LOCUS       NM_001396518            7474 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens taurine up-regulated 1 (TUG1), transcript variant 2,
            mRNA.
ACCESSION   NM_001396518
VERSION     NM_001396518.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7474)
  AUTHORS   Zhan,M., Xu,H., Yu,G., Chen,Q., Yang,R., Chen,Y., Ge,J., Wang,Z.,
            Yang,R. and Xu,B.
  TITLE     Androgen receptor deficiency-induced TUG1 in suppressing
            ferroptosis to promote benign prostatic hyperplasia through the
            miR-188-3p/GPX4 signal pathway
  JOURNAL   Redox Biol 75, 103298 (2024)
   PUBMED   39121689
  REMARK    GeneRIF: Androgen receptor deficiency-induced TUG1 in suppressing
            ferroptosis to promote benign prostatic hyperplasia through the
            miR-188-3p/GPX4 signal pathway.
REFERENCE   2  (bases 1 to 7474)
  AUTHORS   Rasaei,N., Esmaeili,F., Khadem,A., Yekaninejad,M.S. and Mirzaei,K.
  TITLE     lncRNA TUG1 transcript levels and psychological disorders: insights
            into interplay of glycemic index and glycemic load
  JOURNAL   BMC Med Genomics 17 (1), 221 (2024)
   PUBMED   39198825
  REMARK    GeneRIF: lncRNA TUG1 transcript levels and psychological disorders:
            insights into interplay of glycemic index and glycemic load.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7474)
  AUTHORS   Gu,X., Song,Y., Liu,X., Cheng,Z., Min,J. and Zhang,Y.
  TITLE     METTL14-Mediated m6A Modification of TUG1 Represses Ferroptosis in
            Alzheimer's Disease via Inhibiting GDF15 Ubiquitination
  JOURNAL   Front Biosci (Landmark Ed) 29 (8), 298 (2024)
   PUBMED   39206905
  REMARK    GeneRIF: METTL14-Mediated m6A Modification of TUG1 Represses
            Ferroptosis in Alzheimer's Disease via Inhibiting GDF15
            Ubiquitination.
REFERENCE   4  (bases 1 to 7474)
  AUTHORS   Da,M., Zhuang,J., Zhou,Y., Qi,Q. and Han,S.
  TITLE     Role of long noncoding RNA taurine-upregulated gene 1 in cancers
  JOURNAL   Mol Med 27 (1), 51 (2021)
   PUBMED   34039257
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7474)
  AUTHORS   Lewandowski,J.P., Dumbovic,G., Watson,A.R., Hwang,T.,
            Jacobs-Palmer,E., Chang,N., Much,C., Turner,K.M., Kirby,C.,
            Rubinstein,N.D., Groff,A.F., Liapis,S.C., Gerhardinger,C.,
            Bester,A., Pandolfi,P.P., Clohessy,J.G., Hoekstra,H.E.,
            Sauvageau,M. and Rinn,J.L.
  TITLE     The Tug1 lncRNA locus is essential for male fertility
  JOURNAL   Genome Biol 21 (1), 237 (2020)
   PUBMED   32894169
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7474)
  AUTHORS   Fu,C., Chen,M., Hu,S. and Huang,J.
  TITLE     Taurine up-regulated gene 1 and disease development
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 45 (9), 1127-1135 (2020)
   PUBMED   33051429
  REMARK    GeneRIF: Taurine up-regulated gene 1 and disease development.',
            trans '1.
REFERENCE   7  (bases 1 to 7474)
  AUTHORS   van Heesch,S., Witte,F., Schneider-Lunitz,V., Schulz,J.F.,
            Adami,E., Faber,A.B., Kirchner,M., Maatz,H., Blachut,S.,
            Sandmann,C.L., Kanda,M., Worth,C.L., Schafer,S., Calviello,L.,
            Merriott,R., Patone,G., Hummel,O., Wyler,E., Obermayer,B.,
            Mucke,M.B., Lindberg,E.L., Trnka,F., Memczak,S., Schilling,M.,
            Felkin,L.E., Barton,P.J.R., Quaife,N.M., Vanezis,K., Diecke,S.,
            Mukai,M., Mah,N., Oh,S.J., Kurtz,A., Schramm,C., Schwinge,D.,
            Sebode,M., Harakalova,M., Asselbergs,F.W., Vink,A., de Weger,R.A.,
            Viswanathan,S., Widjaja,A.A., Gartner-Rommel,A., Milting,H., Dos
            Remedios,C., Knosalla,C., Mertins,P., Landthaler,M., Vingron,M.,
            Linke,W.A., Seidman,J.G., Seidman,C.E., Rajewsky,N., Ohler,U.,
            Cook,S.A. and Hubner,N.
  TITLE     The Translational Landscape of the Human Heart
  JOURNAL   Cell 178 (1), 242-260 (2019)
   PUBMED   31155234
  REMARK    GeneRIF: Figure 4G shows that this RNA actually encodes a small
            protein localized to mitochondria.
REFERENCE   8  (bases 1 to 7474)
  AUTHORS   Yang,L., Lin,C., Liu,W., Zhang,J., Ohgi,K.A., Grinstein,J.D.,
            Dorrestein,P.C. and Rosenfeld,M.G.
  TITLE     ncRNA- and Pc2 methylation-dependent gene relocation between
            nuclear structures mediates gene activation programs
  JOURNAL   Cell 147 (4), 773-788 (2011)
   PUBMED   22078878
  REMARK    GeneRIF: Pc2, methylation controls the protein's interaction with
            two distinct ncRNAs, TUG1 and NEAT2, which results in the exclusive
            subnuclear localization of methylated and unmethylated Pc2 in
            Polycomb bodies and interchromatin granules, respectively.
            Erratum:[Cell. 2013 Oct 10;155(2):478]
REFERENCE   9  (bases 1 to 7474)
  AUTHORS   Rapicavoli,N.A. and Blackshaw,S.
  TITLE     New meaning in the message: noncoding RNAs and their role in
            retinal development
  JOURNAL   Dev Dyn 238 (9), 2103-2114 (2009)
   PUBMED   19191220
  REMARK    Review article
REFERENCE   10 (bases 1 to 7474)
  AUTHORS   Young,T.L., Matsuda,T. and Cepko,C.L.
  TITLE     The noncoding RNA taurine upregulated gene 1 is required for
            differentiation of the murine retina
  JOURNAL   Curr Biol 15 (6), 501-512 (2005)
   PUBMED   15797018
  REMARK    GeneRIF: taurine upregulated gene 1 (TUG1) is necessary for the
            proper formation of photoreceptors in the developing rodent retina
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004542.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.21549.1,
                                           SRR11853567.19901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000644773.3/ ENSP00000501406.2
            NMD candidate            :: translation inferred from conservation
            non-AUG initiation codon :: PMID: 32894169
            RefSeq Select criteria   :: based on manual assertion,
                                        conservation, expression, longest
                                        protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2515              AC004542.1         123923-126437
            2516-3248           AC004542.1         127513-128245
            3249-7474           AC004542.1         129828-134053
FEATURES             Location/Qualifiers
     source          1..7474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..7474
                     /gene="TUG1"
                     /gene_synonym="LINC00080; NCRNA00080; TI-227H"
                     /note="taurine up-regulated 1"
                     /db_xref="GeneID:55000"
                     /db_xref="HGNC:HGNC:26066"
                     /db_xref="MIM:614971"
     exon            1..2515
                     /gene="TUG1"
                     /gene_synonym="LINC00080; NCRNA00080; TI-227H"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..554
                     /gene="TUG1"
                     /gene_synonym="LINC00080; NCRNA00080; TI-227H"
                     /note="non-AUG (CUG) translation initiation codon; taurine
                     upregulated gene 1"
                     /codon_start=1
                     /product="taurine up-regulated 1"
                     /protein_id="NP_001383447.1"
                     /db_xref="CCDS:CCDS93148.1"
                     /db_xref="GeneID:55000"
                     /db_xref="HGNC:HGNC:26066"
                     /db_xref="MIM:614971"
                     /translation="MARPPPLPGLVGRRNGRAVDRAIGWRLFLLLWHPALGAQARPPR
                     RAPGGRWRSRRVFLLVRRTRAAAYAFAIRRGVVRVVGGGGQLLRPAPGEAAAAAAAGF
                     GAAGEAGVAGAGLEAWRHPSGPARTQLGGQEGAGGWLVVGFLLCLFLLMPP"
     exon            2516..3248
                     /gene="TUG1"
                     /gene_synonym="LINC00080; NCRNA00080; TI-227H"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..7474
                     /gene="TUG1"
                     /gene_synonym="LINC00080; NCRNA00080; TI-227H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6902..6907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUG1"
                     /gene_synonym="LINC00080; NCRNA00080; TI-227H"
                     /note="hexamer: AATAAA"
     polyA_site      6924
                     /gene="TUG1"
                     /gene_synonym="LINC00080; NCRNA00080; TI-227H"
                     /note="major polyA site"
     regulatory      7452..7457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUG1"
                     /gene_synonym="LINC00080; NCRNA00080; TI-227H"
                     /note="hexamer: AATAAA"
     polyA_site      7474
                     /gene="TUG1"
                     /gene_synonym="LINC00080; NCRNA00080; TI-227H"
ORIGIN      
        1 gagcgacgca gccgggacgg tagctgcggt gcggaccgga ggagccatct tgtctcgtcg
       61 ccggggagtc aggcccctaa atcgaagaag ccctggcgcg ccctcccccc ctcccgggtc
      121 tggtagggcg aaggaacggg cgtgcggtcg atcgagcgat cggttggcgg ctctttctcc
      181 tgctctggca tccagctctt ggggcgcagg cccggccgcc gcggcgcgcg cccggtggcc
      241 gttggcgctc gcgccgcgtc tttcttctcg tacgcagaac tcgggcggcg gcctatgcgt
      301 ttgcgattcg acgaggagtc gtccgggtgg tcggcggcgg cgggcagctg ctccgccccg
      361 ctccggggga ggcggcggcg gcagcggccg cgggatttgg agcggccggg gaggcggggg
      421 tggccggggc cggcttggag gcctggcgcc acccttcggg gcctgcaagg acccagttgg
      481 gggggcagga gggggccgga ggatggttgg ttgtgggatt tctactttgc cttttcctcc
      541 ttatgccgcc ttagtgaggg gcgggagctc tggcggcagc cccggggtgg ggagacgagc
      601 tccggagtcg gaagagctgg gttttcttcc gggcctagcc accagttggc ggagtgacct
      661 taggcgagtc actctgtaat ttgtctgcgc ctcagtttcc tcctctgcct atcaatgtgt
      721 gtggggttga aatcgctttg taaactataa agcgtgggtg tacgtaaagg atggttattg
      781 tttataattt tttttgagtt gtaagaaaac ttagcagttc cccaatcctt gggttttgaa
      841 cctgggaacc ttggattgga gttggggatc cccaaacttc ctgaaattgt gggaatgtgc
      901 ggtttggggg aatgatggga atttgtggga atgtgcgttt taggggaatg atgatccatc
      961 gctagcaagt tttccaaggg ggctgtgacc cagaagagtt aagaatcaca atttcttcat
     1021 gctacagaga ggaaactgag gcctagatgt catttgggac ccttcacaac cattttgaag
     1081 ccctgtttga gtccctggga tatgtgagct gtttctatgc ataatggata ttcggggtta
     1141 acaacagtcc cctgcttggc ttctattctg aatccttttc tttcaccatg gggtgcctga
     1201 agggtggctg atgcatatgg tacaatggca cccagtgtaa agcagctaca attaggagtg
     1261 gatgtgttct gtagcatcct atttaaataa gcctatttta tcctttggcc cgtcaactct
     1321 gttatctgct gcttgtactg gtgcctgtac ttttctgact ctcattgacc atattccacg
     1381 accatggttg tcatccatta cttgatccta ctttacatgt ctaggctgtg tggttggtgg
     1441 tgaataggct tctttttaca tggtgctgcc agcccagcta attaatggtg cacgtggact
     1501 tttagcaagc gggctcactg gaagagactg aacctggcat ggaattcctg aagatgtttg
     1561 gggttttttt ctttcttaat cgaaagttaa cattgtctga aaagttttgt tagaactact
     1621 gcggaacctc aaaatcagta gatttggaag tgattcaaag ctaaactttt tccttggccc
     1681 tccttgtgtt ctaattgctt gcaagtgtaa tactaggatg tccaagatgc cagtttttgc
     1741 ttctttgtta gttgtcagct gcttttatca aatttcaggc cattatccaa caaacactat
     1801 aaaaatgttt gaacaattgg atttcaaaca ttttcgtttt gtggagtggt gctcaccaag
     1861 tggtacagcc ctaagcaagt gaacacaaac acatttaagt gtattttgtc tgattagatg
     1921 ttagccagtt atgctatttc attcaaatgt ctgaaaaaat caattgacta ttcccttttc
     1981 ctaaagggca gagacagata atctcacttc cagagaaatg acttggagaa aaaaaagtgt
     2041 tggtcttttt gctcttttgt aattaaatcc ggatgtacct caaaagactt aagactgtgg
     2101 tgataagatg ctttcctcag cagaaaggag ggaaaaaaaa caactggaac tcaaagcttg
     2161 aaattctgtg gcaaaacatg agatgtccag gattggaggt tgaaaagatt tcactacagt
     2221 gttctgcaat agttggagca gataactttc agtgtagcca cagccatgga ctccagattt
     2281 ccagattttc aagacctgga cctggaaccc gaaagagctt gtcacgatgc ggcaggaaca
     2341 ctggaggtag attttttttt atttttgaat tttgggactg ttgaccttgc tgtgagaaaa
     2401 gagacaacga ctgagcaagc actaccacca gcactgttac tgggaattag aagacctgag
     2461 tttctgtcca gaccctcagt gcaaactgag gatgctccat ccaaagtgaa ttatgtcctg
     2521 tgcctcctga ttgctgagtg ttcacctgga ccttctgact accttccctg tgctattcca
     2581 tcagcctaca gacctggtac ctggattttt gcccgagatg attcctacca ccttactact
     2641 gacgaagaca cccattccag tggaccactg tgacccagga ggcattcagc catcatgatg
     2701 tggcctttac ctccactcct gtcttgttct acccagattc agcacagccc tttatagtga
     2761 agtcagagtc ctcaagccaa atagctaaag ctgttttatc acaacaaagg cctagtttgt
     2821 tccatgagtg tgcatttcat ttcttcagtt aaagccttca gagacacaca ataaatttgg
     2881 accaggggat tttttagtta ttaatgctct ctgaagaaag gcaacatctt tttgagagca
     2941 gcattggacc acaccccaca atctcaaatg attgaaattc atgaacatct aggatcccgt
     3001 gaaggtcact ggaccctgtt ttttctactt caaatcctgt agtagcctac tgaatgagaa
     3061 aacatattct gacccattgg gatcaaatca aaggcacagt gaactcctca tagcatcttc
     3121 tttggaatta ctcaggaacc agaacttttt acacaaatgt aagaaattct accaaggagt
     3181 ccccttacct aacagcatct cacaaggctg caccagattc cagaaaaggc ttctcttgat
     3241 acatcaagca ttttgtgacc gacttattct tagatcattg gttttccaaa ggctttgtgg
     3301 ccatgaagcc ctttgagtga aaactgtgca gaagcccaga gtaaaagtga agctgctctg
     3361 gatgaagtag tgaagcaaga gtaggggcct gaatcctgct acaactatct tcctttacca
     3421 ccgtggtgac acctaagggg acttccttac aacaccttga actcttccga acacagtttg
     3481 aaaaccactg ccccagacag caatatgttt gacctgaatg gcattccaat cttttctgta
     3541 cctccactca gcacagttca tgttcagtag atgctgaaca ttcttagaaa tactgtgtgt
     3601 gaacttagaa aagtgcaaga agacaggcat gtctttgacc ccaggaatga tcatttgctg
     3661 aagatggtgt caagtgaacc tagattaaca gccctccact ccagatggat atccagtgat
     3721 tcctagaatg ggatatagcc agagaacaat tctatgcacc ctacactgac agactccctt
     3781 aagcaacacc agatgctcta ctggtacttg aagtacatga ctttgaagtc ttgaccctcc
     3841 atgaatacct gaattatcag caagcgggtt ttgaagctgg tgcctcattg aggccatatt
     3901 agagcaactt gtacatttga cctcttgtta tcagccatgg tactctactt cgtgtgcaag
     3961 agataactat gaaagccaaa ttcaaatact ggcaacattt cctaaagggg ctcaatatct
     4021 atcattcgtc ttcttttcca aactacacat cactgtatga ctcaaccagt agcagttata
     4081 ttgccccttg gtttttattc agtttaacta ctgtttccaa gataaatgag ctaataagct
     4141 ttaaaaaaaa aaaaaaaaaa ggctgaattc ttttttcttc atcactggca tatctgccta
     4201 ttctccagaa ttattatgac tattcagctc actttaacag ttgaacttca agcgacaatc
     4261 tttgaacacc ccttctcatg tgatttaaaa tgaaaccatt tggaaaagtt tcttctagcc
     4321 agtaatagat ttttttttta attgctctgc cttgtgccga gagatgttct tttaagatga
     4381 atcttttgat gtctgatacc accaaatata ggtggtaggg agagttggag gctggccctt
     4441 tgagcaggcc attagcttac ttgctgggca tttccgatag cttattgcct acctttttgc
     4501 tggaaacaaa ctgatttgaa aaacaaaatc tatgaagact gcagctaagg attttatcgg
     4561 tagacttaag agcttttgtc cttgtggata ttttagtgga accacatcag tctcaatact
     4621 gtcattttac actgactcag agcagctgac ttcattcctt gccatgatat atatttaagg
     4681 caggcattgt aacagacata aagacaactt atctgtttca gcaggaagga ttcagtttat
     4741 gaactctcag accagatcat gttgaacaag gagactttga tgtgtgtcat gagaaaactc
     4801 attctttact tcccagtcaa tttaaaggcc agctatcctg agctactcga atgaatgcac
     4861 tggttaaaca ttggaaatag tttgtttata tccttgtctc tctctaggcc aattgtgatt
     4921 acatgactcg actctacatc tcgtcaaaca aggcctaggt ctggttgctg tagactgctc
     4981 gccctcaaca aataaaatct ggttgactag cctccttgta tatacaacta ttatttgtta
     5041 agaagaaatt atcgtcaatt ttctactacc ttccaattgt cagctctttt tttcctctct
     5101 ggtttttcct atactttaca gaaaaagaca ttgatctata ctgccattcc ctctaatcct
     5161 gccatactca gtcaaaagga atgacttaag atgaagatga tcatctgctc gagtctaaaa
     5221 tatacattgt atataagaat tggtgattag aaaagcaaaa aacctaaaac ttaaatctag
     5281 gagtctgtat actgtctcca tgtctccatg cctcagatct catctaaatc tttgaacagc
     5341 accattcaac caatctgagg ccttgacttg cttgtaagat gattctcaga gatcggctga
     5401 gttaaaaaag atgacgactt gattaccaaa gaaagtaggg ccaactttga caaatctggc
     5461 tctgctgacc ctgtcactcc cagatgtagc atagactcct aaacagaacc tcaagtctga
     5521 ttgaggataa ggccttctcc tgagctgaaa gttctttggc agatgagcaa gaaactgaaa
     5581 gctgatgtac ctgactggct ctgtaagatc agaaaactgt atccagaata agccctatgg
     5641 attaacccct gagtacccag agtaaaaact aatttacaga acttccttat tgatctgctg
     5701 gttcttccag atcatattct ggctattggt atggctggcc tttctgaagg taccctgctt
     5761 gtctattttc ctgactcagc tcttgcctgc ctttttcaca tgttgctgca attagactca
     5821 ccgtgaggac tacagtcaat ttcagtctat cttgtgccca atacaacaag gatttttaat
     5881 agtaacaacc cacacctcac ccactaggac tcaatgttca caacaggaag gaccattgct
     5941 gcatactcct tgaccagcaa cttttttgaa gatattttta agtgcagagt aggcctctat
     6001 tcctgtatgt aattgttcat tttcagcacc tggaacctca tctatcgggt ctggaaggaa
     6061 tacagcagtt cgaaagccgc gtccatttct ctccttcagt agtgcagaaa tgagtccgat
     6121 tcaccagtac acacagaact gtaccagttc aacctagcaa aagaagaaaa gtttccactg
     6181 tacttaaaat ttacagctga ctcaaattgc ctcacagaat tatttgatgt agaaggctag
     6241 ttgtcttact tcagatcagc aggacagttg ggctctcaga ctcatgacca ctgagtttgc
     6301 ttgtgttgaa actgtggttt catccaacat atgctattgg acatgattat tattccattc
     6361 aaatggatta cagacttctt gaggacagga caaacttatc tctcatggtg tttttttaga
     6421 atacttttat aaccaaggaa gaaaccatgc cagctgttac cattcaactt cttaagcaga
     6481 gattaagctt tttcatatct gttcttatcc tggacatcag tagtttttaa ttgcccagca
     6541 tccgttccat cttgtaacaa ctccctgatg tttcttaaaa ccacctcttc ctattttcag
     6601 tctgtggttt ggacagtctg acccaacctt gagctttgtg ggtgaacatg taattcagac
     6661 ctcatcaatc agcaaatcca tctgaactgt ggaggagaag ctctctttac tgagggtgct
     6721 ttagctttgt aggatgaaaa cctcaaacta acagggccta ccatgtagag aatgaagcca
     6781 gtgcagggga aagcagagcc aaaatatgga gagacttgaa tcctgatgac agcgtttgtg
     6841 cccctggatc caaccgtgcc tgaagctaga atatcccctg gacttttcag ttatgtgaac
     6901 caataaatac ccttttttgc ttaagttact ttgagttggg tttctgttac ttgaaattga
     6961 atccacacta atatatctac caacattgag acttgacaga tccaagtatt tattaagcta
     7021 gaggtcatgg tcactgaaat tactttccaa agtggaagac aaaatgaaac aggaactgag
     7081 ggaatattta agatcccaca gaagcgtaaa aatgacatgg tagaaagtaa tagaaaacct
     7141 aaatgtctgt cattaaagga taggttaagg tgtggttcag ccatatagga atatctcgta
     7201 tctgttaaaa tgaataaagt acattcattg tgtatggaaa aatggccatg atacattagg
     7261 tgaaacaagt tattaataga aaagtgtaca gtgtgaactc attttaaaat gtgtgtgctt
     7321 atgtttataa atgcatagaa aggtctattc acagctttct ttgaacagtg tagatcacat
     7381 gaaactttca actttataca tttctgtatt aatattttac actacccaca ttatttttaa
     7441 actttatttt aaataaagaa tttttaaaat taaa
//
