LOCUS       NM_001070               1608 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens tubulin gamma 1 (TUBG1), mRNA.
ACCESSION   NM_001070 XM_940251 XM_944507 XM_944510
VERSION     NM_001070.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1608)
  AUTHORS   Zhang,Y., Wang,Z.Z., Han,A.Q., Yang,M.Y., Zhu,L.X., Pan,F.M. and
            Wang,Y.
  TITLE     TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and
            cycling pathways
  JOURNAL   Hepatobiliary Pancreat Dis Int 23 (2), 195-209 (2024)
   PUBMED   37806848
  REMARK    GeneRIF: TuBG1 promotes hepatocellular carcinoma via
            ATR/P53-apoptosis and cycling pathways.
REFERENCE   2  (bases 1 to 1608)
  AUTHORS   Malycheva,D. and Alvarado-Kristensson,M.
  TITLE     Centrosome Movements Are TUBG1-Dependent
  JOURNAL   Int J Mol Sci 24 (17), 13154 (2023)
   PUBMED   37685969
  REMARK    GeneRIF: Centrosome Movements Are TUBG1-Dependent.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1608)
  AUTHORS   Wang,Z.J., Dai,Z.Z., Hu,M.Z., Liu,J.N., Liang,H., Shen,M.M.,
            Zhu,S.J., Sheng,H.J., Gao,J., Huang,A.L. and Tang,K.F.
  TITLE     Upregulation of TUBG1 expression promotes hepatocellular carcinoma
            development
  JOURNAL   Med Oncol 40 (3), 96 (2023)
   PUBMED   36792863
  REMARK    GeneRIF: Upregulation of TUBG1 expression promotes hepatocellular
            carcinoma development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1608)
  AUTHORS   Batman,U., Deretic,J. and Firat-Karalar,E.N.
  TITLE     The ciliopathy protein CCDC66 controls mitotic progression and
            cytokinesis by promoting microtubule nucleation and organization
  JOURNAL   PLoS Biol 20 (7), e3001708 (2022)
   PUBMED   35849559
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1608)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 1608)
  AUTHORS   Kapeller,R., Toker,A., Cantley,L.C. and Carpenter,C.L.
  TITLE     Phosphoinositide 3-kinase binds constitutively to
            alpha/beta-tubulin and binds to gamma-tubulin in response to
            insulin
  JOURNAL   J Biol Chem 270 (43), 25985-25991 (1995)
   PUBMED   7592789
REFERENCE   7  (bases 1 to 1608)
  AUTHORS   Rommens,J.M., Durocher,F., McArthur,J., Tonin,P., LeBlanc,J.F.,
            Allen,T., Samson,C., Ferri,L., Narod,S., Morgan,K. et al.
  TITLE     Generation of a transcription map at the HSD17B locus centromeric
            to BRCA1 at 17q21
  JOURNAL   Genomics 28 (3), 530-542 (1995)
   PUBMED   7490091
REFERENCE   8  (bases 1 to 1608)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
REFERENCE   9  (bases 1 to 1608)
  AUTHORS   Bahi-Buisson,N. and Maillard,C.
  TITLE     Tubulinopathies Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27010057
REFERENCE   10 (bases 1 to 1608)
  AUTHORS   Zheng,Y., Jung,M.K. and Oakley,B.R.
  TITLE     Gamma-tubulin is present in Drosophila melanogaster and Homo
            sapiens and is associated with the centrosome
  JOURNAL   Cell 65 (5), 817-823 (1991)
   PUBMED   1904010
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000619.2 and BG167819.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001070.4.
            
            Summary: This gene encodes a member of the tubulin superfamily. The
            encoded protein localizes to the centrosome where it binds to
            microtubules as part of a complex referred to as the gamma-tubulin
            ring complex. The protein mediates microtubule nucleation and is
            required for microtubule formation and progression of the cell
            cycle. A pseudogene of this gene is found on chromosome 7.
            [provided by RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.319742.1,
                                           SRR3476690.775721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251413.8/ ENSP00000251413.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1604              BC000619.2         8-1611
            1605-1608           BG167819.1         334-337
FEATURES             Location/Qualifiers
     source          1..1608
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..1608
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /note="tubulin gamma 1"
                     /db_xref="GeneID:7283"
                     /db_xref="HGNC:HGNC:12417"
                     /db_xref="MIM:191135"
     exon            1..104
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1411
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /note="tubulin, gamma polypeptide; gamma-tubulin complex
                     component 1"
                     /codon_start=1
                     /product="tubulin gamma-1 chain"
                     /protein_id="NP_001061.2"
                     /db_xref="CCDS:CCDS11433.1"
                     /db_xref="GeneID:7283"
                     /db_xref="HGNC:HGNC:12417"
                     /db_xref="MIM:191135"
                     /translation="MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEG
                     TDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGN
                     NWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDR
                     YPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRL
                     HIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPL
                     TTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVH
                     KSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFERTC
                     RQYDKLRKREAFLEQFRKEDMFKDNFDEMDTSREIVQQLIDEYHAATRPDYISWGTQE
                     Q"
     exon            105..217
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..385
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..454
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..534
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..661
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..748
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..898
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1051
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1213
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1608
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1585..1590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /note="hexamer: AATAAA"
     polyA_site      1608
                     /gene="TUBG1"
                     /gene_synonym="CDCBM4; GCP-1; TUBG; TUBGCP1"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtgcggc gccgttgcgg gcgggagcgg ctgcaacgcc ggtgcctgag gagcgatgcc
       61 gagggaaatc atcaccctac agttgggcca gtgcggcaat cagattgggt tcgagttctg
      121 gaaacagctg tgcgccgagc atggtatcag ccccgagggc atcgtggagg agttcgccac
      181 cgagggcact gaccgcaagg acgtcttttt ctaccaggca gacgatgagc actacatccc
      241 ccgggccgtg ctgctggact tggaaccccg ggtgatccac tccatcctca actcccccta
      301 tgccaagctc tacaacccag agaacatcta cctgtcggaa catggaggag gagctggcaa
      361 caactgggcc agcggattct cccagggaga aaagatccat gaggacattt ttgacatcat
      421 agaccgggag gcagatggta gtgacagtct agagggcttt gtgctgtgtc actccattgc
      481 tggggggaca ggctctggac tgggttccta cctcttagaa cggctgaatg acaggtatcc
      541 taagaagctg gtgcagacat actcagtgtt tcccaaccag gacgagatga gcgatgtggt
      601 ggtccagcct tacaattcac tcctcacact caagaggctg acgcagaatg cagactgtgt
      661 ggtggtgctg gacaacacag ccctgaaccg gattgccaca gaccgcctgc acatccagaa
      721 cccatccttc tcccagatca accagctggt gtctaccatc atgtcagcca gcaccaccac
      781 cctgcgctac cctggctaca tgaacaatga cctcatcggc ctcatcgcct cgctcattcc
      841 caccccacgg ctccacttcc tcatgaccgg ctacacccct ctcactacgg accagtcagt
      901 ggccagcgtg aggaagacca cggtcctgga tgtcatgagg cggctgctgc agcccaagaa
      961 cgtgatggtg tccacaggcc gagaccgcca gaccaaccac tgctacatcg ccatcctcaa
     1021 catcatccag ggagaggtgg accccaccca ggtccacaag agcttgcaga ggatccggga
     1081 acgcaagttg gccaacttca tcccgtgggg ccccgccagc atccaggtgg ccctgtcgag
     1141 gaagtctccc tacctgccct cggcccaccg ggtcagcggg ctcatgatgg ccaaccacac
     1201 cagcatctcc tcgctcttcg agagaacctg tcgccagtat gacaagctgc gtaagcggga
     1261 ggccttcctg gagcagttcc gcaaggagga catgttcaag gacaactttg atgagatgga
     1321 cacatccagg gagattgtgc agcagctcat cgatgagtac catgcggcca cacggccaga
     1381 ctacatctcc tggggcaccc aggagcagtg agtcccccag gacagggacc ctcatctgcc
     1441 ttactggttg gcccaagccc tgcctgactg accaccccct cagagcacag atcagggacc
     1501 tcacgcatct ctttctcata tacatggact ctctgttggc ctgcaaacac atttacttct
     1561 cctcttatga gactatttat ctttaataaa gcactggata taaatcaa
//
