LOCUS       NM_007275               1669 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens tumor suppressor 2, mitochondrial calcium regulator
            (TUSC2), mRNA.
ACCESSION   NM_007275
VERSION     NM_007275.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1669)
  AUTHORS   Rimkus,T.K., Arrigo,A.B., Zhu,D., Carpenter,R.L., Sirkisoon,S.,
            Doheny,D., Regua,A.T., Wong,G.L., Manore,S., Wagner,C., Lin,H.K.,
            Jin,G., Ruiz,J., Chan,M., Debinski,W. and Lo,H.W.
  TITLE     NEDD4 degrades TUSC2 to promote glioblastoma progression
  JOURNAL   Cancer Lett 531, 124-135 (2022)
   PUBMED   35167936
  REMARK    GeneRIF: NEDD4 degrades TUSC2 to promote glioblastoma progression.
REFERENCE   2  (bases 1 to 1669)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1669)
  AUTHORS   Mariniello,R.M., Orlandella,F.M., Stefano,A.E., Iervolino,P.L.C.,
            Smaldone,G., Luciano,N., Cervone,N., Munciguerra,F., Esposito,S.,
            Mirabelli,P. and Salvatore,G.
  TITLE     The TUSC2 Tumour Suppressor Inhibits the Malignant Phenotype of
            Human Thyroid Cancer Cells via SMAC/DIABLO Protein
  JOURNAL   Int J Mol Sci 21 (3), 702 (2020)
   PUBMED   31973107
  REMARK    GeneRIF: The TUSC2 Tumour Suppressor Inhibits the Malignant
            Phenotype of Human Thyroid Cancer Cells via SMAC/DIABLO Protein.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1669)
  AUTHORS   Nama,S., Muhuri,M., Di Pascale,F., Quah,S., Aswad,L., Fullwood,M.
            and Sampath,P.
  TITLE     MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast
            Cancer and Promotes Tumorigenesis via TUSC2 repression
  JOURNAL   Sci Rep 9 (1), 12718 (2019)
   PUBMED   31481748
  REMARK    GeneRIF: MicroRNA-138 is a Prognostic Biomarker for Triple-Negative
            Breast Cancer and Promotes Tumorigenesis via TUSC2 repression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1669)
  AUTHORS   Chen,J., Song,B. and Kong,G.
  TITLE     MicroRNA-663b downregulation inhibits proliferation and induces
            apoptosis in bladder cancer cells by targeting TUSC2
  JOURNAL   Mol Med Rep 19 (5), 3896-3902 (2019)
   PUBMED   30896880
  REMARK    GeneRIF: Low TUSC2 expression is associated with bladder cancer.
REFERENCE   6  (bases 1 to 1669)
  AUTHORS   Lin,J., Xu,K., Gitanjali,J., Roth,J.A. and Ji,L.
  TITLE     Regulation of tumor suppressor gene FUS1 expression by the
            untranslated regions of mRNA in human lung cancer cells
  JOURNAL   Biochem Biophys Res Commun 410 (2), 235-241 (2011)
   PUBMED   21645495
  REMARK    GeneRIF: RNA sequence elements in FUS1 UTRs that regulate FUS1
            protein express were identified.
REFERENCE   7  (bases 1 to 1669)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1669)
  AUTHORS   Kondo,M., Ji,L., Kamibayashi,C., Tomizawa,Y., Randle,D., Sekido,Y.,
            Yokota,J., Kashuba,V., Zabarovsky,E., Kuzmin,I., Lerman,M., Roth,J.
            and Minna,J.D.
  TITLE     Overexpression of candidate tumor suppressor gene FUS1 isolated
            from the 3p21.3 homozygous deletion region leads to G1 arrest and
            growth inhibition of lung cancer cells
  JOURNAL   Oncogene 20 (43), 6258-6262 (2001)
   PUBMED   11593436
  REMARK    GeneRIF: Overexpression of candidate tumor suppressor geneFUS1
            isolated from the 3p21.3 homozygous deletionregion leads to G1
            arrest and growth inhibition oflung cancer cells.
REFERENCE   9  (bases 1 to 1669)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
REFERENCE   10 (bases 1 to 1669)
  AUTHORS   Fischer,W.H. and Schubert,D.
  TITLE     Characterization of a novel platelet-derived growth
            factor-associated protein
  JOURNAL   J Neurochem 66 (5), 2213-2216 (1996)
   PUBMED   8780057
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002455.1.
            
            On Oct 9, 2020 this sequence version replaced NM_007275.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023976.2, SRR11853565.20443.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150385, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000232496.5/
                                                  ENSP00000232496.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            regulatory uORF                    :: PMID: 21645495
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AC002455.1         2624-2893
            271-391             AC002455.1         4370-4490
            392-1669            AC002455.1         4661-5938
FEATURES             Location/Qualifiers
     source          1..1669
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1669
                     /gene="TUSC2"
                     /gene_synonym="C3orf11; FUS1; PAP; PDAP2"
                     /note="tumor suppressor 2, mitochondrial calcium
                     regulator"
                     /db_xref="GeneID:11334"
                     /db_xref="HGNC:HGNC:17034"
                     /db_xref="MIM:607052"
     exon            1..270
                     /gene="TUSC2"
                     /gene_synonym="C3orf11; FUS1; PAP; PDAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      59..82
                     /regulatory_class="uORF"
                     /gene="TUSC2"
                     /gene_synonym="C3orf11; FUS1; PAP; PDAP2"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:21645495]"
                     /note="this uORF is predicted to encode a 7 aa peptide
                     (PMID:21645495)"
     regulatory      106..123
                     /regulatory_class="uORF"
                     /gene="TUSC2"
                     /gene_synonym="C3orf11; FUS1; PAP; PDAP2"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:21645495]"
                     /note="this uORF is predicted to encode a 5 aa peptide
                     (PMID:21645495)"
     CDS             125..457
                     /gene="TUSC2"
                     /gene_synonym="C3orf11; FUS1; PAP; PDAP2"
                     /note="fus-1 protein; fusion 1 protein; PDGFA-associated
                     protein 2"
                     /codon_start=1
                     /product="tumor suppressor candidate 2"
                     /protein_id="NP_009206.1"
                     /db_xref="CCDS:CCDS2819.1"
                     /db_xref="GeneID:11334"
                     /db_xref="HGNC:HGNC:17034"
                     /db_xref="MIM:607052"
                     /translation="MGASGSKARGLWPFASAAGGGGSEAAGAEQALVRPRGRAVPPFV
                     FTRRGSMFYDEDGDLAHEFYEETIVTKNGQKRAKLRRVHKNLIPQGIVKLDHPRIHVD
                     FPVILYEV"
     exon            271..391
                     /gene="TUSC2"
                     /gene_synonym="C3orf11; FUS1; PAP; PDAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..1669
                     /gene="TUSC2"
                     /gene_synonym="C3orf11; FUS1; PAP; PDAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      564..569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC2"
                     /gene_synonym="C3orf11; FUS1; PAP; PDAP2"
                     /note="hexamer: AATAAA"
     polyA_site      585
                     /gene="TUSC2"
                     /gene_synonym="C3orf11; FUS1; PAP; PDAP2"
                     /note="major polyA site"
     regulatory      1645..1650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC2"
                     /gene_synonym="C3orf11; FUS1; PAP; PDAP2"
                     /note="hexamer: AATAAA"
     polyA_site      1669
                     /gene="TUSC2"
                     /gene_synonym="C3orf11; FUS1; PAP; PDAP2"
                     /note="major polyA site"
ORIGIN      
        1 agccgagcct gcggaaggcg gcggcggcgg cacctgcgat cagcggctgg ggcaggttat
       61 ggtagtgcgg actgcggtgt gagcagagcg gccacggggc ccgccatgcg ccggcggccc
      121 tgacatgggc gccagcgggt ccaaagctcg gggcctgtgg cccttcgcct cggcggccgg
      181 aggcggcggc tcagaggcag caggagctga gcaagctttg gtgcggcctc ggggccgagc
      241 tgtgcccccc ttcgtattca cgcgccgcgg ctctatgttc tatgatgagg atggggatct
      301 ggctcacgag ttctatgagg agacaatcgt caccaagaac gggcagaagc gggccaagct
      361 gaggcgagtg cataagaatc tgattcctca gggcatcgtg aagctggatc acccccgcat
      421 ccacgtggat ttccctgtga tcctctatga ggtgtgaccc tgggaggtgg cagacagaag
      481 caccccctgc cccggcaaga aactcccagg ctcaatcaag gtgtggcttc cattgaggag
      541 cccaggctgg ggccacaacc ctgaataaac tctgttggcc cataaccttc agctgtgagc
      601 gggtcggtcc cacagtattg gttgggtgtt ggtttgtgtg tggacaagag gtggttggtg
      661 ggtggtgaag gctaatggca gagttagcac cccactctcc caagccaccc ctgcaagcag
      721 cacagcaggg catataccag tcaggaatgc ccgttacctg gttccttgcc tggtctgctt
      781 tcttccaagt ttgcctgggg cctagccctg ctagaggcta cagcacttta caagcaaggt
      841 atgctttctt ccagccccta ggctgtgggc actgtataca agtaggaact tcctttcctt
      901 cacttccctt ttaaccccta gtcagagcat ttcagccgtt tgctacctcg attcctcctg
      961 tgttggacag aggctggggg cagtgccagc ctgattcttc cgacctacct gccatttgtt
     1021 cccgccttca gatggatgga cagtttgctg gctattgata ggagtgggga ctgggtgggg
     1081 gcttctccct ctacccaggg ctgggctgat ccccctactg caactaactg ttgcccccca
     1141 accccgaacc cccagttgag gagttgagag agtgcaggct ggggtcagga caggctgcgg
     1201 atgcttgtgc ctatggggag ttactccaac ccacctattc tgtctaatct ccatggcttt
     1261 gcaccaaatc ctccacccct ccaattggga ggggactgtt caccaccttg tggtaaggga
     1321 caacacccta aggctggtgc cagtagttat gagtagccta ccaccccctc ccttacagta
     1381 acccccaccc cttcaggatc agtcaaggga aagcactaga acccctgggt agggaaagaa
     1441 aggagggaaa aaccataaaa ggaatactta taatgtgaag gtttgtaaat agtccatgat
     1501 gatgtcgtgg cagagtctga tttctatata gaggtgactt tttttttaag tactgtgcaa
     1561 gctctgtgct tctataatgt gggaaatggc ttggggagga tggcccctag cttaggaaga
     1621 ctgttgtgtt atttgttcaa tttcaataaa atgatttgta gatcctgca
//
