LOCUS       NM_003323               1763 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens TUB like protein 2 (TULP2), mRNA.
ACCESSION   NM_003323
VERSION     NM_003323.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1763)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
REFERENCE   2  (bases 1 to 1763)
  AUTHORS   Carroll,K., Gomez,C. and Shapiro,L.
  TITLE     Tubby proteins: the plot thickens
  JOURNAL   Nat Rev Mol Cell Biol 5 (1), 55-63 (2004)
   PUBMED   14708010
  REMARK    Review article
REFERENCE   3  (bases 1 to 1763)
  AUTHORS   Boggon,T.J., Shan,W.S., Santagata,S., Myers,S.C. and Shapiro,L.
  TITLE     Implication of tubby proteins as transcription factors by
            structure-based functional analysis
  JOURNAL   Science 286 (5447), 2119-2125 (1999)
   PUBMED   10591637
REFERENCE   4  (bases 1 to 1763)
  AUTHORS   North,M.A., Naggert,J.K., Yan,Y., Noben-Trauth,K. and Nishina,P.M.
  TITLE     Molecular characterization of TUB, TULP1, and TULP2, members of the
            novel tubby gene family and their possible relation to ocular
            diseases
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3128-3133 (1997)
   PUBMED   9096357
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026803.7, DB442827.1, BC026070.2 and U82469.1.
            
            On May 17, 2019 this sequence version replaced NM_003323.2.
            
            Summary: TULP2 is a member of a family of tubby-like genes (TULPs)
            that encode proteins of unknown function. Members of this family
            have been identified in plants, vertebrates, and invertebrates. The
            TULP proteins share a conserved C-terminal region of approximately
            200 amino acid residues. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026070.2, U82469.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221399.8/ ENSP00000221399.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC026803.7         136074-136078       c
            6-61                DB442827.1         1-56
            62-62               AC026803.7         136017-136017       c
            63-1758             BC026070.2         52-1747
            1759-1763           U82469.1           1696-1700
FEATURES             Location/Qualifiers
     source          1..1763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..1763
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /note="TUB like protein 2"
                     /db_xref="GeneID:7288"
                     /db_xref="HGNC:HGNC:12424"
                     /db_xref="MIM:602309"
     exon            1..155
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..188
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1719
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /note="cancer testis antigen 65; tubby like protein 2"
                     /codon_start=1
                     /product="tubby-related protein 2"
                     /protein_id="NP_003314.2"
                     /db_xref="CCDS:CCDS12739.1"
                     /db_xref="GeneID:7288"
                     /db_xref="HGNC:HGNC:12424"
                     /db_xref="MIM:602309"
                     /translation="MSQDNDTLMRDILGHELAAMRLQKLEQQRRLFEKKQRQKRQELL
                     MVQANPDASPWLWRSCLREERLLGDRGLGNPFLRKKVSEAHLPSGIHSALGTVSCGGD
                     GRGERGLPTPRTEAVFRNLGLQSPFLSWLPDNSDAELEEVSVENGSVSPPPFKQSPRI
                     RRKGWQAHQRPGTRAEGESDSQDMGDAHKSPNMGPNPGMDGDCVYENLAFQKEEDLEK
                     KREASESTGTNSSAAHNEELSKALKGEGGTDSDHMRHEASLAIRSPCPGLEEDMEAYV
                     LRPALPGTMMQCYLTRDKHGVDKGLFPLYYLYLETSDSLQRFLLAGRKRRRSKTSNYL
                     ISLDPTHLSRDGDNFVGKVRSNVFSTKFTIFDNGVNPDREHLTRNTARIRQELGAVCY
                     EPNVLGYLGPRKMTVILPGTNSQNQRINVQPLNEQESLLSRYQRGDKQGLLLLHNKTP
                     SWDKENGVYTLNFHGRVTRASVKNFQIVDPKHQEHLVLQFGRVGPDTFTMDFCFPFSP
                     LQAFSICLSSFN"
     exon            189..240
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            241..367
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..505
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..670
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            671..792
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1104
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1217
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1332
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1431
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1603
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1763
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1741..1746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /note="hexamer: AATAAA"
     polyA_site      1763
                     /gene="TULP2"
                     /gene_synonym="CT65; TUBL2"
                     /note="major polyA site"
ORIGIN      
        1 gttactttgt tggaagtgga gagtggaggg tcagaaggga gtggaccagt tcaggtccca
       61 gagggaatcc tccctccctc tgagccgtct ttcttctcct ccctatttcg cagatatccc
      121 gagattaggt ccccagcttc caaagagagg atcagaatgt ctcaggataa tgacacattg
      181 atgagagaca tcctggggca tgagctcgct gctatgaggc tgcagaagct ggaacagcag
      241 cggcggctgt ttgaaaagaa gcagcgacag aagcgccagg agctcctcat ggttcaggcc
      301 aatcctgacg cttccccgtg gctttggcgc tcttgtctgc gggaggagcg ccttttaggt
      361 gacagaggcc ttgggaaccc tttcctccgg aagaaagtgt cagaggcaca tctgccctct
      421 ggcatccaca gtgccctggg caccgtgagc tgtggtggag acggcagggg cgagcgcggc
      481 ctcccgacac cgcggacaga agcagtgttc aggaatctcg gtctccagtc ccctttctta
      541 tcctggctcc cagacaattc cgatgcagaa ttggaggaag tctccgtgga gaatggttcc
      601 gtctctcccc caccttttaa acagtctccg agaatccgac gcaagggttg gcaagcccac
      661 caacgacctg ggacccgtgc agagggtgag agtgactccc aggatatggg agatgcacac
      721 aagtcaccca atatgggacc aaaccctgga atggatggtg actgtgtata tgaaaacttg
      781 gccttccaaa aggaagaaga cttggaaaag aagagagagg cctctgagtc tacagggacg
      841 aactcctcag cagcacacaa cgaagagttg tccaaggccc tgaaaggcga gggtggcacg
      901 gacagcgacc atatgaggca cgaagcctcc ttggcaatcc gctccccctg ccctgggctg
      961 gaggaggaca tggaagccta cgtgctgcgg ccagcgctcc cgggcaccat gatgcagtgc
     1021 tacctcaccc gtgacaagca cggcgtggac aagggcttgt tccccctcta ctacctctac
     1081 ctggagacct ctgacagcct gcagcgcttc ctcctggctg ggcgaaagag aagaaggagc
     1141 aaaacttcta attacctcat ctccctggat cctacacacc tatctcggga cggggacaat
     1201 ttcgtgggca aagtcagatc caatgtcttc agcaccaagt tcaccatctt tgacaatggg
     1261 gtgaatcctg accgggagca tttaaccagg aatactgccc ggatcagaca ggagctgggg
     1321 gctgtgtgtt atgagcccaa cgtcttagga tacctggggc ctcggaaaat gactgtgatt
     1381 ctcccaggaa ccaacagcca gaaccagcga atcaatgtcc agccactaaa tgaacaggag
     1441 tcgctactga gtcgttacca acgtggggac aaacaagggt tgcttttgtt gcacaacaaa
     1501 accccgtcgt gggacaagga gaacggtgtc tacacgctca atttccatgg tcgagtcact
     1561 cgggcttcgg tgaagaactt ccaaatcgtg gatcccaaac accaagaaca tctggtgctc
     1621 cagttcggcc gagtgggccc agacacattc accatggact tctgctttcc atttagcccg
     1681 ctccaggcct tcagcatctg cttgtccagt ttcaattaga agctggctgt tgaataactc
     1741 aataaaatac catacccttg cca
//
