LOCUS       NM_052903               3744 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens tubulin gamma complex component 5 (TUBGCP5),
            transcript variant 1, mRNA.
ACCESSION   NM_052903
VERSION     NM_052903.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3744)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3744)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   3  (bases 1 to 3744)
  AUTHORS   Izumi,N., Fumoto,K., Izumi,S. and Kikuchi,A.
  TITLE     GSK-3beta regulates proper mitotic spindle formation in cooperation
            with a component of the gamma-tubulin ring complex, GCP5
  JOURNAL   J Biol Chem 283 (19), 12981-12991 (2008)
   PUBMED   18316369
  REMARK    GeneRIF: GSK-3beta regulates the localization of gamma-tubulin ring
            complex, including GCP5, to the spindle poles, thereby controlling
            the formation of proper mitotic spindles
REFERENCE   4  (bases 1 to 3744)
  AUTHORS   Bittel,D.C., Kibiryeva,N. and Butler,M.G.
  TITLE     Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and
            behavioral outcomes in Prader-Willi syndrome
  JOURNAL   Pediatrics 118 (4), e1276-e1283 (2006)
   PUBMED   16982806
  REMARK    GeneRIF: quantitated mRNA levels of NIPA2, NIPA2,l CYFIP1, and GCP5
            in Prader-Willi syndrome and correlated levels with psychological
            and behavior scales
REFERENCE   5  (bases 1 to 3744)
  AUTHORS   Chai,J.H., Locke,D.P., Greally,J.M., Knoll,J.H., Ohta,T., Dunai,J.,
            Yavor,A., Eichler,E.E. and Nicholls,R.D.
  TITLE     Identification of four highly conserved genes between breakpoint
            hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes
            deletion region that have undergone evolutionary transposition
            mediated by flanking duplicons
  JOURNAL   Am J Hum Genet 73 (4), 898-925 (2003)
   PUBMED   14508708
  REMARK    GeneRIF: located in the genomic domain between break points 1 and 2
            on chromosome 15, of the Prader-Willi/Angelman syndromes
REFERENCE   6  (bases 1 to 3744)
  AUTHORS   Takahashi,M., Yamagiwa,A., Nishimura,T., Mukai,H. and Ono,Y.
  TITLE     Centrosomal proteins CG-NAP and kendrin provide microtubule
            nucleation sites by anchoring gamma-tubulin ring complex
  JOURNAL   Mol Biol Cell 13 (9), 3235-3245 (2002)
   PUBMED   12221128
REFERENCE   7  (bases 1 to 3744)
  AUTHORS   Haren,L. and Merdes,A.
  TITLE     Direct binding of NuMA to tubulin is mediated by a novel sequence
            motif in the tail domain that bundles and stabilizes microtubules
  JOURNAL   J Cell Sci 115 (Pt 9), 1815-1824 (2002)
   PUBMED   11956313
REFERENCE   8  (bases 1 to 3744)
  AUTHORS   Murphy,S.M., Preble,A.M., Patel,U.K., O'Connell,K.L., Dias,D.P.,
            Moritz,M., Agard,D., Stults,J.T. and Stearns,T.
  TITLE     GCP5 and GCP6: two new members of the human gamma-tubulin complex
  JOURNAL   Mol Biol Cell 12 (11), 3340-3352 (2001)
   PUBMED   11694571
REFERENCE   9  (bases 1 to 3744)
  AUTHORS   Hsu,H.L. and Yeh,N.H.
  TITLE     Dynamic changes of NuMA during the cell cycle and possible
            appearance of a truncated form of NuMA during apoptosis
  JOURNAL   J Cell Sci 109 (Pt 2), 277-288 (1996)
   PUBMED   8838651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB067486.2 and BC071560.1.
            
            On Nov 23, 2018 this sequence version replaced NM_052903.5.
            
            Transcript Variant: This variant (1) encodes isoform a. Isoforms a
            and b are identical in length but differ in their C-termini.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071560.1, AB067486.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615383.5/ ENSP00000480316.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3743              AB067486.2         19-3761
            3744-3744           BC071560.1         3744-3744
FEATURES             Location/Qualifiers
     source          1..3744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q11.2"
     gene            1..3744
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /note="tubulin gamma complex component 5"
                     /db_xref="GeneID:114791"
                     /db_xref="HGNC:HGNC:18600"
                     /db_xref="MIM:608147"
     exon            1..172
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..3101
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /note="isoform a is encoded by transcript variant 1;
                     gamma-tubulin complex component GCP5; gamma-tubulin
                     complex component 5; tubulin gamma complex associated
                     protein 5"
                     /codon_start=1
                     /product="gamma-tubulin complex component 5 isoform a"
                     /protein_id="NP_443135.3"
                     /db_xref="CCDS:CCDS73698.1"
                     /db_xref="GeneID:114791"
                     /db_xref="HGNC:HGNC:18600"
                     /db_xref="MIM:608147"
                     /translation="MARHGPPWSRLDAQQERDVRELVRGVAGLQDEADPNFQLALNFA
                     WSNFRFHRFLDVNSHKIEKTIEGIYEKFVIHSDLSKAASWKRLTEEFLNAPLPSIKEI
                     KTDAHYSILSLLLCLSDSPSNSSYVETPRNKEVEKKDDFDWGKYLMEDEEMDIGPYMD
                     TPNWSEESEEENDQQPLSREDSGIQVDRTPLEEQDQNRKLDPCISWKDEPDDRSWLEH
                     HVVHQYWTARPSQFPHSLHLHSNLAAVWDQHLYSSDPLYVPDDRVLVTETQVIRETLW
                     LLSGVKKLFIFQLIDGKVTVRNNIIVTHLTHSCLRSVLEQIAAYGQVVFRLQEFIDEV
                     MGHSSESMLPGSGSVPKKSTEAPFRTYQAFMWALYKYFISFKEELAEIEKCIINNDTT
                     ITLAIVVDKLAPRLSQLKVLHKVFSTGVAEVPPDTRNVVRASHLLNTLYKAILEYDNV
                     GEASEQTVSLLFSLWVETVRPYLQTVDEWIVHGHLWDGAREFIIQRNKNVPVNHRDFW
                     YATYTLYSVSEKTENEEKMSDNASASSGSDQGPSSRQHTMVSFLKPVLKQIIMAGKSM
                     QLLKNLQCAESTTCQAGARDAERKSLYTLFLESVQSRLRHGEDSTPQVLTEQQATKEN
                     LMKMQSIAESHLELDDVHDPLLAINFARMYLEQSDFHEKFAGGDVCVDRSSESVTCQT
                     FELTLRSCLYPHIDKQYLDCCGNLMQTLKKDYRLVEYLQAMRNFFLMEGGDTMYDFYT
                     SIFDKIREKETWQNVSFLNVQLQEAVGQRYPEDSSRLSISFENVDTAKKKLPVHILDG
                     LTLSYKVPWPVDIVISLECQKIYNQVFLLLLQIKWAKYSLDVLLFGELVSTAEKPRLK
                     EGLIHEQDTVAQFGPQKEPVRQQIHRMFLLRVKLMHFVNSLHNYIMTRILHSTGLEFQ
                     HQVEEAKDLDQLIKIHYRYLSTIHDRCLLREKVSFVKEAIMKVLNLALMFADGWQAGL
                     GTWRMESIEKMESDFKNCHMFLVTILNKAVCRGSFPHLESLALSLMAGMEQS"
     exon            173..226
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            227..335
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            336..432
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            433..512
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            513..648
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            649..763
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            764..853
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            854..947
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1194
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1397
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1513
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1782
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1981
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2170
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2353
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2438
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2559
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2738
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2864
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..2953
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3054
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3744
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3721..3726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /note="hexamer: AATAAA"
     polyA_site      3744
                     /gene="TUBGCP5"
                     /gene_synonym="GCP5"
                     /note="major polyA site"
ORIGIN      
        1 agacgcgcgc tgcaggagcg cggaacatgg cgcggcacgg gccaccgtgg agtcggttgg
       61 acgcgcagca ggagcgcgac gtgcgggagc tcgtccgggg tgtcgccggc ctccaggacg
      121 aggcagaccc caacttccag ctcgccctaa acttcgcctg gtccaacttc agatttcatc
      181 gtttcttgga tgtcaacagc cacaaaatag aaaaaacaat cgaaggaatt tatgaaaaat
      241 ttgtcattca ttctgatcta agcaaagctg ctagttggaa gagattaacg gaggaatttc
      301 taaatgcacc acttcccagt ataaaggaaa taaagacaga tgcacattat tccatactgt
      361 cacttcttct gtgtctgtca gactctcctt caaacagcag ttatgtggag acaccaagaa
      421 ataaagaagt ggaaaagaaa gatgatttcg actggggaaa atacttgatg gaagatgaag
      481 aaatggacat tggtccgtac atggacacac caaattggtc tgaagaaagt gaagaggaaa
      541 atgatcaaca gcccttaagc agagaggact ctggaattca ggtagacagg acaccgttag
      601 aagaacaaga tcaaaacaga aaactggatc cttgtatcag ttggaaagat gagccagatg
      661 accgaagctg gctggaacat catgtggtcc atcagtactg gacagccagg ccctcccagt
      721 ttcctcatag tttacatttg cactctaatt tagctgctgt ctgggaccaa cacttgtaca
      781 gcagtgatcc attgtatgtt ccagatgaca gggttttggt tactgagact caggttattc
      841 gggaaaccct atggttactt tcaggagtga aaaagctctt tatatttcag ttgatagatg
      901 ggaaggtaac tgtgagaaac aatattatag taactcattt aacacatagc tgtttacgat
      961 ctgtgctgga acaaatagca gcatatggcc aggttgtgtt tcgactccag gagttcattg
     1021 atgaagtcat gggacacagt tctgagagca tgctgcctgg aagtgggtct gttcctaaga
     1081 agtcaactga agctcccttt agaacctacc aggctttcat gtgggccctg tacaaatatt
     1141 tcattagttt caaagaggaa cttgcagaaa ttgagaagtg catcatcaat aatgatacta
     1201 caataactct tgcaatagtg gtggacaagt tggcacctcg attgtctcag ctcaaggttc
     1261 tgcacaaagt gtttagtact ggagtagcag aagttccacc tgatactcga aatgtcgtcc
     1321 gggcctctca cctgcttaac accctgtaca aggccattct tgaatatgac aatgttggag
     1381 aagcctctga gcaaaccgtc tccctccttt tctctctctg ggtggaaacg gtgcggcctt
     1441 acctgcagac ggtggacgag tggatcgtgc acgggcacct gtgggatggc gccagggagt
     1501 tcatcatcca gagaaacaaa aatgttccag ttaatcacag agacttctgg tatgcaactt
     1561 acacgttata tagcgtatca gaaaagacag aaaatgaaga aaaaatgagt gataacgcta
     1621 gtgcgagttc cggcagtgac caggggccct ccagcaggca gcacaccatg gtgtccttcc
     1681 tcaaacctgt cctgaagcag atcataatgg ctggcaagtc gatgcagctg ctgaagaacc
     1741 tgcagtgtgc ggagagcacc acctgccagg caggagccag agatgcagaa agaaaaagtt
     1801 tatacactct ctttctggaa tctgtacagt cccgtcttcg acatggagaa gattccactc
     1861 cacaggttct tactgagcaa caggcaacca aggagaacct gatgaagatg cagtccattg
     1921 ctgaaagcca tcttgaactg gatgatgttc atgatccact gcttgccatt aactttgcaa
     1981 ggatgtattt ggagcagagt gactttcacg agaagtttgc tggtggtgat gtatgtgtgg
     2041 atagatcatc ggaatctgtg acatgccaga cttttgaatt aacgctgaga tcctgcctct
     2101 atcctcatat tgacaagcag tatctagatt gctgtggaaa tctcatgcaa actctaaaaa
     2161 aagattacag gttggtagaa tacttgcaag ctatgaggaa ttttttctta atggaaggag
     2221 gagataccat gtatgacttc tacacgtcaa tttttgataa aataagagaa aaggaaacat
     2281 ggcagaatgt gtcttttctt aatgtccaac tccaagaagc agtaggacag cgttatcctg
     2341 aagatagttc acgtctatct atatcttttg aaaatgttga cacagctaag aagaagctgc
     2401 ctgttcatat cttagatggt ctgaccctca gctacaaggt cccatggccc gtggacattg
     2461 ttataagttt ggaatgtcaa aaaatttata atcaagtgtt tcttctctta ttgcaaataa
     2521 agtgggcaaa atatagtctg gatgttttac tttttggtga actggttagt actgcagaaa
     2581 aaccacgact taaagaaggc cttatacatg aacaagacac agttgctcag ttcggaccac
     2641 aaaaagaacc agtaagacag cagattcatc gcatgttcct cttaagagtg aagctcatgc
     2701 atttcgtgaa cagcttgcac aactacatca tgaccaggat tctacacagt acagggctgg
     2761 agtttcaaca tcaagtcgag gaagccaagg atttagatca attgattaaa attcactata
     2821 ggtatctgtc aaccatccat gaccggtgtc tgctgagaga aaaggtcagc tttgtgaaag
     2881 aagctatcat gaaggtgttg aacttggctc tcatgtttgc agacggttgg caggcaggcc
     2941 tgggcacttg gcgaatggaa tctatagaga aaatggaatc tgattttaaa aactgccata
     3001 tgtttcttgt aaccatttta aacaaagccg tctgtagagg atcctttccc catttggaat
     3061 ctctagcgtt gtcactcatg gctggcatgg aacaaagtta aatgtcttca gcgtaataaa
     3121 tatctccgac tttgtcatca tacatgtaca tttccaccat gtgcagctga aaagtgaaaa
     3181 tatttttatt ttggtttatt tgtaaaactt gtccacagtc agcctggcac agtcgctcat
     3241 gcctctaatc ccagcacgat gggaggccaa gacaggcaga tcacttgagc ccaggagttt
     3301 gaggccagcc tgggcaacat ggtgaaaccc ggtgtctacc aaaaatacaa aatgtatcca
     3361 gacatggtgg tgtgtacctg tagtcccagc tactcaggag gcaaagatgg gaggattact
     3421 tgagcccagg aggtcaaggc tacagtgagc catgattgca ctactgcagt gcaacctggg
     3481 tgacagagtg agaccctgac tcagaaagaa ccacttgccc acagtccaga cagatggatt
     3541 gtaggtgggt tttctggaga ttagtagata ctgtatagag ttgtatacat aaaattgtgt
     3601 cagtagtaca aagtgtatat aggctgttta ctcttacatt tcctactgta agatacagat
     3661 ttatggtact gataccttta aattatatca tattttgaaa atgtaattac tgatattcaa
     3721 aataaattaa aggacttaaa atca
//
