LOCUS       NM_006659               3929 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens tubulin gamma complex component 2 (TUBGCP2),
            transcript variant 2, mRNA.
ACCESSION   NM_006659
VERSION     NM_006659.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3929)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3929)
  AUTHORS   Mitani,T., Punetha,J., Akalin,I., Pehlivan,D., Dawidziuk,M., Coban
            Akdemir,Z., Yilmaz,S., Aslan,E., Hunter,J.V., Hijazi,H.,
            Grochowski,C.M., Jhangiani,S.N., Karaca,E., Fatih,J.M.,
            Iwanowski,P., Gambin,T., Wlasienko,P., Goszczanska-Ciuchta,A.,
            Bekiesinska-Figatowska,M., Hosseini,M., Arzhangi,S., Najmabadi,H.,
            Rosenfeld,J.A., Du,H., Marafi,D., Blaser,S., Teitelbaum,R.,
            Silver,R., Posey,J.E., Ropers,H.H., Gibbs,R.A., Wiszniewski,W.,
            Lupski,J.R., Chitayat,D., Kahrizi,K. and Gawlinski,P.
  CONSRTM   Baylor-Hopkins Center for Mendelian Genomics
  TITLE     Bi-allelic Pathogenic Variants in TUBGCP2 Cause Microcephaly and
            Lissencephaly Spectrum Disorders
  JOURNAL   Am J Hum Genet 105 (5), 1005-1015 (2019)
   PUBMED   31630790
  REMARK    GeneRIF: Pathogenic variants in TUBGCP2 cause an autosomal
            recessive neurodevelopmental trait consisting of a neuronal
            migration disorder.
REFERENCE   3  (bases 1 to 3929)
  AUTHORS   Madarampalli,B., Yuan,Y., Liu,D., Lengel,K., Xu,Y., Li,G., Yang,J.,
            Liu,X., Lu,Z. and Liu,D.X.
  TITLE     ATF5 Connects the Pericentriolar Materials to the Proximal End of
            the Mother Centriole
  JOURNAL   Cell 162 (3), 580-592 (2015)
   PUBMED   26213385
REFERENCE   4  (bases 1 to 3929)
  AUTHORS   Riehlman,T.D., Olmsted,Z.T., Branca,C.N., Winnie,A.M., Seo,L.,
            Cruz,L.O. and Paluh,J.L.
  TITLE     Functional replacement of fission yeast gamma-tubulin small complex
            proteins Alp4 and Alp6 by human GCP2 and GCP3
  JOURNAL   J Cell Sci 126 (Pt 19), 4406-4413 (2013)
   PUBMED   23886939
  REMARK    GeneRIF: Authors show genetically that GCP3/Spc98 function is fully
            conserved with Alp6 across species but that functional differences
            exist between GCP2/Spc97 and Alp4.
REFERENCE   5  (bases 1 to 3929)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 3929)
  AUTHORS   Haren,L. and Merdes,A.
  TITLE     Direct binding of NuMA to tubulin is mediated by a novel sequence
            motif in the tail domain that bundles and stabilizes microtubules
  JOURNAL   J Cell Sci 115 (Pt 9), 1815-1824 (2002)
   PUBMED   11956313
REFERENCE   7  (bases 1 to 3929)
  AUTHORS   Murphy,S.M., Preble,A.M., Patel,U.K., O'Connell,K.L., Dias,D.P.,
            Moritz,M., Agard,D., Stults,J.T. and Stearns,T.
  TITLE     GCP5 and GCP6: two new members of the human gamma-tubulin complex
  JOURNAL   Mol Biol Cell 12 (11), 3340-3352 (2001)
   PUBMED   11694571
REFERENCE   8  (bases 1 to 3929)
  AUTHORS   Murphy,S.M., Urbani,L. and Stearns,T.
  TITLE     The mammalian gamma-tubulin complex contains homologues of the
            yeast spindle pole body components spc97p and spc98p
  JOURNAL   J Cell Biol 141 (3), 663-674 (1998)
   PUBMED   9566967
REFERENCE   9  (bases 1 to 3929)
  AUTHORS   Hsu,H.L. and Yeh,N.H.
  TITLE     Dynamic changes of NuMA during the cell cycle and possible
            appearance of a truncated form of NuMA during apoptosis
  JOURNAL   J Cell Sci 109 (Pt 2), 277-288 (1996)
   PUBMED   8838651
REFERENCE   10 (bases 1 to 3929)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK223586.1, AA377890.1, AF042379.1 and AL592071.13.
            
            On Feb 3, 2020 this sequence version replaced NM_006659.3.
            
            Transcript Variant: This variant (2) lacks an exon in the 5' coding
            region, but maintains the reading frame, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.3560423.1, AK223586.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252936.8/ ENSP00000252936.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2029              AK223586.1         176-2204
            2030-2030           AA377890.1         42-42
            2031-2185           AK223586.1         2206-2360
            2186-2186           AA377890.1         196-196
            2187-2588           AK223586.1         2362-2763
            2589-2872           AF042379.1         2563-2846
            2873-3929           AL592071.13        37519-38575         c
FEATURES             Location/Qualifiers
     source          1..3929
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..3929
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /note="tubulin gamma complex component 2"
                     /db_xref="GeneID:10844"
                     /db_xref="HGNC:HGNC:18599"
                     /db_xref="MIM:617817"
     exon            1..50
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            51..239
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2798
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /note="isoform 2 is encoded by transcript variant 2;
                     gamma-tubulin complex component 2; gamma-ring complex
                     protein 103 kDa; spindle pole body protein Spc97 homolog;
                     hGrip103; tubulin gamma complex associated protein 2"
                     /codon_start=1
                     /product="gamma-tubulin complex component 2 isoform 2"
                     /protein_id="NP_006650.1"
                     /db_xref="CCDS:CCDS7676.1"
                     /db_xref="GeneID:10844"
                     /db_xref="HGNC:HGNC:18599"
                     /db_xref="MIM:617817"
                     /translation="MSEFRIHHDVNELLSLLRVHGGDGAEVYIDLLQKNRTPYVTTTV
                     SAHSAKVKIAEFSRTPEDFLKKYDELKSKNTRNLDPLVYLLSKLTEDKETLQYLQQNA
                     KERAELAAAAVGSSTTSINVPAAASKISMQELEELRKQLGSVATGSTLQQSLELKRKM
                     LRDKQNKKNSGQHLPIFPAWVYERPALIGDFLIGAGISTDTALPIGTLPLASQESAVV
                     EDLLYVLVGVDGRYVSAQPLAGRQSRTFLVDPNLDLSIRELVHRILPVAASYSAVTRF
                     IEEKSSFEYGQVNHALAAAMRTLVKEHLILVSQLEQLHRQGLLSLQKLWFYIQPAMRT
                     MDILASLATSVDKGECLGGSTLSLLHDRSFSYTGDSQAQELCLYLTKAASAPYFEVLE
                     KWIYRGIIHDPYSEFMVEEHELRKERIQEDYNDKYWDQRYTIVQQQIPSFLQKMADKI
                     LSTGKYLNVVRECGHDVTCPVAKEIIYTLKERAYVEQIEKAFNYASKVLLDFLMEEKE
                     LVAHLRSIKRYFLMDQGDFFVHFMDLAEEELRKPVEDITPPRLEALLELALRMSTANT
                     DPFKDDLKIDLMPHDLITQLLRVLAIETKQEKAMAHADPTELALSGLEAFSFDYIVKW
                     PLSLIINRKALTRYQMLFRHMFYCKHVERQLCSVWISNKTAKQHSLHSAQWFAGAFTL
                     RQRMLNFVQNIQYYMMFEVMEPTWHILEKNLKSASNIDDVLGHHTGFLDTCLKDCMLT
                     NPELLKVFSKLMSVCVMFTNCMQKFTQSMKLDGELGGQTLEHSTVLGLPAGAEERARK
                     ELARKHLAEHADTVQLVSGFEATINKFDKNFSAHLLDLLARLSIYSTSDCEHGMASVI
                     SRLDFNGFYTERLERLSAERSQKATPQVPVLRGPPAPAPRVAVTAQ"
     exon            240..368
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            369..545
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            546..705
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            706..913
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1113
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1303
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1449
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1630
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1811
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1984
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2113
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2234
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2378
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2498
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2662
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..3929
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2905..2910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /note="hexamer: TATAAA"
     polyA_site      2924
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /note="major polyA site"
     regulatory      3027..3032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /note="hexamer: ATTACA"
     polyA_site      3064
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
     regulatory      3909..3914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
                     /note="hexamer: AGTAAA"
     polyA_site      3929
                     /gene="TUBGCP2"
                     /gene_synonym="ALP4; GCP-2; GCP2; Grip103; h103p; hGCP2;
                     hSpc97; PAMDDFS; SPBC97; SPC97; Spc97p"
ORIGIN      
        1 acttccgccg ccgtcggggg ctgcgcgggg gctgtggctc cgggactgcg gagaacatat
       61 tgtgatgttc gtgcctcaga gctaaaacta tgagtgaatt tcggattcac catgacgtca
      121 atgaactgct tagcctgctg cgtgtccacg gaggagatgg ggctgaggtc tacattgacc
      181 tgcttcaaaa gaacaggacc ccgtacgtca ctaccactgt ctctgctcac agtgccaagg
      241 ttaaaattgc agagttttct cgtactccag aagactttct aaagaaatat gatgaactga
      301 aatctaaaaa tacaaggaac cttgacccgc tggtgtacct gttgtcaaag ctcacggaag
      361 acaaagagac tctgcagtac ttacaacaga atgcaaaaga aagagctgag cttgcagccg
      421 ctgctgtggg cagcagtacc accagcatca acgtccctgc cgcggcctcc aagatctcca
      481 tgcaggagct tgaggaactg aggaagcagc ttggcagcgt ggccacaggc tccacgctgc
      541 agcagtctct ggaacttaaa agaaagatgc ttcgagacaa gcagaacaaa aaaaattcag
      601 gccagcacct ccccatcttc ccagcatggg tgtatgagag acctgccctg atcggggatt
      661 tcctgattgg tgctggcatc agcacagaca ccgctttgcc gataggcacg ttgcccctgg
      721 cctcgcagga gtcggccgtg gtggaggacc tgctgtacgt gctggtgggc gtggacggga
      781 ggtacgtcag tgctcagccc ctggctggga ggcagagccg gaccttcctc gtggacccca
      841 acctggacct gtccatcagg gagctggtgc acaggatcct cccagtggcc gccagctact
      901 ccgctgtgac caggttcatt gaagagaagt cttccttcga gtacgggcag gtgaaccacg
      961 ccctggcggc cgccatgcgc accctggtga aggagcacct gattctggtg tcacagctgg
     1021 agcagctgca caggcagggc ctcctttcgc tgcagaagct ctggttctac atccagccag
     1081 ccatgcgcac catggacatc ctggcctccc tcgccacctc ggtggacaaa ggcgaatgtc
     1141 ttggggggtc cacgctgagc ctgctccacg acaggagctt cagctacaca ggggacagcc
     1201 aggcgcagga gctatgcctg tacctaacca aggcggccag tgctccctac ttcgaggttc
     1261 tggagaagtg gatctacagg ggcatcatcc acgacccata cagtgagttt atggtcgagg
     1321 agcacgagct gcggaaggag aggatccagg aggattacaa cgacaagtac tgggaccagc
     1381 ggtacaccat cgtccagcag cagatcccgt ccttcctgca gaaaatggcg gacaagatcc
     1441 tcagcacagg aaaatatcta aatgtggtca gagagtgtgg ccatgacgtc acctgcccgg
     1501 tggctaaaga gatcatctac acgttaaaag agcgggcgta tgtggagcag atcgagaagg
     1561 cgtttaacta cgccagcaag gtgctgctgg acttcctgat ggaggagaag gagctggtgg
     1621 ctcacctcag gtccatcaag cgctacttcc tcatggacca gggcgacttc ttcgtgcact
     1681 tcatggacct cgcggaggag gagctccgga agccggtgga ggacatcacg ccccctcgcc
     1741 tggaagcgct cctggagctg gcgctgcgca tgagcacggc caacactgac cccttcaagg
     1801 acgacctcaa gatcgacctg atgccccatg acctcatcac tcagctcttg cgcgtcctgg
     1861 ccatcgagac caagcaggag aaggcgatgg cgcacgccga ccccacggag ctggcgctga
     1921 gcggcctgga ggccttctct ttcgactaca tcgtcaagtg gcccctttcg ctcatcatca
     1981 acaggaaagc cctcactcgc taccagatgc tcttcaggca catgttctac tgcaagcacg
     2041 tggagcggca gctctgcagc gtctggatca gcaacaaaac cgccaagcag cactcgctgc
     2101 actccgccca gtggtttgct ggggctttca ctctgcggca gcgaatgctc aacttcgtcc
     2161 agaatattca atactacatg atgtttgaag tgatggaacc gacctggcac atcctggaga
     2221 aaaacctgaa atccgcctcc aacattgacg acgtccttgg ccaccacaca ggcttcctgg
     2281 acacctgcct gaaggactgc atgctcacca accccgagct gctgaaggtc ttctccaagc
     2341 tcatgtctgt gtgcgtcatg ttcaccaact gcatgcagaa atttacacag agcatgaaat
     2401 tagatggcga gctgggcggg cagacgctgg agcacagcac cgtcctgggg ctgcccgcag
     2461 gggccgagga gcgggcccgg aaggagctcg ccaggaagca cctggctgag cacgcagaca
     2521 ctgtgcagct ggtgtccggc ttcgaggcca ccatcaacaa gtttgacaag aacttctcag
     2581 cccacctgct ggacctcctg gcccggctga gcatctatag caccagtgac tgtgagcacg
     2641 gcatggccag cgtcatctcc aggcttgact tcaatggttt ctacacggag cgcctggagc
     2701 gcctgtctgc agagaggagc cagaaggcca ccccccaagt gcctgtcctg cgggggcccc
     2761 cggctcctgc acccagggtc gcagtcaccg cacagtgagc cctggctgtg acaggaagga
     2821 agggtgtggg gtcagcaggg actggtgcaa atgggtccag aattttcaaa tcgaatgctc
     2881 tgtgttctgt ctttgcagtt taaatataaa gcaggaatga ttgactcagc tcactttgtt
     2941 tctcaaggcg ctgggtttcg ttttatagaa gctgcccagg cagggtggat gtctccctgg
     3001 atttgctaat ctgtttgctt tttgaaatta cactatcacc tttttgggtg tttttggcct
     3061 caaagtggaa atacatggtg tttaagccag gagcaagcaa agatgcatgt ggggtaagat
     3121 ccaggcctgg tgtccacatc tttccgggtg agctggggcc gggcttcctg aggtctgtcg
     3181 gaaccgggac aagcctctgg aaacggtcag ggagttgtgg aaacccaccg ggcatcgggt
     3241 gtcgggtttg ctttggcccc agaggcagcc ccgttccttc tcctgaggac tcacccgcct
     3301 ccacgaccct cctcctgctg ctgctccaac tggtccaggg caggaggcca cagacagggc
     3361 cctcaggcac cctgggagcc cacacctccc cctccgtggg agtgggtcga ggggcaggct
     3421 ctgctgctgg ctggaaaccc caccccgccc tatccggtac cgccttgtta cgtagaactt
     3481 actcagcaga ctgacaccca atccccctcg ggcgatcatc tgccctgtct tcccacctcc
     3541 agggctacag tgggcagcac cgccatcccc agtgtgacag ggccctggga gcctcagggc
     3601 tgcccggcca ggttggtctg ctctggttac attctggcca agctgcccct tcctgctgac
     3661 ctgcatgtgt attgttgtca ccttcagctc tcagcacctc ggcccccttg ggcagtgagg
     3721 aagggccctg gaggcgaggt tgggagaaag gatagctaga acaggatcct gcggggaaca
     3781 agggttgtgg gcagctctca cccggggctg cctcactgag agcaccgccg agtgggggtg
     3841 ggggtgtcca actctccagc cacaaaccgc ttcctccttg tctgcaggct gtgcaggtct
     3901 ggcctgtgag taaacacatt tatcagcaa
//
