AC019292.10        28553-28643
            1079-4428           AC019292.10        44381-47730
FEATURES             Location/Qualifiers
     source          1..4428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..4428
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="tumor suppressor candidate 3"
                     /db_xref="GeneID:7991"
                     /db_xref="HGNC:HGNC:30242"
                     /db_xref="MIM:601385"
     exon            1..306
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            307..476
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..617
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..1094
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="isoform 10 is encoded by transcript variant 13;
                     oligosaccharyltransferase 3 homolog A; magnesium
                     uptake/transporter TUSC3; putative prostate cancer tumor
                     suppressor; oligosaccharyl transferase subunit TUSC3;
                     dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit TUSC3"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit TUSC3 isoform 10"
                     /protein_id="NP_001400606.1"
                     /db_xref="GeneID:7991"
                     /db_xref="HGNC:HGNC:30242"
                     /db_xref="MIM:601385"
                     /translation="MNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDV
                     HIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQ
                     MWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATS
                     KGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSFLIK"
     exon            618..758
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..848
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..912
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..987
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1078
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..4428
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1339..1344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: AATAAA"
     polyA_site      1362
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="major polyA site"
     regulatory      1498..1503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: ATTAAA"
     polyA_site      1541
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
     regulatory      2115..2120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: AATAAA"
     polyA_site      2149
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
     regulatory      2763..2768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: ATTAAA"
     polyA_site      2784
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
     regulatory      2841..2846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: ATTAAA"
     polyA_site      2861
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
     regulatory      3408..3413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: TATAAA"
     polyA_site      3428
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
     regulatory      4406..4411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: ATTAAA"
     polyA_site      4428
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
ORIGIN      
        1 agtctcctcc tctgcgtcct cggccgcggc ccgggtccct cgcaaagccg ctgccatccc
       61 ggagggccca gccagcgggc tcccggaggc tggccgggca ggcgtggtgc gcggtaggag
      121 ctgggcgcgc acggctaccg cgcgtggagg agacactgcc ctgccgcgat gggggcccgg
      181 ggcgctcctt cacgccgtag gcaagcgggg cggcggctgc ggtacctgcc caccgggagc
      241 tttcccttcc ttctcctgct gctgctgctc tgcatccagc tcgggggagg acagaagaaa
      301 aaggagaatc ttttagctga aaaagtagag cagctgatgg aatggagttc cagacgctca
      361 atcttccgaa tgaatggtga taaattccga aaatttataa aggcaccacc tcgaaactat
      421 tccatgattg ttatgttcac tgctcttcag cctcagcggc agtgttctgt gtgcagctca
      481 acatgaactc tgctcctaca ttcatgcatt ttcctccaaa aggcagacct aagagagctg
      541 atacttttga cctccaaaga attggatttg cagctgagca actagcaaag tggattgctg
      601 acagaacgga tgttcatatt cgggttttca gaccacccaa ctactctggt accattgctt
      661 tggccctgtt agtgtcgctt gttggaggtt tgctttattt gagaaggaac aacttggagt
      721 tcatctataa caagactggt tgggccatgg tgtctctgtg tatagtcttt gctatgactt
      781 ctggccagat gtggaaccat atccgtggac ctccatatgc tcataagaac ccacacaatg
      841 gacaagtgag ctacattcat gggagcagcc aggctcagtt tgtggcagaa tcacacatta
      901 ttctggtact gaatgccgct atcaccatgg ggatggttct tctaaatgaa gcagcaactt
      961 cgaaaggcga tgttggaaaa agacggataa tttgcctagt gggattgggc ctggtggtct
     1021 tcttcttcag ttttctactt tcaatatttc gttccaagta ccacggctat ccttatagct
     1081 ttttaattaa atgaagccaa gtgggatttg cataaagtga atgtttacca tgaagataaa
     1141 ctgttcctga ctttatacta ttttgaattc attcatttca ttgtgatcag ctagcttatt
     1201 cttgtgtact ttttttaaac tgtgggtttt cctagtaaat ttaatttaca gaaatcaatg
     1261 gtagcattta gtaatctaca aaggaaatat caaagtgttt ttcaagcctg ttatattcag
     1321 tgtgtgccac aggattgaaa taaatgacaa tgtaattatg aattcatgtt ttagagctgt
     1381 ttactcatta gtaaaggacc gcaatgttag taaagaaaac ctatgaaatg tatgttaaag
     1441 attcttagta ttgtacaggg ataaagcaaa tgcatgaaaa tatgtcatgt actgaaaatt
     1501 aaacttactt cagtttcagt tataaaggac gtgcactgtt acgaatagtg ttttgttatt
     1561 aattataact agataaaggt atataggaca gggaactgga tgaatggtac ctacaatttg
     1621 gatgcctaac caaggactag agctccttct tgagatctaa atctaaagta aatgtgcatt
     1681 aaagcagtgt gcttcaaagg catcagacga tgaaagcaac ataccacaac taggagttat
     1741 ttctcaaact taaatgtcct ctgggaatcc agacttaaaa ataagagcaa acttaacaca
     1801 ctatccattt tcgagcaaac ctaacccact atatccattt tgctcatgtg ttttatgcaa
     1861 ccagctttcc atcaaatcct caatctttga atccaggtaa aaggttaatt atcctaggat
     1921 tagtgaatga ttcaatgaag ctttcttgaa aacaaacata ggagtgtaat gtactattat
     1981 gtttgtatcc tgttttagtt tataaagcac tttcacatac attatggtat ttcttcctca
     2041 caataacctt gtaaattagt caggaaatgt aaattttatc tgactcatag aactaatgga
     2101 agctgaaagc caaaaataaa gtttataacc aggccttcaa actctcaaac atggattttt
     2161 atattctgtg gagttatcca aattaattag ggtttaggaa agcagttctt cttgagtcag
     2221 ttcaataagt gtttgctttt tgtttttaag gtttgttatc taattttcat taagatttga
     2281 gtaacagacc atggagaatt gttttcattg ggagttccag ctatatagcc tcaaacaaga
     2341 aacgggtgta caaccattga gtttacttac ttaaatctgt gaatttcaat gaagaatggg
     2401 aatataaagg cctactgggg catgtttatc aagttatatc ccagggcaat gtgtatgcta
     2461 gcaggatgaa tgctatcttt tcaaaacata atattcagtg aaaattacgt aataattgta
     2521 agtttataat catactccca aatctgttac taaaaataac ataaattctc ctagttcatg
     2581 tacttagatg aataaattta gttttggaat gacgtttatg gaaaagcaat agatgaactt
     2641 aatcatttga tcactgccta tcactaggca gaacttgacc tgtaattctt aatccattgt
     2701 agatttttta cattttactc aaaacttcat acatagagac tctcaggtca aattttacaa
     2761 gtattaaaca tttgttaatt ataatcactt ttgtttgtat ccttaaatct cagaattatc
     2821 ttgcagttaa tatgcagctg attaaatgat attacaaatt atctctaatc tcactgtaaa
     2881 tcttttaatc atatcaaagt caggtcatcc tcagacacta taactaagat agataaggag
     2941 tactttacta taccatatta gtaaaggttt tctagctctt attttctaat ttcctctgag
     3001 catttaaaat tacatccagt gataaaaaca atattttttt ttcagaattt catgctttaa
     3061 aaagctgtgg cttctctata gacaactgtt acattaggga agtgattcta gagcaaaata
     3121 tactgcctca acataagtcg ttactgactg gaaaatgcta taggcagaat tgcaaagagt
     3181 ggctcaaaca tatagtttgc ttgcagaatg taacgtgcaa aatcacatac atgcgatgta
     3241 tttacctttg ctagacaatg agaattgaat aattgatttg tacctggtat gttatatcct
     3301 ccagtgtcac tttttaacca gattcactgt gcgttccaaa ctgtcataaa aattgattat
     3361 atgtttaaca attgtttttc tactacagtg gagagaaaaa tcccaattat aaaattccac
     3421 ctaaaggagt ttcattttgt aataacatct gattaataac ttgttgcatt ttgcttaaca
     3481 tactgttcct ggcattagat attcacatga gtaagcccag tagcattttg tgcttactgc
     3541 agttttcttt tacacacgaa gtaacatccc ttgtcaatta caattcagca ggcatggtga
     3601 tttggggaga cgactagatg ttgctgtaac cgtagagcgt ggcaagtatt ccctttcttg
     3661 ctatcaccta agcaaacctc cctaagggta cgtgaaggga gtggttattc taaataaggc
     3721 atgacaaatt acttttcaac cagtgacatt aaacattgtg ttttaaaaag gactggtcac
     3781 tggggcgaac acattagctg gagcatgtag ggacaaaata cttgaattga cgcttgaaga
     3841 ctcaatgttc tcaaagtcca cagagctcat taagtttaaa atagtaaaac aaggtcttct
     3901 tcatactcca gcaatatgct atattggatc agaccaatat atgtaataat gttttctcta
     3961 atagtaggaa aaggatgagc attgtagcta gtcacactca aagggtacaa gtatgcattc
     4021 attagctcct aaattccctg atgatataat tcacgagcat ctgccattta tgaattttcg
     4081 atattcctct atgtctgaaa tacatgcata tatttatatc atataccaag ggtccaacta
     4141 ctatacaaag atttaacaaa gcatctcacc ttccggccat aataggaaaa tcatgtcaca
     4201 tttacccaaa tgtggataca tctatctatt tccattaaaa attatgcata gatgtcagga
     4261 aaaatgacag caaggaattc cagggacata cctgtcctta gaaaaacagg aaaaaaaaaa
     4321 aacactgtca cattccattt tattggaaat ttgttttaaa aaaaaaagtt taccaaacca
     4381 ctgtttaaaa caagaaaatg cttaaattaa aaaagcaact gaaactca
//
