LOCUS       NM_001413583            5592 bp    mRNA    linear   PRI 15-MAR-2025
DEFINITION  Homo sapiens tumor suppressor candidate 3 (TUSC3), transcript
            variant 4, mRNA.
ACCESSION   NM_001413583
VERSION     NM_001413583.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5592)
  AUTHORS   Deng,R., Lu,X., Hong,C., Cai,R., Wang,P., Xiong,L., Wang,X.,
            Chen,Q. and Lin,J.
  TITLE     Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma
            progression through LIPC/AKT axis
  JOURNAL   J Transl Med 20 (1), 485 (2022)
   PUBMED   36274132
  REMARK    GeneRIF: Downregulation of TUSC3 promotes EMT and hepatocellular
            carcinoma progression through LIPC/AKT axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5592)
  AUTHORS   Sun,F., Jie,Q., Li,Q., Wei,Y., Li,H., Yue,X. and Ma,Y.
  TITLE     TUSC3 inhibits cell proliferation and invasion in cervical squamous
            cell carcinoma via suppression of the AKT signalling pathway
  JOURNAL   J Cell Mol Med 26 (5), 1629-1642 (2022)
   PUBMED   35137520
  REMARK    GeneRIF: TUSC3 inhibits cell proliferation and invasion in cervical
            squamous cell carcinoma via suppression of the AKT signalling
            pathway.
REFERENCE   3  (bases 1 to 5592)
  AUTHORS   Ren,Y., Deng,R., Cai,R., Lu,X., Luo,Y., Wang,Z., Zhu,Y., Yin,M.,
            Ding,Y. and Lin,J.
  TITLE     TUSC3 induces drug resistance and cellular stemness via Hedgehog
            signaling pathway in colorectal cancer
  JOURNAL   Carcinogenesis 41 (12), 1755-1766 (2020)
   PUBMED   32338281
  REMARK    GeneRIF: TUSC3 induces drug resistance and cellular stemness via
            Hedgehog signaling pathway in colorectal cancer.
REFERENCE   4  (bases 1 to 5592)
  AUTHORS   Ouidir,M., Mendola,P., Buck Louis,G.M., Kannan,K., Zhang,C. and
            Tekola-Ayele,F.
  TITLE     Concentrations of persistent organic pollutants in maternal plasma
            and epigenome-wide placental DNA methylation
  JOURNAL   Clin Epigenetics 12 (1), 103 (2020)
   PUBMED   32653021
  REMARK    GeneRIF: Concentrations of persistent organic pollutants in
            maternal plasma and epigenome-wide placental DNA methylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5592)
  AUTHORS   Wang,S. and Zhu,W.
  TITLE     Tumour suppressor candidate 3 inhibits biological function and
            increases endoplasmic reticulum stress of melanoma cells WM451 by
            regulating AKT/GSK3-beta/beta-catenin pathway
  JOURNAL   Cell Biochem Funct 38 (5), 604-612 (2020)
   PUBMED   32090352
  REMARK    GeneRIF: Tumour suppressor candidate 3 inhibits biological function
            and increases endoplasmic reticulum stress of melanoma cells WM451
            by regulating AKT/GSK3-beta/beta-catenin pathway.
REFERENCE   6  (bases 1 to 5592)
  AUTHORS   Kelleher,D.J., Karaoglu,D., Mandon,E.C. and Gilmore,R.
  TITLE     Oligosaccharyltransferase isoforms that contain different catalytic
            STT3 subunits have distinct enzymatic properties
  JOURNAL   Mol Cell 12 (1), 101-111 (2003)
   PUBMED   12887896
REFERENCE   7  (bases 1 to 5592)
  AUTHORS   Ishii,H., Baffa,R., Numata,S.I., Murakumo,Y., Rattan,S., Inoue,H.,
            Mori,M., Fidanza,V., Alder,H. and Croce,C.M.
  TITLE     The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein,
            and its expression is altered in multiple human tumors
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3928-3933 (1999)
   PUBMED   10097140
REFERENCE   8  (bases 1 to 5592)
  AUTHORS   Pak,B.J., Park,H., Chang,E.R., Pang,S.C. and Graham,C.H.
  TITLE     Differential display analysis of oxygen-mediated changes in gene
            expression in first trimester human trophoblast cells
  JOURNAL   Placenta 19 (7), 483-488 (1998)
   PUBMED   9778121
REFERENCE   9  (bases 1 to 5592)
  AUTHORS   MacGrogan,D., Levy,A., Bova,G.S., Isaacs,W.B. and Bookstein,R.
  TITLE     Structure and methylation-associated silencing of a gene within a
            homozygously deleted region of human chromosome band 8p22
  JOURNAL   Genomics 35 (1), 55-65 (1996)
   PUBMED   8661104
REFERENCE   10 (bases 1 to 5592)
  AUTHORS   Sparks,S.E. and Krasnewich,D.M.
  TITLE     Congenital Disorders of N-Linked Glycosylation and Multiple Pathway
            Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301507
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091559.7, AC010656.7 and
            AC019292.10.
            
            Summary: This gene encodes a protein that has been associated with
            several biological functions including cellular magnesium uptake,
            protein glycosylation and embryonic development. This protein
            localizes to the endoplasmic reticulum and acts as a component of
            the oligosaccharyl transferase complex which is responsible for
            N-linked protein glycosylation. This gene is a candidate tumor
            suppressor gene. Homozygous mutations in this gene are associated
            with autosomal recessive nonsyndromic mental retardation-7 and in
            the proliferation and invasiveness of several cancers including
            metastatic pancreatic cancer, ovarian cancer and glioblastoma
            multiform. [provided by RefSeq, Oct 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.110864.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC091559.7         162788-163093
            307-476             AC010656.7         58176-58345         c
            477-594             AC010656.7         30611-30728         c
            595-735             AC010656.7         21778-21918         c
            736-876             AC010656.7         19129-19269         c
            877-966             AC010656.7         7589-7678           c
            967-1030            AC019292.10        10844-10907
            1031-1105           AC019292.10        23716-23790
            1106-1196           AC019292.10        28553-28643
            1197-1261           AC019292.10        37969-38033
            1262-5592           AC019292.10        40334-44664
FEATURES             Location/Qualifiers
     source          1..5592
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..5592
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="tumor suppressor candidate 3"
                     /db_xref="GeneID:7991"
                     /db_xref="HGNC:HGNC:30242"
                     /db_xref="MIM:601385"
     exon            1..306
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1215
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 4; oligosaccharyltransferase 3 homolog A;
                     magnesium uptake/transporter TUSC3; putative prostate
                     cancer tumor suppressor; oligosaccharyl transferase
                     subunit TUSC3; dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit TUSC3"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit TUSC3 isoform 1 precursor"
                     /protein_id="NP_001400512.1"
                     /db_xref="GeneID:7991"
                     /db_xref="HGNC:HGNC:30242"
                     /db_xref="MIM:601385"
                     /translation="MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKK
                     KENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVC
                     RQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRP
                     KRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLR
                     RNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQ
                     FVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFR
                     SKYHGYPYSDLDFE"
     exon            307..476
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..594
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            595..735
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            736..876
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..966
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1030
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1105
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1196
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1261
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..5592
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5569..5574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="hexamer: AATAAA"
     polyA_site      5592
                     /gene="TUSC3"
                     /gene_synonym="D8S1992; M33; MagT2; MRT22; MRT7; N33;
                     OST3A; SLC58A2"
                     /note="major polyA site"
ORIGIN      
        1 agtctcctcc tctgcgtcct cggccgcggc ccgggtccct cgcaaagccg ctgccatccc
       61 ggagggccca gccagcgggc tcccggaggc tggccgggca ggcgtggtgc gcggtaggag
      121 ctgggcgcgc acggctaccg cgcgtggagg agacactgcc ctgccgcgat gggggcccgg
      181 ggcgctcctt cacgccgtag gcaagcgggg cggcggctgc ggtacctgcc caccgggagc
      241 tttcccttcc ttctcctgct gctgctgctc tgcatccagc tcgggggagg acagaagaaa
      301 aaggagaatc ttttagctga aaaagtagag cagctgatgg aatggagttc cagacgctca
      361 atcttccgaa tgaatggtga taaattccga aaatttataa aggcaccacc tcgaaactat
      421 tccatgattg ttatgttcac tgctcttcag cctcagcggc agtgttctgt gtgcaggcaa
      481 gctaatgaag aatatcaaat actggcgaac tcctggcgct attcatctgc tttttgtaac
      541 aagctcttct tcagtatggt ggactatgat gaggggacag acgtttttca gcagctcaac
      601 atgaactctg ctcctacatt catgcatttt cctccaaaag gcagacctaa gagagctgat
      661 acttttgacc tccaaagaat tggatttgca gctgagcaac tagcaaagtg gattgctgac
      721 agaacggatg ttcatattcg ggttttcaga ccacccaact actctggtac cattgctttg
      781 gccctgttag tgtcgcttgt tggaggtttg ctttatttga gaaggaacaa cttggagttc
      841 atctataaca agactggttg ggccatggtg tctctgtgta tagtctttgc tatgacttct
      901 ggccagatgt ggaaccatat ccgtggacct ccatatgctc ataagaaccc acacaatgga
      961 caagtgagct acattcatgg gagcagccag gctcagtttg tggcagaatc acacattatt
     1021 ctggtactga atgccgctat caccatgggg atggttcttc taaatgaagc agcaacttcg
     1081 aaaggcgatg ttggaaaaag acggataatt tgcctagtgg gattgggcct ggtggtcttc
     1141 ttcttcagtt ttctactttc aatatttcgt tccaagtacc acggctatcc ttatagtgat
     1201 ctggactttg agtgagaaga tgtgatttgg accatggcac ttaaaaactc tataacctca
     1261 gctaataaca aagaggaagg caaagttaat acatgttcct tctagaagat acaggtaagc
     1321 aaaatgaaga aaatatattc ataaatccca acacccaggt catcaaatgt catcagttta
     1381 gcctgtacat attttgaacc ttgggaatta tgtaatacat attttgtaag ctgcttattt
     1441 ttcttttata catcatgagc atattcctat gcagttaact acattctaca atatatatga
     1501 ttttacacct atgtagtaat atcaatgtat gaattgccac aactatttta agttttatgc
     1561 catccagctt tttatggtgt atctttcagt acaccctgtg gtttaataca agactaagta
     1621 actgctgtct gtgttagttt atcctacaaa ctaagaatgg cttctacagt tctaaatcat
     1681 tggggggtgg gacgtcaaca aagaatattt tgtgacatga aaattatgaa attcagatat
     1741 cagtgcctat gaataaagtt tcattgaaac gcagccaggt ttgttttatg tgttggctgc
     1801 ttttgcacta cgacagttca gctgagtggt ttcagcaaag acccatggcc cacaaagttt
     1861 aaaatactta accttctggc tctttacaga aaatgtgcta actcccggtt tagccatgct
     1921 gaacacagca ctgaatatgt tcccatactt tcataccttt cctcatccag tttcttcggt
     1981 cgaggctgct gtccctgcat cttacttgtt ctcagagttt tgctttttca gttcttgtaa
     2041 caccgtcatc atctcaaata tgtcactgta tcatacttaa tcacacccag gtctttcctt
     2101 tagctaaaag aaatgtaagg gccatgactt tcagtcattt cattttctgc aacatgcttc
     2161 tatgcacaga atctagtaca caatggttgt taaatgctga ttgaaacaga cttttggggg
     2221 ccctgagatt aagaaaatag ctaacacttg cgtgtttctc tagaaaaatc ttttgaattt
     2281 caagtaataa acttgctaat aaacctatgg aatattaatc cttagcaaat caaagacagc
     2341 attttcatct aaattgtggt tttctaccat gagggagtgc tgaggagaga gccagcctta
     2401 aggagagaaa cggtttgaag tttcttcttt gtgtaaacag tctctctgca tccctgatgg
     2461 actttaagca aaaataaagt gacacagact agaaaggaat ggttgcttct cttaggctag
     2521 gggaagtggg agcttctggg ggcacatttg tgctagtcct agccttctat ctatcttatc
     2581 ccttgtgtgc gatttgctac tcttgccaat tagcttccat tttctattac tatctcagtt
     2641 acagttgacc atgcatatat tctcttcaga atacgcgaat aagccagtca cagcaatcag
     2701 tgctatgcac atgcagacta ctactatgga taactacagt gcgattcgtt catgactgag
     2761 cgtggagcag agtccacaca gaagttgatc gtggtaccca aggctgcttc tcactcattc
     2821 tggaagcaga ccgcaaaagt gaaaagcaca catcagggga atacattcag ttttcattat
     2881 tgacagttgt ttttaaaaaa gtatgatacg aaggcattta tacatttttg tgataggcat
     2941 tattagaaaa aacaatatcc aggcactcct gaaccataag tttgtgagaa ctattatact
     3001 gttagattaa gaagcaaaag tatttattag acagataaat gtgaaaaggg aaaaaaatac
     3061 gtgtcagatc ttgtttagaa atgagagact aattccttga gtgataatat caatataaaa
     3121 cattcatact ggaacatact ttggaaattt aatatttata atttaatatt tatataatga
     3181 aaataaaagt gaaacctgaa atactgatta gagaacagca gttcatactt ttctcagaaa
     3241 cgttttaacc agtcaaaaca tttttgacat ttttgtgctt caagtgtttc cagtgtcttg
     3301 aacaaataaa gaaattttta taactattta aaatgaaaat gatagttttg aaaatgatag
     3361 aagcatagga agtactctaa ttgtcctaca ataaaggata catctaacta acaagtaatc
     3421 agtttcagat taaatatata tttatcattt cataatgata taaacaactg attgttacac
     3481 caggttaaga aaattactaa atgaaaaaaa cagtagcata actaaagata acattaataa
     3541 agtactcaca gagatccttt tactgtgaat atacctaagt atcataaaac tgctaaaaag
     3601 ttagaaggta taaaattacc agtatggatc agattagtat ttttgctttt acaggggtaa
     3661 tatcgttagc agcaataaag attaccttta gtgctccgta acttgaaatc tgcagagcct
     3721 ttaaacacta aacaacaaaa agctacaaat ccctagtttt aagtatcagt tcattttatg
     3781 attaaggttt cttttttcat taaccctcat tcttcagtta gcttcatctt cagagcaagc
     3841 tgatgatggc ttgtgtgtgc tagcaggatg aacgctatct tttcaaaaca taatgccaca
     3901 gttcatgtac agctggcaca tctatctgct ttaccagcag tgtttttaag gatcatgcgg
     3961 attgaacagc aactacagct taaggccctg acaaggttta ctgctgacat tcttcatgga
     4021 gatggtcacc cttatcgtac gctttattcg ttacttatta tcttgaaagt agaggcgacg
     4081 tctcattgca tcctgatatc accacatcat ttttatcttc taatttaaca atttctcaga
     4141 aacagctaac aagagtaatt tttctagttt gtattgtact gtgactttat ttacatttta
     4201 attgatgtta tataatatac actgtatatt atataattta aatatatatt tcatgtttta
     4261 tactaaaatg ttacatttta aaatacatat ttattcttgc acatagtatc accagaatcc
     4321 taaaatatta gcacgaaaag aacttcggga atcatccaaa acaaacgttc ttttcactaa
     4381 tgaggaaacc gaggttcaga aagacgaaac aatttatgcc taggatgata tgatttaaac
     4441 atccaaatat aaaacttacc tactttggac atttttccag ctacatgttt tttttttgat
     4501 gttgttgttt tttgttttct ttttttaagt acaagaacta ttaatttcat ttttgctttt
     4561 atatttaatt aaaaattggt ttgtctctgg ttgccttgca aagttgtctt gtgttgtcaa
     4621 gactcaaaaa gaacatgcca cgtgttagca gaaaggtaca gatgtaaaca aaagcttcat
     4681 aaatgttatt taaattgatt taccatctta caaaattaaa ttttgtttca taaattaaag
     4741 ctttgcttag ggaagtttaa aaaaataaca tagttatctt ttacttttat atgtacaagt
     4801 atctctgctg atgtttcatc agaaatttta tgattcatga tttgtgtata ctctttttgg
     4861 ttgttcaata tgatgaaatt gtaaattaac aaaagaccaa gtgattaaat tatacggtta
     4921 gagaaaaaat atttttagga cattcaaatg acccacttca cgcatttgtt tcagtccatt
     4981 cccttgtatt tcccctacat taccatttta aatgctgatt taactgctgt tctagccagc
     5041 aatgaaagga atgtctatgt aaatttaaac cacaaattaa agctttcagc atcttctctc
     5101 accctgaccc tgttcccaac ctaagcctca tctggttaaa ggcactagtt tagaaaaatt
     5161 gccctgatgt aaaaattaca attagttgaa tacaattatg acattttaat gttatattta
     5221 catgtgctaa tttagaatgg aataacaaac atattgtatt ttccttatgt tctatgttca
     5281 gcacataata attttctttc tttttcagct ttttaattaa atgaagccaa gtgggatttg
     5341 cataaagtga atgtttacca tgaagataaa ctgttcctga ctttatacta ttttgaattc
     5401 attcatttca ttgtgatcag ctagcttatt cttgtgtact ttttttaaac tgtgggtttt
     5461 cctagtaaat ttaatttaca gaaatcaatg gtagcattta gtaatctaca aaggaaatat
     5521 caaagtgttt ttcaagcctg ttatattcag tgtgtgccac aggattgaaa taaatgacaa
     5581 tgtaattatg aa
//
