LOCUS       NM_020245              11318 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens TUB like protein 4 (TULP4), transcript variant 1,
            mRNA.
ACCESSION   NM_020245
VERSION     NM_020245.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11318)
  AUTHORS   Jager,R., Geyer,S.H., Kavirayani,A., Kiss,M.G., Waltenberger,E.,
            Rulicke,T., Binder,C.J., Weninger,W.J. and Kralovics,R.
  TITLE     Effects of Tulp4 deficiency on murine embryonic development and
            adult phenotype
  JOURNAL   Microsc Res Tech 87 (4), 854-866 (2024)
   PUBMED   38115643
  REMARK    GeneRIF: Effects of Tulp4 deficiency on murine embryonic
            development and adult phenotype.
REFERENCE   2  (bases 1 to 11318)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 11318)
  AUTHORS   Vieira,A.R., de Carvalho,F.M., Johnson,L., DeVos,L., Swailes,A.L.,
            Weber,M.L. and Deeley,K.
  TITLE     Fine Mapping of 6q23.1 Identifies TULP4 as Contributing to Clefts
  JOURNAL   Cleft Palate Craniofac J 52 (2), 128-134 (2015)
   PUBMED   24066709
  REMARK    GeneRIF: In Philippines families, overtransmission of alleles to
            persons born with CL+/-P. Results : We found statistical evidence
            of association between a marker of TULP4 (rs651333) with CL+/-P (P
            = .00007). Conclusions : Our results further support the linkage
            results for the chromosome 6q region and reveal a novel candidate
            gene for CL+/-P.
REFERENCE   4  (bases 1 to 11318)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   5  (bases 1 to 11318)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   6  (bases 1 to 11318)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   7  (bases 1 to 11318)
  AUTHORS   Li,Q.Z., Wang,C.Y., Shi,J.D., Ruan,Q.G., Eckenrode,S.,
            Davoodi-Semiromi,A., Kukar,T., Gu,Y., Lian,W., Wu,D. and She,J.X.
  TITLE     Molecular cloning and characterization of the mouse and human TUSP
            gene, a novel member of the tubby superfamily
  JOURNAL   Gene 273 (2), 275-284 (2001)
   PUBMED   11595174
REFERENCE   8  (bases 1 to 11318)
  AUTHORS   Kleyn,P.W., Fan,W., Kovats,S.G., Lee,J.J., Pulido,J.C., Wu,Y.,
            Berkemeier,L.R., Misumi,D.J., Holmgren,L., Charlat,O., Woolf,E.A.,
            Tayber,O., Brody,T., Shu,P., Hawkins,F., Kennedy,B., Baldini,L.,
            Ebeling,C., Alperin,G.D., Deeds,J., Lakey,N.D., Culpepper,J.,
            Chen,H., Glucksmann-Kuis,M.A., Carlson,G.A., Duyk,G.M. and
            Moore,K.J.
  TITLE     Identification and characterization of the mouse obesity gene
            tubby: a member of a novel gene family
  JOURNAL   Cell 85 (2), 281-290 (1996)
   PUBMED   8612280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL360169.17, AF219946.2 and AL353800.10.
            
            On Nov 22, 2018 this sequence version replaced NM_020245.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF219946.2, SRR7346977.3016888.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367097.8/ ENSP00000356064.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AL360169.17        164385-164579       c
            196-220             AF219946.2         1-25
            221-1594            AL360169.17        162986-164359       c
            1595-3771           AF219946.2         1400-3576
            3772-4945           AL353800.10        10338-11511         c
            4946-6444           AF219946.2         4754-6252
            6445-7394           AL353800.10        5490-6439           c
            7395-11318          AF219946.2         7204-11127
FEATURES             Location/Qualifiers
     source          1..11318
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..11318
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /note="TUB like protein 4"
                     /db_xref="GeneID:56995"
                     /db_xref="HGNC:HGNC:15530"
                     /db_xref="MIM:619442"
     exon            1..1804
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     CDS             1553..6184
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /note="isoform 1 is encoded by transcript variant 1; tubby
                     super-family protein; tubby-related protein 4; tubby
                     superfamily protein; tubby like protein 4"
                     /codon_start=1
                     /product="tubby-related protein 4 isoform 1"
                     /protein_id="NP_064630.2"
                     /db_xref="CCDS:CCDS34561.1"
                     /db_xref="GeneID:56995"
                     /db_xref="HGNC:HGNC:15530"
                     /db_xref="MIM:619442"
                     /translation="MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVCRRRYYEEG
                     WLATGNGRGVVGVTFTSSHCRRDRSTPQRINFNLRGHNSEVVLVRWNEPYQKLATCDA
                     DGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSGQRHW
                     SSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVLLHESDGVLGMSWN
                     YPIFLVEDSSESDTDSDDYAPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLMNNYDDL
                     SPTVIRSGLKEVVAQWCTQGDLLAVAGMERQTQLGELPNGPLLKSAMVKFYNVRGEHI
                     FTLDTLVQRPIISICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASTLRED
                     KDVSKLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDD
                     PEVGGPCYTLYLEYLGGLVPILKGRRISKLRPEFVIMDPRTDSKPDEIYGNSLISTVI
                     DSCNCSDSSDIELSDDWAAKKSPKISRASKSPKLPRISIEARKSPKLPRAAQELSRSP
                     RLPLRKPSVGSPSLTRREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAV
                     IYKTSLLHLQPRQMTIYLPEVRKISMDYINLPVFNPNVFSEDEDDLPVTGASGVPENS
                     PPCTVNIPIAPIHSSAQAMSPTQSIGLVQSLLANQNVQLDVLTNQTTAVGTAEHAGDS
                     ATQYPVSNRYSNPGQVIFGSVEMGRIIQNPPPLSLPPPPQGPMQLSTVGHGDRDHEHL
                     QKSAKALRPTPQLAAEGDAVVFSAPQEVQVTKINPPPPYPGTIPAAPTTAAPPPPLPP
                     PQPPVDVCLKKGDFSLYPTSVHYQTPLGYERITTFDSSGNVEEVCRPRTRMLCSQNTY
                     TLPGPGSSATLRLTATEKKVPQPCSSATLNRLTVPRYSIPTGDPPPYPEIASQLAQGR
                     GAAQRSDNSLIHATLRRNNREATLKMAQLADSPRAPLQPLAKSKGGPGGVVTQLPARP
                     PPALYTCSQCSGTGPSSQPGASLAHTASASPLASQSSYSLLSPPDSARDRTDYVNSAF
                     TEDEALSQHCQLEKPLRHPPLPEAAVTLKRPPPYQWDPMLGEDVWVPQERTAQTSGPN
                     PLKLSSLMLSQGQHLDVSRLPFISPKSPASPTATFQTGYGMGVPYPGSYNNPPLPGVQ
                     APCSPKDALSPTQFAQQEPAVVLQPLYPPSLSYCTLPPMYPGSSTCSSLQLPPVALHP
                     WSSYSACPPMQNPQGTLPPKPHLVVEKPLVSPPPADLQSHLGTEVMVETADNFQEVLS
                     LTESPVPQRTEKFGKKNRKRLDSRAEEGSVQAITEGKVKKEARTLSDFNSLISSPHLG
                     REKKKVKSQKDQLKSKKLNKTNEFQDSSESEPELFISGDELMNQSQGSRKGWKSKRSP
                     RAAGELEEAKCRRASEKEDGRLGSQGFVYVMANKQPLWNEATQVYQLDFGGRVTQESA
                     KNFQIELEGRQVMQFGRIDGSAYILDFQYPFSAVQAFAVALANVTQRLK"
     exon            1805..1933
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2095
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2276
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2411
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2578
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2803
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..3038
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3183
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3328
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3422
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3566
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     exon            3567..6067
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     exon            6068..11318
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11295..11300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /note="hexamer: AATAAA"
     polyA_site      11318
                     /gene="TULP4"
                     /gene_synonym="TUSP"
                     /note="major polyA site"
ORIGIN      
        1 aaacattgca gcggctcaca cagtgtttgt tgcactttat ttttcagtgg gtttggtgat
       61 ttggacggat taaaattcta gactgaaaag taactcctac tgtggttatg gctagaggaa
      121 agcaagttca agtatgatgg gacaagtttg aataatgaac tgattccttt gcctatctta
      181 attaactgta tttgagaaat tttaatttat tattcccccc cttttttcct gcatctatag
      241 gataatattg taaaatagca attgaaacca ataattatta aataaatatc aaggaaaatc
      301 caagcaaagc tttctttttg ttggactagt ggtgtggtgt ttggagacag tctctgaatg
      361 tgaacaggaa agcacccatc agcaaaacac tatcactctc tagggagaca gctgggggaa
      421 tctgactctg gcttctgctt ttgttttaag ggattaactt ccctgtcaag tccaagaaga
      481 cttgcgtatg agaagattac ctgatggact taattctaag attagctttt ttcatcaaga
      541 tggaaaaaga tctttaggag cagaaaaggg gagtgctaac tgggggagcg agaagggaga
      601 cgagcaaaag aaacaaaatc ttgccacgtg gctctgtttt gtcagcaaga ggatttaaga
      661 ctcacccagg gcaaacactg ggaccactgt aagagcgctg gaacattctg cctcttgagt
      721 gaaggggcct tctttctagc ctctatggca ctgaggggtg cgccggctgg tggaggagca
      781 gtccgatgga gccctgcgtt ccccggggac acagggccaa gctttgaggt ggaaagtttc
      841 tggttctgaa acaacaagga gagagtctgt ttttcttcct aaaatttgga ctcttgtctg
      901 cacaaactct ggtctgtttt gcacggtttg tgtgcctttt tttcccttta tgcaatcttt
      961 ttcagcttta gcagcagaaa tttgtctagt tcaggaaaca tgctagaggg tggcttcaga
     1021 aggaagatga tcctgtgtat tctgtctctg catccgaact tttgaagaga aaaattcgag
     1081 ctagagggat tcttaaagcc ttaagttact tgaaatctat gtatttgcaa ccctttgtct
     1141 ctggaatcat attacactaa actggaatct caggctgaat gagaataacc aagtggagta
     1201 aaaagaagaa aaccgtttct tgatcaccac ttaattaacg atgctctttc tccaaaggat
     1261 cagcacgttc ttcctctgag aacttgaaaa tacaaatgga ccccatgttt ttttaagcat
     1321 taccttttct tagaagactg ccatcatctt ttatagagga attttttcac tatgcattcg
     1381 gtggatcttt ataaaatact gaccttctaa ttagattcag gtcagtctta attaaagggg
     1441 gaaaaaagca acgcaagcca accacaaaaa cacatatacc aatgaaagaa attggtttaa
     1501 atttcacagc attaacatta ctttttaagt aaaacagttc attgaagaaa gtatgtatgc
     1561 agcagtggaa catgggcctg tgctttgcag cgattccaac atcctgtgcc tgtcctggaa
     1621 ggggcgtgtc cccaagagtg agaaggagaa gcctgtgtgc aggagacgct actatgagga
     1681 aggctggctg gccacgggca acgggcgagg agtggttggg gtgactttca cctctagtca
     1741 ctgtcgcagg gacaggagta ctccacagag gataaatttc aacctccggg gccacaatag
     1801 cgaggttgtg ctggtgaggt ggaatgagcc ctaccagaaa ctggccacgt gcgatgcgga
     1861 cggaggcata ttcgtgtgga ttcagtacga gggcaggtgg tctgtggagc tggtcaacga
     1921 ccgcggggcg caggtgagtg atttcacgtg gagccatgat ggaactcaag cacttatttc
     1981 ctatcgagat gggtttgtcc tggttgggtc tgtcagtgga caaagacact ggtcatccga
     2041 aatcaacttg gaaagtcaaa ttacgtgtgg catatggact cctgacgacc aacaggtgct
     2101 gtttggcacg gccgatgggc aggtgattgt catggattgc cacggcagaa tgctggccca
     2161 cgtcctcttg cacgagtcag acggtgtcct cggcatgtcc tggaactacc cgatcttcct
     2221 ggtggaggac agcagcgaga gcgacacgga ctcagatgac tacgcccctc cccaagatgg
     2281 tccggcagca tatcccatcc cagtgcagaa catcaagcct ctgctcaccg tcagcttcac
     2341 ctcgggagac atcagcttaa tgaacaacta cgatgacttg tctcccacgg tcatccgctc
     2401 agggctgaaa gaggtggtag cccagtggtg cacacagggg gacttgctgg cagtcgctgg
     2461 gatggaacgg cagacccagc ttggtgagct tcccaatggt ccccttctga agagtgccat
     2521 ggtcaagttc tacaatgttc gtggggagca catcttcaca ctggacactc tcgtgcagcg
     2581 ccccatcatc tccatctgct ggggtcaccg ggattcgagg ctgttgatgg catcaggacc
     2641 agccctgtac gtggtgcgtg tggagcaccg ggtgtccagc ctgcagctgc tgtgccagca
     2701 ggccatcgcc agcaccttgc gtgaggacaa ggacgtcagc aagctgactc tgcccccccg
     2761 cctctgctcc tacctctcca ctgccttcat ccccaccatc aagcccccaa ttccagatcc
     2821 gaacaacatg agagactttg tcagctaccc atcagccggc aacgagcggc tgcactgcac
     2881 catgaagcgc acagaggacg acccggaggt gggcggcccg tgctacacgc tctacctgga
     2941 gtacctgggc gggcttgtgc ccatcctcaa agggcggcgc atcagcaagc tgcggccaga
     3001 gttcgtcatc atggacccgc ggacagatag caaaccagat gaaatctatg ggaacagctt
     3061 gatttctact gtgatcgaca gctgcaactg ctcagactcc agtgacattg agctgagtga
     3121 tgactgggct gccaagaaat ctcccaaaat ctccagagct agcaaatcac ccaaactccc
     3181 aaggatcagc attgaggccc gcaagtcacc caagctgccc cgggctgctc aggagctctc
     3241 ccggtcccca cggttgcccc tgcgcaagcc ctctgtgggc tcgcccagcc tgactcggag
     3301 agagtttcct tttgaagaca tcactcagca caactatctt gctcaggtca cgtctaatat
     3361 ctggggaacc aaatttaaga ttgtgggctt ggctgctttc ctgccaacca acctcggtgc
     3421 agtaatctat aaaaccagcc tcctgcatct ccagccgcgg cagatgacca tttatctccc
     3481 agaagttcgg aaaatttcca tggactatat taatttacct gtcttcaacc caaatgtttt
     3541 cagtgaagat gaagatgatt taccagtgac aggagcatct ggtgtccctg agaacagccc
     3601 accttgtacc gtgaacatcc ctattgcacc gatccacagc tcggctcagg ctatgtcccc
     3661 cacgcagagc atagggctgg tgcagtccct actggccaat cagaatgtgc agctagatgt
     3721 cctgaccaac cagacgacag ctgtagggac agcagaacat gcaggtgaca gtgccaccca
     3781 gtacccagtc tccaaccggt actccaatcc tggacaggtg attttcggaa gcgtggaaat
     3841 gggccgcatc attcagaacc cccctccact gtccctgcct cccccgccgc aggggcccat
     3901 gcagctgtcc acggtgggcc atggagaccg agaccacgaa cacctgcaga agtcagccaa
     3961 ggccctgcgg ccaacaccgc agctggcagc tgagggggac gcagtggtct ttagtgcccc
     4021 ccaggaggtc caggtgacga agataaaccc tccacccccg tacccaggaa ccatccccgc
     4081 tgcccccacc acagcagcac ccccgccccc tctgccgccc ccacagcccc cagtggatgt
     4141 gtgcttgaag aagggcgact tctccctcta ccccacgtca gtgcactacc agacccccct
     4201 gggctatgag aggatcacca ccttcgacag cagtggcaac gtggaggagg tgtgccggcc
     4261 ccgcacccgg atgctgtgct cccagaacac gtacaccctc cccggcccgg gtagctctgc
     4321 caccttgagg ctcacggcca ctgagaagaa ggtccctcag ccctgcagca gtgccaccct
     4381 gaaccgcctg accgtccctc gctactccat ccccaccggg gacccacccc cgtatcctga
     4441 aattgccagc cagctggccc aggggcgggg ggctgcccag aggtccgaca atagcctcat
     4501 ccacgctacc ctgcggagga acaaccgtga ggctacgctc aagatggccc agctggccga
     4561 cagcccgcgg gcccccctgc agcccctggc caagtccaag ggcgggcccg ggggggtggt
     4621 gacacagctc ccagcgcggc ccccacctgc cctgtacacc tgcagtcagt gcagtggcac
     4681 agggcccagc tcacagcccg gagcctccct ggcccatacc gccagcgcct ccccgttggc
     4741 ctcccagtcc tcctacagcc tcctgagccc acccgacagc gcccgcgacc gcaccgacta
     4801 cgtcaactcg gccttcacgg aggacgaggc cctgtcccag cactgtcagc ttgagaagcc
     4861 cttgaggcac cctcccctgc ctgaagctgc tgtcaccctg aaacggccac ccccttacca
     4921 gtgggacccc atgctgggtg aggatgtttg ggttcctcaa gaaaggacag cacagacttc
     4981 agggcccaac cccttaaaac tgtcctctct gatgctgagt cagggccagc acctggacgt
     5041 gtcccgactg cccttcatct cccccaagtc tcctgccagc cccactgcca ctttccaaac
     5101 aggctatggg atgggagtgc catatccagg aagctataac aacccccctt tgcctggagt
     5161 gcaggctccc tgctctccca aagatgccct gtccccaacg cagtttgcac aacaggagcc
     5221 tgctgtggtc cttcagccgc tgtacccacc cagcctctcc tattgcaccc tgccccccat
     5281 gtacccagga agcagcacgt gctctagttt acagctgcca cctgtcgcct tgcatccatg
     5341 gagttcctac agcgcctgcc cgcccatgca gaacccccag ggcactctcc ccccaaagcc
     5401 acacttggtg gtggagaagc cccttgtgtc cccaccacct gccgacctcc aaagccactt
     5461 gggcacagag gtgatggtag agactgcaga caacttccag gaagtcctct ccctgaccga
     5521 aagcccagtc ccccagcgga cagaaaaatt tggaaagaag aaccggaagc gcctggacag
     5581 ccgagcagaa gaaggcagcg ttcaggccat cactgagggc aaagtgaaga aggaggctag
     5641 gactttgagt gactttaatt ccctaatctc cagcccacac ctggggagag agaagaagaa
     5701 agtgaagagt cagaaagacc aactgaagtc aaagaagttg aataagacaa acgagttcca
     5761 ggacagctcc gagagcgagc ctgagctgtt catcagcggg gatgagctca tgaaccagag
     5821 ccagggcagc agaaagggct ggaaaagcaa gcgctcccca cgggccgccg gcgagctgga
     5881 ggaggccaag tgccggcggg ccagtgagaa ggaggacggg cggctgggca gccaaggctt
     5941 cgtgtacgtg atggccaaca agcagccgct gtggaacgag gccacccagg tctaccagct
     6001 ggacttcggg gggcgggtga cccaggagtc cgccaagaac ttccagattg agttagaggg
     6061 gcggcaggtg atgcagtttg gacggattga tggcagtgcg tacattctag acttccagta
     6121 tccgttctca gccgtgcagg cctttgcagt tgccctggcc aacgtgactc agcgcctcaa
     6181 atgaagagac tggtgtgggg aggagagaga tgcagagagc ctttggaaga ggtcttcgga
     6241 gatgccagag gagccctcta ggggtccgat gcctgggagg accagaagcc aacagcaaaa
     6301 ctggaaaagc ccggcaggcc caggagaggg cgctgacctg tggtcgtcat ttatttggtt
     6361 gggttttatt accttttatt gtctgttctt cttttcttct ttcatttcag tggcatttgg
     6421 aagcaaagag tgctaggcac ctgctgttct ttcaggaaac agcttggctg tggtaatgct
     6481 ctactgggcc cttcagaatg aagacagtct gccttagagc ctgctattct tttagacata
     6541 gggaggatgc attatcctgt attctcctcc aacatcacca ctagcgtaaa agcaaaaagc
     6601 ttttacaaaa cacagccaaa aattctcaag atgcaggttc ttggggaatg ggatggggac
     6661 agcatttgat ttacactgat tatgttactc cccaaaaggt gacttaatta ataaagggca
     6721 tttgggcaga cacactgtgt tggaccaaca aagtaggctc tttacagggg tgttctcacc
     6781 aggtagaaat gcgatttgct cactgaggat gttggggaag ggacgaaggg taaagaagaa
     6841 actgcacgta tacacaggtt cacatcactc tgcagacagc aatgtgactc agcgtgtgac
     6901 ttgtagcagc agtacgaggg ctacactcct ctgctgagga tgtctacatt gaaagcctcc
     6961 actagtttca tcgtttgtca aagttccgta ggatcagtga tggtcattca gcatgactgg
     7021 ttctgggaga aggtgagaga caaaaatgga aagatcctgg cctgtggtag tggtagcagt
     7081 tttctcaaat aatgtggtga cagtcactag atcctcacat gctgagaaac agcctctact
     7141 ctctctgccc cttttacttt ttaatctgga atgcattact gtaaacatga tctttcccat
     7201 gagataccat gttctatgcc ttcccattct aaaagtgtgg acaacgcttg atttgaaacc
     7261 actccttttc tcctcttggc tacattaaaa ttcagttgac tacaaatgct ttctatcaaa
     7321 ttagaaatgt aaccaaaaaa atgttaagtg ttcaccaggg tattaaaata cagaggagta
     7381 tggtcaaatc tttgacaaaa ttttcatgat cttctctaac aaaaaaagtt gtttattaac
     7441 tgtacagact gtttactaag gagctaaacc actgagaaaa cgttattaaa attgtaatac
     7501 ctaggtagtt ggttgatcac agtttgttaa ttgtataaaa aaaaattacc tagaatatct
     7561 cttcccactt cctcgtcctc gtgagaacct gtgggcagta ttcaagccct gatgacaaaa
     7621 cccagtgttt tttgttgttg ttttttgttg ttgttttttg tttttgtttt tgtttttctc
     7681 agtcttacct gtgatgttgt ttaggatcag gcccctctcc tgggcctgct gtgcaggagc
     7741 acaggaacta tctgctggcg ttgggttcca aatttgcatt ttatttggaa acagacaagt
     7801 agaagatgct acagaaaagt attttcaaat ttaaacgttt tttaatcccc tgttttagtt
     7861 aaaaaattgg aaaagaaacc gacccatttt tttcccagat caagatgaca tgacatcact
     7921 cccaattctc tccaaacccc agagaaatac tgacgaagtt ttctgatgtg gcaaaggata
     7981 tttcccatct aataccagtt tctcatttat atttaacgta ttggacctga tatttttagt
     8041 gggtgcattc ttccagaaag aattcagcaa tgttatcaga attaattctt ttatatgagt
     8101 ttatgtagct tgatatggtg tttcagtgct tattggttgt gcaataatgg ttatagcctg
     8161 ttagataatc taaatgcaat tcccctgttt tgtcgtttag gagataatta tttatcttgc
     8221 ttttcatagt gttcttagga attattttgt tgttacgttt tggtgagtta tacccatttt
     8281 atttatttag aaaaatagta tctttgttaa cgacttacat ggtcacagta tattttgctg
     8341 caagaaataa agaggatatg atagaaggtt tttttttttt tttttttttt tttttgagac
     8401 ggagtcccac tcttgtcgcc caactagagt gtagtggcac aatctcggct ccccacaacc
     8461 tctgactcca gggttcaggt gattattttg cctcagcctc ccaagcagct gggattatag
     8521 acacccgcca acacgccagg ctaatgtttt tgtattttta atagagatgg ggttttgcca
     8581 tgttggccag gctggtcttg aactcctgac ctcaggtgat ccgcccgcct cggcctccca
     8641 aagtgctggg attacagacg tgagccacca ctcccggccc atagaaggtt ttttgctgga
     8701 taatttgtaa cttttctaat tgggaaaaaa ttcctattaa tcacttaaaa attttttttt
     8761 gtattttgtg ttattgatta tatacaaagg agactttttt tttgagataa cactcaaata
     8821 gtattctctt cttttgaaaa ttttattttt atctgaaaat aacagttgat ctgaaataaa
     8881 aaggggagac ctattagaat gagagtagcc aaggaaagag ttactaggta ataagcttca
     8941 ctttttgtgt tctaattgtt tttgagatat aaagaccctg aaaaagccca ttttagaacc
     9001 tgtttaataa gagcaaatat aggggaaaat ctttgaaatg aaagctacaa atacatgtga
     9061 gaagaaaaaa atggattttt ttagcaaata attaactaag cttctaaatg cctagctccc
     9121 tcccccaaag gcgctttccc ccgatggagg cacaggcttc tgtctcggat gtttggcgca
     9181 cgtgagtttg tatgagtttg taccggagtg accccggcag ccactgccca cctcccctct
     9241 acccaggggc ctgaaaagag gggctgccct cctgcgccaa ggcagacaca agctgcgggc
     9301 tgtgcggtcc tagtagtgtg acgtttcagt taatagtggt ggtcttattt tcaactatgc
     9361 tttcattcag tcagtctctg ttgactaaat acgacgaaaa ttcatacttt atgcaggaga
     9421 tttctaaaaa tttaatgttt attaatagtt tatgaatatc aagatacctc attgaatccc
     9481 taaatttaaa agcagtccag taaaaggtta actgtataaa gaatctatga ctttttgagg
     9541 gaagtgtgat atattaacaa atataaccaa ttctaaattt gttttagctc taacctcatc
     9601 aaaccaaagg cacagatttg tgtacaatat acccattgaa tgtatatcct gagaaaaatt
     9661 ggggccaaag aagcaggaaa atctcaaagc tctaatggca gcataaatca aagaatttca
     9721 caggctagtg tttttatcca tagccattgc tcccttgtca agtgtctcac aaggacatgg
     9781 aagaatgtgt tatgttcatc ttgtaatcat agcaaaaagt ctgcaaaccc cagggtcaag
     9841 cctgctctgc cacagggttg gatggtgacc ttgggcaagt ccctggggct ggctaggcct
     9901 ccacttgtcc atctgtgaaa tgaaaggatc agcctggaca gccctctaaa ctcccttaca
     9961 gctctcagcc taagagcgca gcactgaaca gcctcatcat tccacttttc atgggaaata
    10021 tatttcacac cattgccttt gtgtagagaa atatttcttt tcctgtgtta atgagctatg
    10081 tactgaatat aaaccagtgc atttaaagta atatcttttg tgcacctcta aatgtgtttg
    10141 gaattgtgtt tgttctcata gaatatacaa aagtactgat tctaggtaag aaggagtctc
    10201 cacgggtgtg ccctgctcag ctggatgtcc atgagaacag ccatgaaata agtcactact
    10261 tgtccccaaa accacaggaa tatataccta ggtcacctca aattcctgag tgtgctctgc
    10321 catgttacac ggtcttcaaa ttgaaaaggt ttcttgaaaa ggaaagtttg gcccagcaac
    10381 tggagaagga gtccatggtg tcgctgtgtg cctgtatcat ttggccaagt caatggttgt
    10441 aagcaaagtt agtggagaca aaaatgtgtc caaaatgtcg tttgagttcc tgggatttct
    10501 gtaatagcac acaactcaga actcttcagc atttgtgtga ttccttacct ctggctgata
    10561 aaactctaat gggttgtggc ttactttgtt tccattttct ttggctttgt gcaatttttg
    10621 tgtaacttta cttgtaccta tattttctgt ttacagttct ttttaagggg aggggtaggg
    10681 ttctaagatc ttgttgttta ttgtagataa aaattttttc gtgttgtaga aaagcatggg
    10741 ttatgcgttt gactgaaaaa gacactgtat tatttaccaa aggggtattg tttttgcatt
    10801 tgtttataaa tgcattattt tggtactgta aatttggaca taatttctga gtttattact
    10861 actggcattt tctttttccc tttttttttt ttttaaccgt aagtgcacga tgcaggtgca
    10921 taggccccag accaaactag accaccagca tgttcatgtc cagacctcgg cagtggcgtg
    10981 cactgcttgt gcacctcagt tcctccagtg ttggtttgtt tgttttttaa ttcagcatcc
    11041 tgctggtttt actttccaag caagatctgt tgcgactccc aaatgcgttt taatgagctc
    11101 atccttattt gcctttcttc ttacgtattt tgtgtattag attgtgcagg agatattcta
    11161 gaaggcatta atggtttgca ttcaaaacga tgtggtttgt ccaagttatt ttctgtcttt
    11221 attactgaga cggattaatc tccttatttt tttcttgatg atttgaagtt gtaagagttg
    11281 tccagctatt gcttaataaa attttgcaga tcaaaaaa
//
