LOCUS       NM_001413674            4455 bp    mRNA    linear   PRI 15-MAR-2025
DEFINITION  Homo sapiens tumor suppressor candidate 3 (TUSC3), transcript
            variant 10, mRNA.
ACCESSION   NM_001413674
VERSION     NM_001413674.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4455)
  AUTHORS   Deng,R., Lu,X., Hong,C., Cai,R., Wang,P., Xiong,L., Wang,X.,
            Chen,Q. and Lin,J.
  TITLE     Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma
            progression through LIPC/AKT axis
  JOURNAL   J Transl Med 20 (1), 485 (2022)
   PUBMED   36274132
  REMARK    GeneRIF: Downregulation of TUSC3 promotes EMT and hepatocellular
            carcinoma progression through LIPC/AKT axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4455)
  AUTHORS   Sun,F., Jie,Q., Li,Q., Wei,Y., Li,H., Yue,X. and Ma,Y.
  TITLE     TUSC3 inhibits cell proliferation and invasion in cervical squamous
            cell carcinoma via suppression of the AKT signalling pathway
  JOURNAL   J Cell Mol Med 26 (5), 1629-1642 (2022)
   PUBMED   35137520
  REMARK    GeneRIF: TUSC3 inhibits cell proliferation and invasion in cervical
            squamous cell carcinoma via suppression of the AKT signalling
            pathway.
REFERENCE   3  (bases 1 to 4455)
  AUTHORS   Ren,Y., Deng,R., Cai,R., Lu,X., Luo,Y., Wang,Z., Zhu,Y., Yin,M.,
            Ding,Y. and Lin,J.
  TITLE     TUSC3 induces drug resistance and cellular stemness via Hedgehog
            signaling pathway in colorectal cancer
  JOURNAL   Carcinogenesis 41 (12), 1755-1766 (2020)
   PUBMED   32338281
  REMARK    GeneRIF: TUSC3 induces drug resistance and cellular stemness via
            Hedgehog signaling pathway in colorectal cancer.
REFERENCE   4  (bases 1 to 4455)
  AUTHORS   Ouidir,M., Mendola,P., Buck Louis,G.M., Kannan,K., Zhang,C. and
            Tekola-Ayele,F.
  TITLE     Concentrations of persistent organic pollutants in maternal plasma
            and epigenome-wide placental DNA methylation
  JOURNAL   Clin Epigenetics 12 (1), 103 (2020)
   PUBMED   32653021
  REMARK    GeneRIF: Concentrations of persistent organic pollutants in
            maternal plasma and epigenome-wide placental DNA methylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4455)
  AUTHORS   Wang,S. and Zhu,W.
  TITLE     Tumour suppressor candidate 3 inhibits biological function and
            increases endoplasmic reticulum stress of melanoma cells WM451 by
            regulating AKT/GSK3-beta/beta-catenin pathway
  JOURNAL   Cell Biochem Funct 38 (5), 604-612 (2020)
   PUBMED   32090352
  REMARK    GeneRIF: Tumour suppressor candidate 3 inhibits biological function
            and increases endoplasmic reticulum stress of melanoma cells WM451
            by regulating AKT/GSK3-beta/beta-catenin pathway.
REFERENCE   6  (bases 1 to 4455)
  AUTHORS   Kelleher,D.J., Karaoglu,D., Mandon,E.C. and Gilmore,R.
  TITLE     Oligosaccharyltransferase isoforms that contain different catalytic
            STT3 subunits have distinct enzymatic properties
  JOURNAL   Mol Cell 12 (1), 101-111 (2003)
   PUBMED   12887896
REFERENCE   7  (bases 1 to 4455)
  AUTHORS   Ishii,H., Baffa,R., Numata,S.I., Murakumo,Y., Rattan,S., Inoue,H.,
            Mori,M., Fidanza,V., Alder,H. and Croce,C.M.
  TITLE     The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein,
            and its expression is altered in multiple human tumors
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3928-3933 (1999)
   PUBMED   10097140
REFERENCE   8  (bases 1 to 4455)
  AUTHORS   Pak,B.J., Park,H., Chang,E.R., Pang,S.C. and Graham,C.H.
  TITLE     Differential display analysis of oxygen-mediated changes in gene
            expression in first trimester human trophoblast cells
  JOURNAL   Placenta 19 (7), 483-488 (1998)
   PUBMED   9778121
REFERENCE   9  (bases 1 to 4455)
  AUTHORS   MacGrogan,D., Levy,A., Bova,G.S., Isaacs,W.B. and Bookstein,R.
  TITLE     Structure and methylation-associated silencing of a gene within a
            homozygously deleted region of human chromosome band 8p22
  JOURNAL   Genomics 35 (1), 55-65 (1996)
   PUBMED   8661104
REFERENCE   10 (bases 1 to 4455)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091559.7, AC010656.7 and
            AC019292.10.
            
            Summary: This gene encodes a protein that has been associated with
            several biological functions including cellular magnesium uptake,
            protein glycosylation and embryonic development. This protein
            localizes to the endoplasmic reticulum and acts as a component of
            the oligosaccharyl transferase complex which is responsible for
            N-linked protein glycosylation. This gene is a candidate tumor
            suppressor gene. Homozygous mutations in this gene are associated
            with autosomal recessive nonsyndromic mental retardation-7 and in
            the proliferation and invasiveness of several cancers including
            metastatic pancreatic cancer, ovarian cancer and glioblastoma
            multiform. [provided by RefSeq, Oct 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3215172.1,
                                           SRR14038197.666980.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC091559.7         162788-163093
            307-476             AC010656.7         58176-58345         c
            477-594             AC010656.7         30611-30728         c
            595-735             AC010656.7         21778-21918         c
            736-876             AC010656.7         19129-19269         c
            877-966             AC010656.7         7589-7678           c
            967-1030            AC019292.10        10844-10907
            1031-1105           AC019292.10        23716-23790
            1106-4455           AC019292.10        44381-47730
FEATURES             Location/Qualifiers
     source          1..4455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..4455
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="tumor suppressor candidate 3"
                     /db_xref="GeneID:7991"
                     /db_xref="HGNC:HGNC:30242"
                     /db_xref="MIM:601385"
     exon            1..306
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1113
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="isoform 7 precursor is encoded by transcript
                     variant 10; oligosaccharyltransferase 3 homolog A;
                     magnesium uptake/transporter TUSC3; putative prostate
                     cancer tumor suppressor; oligosaccharyl transferase
                     subunit TUSC3; dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit TUSC3"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit TUSC3 isoform 7 precursor"
                     /protein_id="NP_001400603.1"
                     /db_xref="GeneID:7991"
                     /db_xref="HGNC:HGNC:30242"
                     /db_xref="MIM:601385"
                     /translation="MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKK
                     KENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVC
                     RQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRP
                     KRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLR
                     RNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQ
                     FVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRTF"
     exon            307..476
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..594
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            595..735
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            736..876
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..966
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1030
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1105
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..4455
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1366..1371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: AATAAA"
     polyA_site      1389
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="major polyA site"
     regulatory      1525..1530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: ATTAAA"
     polyA_site      1568
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
     regulatory      2142..2147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: AATAAA"
     polyA_site      2176
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
     regulatory      2790..2795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: ATTAAA"
     polyA_site      2811
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
     regulatory      2868..2873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: ATTAAA"
     polyA_site      2888
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
     regulatory      3435..3440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: TATAAA"
     polyA_site      3455
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
     regulatory      4433..4438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: ATTAAA"
     polyA_site      4455
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
ORIGIN      
        1 agtctcctcc tctgcgtcct cggccgcggc ccgggtccct cgcaaagccg ctgccatccc
       61 ggagggccca gccagcgggc tcccggaggc tggccgggca ggcgtggtgc gcggtaggag
      121 ctgggcgcgc acggctaccg cgcgtggagg agacactgcc ctgccgcgat gggggcccgg
      181 ggcgctcctt cacgccgtag gcaagcgggg cggcggctgc ggtacctgcc caccgggagc
      241 tttcccttcc ttctcctgct gctgctgctc tgcatccagc tcgggggagg acagaagaaa
      301 aaggagaatc ttttagctga aaaagtagag cagctgatgg aatggagttc cagacgctca
      361 atcttccgaa tgaatggtga taaattccga aaatttataa aggcaccacc tcgaaactat
      421 tccatgattg ttatgttcac tgctcttcag cctcagcggc agtgttctgt gtgcaggcaa
      481 gctaatgaag aatatcaaat actggcgaac tcctggcgct attcatctgc tttttgtaac
      541 aagctcttct tcagtatggt ggactatgat gaggggacag acgtttttca gcagctcaac
      601 atgaactctg ctcctacatt catgcatttt cctccaaaag gcagacctaa gagagctgat
      661 acttttgacc tccaaagaat tggatttgca gctgagcaac tagcaaagtg gattgctgac
      721 agaacggatg ttcatattcg ggttttcaga ccacccaact actctggtac cattgctttg
      781 gccctgttag tgtcgcttgt tggaggtttg ctttatttga gaaggaacaa cttggagttc
      841 atctataaca agactggttg ggccatggtg tctctgtgta tagtctttgc tatgacttct
      901 ggccagatgt ggaaccatat ccgtggacct ccatatgctc ataagaaccc acacaatgga
      961 caagtgagct acattcatgg gagcagccag gctcagtttg tggcagaatc acacattatt
     1021 ctggtactga atgccgctat caccatgggg atggttcttc taaatgaagc agcaacttcg
     1081 aaaggcgatg ttggaaaaag acggactttt taattaaatg aagccaagtg ggatttgcat
     1141 aaagtgaatg tttaccatga agataaactg ttcctgactt tatactattt tgaattcatt
     1201 catttcattg tgatcagcta gcttattctt gtgtactttt tttaaactgt gggttttcct
     1261 agtaaattta atttacagaa atcaatggta gcatttagta atctacaaag gaaatatcaa
     1321 agtgtttttc aagcctgtta tattcagtgt gtgccacagg attgaaataa atgacaatgt
     1381 aattatgaat tcatgtttta gagctgttta ctcattagta aaggaccgca atgttagtaa
     1441 agaaaaccta tgaaatgtat gttaaagatt cttagtattg tacagggata aagcaaatgc
     1501 atgaaaatat gtcatgtact gaaaattaaa cttacttcag tttcagttat aaaggacgtg
     1561 cactgttacg aatagtgttt tgttattaat tataactaga taaaggtata taggacaggg
     1621 aactggatga atggtaccta caatttggat gcctaaccaa ggactagagc tccttcttga
     1681 gatctaaatc taaagtaaat gtgcattaaa gcagtgtgct tcaaaggcat cagacgatga
     1741 aagcaacata ccacaactag gagttatttc tcaaacttaa atgtcctctg ggaatccaga
     1801 cttaaaaata agagcaaact taacacacta tccattttcg agcaaaccta acccactata
     1861 tccattttgc tcatgtgttt tatgcaacca gctttccatc aaatcctcaa tctttgaatc
     1921 caggtaaaag gttaattatc ctaggattag tgaatgattc aatgaagctt tcttgaaaac
     1981 aaacatagga gtgtaatgta ctattatgtt tgtatcctgt tttagtttat aaagcacttt
     2041 cacatacatt atggtatttc ttcctcacaa taaccttgta aattagtcag gaaatgtaaa
     2101 ttttatctga ctcatagaac taatggaagc tgaaagccaa aaataaagtt tataaccagg
     2161 ccttcaaact ctcaaacatg gatttttata ttctgtggag ttatccaaat taattagggt
     2221 ttaggaaagc agttcttctt gagtcagttc aataagtgtt tgctttttgt ttttaaggtt
     2281 tgttatctaa ttttcattaa gatttgagta acagaccatg gagaattgtt ttcattggga
     2341 gttccagcta tatagcctca aacaagaaac gggtgtacaa ccattgagtt tacttactta
     2401 aatctgtgaa tttcaatgaa gaatgggaat ataaaggcct actggggcat gtttatcaag
     2461 ttatatccca gggcaatgtg tatgctagca ggatgaatgc tatcttttca aaacataata
     2521 ttcagtgaaa attacgtaat aattgtaagt ttataatcat actcccaaat ctgttactaa
     2581 aaataacata aattctccta gttcatgtac ttagatgaat aaatttagtt ttggaatgac
     2641 gtttatggaa aagcaataga tgaacttaat catttgatca ctgcctatca ctaggcagaa
     2701 cttgacctgt aattcttaat ccattgtaga ttttttacat tttactcaaa acttcataca
     2761 tagagactct caggtcaaat tttacaagta ttaaacattt gttaattata atcacttttg
     2821 tttgtatcct taaatctcag aattatcttg cagttaatat gcagctgatt aaatgatatt
     2881 acaaattatc tctaatctca ctgtaaatct tttaatcata tcaaagtcag gtcatcctca
     2941 gacactataa ctaagataga taaggagtac tttactatac catattagta aaggttttct
     3001 agctcttatt ttctaatttc ctctgagcat ttaaaattac atccagtgat aaaaacaata
     3061 tttttttttc agaatttcat gctttaaaaa gctgtggctt ctctatagac aactgttaca
     3121 ttagggaagt gattctagag caaaatatac tgcctcaaca taagtcgtta ctgactggaa
     3181 aatgctatag gcagaattgc aaagagtggc tcaaacatat agtttgcttg cagaatgtaa
     3241 cgtgcaaaat cacatacatg cgatgtattt acctttgcta gacaatgaga attgaataat
     3301 tgatttgtac ctggtatgtt atatcctcca gtgtcacttt ttaaccagat tcactgtgcg
     3361 ttccaaactg tcataaaaat tgattatatg tttaacaatt gtttttctac tacagtggag
     3421 agaaaaatcc caattataaa attccaccta aaggagtttc attttgtaat aacatctgat
     3481 taataacttg ttgcattttg cttaacatac tgttcctggc attagatatt cacatgagta
     3541 agcccagtag cattttgtgc ttactgcagt tttcttttac acacgaagta acatcccttg
     3601 tcaattacaa ttcagcaggc atggtgattt ggggagacga ctagatgttg ctgtaaccgt
     3661 agagcgtggc aagtattccc tttcttgcta tcacctaagc aaacctccct aagggtacgt
     3721 gaagggagtg gttattctaa ataaggcatg acaaattact tttcaaccag tgacattaaa
     3781 cattgtgttt taaaaaggac tggtcactgg ggcgaacaca ttagctggag catgtaggga
     3841 caaaatactt gaattgacgc ttgaagactc aatgttctca aagtccacag agctcattaa
     3901 gtttaaaata gtaaaacaag gtcttcttca tactccagca atatgctata ttggatcaga
     3961 ccaatatatg taataatgtt ttctctaata gtaggaaaag gatgagcatt gtagctagtc
     4021 acactcaaag ggtacaagta tgcattcatt agctcctaaa ttccctgatg atataattca
     4081 cgagcatctg ccatttatga attttcgata ttcctctatg tctgaaatac atgcatatat
     4141 ttatatcata taccaagggt ccaactacta tacaaagatt taacaaagca tctcaccttc
     4201 cggccataat aggaaaatca tgtcacattt acccaaatgt ggatacatct atctatttcc
     4261 attaaaaatt atgcatagat gtcaggaaaa atgacagcaa ggaattccag ggacatacct
     4321 gtccttagaa aaacaggaaa aaaaaaaaac actgtcacat tccattttat tggaaatttg
     4381 ttttaaaaaa aaaagtttac caaaccactg tttaaaacaa gaaaatgctt aaattaaaaa
     4441 agcaactgaa actca
//
