LOCUS       NM_001004125            1476 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens tumor suppressor candidate 1 (TUSC1), mRNA.
ACCESSION   NM_001004125 XM_372077
VERSION     NM_001004125.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1476)
  AUTHORS   Yan,D., Liu,W., Liu,Y. and Zhu,X.
  TITLE     Circular RNA circ_0065378 upregulates tumor suppressor candidate 1
            by competitively binding with miR-4701-5p to alleviate colorectal
            cancer progression
  JOURNAL   J Gastroenterol Hepatol 37 (6), 1107-1118 (2022)
   PUBMED   35434854
  REMARK    GeneRIF: Circular RNA circ_0065378 upregulates tumor suppressor
            candidate 1 by competitively binding with miR-4701-5p to alleviate
            colorectal cancer progression.
REFERENCE   2  (bases 1 to 1476)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   3  (bases 1 to 1476)
  AUTHORS   Sato,Y., Hasegawa,C., Tajima,A., Nozawa,S., Yoshiike,M., Koh,E.,
            Kanaya,J., Namiki,M., Matsumiya,K., Tsujimura,A., Komatsu,K.,
            Itoh,N., Eguchi,J., Yamauchi,A. and Iwamoto,T.
  TITLE     Association of TUSC1 and DPF3 gene polymorphisms with male
            infertility
  JOURNAL   J Assist Reprod Genet 35 (2), 257-263 (2018)
   PUBMED   28975488
  REMARK    GeneRIF: TUSC1 single nucleotide polymorphisms were significantly
            correlated with azoospermia and/or oligozoospermia in a Japanese
            population.
REFERENCE   4  (bases 1 to 1476)
  AUTHORS   Zhang,R., Yu,W., Liang,G., Jia,Z., Chen,Z., Zhao,L., Yuan,Y.,
            Zhou,X., Li,D., Shen,S., Liu,N., Zhang,A., Wang,H. and Wang,G.
  TITLE     Tumor Suppressor Candidate 1 Suppresses Cell Growth and Predicts
            Better Survival in Glioblastoma
  JOURNAL   Cell Mol Neurobiol 37 (1), 37-42 (2017)
   PUBMED   26897357
  REMARK    GeneRIF: The expression of TUSC1 is significantly decreased in
            glioblastoma brain tumor tissues.
REFERENCE   5  (bases 1 to 1476)
  AUTHORS   Bunyavanich,S., Schadt,E.E., Himes,B.E., Lasky-Su,J., Qiu,W.,
            Lazarus,R., Ziniti,J.P., Cohain,A., Linderman,M., Torgerson,D.G.,
            Eng,C.S., Pino-Yanes,M., Padhukasahasram,B., Yang,J.J.,
            Mathias,R.A., Beaty,T.H., Li,X., Graves,P., Romieu,I., Navarro
            Bdel,R., Salam,M.T., Vora,H., Nicolae,D.L., Ober,C., Martinez,F.D.,
            Bleecker,E.R., Meyers,D.A., Gauderman,W.J., Gilliland,F.,
            Burchard,E.G., Barnes,K.C., Williams,L.K., London,S.J., Zhang,B.,
            Raby,B.A. and Weiss,S.T.
  TITLE     Integrated genome-wide association, coexpression network, and
            expression single nucleotide polymorphism analysis identifies novel
            pathway in allergic rhinitis
  JOURNAL   BMC Med Genomics 7, 48 (2014)
   PUBMED   25085501
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1476)
  AUTHORS   Kosova,G., Scott,N.M., Niederberger,C., Prins,G.S. and Ober,C.
  TITLE     Genome-wide association study identifies candidate genes for male
            fertility traits in humans
  JOURNAL   Am J Hum Genet 90 (6), 950-961 (2012)
   PUBMED   22633400
REFERENCE   7  (bases 1 to 1476)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   8  (bases 1 to 1476)
  AUTHORS   Furney,S.J., Simmons,A., Breen,G., Pedroso,I., Lunnon,K.,
            Proitsi,P., Hodges,A., Powell,J., Wahlund,L.O., Kloszewska,I.,
            Mecocci,P., Soininen,H., Tsolaki,M., Vellas,B., Spenger,C.,
            Lathrop,M., Shen,L., Kim,S., Saykin,A.J., Weiner,M.W. and
            Lovestone,S.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative; AddNeuroMed Consortium
  TITLE     Genome-wide association with MRI atrophy measures as a quantitative
            trait locus for Alzheimer's disease
  JOURNAL   Mol Psychiatry 16 (11), 1130-1138 (2011)
   PUBMED   21116278
REFERENCE   9  (bases 1 to 1476)
  AUTHORS   Yang,X.R., Liang,X., Pfeiffer,R.M., Wheeler,W., Maeder,D.,
            Burdette,L., Yeager,M., Chanock,S., Tucker,M.A. and Goldstein,A.M.
  TITLE     Associations of 9p21 variants with cutaneous malignant melanoma,
            nevi, and pigmentation phenotypes in melanoma-prone families with
            and without CDKN2A mutations
  JOURNAL   Fam Cancer 9 (4), 625-633 (2010)
   PUBMED   20574843
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 1476)
  AUTHORS   Shan,Z., Parker,T. and Wiest,J.S.
  TITLE     Identifying novel homozygous deletions by microsatellite analysis
            and characterization of tumor suppressor candidate 1 gene, TUSC1,
            on chromosome 9p in human lung cancer
  JOURNAL   Oncogene 23 (39), 6612-6620 (2004)
   PUBMED   15208665
  REMARK    GeneRIF: TUSC1 may play a role in lung tumorigenesis
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590322.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 11, 2020 this sequence version replaced NM_001004125.2.
            
            Summary: This gene is located within the region of chromosome 9p
            that harbors tumor suppressor genes critical in carcinogenesis. It
            is an intronless gene which is downregulated in non-small-cell lung
            cancer and small-cell lung cancer cell lines, suggesting that it
            may play a role in lung tumorigenesis. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC110824.1, AY168647.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000358022.6/
                                                ENSP00000350716.4
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1476              AL590322.4         95371-96846         c
FEATURES             Location/Qualifiers
     source          1..1476
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.2"
     gene            1..1476
                     /gene="TUSC1"
                     /gene_synonym="CCDC89B; TSG-9; TSG9"
                     /note="tumor suppressor candidate 1"
                     /db_xref="GeneID:286319"
                     /db_xref="HGNC:HGNC:31010"
                     /db_xref="MIM:610529"
     exon            1..1476
                     /gene="TUSC1"
                     /gene_synonym="CCDC89B; TSG-9; TSG9"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..762
                     /gene="TUSC1"
                     /gene_synonym="CCDC89B; TSG-9; TSG9"
                     /codon_start=1
                     /product="tumor suppressor candidate gene 1 protein"
                     /protein_id="NP_001004125.2"
                     /db_xref="CCDS:CCDS34999.2"
                     /db_xref="GeneID:286319"
                     /db_xref="HGNC:HGNC:31010"
                     /db_xref="MIM:610529"
                     /translation="MWRMRGGATRRGSCCGGDGAADGRGPGRSGRARGGGSPSGGGGG
                     VGWRGRADGARQQLEERFADLAASHLEAIRARDEWDRQNARLRQENARLRLENRRLKR
                     ENRSLFRQALRLPGEGGNGTPAEARRVPEEASTNRRARDSGREDEPGSPRALRARLEK
                     LEAMYRRALLQLHLEQRGPRPSGDKEEQPLQEPDSGLRSRDSEPSGPWL"
     regulatory      1452..1457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUSC1"
                     /gene_synonym="CCDC89B; TSG-9; TSG9"
                     /note="hexamer: AATAAA"
     polyA_site      1476
                     /gene="TUSC1"
                     /gene_synonym="CCDC89B; TSG-9; TSG9"
                     /note="major polyA site"
ORIGIN      
        1 agcagccgcc gcccgcgacc tcctctcctc ctccgtcgtc accccggccg ccctgccagc
       61 cccgaacttg cccgcgcctg gccgcgcggc ccctcagccc acggggctgg cggcgcggtt
      121 gggatgggac cgatgtggcg catgcgtggt ggcgccacta ggcgcgggag ttgctgcggc
      181 ggggacggtg ctgcggacgg ccgagggcca ggccgctccg gccgggctcg tggtgggggc
      241 agccccagcg gcggcggcgg cggcgtgggc tggcgaggcc gcgcggacgg cgcccgacag
      301 cagctggagg agcggtttgc cgacctggcg gcgagccact tggaggccat ccgtgcgcgg
      361 gacgagtggg accggcagaa cgcgcggctg cgtcaggaga acgcccggct gcggctcgag
      421 aaccggcggc tgaagcgcga gaaccgcagc ctcttccgtc aggctttgcg gctccccggc
      481 gaaggcggca acgggacgcc cgcggaggca cgccgggtcc ctgaagaggc cagcacgaac
      541 cggagggcta gagacagcgg ccgagaggac gagccgggca gccccagggc cctgagggcc
      601 cgacttgaga agctggaagc catgtaccgc cgggccctgc tgcagctgca cctcgagcag
      661 cggggaccac gtccgagcgg ggacaaggag gagcagcctc tacaggaacc cgactccggc
      721 ctccgctccc gggactcgga gccctctggg ccctggctgt agccgaggcc gcagccggtg
      781 agaggcggag cctcgagcgg gcccctcctc ctccgttccc agctaccccc gacctcgcgc
      841 acgccctggc ccgctccctg cccgcggata ccttggacta cggtgccttc ccgcccccac
      901 cagtggacac ttccgggtgg cgcttggcca tccgcttggt ggaggtcgag tgggtgcaag
      961 ggccctcagg acctcccaca tgtacagttc ccctgcctct tgccccggct agtttccctg
     1021 gagagaggcc tagccaacaa cgaagggacg gattttaaaa cagcgagaac tgggtgccaa
     1081 gaaacacttc atattccctg aacttttctg gatgttgtgc gaacctgttg tatttttttt
     1141 tttcctgtat tttggttctg agggatgagt aatgtgtttt tagttggttg agtttatcca
     1201 ttcttcaatc ccctaaagcc ttcagctatt ctttcatatg tggccaacat tttaagtaca
     1261 gtgtttgctt ttataagtcg gtgttacttg gatgtcctat aaaataccca ctttttataa
     1321 agatgatatt tataacctag gaactcatgc ctgtcttggc tgcagtccct gtacatctaa
     1381 tatatactga tttgtttgcc cccagagaat ttttaaggta tctgcctata tcgtgatctt
     1441 ttgaaatggt aaataaatct ggtgcattaa aaatta
//
