LOCUS       NM_006322               3879 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens tubulin gamma complex component 3 (TUBGCP3),
            transcript variant 1, mRNA.
ACCESSION   NM_006322
VERSION     NM_006322.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3879)
  AUTHORS   Wang,Y., Wang,H., Li,C., Zhang,J., Chu,Z., Liu,P., Zhang,X. and
            Gu,X.
  TITLE     CircTUBGCP3 Contributes to the Malignant Progression of Rectal
            Cancer
  JOURNAL   Dig Dis Sci 67 (7), 2957-2970 (2022)
   PUBMED   34515875
  REMARK    GeneRIF: CircTUBGCP3 Contributes to the Malignant Progression of
            Rectal Cancer.
REFERENCE   2  (bases 1 to 3879)
  AUTHORS   Cukier,C.D., Tourdes,A., El-Mazouni,D., Guillet,V., Nomme,J.,
            Mourey,L., Milon,A., Merdes,A. and Gervais,V.
  TITLE     NMR secondary structure and interactions of recombinant human
            MOZART1 protein, a component of the gamma-tubulin complex
  JOURNAL   Protein Sci 26 (11), 2240-2248 (2017)
   PUBMED   28851027
  REMARK    GeneRIF: NMR secondary structure and interactions of recombinant
            human MOZART1 protein with its binding partner, GCP3, has been
            presented.
REFERENCE   3  (bases 1 to 3879)
  AUTHORS   Draberova,E., D'Agostino,L., Caracciolo,V., Sladkova,V.,
            Sulimenko,T., Sulimenko,V., Sobol,M., Maounis,N.F., Tzelepis,E.,
            Mahera,E., Kren,L., Legido,A., Giordano,A., Mork,S., Hozak,P.,
            Draber,P. and Katsetos,C.D.
  TITLE     Overexpression and Nucleolar Localization of gamma-Tubulin Small
            Complex Proteins GCP2 and GCP3 in Glioblastoma
  JOURNAL   J Neuropathol Exp Neurol 74 (7), 723-742 (2015)
   PUBMED   26079448
  REMARK    GeneRIF: This study demonstrated that Overexpression and Nucleolar
            Localization gcp3 in glioblastoma.
REFERENCE   4  (bases 1 to 3879)
  AUTHORS   Riehlman,T.D., Olmsted,Z.T., Branca,C.N., Winnie,A.M., Seo,L.,
            Cruz,L.O. and Paluh,J.L.
  TITLE     Functional replacement of fission yeast gamma-tubulin small complex
            proteins Alp4 and Alp6 by human GCP2 and GCP3
  JOURNAL   J Cell Sci 126 (Pt 19), 4406-4413 (2013)
   PUBMED   23886939
  REMARK    GeneRIF: Authors show genetically that GCP3/Spc98 function is fully
            conserved with Alp6 across species but that functional differences
            exist between GCP2/Spc97 and Alp4.
REFERENCE   5  (bases 1 to 3879)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 3879)
  AUTHORS   Tassin,A.M., Celati,C., Moudjou,M. and Bornens,M.
  TITLE     Characterization of the human homologue of the yeast spc98p and its
            association with gamma-tubulin
  JOURNAL   J Cell Biol 141 (3), 689-701 (1998)
   PUBMED   9566969
REFERENCE   7  (bases 1 to 3879)
  AUTHORS   Murphy,S.M., Urbani,L. and Stearns,T.
  TITLE     The mammalian gamma-tubulin complex contains homologues of the
            yeast spindle pole body components spc97p and spc98p
  JOURNAL   J Cell Biol 141 (3), 663-674 (1998)
   PUBMED   9566967
REFERENCE   8  (bases 1 to 3879)
  AUTHORS   Navara,C.S., Hewitson,L.C., Simerly,C.R., Sutovsky,P. and
            Schatten,G.
  TITLE     The implications of a paternally derived centrosome during human
            fertilization: consequences for reproduction and the treatment of
            male factor infertility
  JOURNAL   Am J Reprod Immunol 37 (1), 39-49 (1997)
   PUBMED   9138452
  REMARK    Review article
REFERENCE   9  (bases 1 to 3879)
  AUTHORS   Hsu,H.L. and Yeh,N.H.
  TITLE     Dynamic changes of NuMA during the cell cycle and possible
            appearance of a truncated form of NuMA during apoptosis
  JOURNAL   J Cell Sci 109 (Pt 2), 277-288 (1996)
   PUBMED   8838651
REFERENCE   10 (bases 1 to 3879)
  AUTHORS   Lajoie-Mazenc,I., Tollon,Y., Detraves,C., Julian,M., Moisand,A.,
            Gueth-Hallonet,C., Debec,A., Salles-Passador,I., Puget,A.,
            Mazarguil,H. et al.
  TITLE     Recruitment of antigenic gamma-tubulin during mitosis in animal
            cells: presence of gamma-tubulin in the mitotic spindle
  JOURNAL   J Cell Sci 107 (Pt 10), 2825-2837 (1994)
   PUBMED   7876350
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC046634.2, AF042378.1 and AA720688.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006322.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.10068.1, BC046634.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261965.8/ ENSP00000261965.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3125              BC046634.2         16-3140
            3126-3635           AF042378.1         3037-3546
            3636-3879           AA720688.1         18-261              c
FEATURES             Location/Qualifiers
     source          1..3879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..3879
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /note="tubulin gamma complex component 3"
                     /db_xref="GeneID:10426"
                     /db_xref="HGNC:HGNC:18598"
                     /db_xref="MIM:617818"
     exon            1..249
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2897
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gamma-tubulin complex component 3; gamma-ring complex
                     protein 104 kDa; spindle pole body protein Spc98 homolog;
                     tubulin gamma complex associated protein 3"
                     /codon_start=1
                     /product="gamma-tubulin complex component 3 isoform 1"
                     /protein_id="NP_006313.1"
                     /db_xref="CCDS:CCDS9525.1"
                     /db_xref="GeneID:10426"
                     /db_xref="HGNC:HGNC:18598"
                     /db_xref="MIM:617818"
                     /translation="MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFA
                     PTVERDEFLVAEKIKKELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLSLSE
                     DPRRQPSKVSSYATLFAQALPRDAHSTPYYYARPQTLPLSYQDRSAQSAQSSGSVGSS
                     GISSIGLCALSGPAPAPQSLLPGQSNQAPGVGDCLRQQLGSRLAWTLTANQPSSQATT
                     SKGVPSAVSRNMTRSRREGDTGGTMEITEAALVRDILYVFQGIDGKNIKMNNTENCYK
                     VEGKANLSRSLRDTAVRLSELGWLHNKIRRYTDQRSLDRSFGLVGQSFCAALHQELRE
                     YYRLLSVLHSQLQLEDDQGVNLGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRK
                     GGELASAVHAYTKTGDPYMRSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVAS
                     DPTVKTDRLWHDKYTLRKSMIPSFMTMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIA
                     VTKSAESPQDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNKKYSLLDHMQAMRRYL
                     LLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGILETAVRATNAQFDSPEILRRLDVR
                     LLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIRK
                     GHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQYYITFEVLECSWDELWNKVQQ
                     AQDLDHIIAAHEVFLDTIISRCLLDSDSRALLNQLRAVFDQIIELQNAQDAIYRAALE
                     ELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIGEFKESIPKMCSQLRILTHFYQG
                     IVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAREPRLRVSLGTRGRRSSHT"
     exon            250..357
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            358..425
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            426..503
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            504..721
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            722..894
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1013
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1139
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1208
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1341
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1508
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1619
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1728
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1918
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2054
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2123
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2259
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2348
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2480
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2621
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2738
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..3879
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3859..3864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /note="hexamer: ATTAAA"
     polyA_site      3879
                     /gene="TUBGCP3"
                     /gene_synonym="104p; ALP6; GCP3; Grip104; SPBC98; Spc98;
                     Spc98p"
                     /note="major polyA site"
ORIGIN      
        1 gcgctttcgg cgggttccgt taaaatggcg ccctggtggc cggcggcgcc cgcgccttag
       61 cctgtcagga gcagggagct tgcggggcgc aggaagggcg cgggccgcgg tccctgcgcg
      121 tgcggcggca gtggcggctc tgcccggacc accgtgcacg gctccgggcg aggatggcga
      181 ccccggacca gaagtcgccg aacgttctgc tgcagaacct gtgctgcagg atcctgggca
      241 ggagcgaagc tgatgtagcc cagcagttcc agtatgctgt gcgggtgatt ggcagcaact
      301 tcgccccaac tgttgaaaga gatgaatttt tagtagctga aaaaatcaag aaagagctta
      361 ttcgacaacg aagagaagca gatgctgcat tattttcaga actccacaga aaacttcatt
      421 cacagggagt tttgaaaaat aaatggtcaa tactctacct cttgctgagc ctcagtgagg
      481 acccacgcag gcagccaagc aaggtttcta gctatgctac gttatttgct caggccttac
      541 caagagatgc ccactcaacc ccttactact atgccaggcc tcagaccctt cccctgagct
      601 accaagatcg gagtgcccag tcagcccaga gctccggcag cgtgggcagc agtggcatca
      661 gcagcattgg cctgtgtgcc ctcagtggcc ccgcgcctgc gccacaatct ctcctcccag
      721 gacagtctaa tcaagctcca ggagtaggag attgccttcg acagcagttg gggtcacgac
      781 tcgcatggac tttaactgca aatcagcctt cttcacaagc cactacctca aaaggtgtcc
      841 ccagtgctgt gtctcgcaac atgacaaggt ccaggagaga aggggatacg ggtggtacta
      901 tggaaattac agaagcagct ctggtaaggg acattttgta cgtctttcag ggcatagatg
      961 gcaaaaacat caaaatgaac aacactgaaa attgttacaa agtagaagga aaggcaaatc
     1021 taagtaggtc tttgagagac acagcagtca ggctttctga gttgggatgg ttgcataata
     1081 aaatcagaag atacacggac cagaggagcc tggaccgctc attcggactc gtcgggcaga
     1141 gcttttgtgc tgccttgcac caggaactca gagaatacta tcgattgctc tctgttttac
     1201 attctcagct acaactagag gatgaccagg gtgtgaattt gggacttgag agtagtttaa
     1261 cacttcggcg cctcctggtt tggacctatg atcccaaaat acgactgaag acccttgcgg
     1321 ccctagtgga ccactgccaa ggaaggaaag gaggtgagct ggcctcagct gtccacgcct
     1381 acacaaaaac aggagacccg tacatgcggt ctctggtgca gcacatcctc agcctcgtgt
     1441 ctcatcctgt tttgagcttc ctgtaccgct ggatatatga tggggagctt gaggacactt
     1501 accacgaatt ttttgtagca tcagatccaa cagttaaaac agatcgactg tggcacgaca
     1561 agtatacttt gaggaaatcg atgattcctt cgtttatgac gatggatcag tctaggaagg
     1621 tccttttgat aggaaaatca ataaatttct tgcaccaagt ttgtcatgat cagactccca
     1681 ctacaaagat gatagctgtg accaagtctg cagagtcacc ccaggacgct gcagacctat
     1741 tcacagactt ggaaaatgca tttcagggga agattgatgc tgcttatttt gagaccagca
     1801 aatacctgtt ggatgttctc aataaaaagt acagcttgct ggaccacatg caggcaatga
     1861 ggcggtacct gcttcttggt caaggagact ttataaggca cttaatggac ttgctaaaac
     1921 cagaacttgt ccgtccagct acgactttgt atcagcataa cttgactgga attctagaaa
     1981 ccgctgtcag agccaccaac gcacagtttg acagtcctga gatcctgcga aggctggacg
     2041 tgcggctgct ggaggtctct ccaggtgaca ctggatggga tgtcttcagc ctcgattatc
     2101 atgttgacgg accaattgca actgtgttta ctcgagaatg tatgagccac tacctaagag
     2161 tatttaactt cctctggagg gcgaagcgga tggaatacat cctcactgac atacggaagg
     2221 gacacatgtg caatgcaaag ctcctgagaa acatgccaga gttctccggg gtgctgcacc
     2281 agtgtcacat tttggcctct gagatggtcc atttcattca tcagatgcag tattacatca
     2341 catttgaggt gcttgaatgt tcttgggatg agctttggaa caaagtccag caggcccagg
     2401 atttggatca catcattgct gcacacgagg tgttcttaga caccatcatc tcccgctgcc
     2461 tgctggacag tgactccagg gcacttttaa atcaacttag agctgtgttt gatcaaatta
     2521 ttgaacttca gaatgctcaa gatgcaatat acagagctgc tctggaagaa ttgcagagac
     2581 gattacagtt tgaagagaaa aagaaacagc gtgaaattga gggccagtgg ggagtgacgg
     2641 cagcagagga agaggaggaa aataagagga ttggagaatt taaagaatct ataccaaaaa
     2701 tgtgctcaca gttgcgaata ttgacccatt tctaccaggg tatcgtgcag cagtttttgg
     2761 tgttactgac gaccagctct gacgagagtc ttcggtttct tagcttcagg ctggacttca
     2821 acgagcatta caaagccagg gagcccaggc tccgtgtgtc tctgggtacc agggggcggc
     2881 gcagctccca cacgtgaagc tcgcggtcct cccagggagc tgcgggtgat gttcgttgca
     2941 ctgctagaca cgaaattccc attgacgtcc tgcaggaact gcatgctgca ggtgtcctgc
     3001 ccttccgccc acgagtgcgc catgtttcag cggagcggcg tgtgggagaa gccacgtcgt
     3061 gtttcacatg tcggagtcga atgcatttgt aaatccctaa gtcaagtagg ctggctgcac
     3121 tgttcacatt tgtctctaaa agtcttcatc gctaaaagat accataattt gctgaggctt
     3181 cttaagcttt ctatgttata atttatattt gtcactttaa aaaatccatt tcttttagaa
     3241 aaaattaggg tgataggata ttcattagtt aagatggtaa cgtcattgct atttttttaa
     3301 catcctcttt agaggtaatt tttgttaaca taaccaaaaa ttaaattgaa acaaaatgtc
     3361 ccaactaaga aaatatatag agcattttat ttttttttag tgttgtaaaa tattaacctc
     3421 tgtgagatcc tttgtatctt aatgcattac ctttacacat atttattctt attttctctc
     3481 ctttcagagt ttacattttt atatttaatt tactatttca gatttttaaa atagtataga
     3541 aaaaagtagg agtgatagag aacaaaaata ctcttataca gtgcaaccca aataccgcga
     3601 atgcatcagc taaagcagcg tgtaaatagg agtgacgaga aagttaatgg agtattttat
     3661 tttcaaagtt cctgataagc attggaaaga aatcgacatg gataatgaag atttcctttt
     3721 tccttgccta ttttttcatt gtaaatattt atatactact gaccaagatg ttggggtggg
     3781 ggggattgtt ttttgtaaaa atgtcattat caggtcacat aaatctgcct ttatgttgca
     3841 taagtgaaaa tttagaaaat taaaagcaat tatctttca
//
