LOCUS       NM_001416131            3137 bp    mRNA    linear   PRI 01-DEC-2024
DEFINITION  Homo sapiens transmembrane neural differentiation associated
            intracellular calcium regulator (TUNAR), transcript variant 2,
            mRNA.
ACCESSION   NM_001416131
VERSION     NM_001416131.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3137)
  AUTHORS   Senis,E., Esgleas,M., Najas,S., Jimenez-Sabado,V., Bertani,C.,
            Gimenez-Alejandre,M., Escriche,A., Ruiz-Orera,J.,
            Hergueta-Redondo,M., Jimenez,M., Giralt,A., Nuciforo,P., Alba,M.M.,
            Peinado,H., Del Toro,D., Hove-Madsen,L., Gotz,M. and Abad,M.
  TITLE     TUNAR lncRNA Encodes a Microprotein that Regulates Neural
            Differentiation and Neurite Formation by Modulating Calcium
            Dynamics
  JOURNAL   Front Cell Dev Biol 9, 747667 (2021)
   PUBMED   35036403
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3137)
  AUTHORS   Li,M., Shao,F., Qian,Q., Yu,W., Zhang,Z., Chen,B., Su,D., Guo,Y.,
            Phan,A.V., Song,L.S., Stephens,S.B., Sebag,J., Imai,Y., Yang,L. and
            Cao,H.
  TITLE     A putative long noncoding RNA-encoded micropeptide maintains
            cellular homeostasis in pancreatic beta cells
  JOURNAL   Mol Ther Nucleic Acids 26, 307-320 (2021)
   PUBMED   34513312
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3137)
  AUTHORS   Zhou,A.X., Mondal,T., Tabish,A.M., Abadpour,S., Ericson,E.,
            Smith,D.M., Knoll,R., Scholz,H., Kanduri,C., Tyrberg,B. and
            Althage,M.
  TITLE     The long noncoding RNA TUNAR modulates Wnt signaling and regulates
            human beta-cell proliferation
  JOURNAL   Am J Physiol Endocrinol Metab 320 (4), E846-E857 (2021)
   PUBMED   33682459
  REMARK    GeneRIF: The long noncoding RNA TUNAR modulates Wnt signaling and
            regulates human beta-cell proliferation.
REFERENCE   4  (bases 1 to 3137)
  AUTHORS   Li,H., Zhu,L., Xu,L., Qin,K., Liu,C., Yu,Y., Su,D., Wu,K. and
            Sheng,Y.
  TITLE     Long noncoding RNA linc00617 exhibits oncogenic activity in breast
            cancer
  JOURNAL   Mol Carcinog 56 (1), 3-17 (2017)
   PUBMED   26207516
  REMARK    GeneRIF: This study found the human ortholog of TUNA, linc00617,
            was upregulated in breast cancer samples.
REFERENCE   5  (bases 1 to 3137)
  AUTHORS   Lin,N., Chang,K.Y., Li,Z., Gates,K., Rana,Z.A., Dang,J., Zhang,D.,
            Han,T., Yang,C.S., Cunningham,T.J., Head,S.R., Duester,G.,
            Dong,P.D. and Rana,T.M.
  TITLE     An evolutionarily conserved long noncoding RNA TUNA controls
            pluripotency and neural lineage commitment
  JOURNAL   Mol Cell 53 (6), 1005-1019 (2014)
   PUBMED   24530304
  REMARK    Erratum:[Mol Cell. 2014 Mar 20;53(6):1067]
REFERENCE   6  (bases 1 to 3137)
  AUTHORS   Moran,I., Akerman,I., van de Bunt,M., Xie,R., Benazra,M., Nammo,T.,
            Arnes,L., Nakic,N., Garcia-Hurtado,J., Rodriguez-Segui,S.,
            Pasquali,L., Sauty-Colace,C., Beucher,A., Scharfmann,R., van
            Arensbergen,J., Johnson,P.R., Berry,A., Lee,C., Harkins,T.,
            Gmyr,V., Pattou,F., Kerr-Conte,J., Piemonti,L., Berney,T.,
            Hanley,N., Gloyn,A.L., Sussel,L., Langman,L., Brayman,K.L.,
            Sander,M., McCarthy,M.I., Ravassard,P. and Ferrer,J.
  TITLE     Human beta cell transcriptome analysis uncovers lncRNAs that are
            tissue-specific, dynamically regulated, and abnormally expressed in
            type 2 diabetes
  JOURNAL   Cell Metab 16 (4), 435-448 (2012)
   PUBMED   23040067
REFERENCE   7  (bases 1 to 3137)
  AUTHORS   Ulitsky,I., Shkumatava,A., Jan,C.H., Sive,H. and Bartel,D.P.
  TITLE     Conserved function of lincRNAs in vertebrate embryonic development
            despite rapid sequence evolution
  JOURNAL   Cell 147 (7), 1537-1550 (2011)
   PUBMED   22196729
  REMARK    Erratum:[Cell. 2012 Oct 26;151(3):684-6]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133167.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016484.1, AK091547.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000503525.3/ ENSP00000489624.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               AL133167.4         113923-114268       c
            347-3137            AL133167.4         65529-68319         c
FEATURES             Location/Qualifiers
     source          1..3137
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.2"
     gene            1..3137
                     /gene="TUNAR"
                     /gene_synonym="BNLN; HI-LNC78; LINC00617; pTUNAR; TUNA"
                     /note="transmembrane neural differentiation associated
                     intracellular calcium regulator"
                     /db_xref="GeneID:100507043"
                     /db_xref="HGNC:HGNC:44088"
                     /db_xref="MIM:615719"
     exon            1..346
                     /gene="TUNAR"
                     /gene_synonym="BNLN; HI-LNC78; LINC00617; pTUNAR; TUNA"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..532
                     /gene="TUNAR"
                     /gene_synonym="BNLN; HI-LNC78; LINC00617; pTUNAR; TUNA"
                     /note="isoform 2 is encoded by transcript variant 2; long
                     intergenic non-protein coding RNA 617; Tcl1 upstream
                     neuron-associated lincRNA; Human Islet Long Non Coding RNA
                     78; beta cell- and neural cell-regulin; protein TUNAR;
                     TUNAR lncRNA; TCL1 upstream neural
                     differentiation-associated RNA"
                     /codon_start=1
                     /product="protein TUNAR isoform 2"
                     /protein_id="NP_001403060.1"
                     /db_xref="GeneID:100507043"
                     /db_xref="HGNC:HGNC:44088"
                     /db_xref="MIM:615719"
                     /translation="MRFSVSLARKIKTFATKMVITSENDEDRGGQEKESKEESVLAML
                     GIIGTILNLIVIIFVYIYTTL"
     exon            347..3137
                     /gene="TUNAR"
                     /gene_synonym="BNLN; HI-LNC78; LINC00617; pTUNAR; TUNA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3113..3118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUNAR"
                     /gene_synonym="BNLN; HI-LNC78; LINC00617; pTUNAR; TUNA"
                     /note="hexamer: AATAAA"
     polyA_site      3137
                     /gene="TUNAR"
                     /gene_synonym="BNLN; HI-LNC78; LINC00617; pTUNAR; TUNA"
                     /note="major polyA site"
ORIGIN      
        1 ctctttccct ccgcgctgcc tctccgaggt cctcccgccg agccccggcg cggggcatga
       61 ggagcccccg ggtgccgccc agagaccagc aggctgcgcg cacacctagc cagcggcaga
      121 cggggacatg agcagcgcgc acggggtccc gcgcccggcg gccagcccta tccggcggcg
      181 gccagcgggt caacgctgcc cgggagaatg aggcaggagc cggcggcagc ctcctttttt
      241 tccttctcct cgccttcctg cggctccggc gctccgggtc cgggccgggc tgcggctctg
      301 ctgcgtgccc cgcgcgcccc tcaaccgcct ccggatgcgc ttctcggtta gcctggcaag
      361 gaagataaag acatttgcaa ccaagatggt aatcactagt gaaaatgatg aagacagagg
      421 aggtcaagaa aaagaaagta aagaggagag tgtcttggca atgctgggga ttatcgggac
      481 cattctgaac ctgattgtga tcatatttgt ctacatatac accaccctgt gaatggccca
      541 gagcgtcctc agaggcctca gaatggccaa agacggaagt cctgcgtgtc ggcgcatcac
      601 tgaccagacc ctgcgagaac aagcaggctt gacccgcaca taccacccaa tcaaatgcac
      661 cttcaaactt tacaaaaggt cacacaaata gaccgatcct gctgcaggga gcagacacta
      721 aagcacaatg attccaacaa aactcattca cagcactagg aactcaacgt ctttggcagg
      781 gggcccagaa gaatgcttgg aagaccagcc tctgacacca tcagtgagcg gatgggtgca
      841 gaaattcatt attccagatc gctgacagat atcacatatt tgaaaagatg aatagggcgg
      901 acatggctca gatgtgtgtc tcccaggaca agtgtttcat cttcacttga cgagctattt
      961 agtggaaaaa ccacaggcgc agccctttga caggcatccc attcatcaaa agtgtctaac
     1021 tatttgatac tggggagata acttattttt cttttttcat tggcttgaca tgtgtatctg
     1081 ttcatgtcaa ggtttataaa tatatatttt taataaatgt gctctatttt ttagcatgaa
     1141 ccaaatactt ggagaggcac tcccagatcc atagagcttt ccttagtttt atctgctttg
     1201 tcccctcctc ccccaactac agatgttctg ttgtggagcc attctagtcc ttttgtctca
     1261 tcttgagtct tttaccttgc gcttttgttc tctctctctc ctctctctct gcctctttgg
     1321 tctgaaggac attttcccat actgtcagcc atggttttgg gtgcatgttt taagattgtc
     1381 cattgagtgg ctttttgttg ttatctcgga gatataaaat gattgtgggc atgcagacct
     1441 tagatgcacc ctatctttac tgagaattat gcatgaataa gggctgagtg atagatcagc
     1501 ttaaaattaa aaggactacc tttgaggaag aagagcgtgg ctatatttgc agatgaactt
     1561 ttgaacagaa tattcagctt cttaccggca gcgttattgt ttcattcttg tgaccattcg
     1621 tttatcagat tttgatttta gcggtcatgt accgcgagag ttgggaagaa caagggggaa
     1681 agctcgggat taggtgcatt actccttcct ttgcaagata cctgggatcc tcctcaaaag
     1741 cgggtggggt ataaatgaca caagaactcc cccaggagat ctcatggtga ttcaggctgt
     1801 gaggacagcc ctgtgacagg tgacttttca gggacatgag gaggggattt aatgattgcc
     1861 ctaaaggact tctgtatttt taaagcccct ggtttacacc cacatgaagc tatttcctct
     1921 ctggcaggga tggttgcata aaaacaaatt agctcccttc tggctccctg aaatgggccc
     1981 ttgcctggct acagtggcat ggccttaaag agagggttag tattccttct gccattgcca
     2041 gctgtattag tctgttttca cactgctgaa aaagacatcc ccaagactgg gcaatttaca
     2101 aagaaagagg tttattggac ttacagttcc acgtggctga ggaggcctca caattacggt
     2161 ggaaggtgaa aggcacgtct cacatggtgg cagacaagag aagtgaacat gtgcaaggag
     2221 actcccattt ttaaaacaga tctcgtgaga ctttttcact atcatgcaaa cagcatggga
     2281 aacctgcccc cgtgattcag ttacctccca ccgggtccct cccacaacac atgggtattc
     2341 aagatgagat ttgggtgggg ttacagccaa actctatcac cagccttgcc cctgggcaga
     2401 agcagcagca gtctgcctgg ctggattcaa atgattctga ggcttctata gtctatgcct
     2461 gcagatctct ccctcaccca tgctatagtg tctgaaattc caccattaga gagtcatttc
     2521 ttgggctctg ttaaatggac caggctcttt tataaagaaa atgcccctga gcagctggct
     2581 ctggcattga tttatgatat cttctcttcc ctgccagaag gaaggaagct aaggtgcatg
     2641 tagggcgtac tgtgtgccca ggcactgtgc cagatgcttt ggatacttgg agtcattgaa
     2701 ttcttgtagt aaccctgtga gagagggagt cttttctcca cattgtagaa gaaggaaaaa
     2761 gggctcagag aggtcaagaa atgtccctga gatcacatgg cttctagtgg agtcaagatc
     2821 caaacccaat gtgtctgatt ccttagccct tgggggtccg gaggctgctg aacaagaaag
     2881 gaggtggaga ggagagaaag ctgcaggcat accaccgcac acccttctcc ctcccctgta
     2941 aaaacaaccc tgggaactcc ctggacacta gcagaatatc atacactaag gataagggat
     3001 gagaggaggc tggttagaaa taaagcagtg tcagggggaa ggagctactc agtaggctct
     3061 gtgtgattct agaaagactg tatgaaaatt ctgaacagtg aacagaataa acaataaagg
     3121 tgcaatggaa aaaaata
//
