LOCUS       NM_016261               2491 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tubulin delta 1 (TUBD1), transcript variant 1, mRNA.
ACCESSION   NM_016261
VERSION     NM_016261.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2491)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2491)
  AUTHORS   Wang,J.T., Kong,D., Hoerner,C.R., Loncarek,J. and Stearns,T.
  TITLE     Centriole triplet microtubules are required for stable centriole
            formation and inheritance in human cells
  JOURNAL   Elife 6, e29061 (2017)
   PUBMED   28906251
  REMARK    GeneRIF: Here, the authors report that centrioles in delta-tubulin
            and epsilon-tubulin null mutant human cells lack triplet
            microtubules and fail to undergo centriole maturation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2491)
  AUTHORS   Villegas-Ruiz,V., Hendlmeier,F., Buentello-Volante,B.,
            Rodriguez-Loaiza,J.L., Miranda-Duarte,A. and Zenteno,J.C.
  TITLE     Genome-wide mRNA analysis reveals a TUBD1 isoform profile as a
            potential biomarker for diabetic retinopathy development
  JOURNAL   Exp Eye Res 155, 99-106 (2017)
   PUBMED   28137601
  REMARK    GeneRIF: our data suggest that TUBD1 mRNA isoform expression
            profile in peripheral blood could be an accessible biomarker for
            predicting the risk for diabetic retinopathy development.
REFERENCE   4  (bases 1 to 2491)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   5  (bases 1 to 2491)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 2491)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2491)
  AUTHORS   Kato,A., Nagata,Y. and Todokoro,K.
  TITLE     Delta-tubulin is a component of intercellular bridges and both the
            early and mature perinuclear rings during spermatogenesis
  JOURNAL   Dev Biol 269 (1), 196-205 (2004)
   PUBMED   15081367
REFERENCE   8  (bases 1 to 2491)
  AUTHORS   Sidjanin,D.J., Zangerl,B., Johnson,J.L., Xue,F., Mellersh,C.,
            Ostrander,E.A., Acland,G. and Aguirre,G.D.
  TITLE     Cloning of the canine delta tubulin cDNA (TUBD) and mapping to CFA9
  JOURNAL   Anim Genet 33 (2), 161-162 (2002)
   PUBMED   12047234
REFERENCE   9  (bases 1 to 2491)
  AUTHORS   Smrzka,O.W., Delgehyr,N. and Bornens,M.
  TITLE     Tissue-specific expression and subcellular localisation of
            mammalian delta-tubulin
  JOURNAL   Curr Biol 10 (7), 413-416 (2000)
   PUBMED   10753753
REFERENCE   10 (bases 1 to 2491)
  AUTHORS   Chang,P. and Stearns,T.
  TITLE     Delta-tubulin and epsilon-tubulin: two new human centrosomal
            tubulins reveal new aspects of centrosome structure and function
  JOURNAL   Nat Cell Biol 2 (1), 30-35 (2000)
   PUBMED   10620804
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG682935.1, DA607129.1, AB030837.1, AK024741.1 and BX119803.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016261.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.103777.1,
                                           SRR1803616.250902.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325752.8/ ENSP00000320797.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BG682935.1         4-11
            9-564               DA607129.1         1-556
            565-1745            AB030837.1         280-1460
            1746-2420           AK024741.1         1008-1682
            2421-2491           BX119803.1         417-487
FEATURES             Location/Qualifiers
     source          1..2491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.1"
     gene            1..2491
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /note="tubulin delta 1"
                     /db_xref="GeneID:51174"
                     /db_xref="HGNC:HGNC:16811"
                     /db_xref="MIM:607344"
     exon            1..247
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /inference="alignment:Splign:2.1.0"
     exon            248..458
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1648
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /note="isoform 1 is encoded by transcript variant 1;
                     delta-tubulin; tubulin delta chain"
                     /codon_start=1
                     /product="tubulin delta chain isoform 1"
                     /protein_id="NP_057345.2"
                     /db_xref="CCDS:CCDS11620.1"
                     /db_xref="GeneID:51174"
                     /db_xref="HGNC:HGNC:16811"
                     /db_xref="MIM:607344"
                     /translation="MSIVTVQLGQCGNQIGFEVFDALLSDSHSSQGLCSMRENEAYQA
                     SCKERFFSEEENGVPIARAVLVDMEPKVINQMLSKAAQSGQWKYGQHACFCQKQGSGN
                     NWAYGYSVHGPRHEESIMNIIRKEVEKCDSFSGFFIIMSMAGGTGSGLGAFVTQNLED
                     QYSNSLKMNQIIWPYGTGEVIVQNYNSILTLSHLYRSSDALLLHENDAIHKICAKLMN
                     IKQISFSDINQVLAHQLGSVFQPTYSAESSFHYRRNPLGDLMEHLVPHPEFKMLSVRN
                     IPHMSENSLAYTTFTWAGLLKHLRQMLISNAKMEEGIDRHVWPPLSGLPPLSKMSLNK
                     DLHFNTSIANLVILRGKDVQSADVEGFKDPALYTSWLKPVNAFNVWKTQRAFSKYEKS
                     AVLVSNSQFLVKPLDMIVGKAWNMFASKAYIHQYTKFGIEEEDFLDSFTSLEQVVASY
                     CNL"
     exon            459..606
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /inference="alignment:Splign:2.1.0"
     exon            607..823
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1055
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1220
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1361
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1545
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..2491
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2439..2444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /note="hexamer: AATAAA"
     regulatory      2460..2465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /note="hexamer: AATAAA"
     polyA_site      2461
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
     polyA_site      2491
                     /gene="TUBD1"
                     /gene_synonym="TUBD"
                     /note="major polyA site"
ORIGIN      
        1 gcattgtcag ctggagcgtt cggtggacag tgagcatgcg taccatatct gaagttcgta
       61 aattgaaatt gaacatgcgt aattaatctt tctgaatagg aaaaaatata tacacaacaa
      121 aactctccgt ttatggaaca tgcgcatttg ttctcagtaa gtttttcgtt ttgaaagtga
      181 gcatgcgcat ggtgagtagg ttggtccgaa gtttgaaccg gacagaagcg ctggtcggcg
      241 tctggcggtt gtttttagag gtaatacacc tagtttgtgg ctcagcatgt caattgtaac
      301 agtgcaactt ggtcagtgtg gcaatcagat tggttttgaa gtttttgatg ctttgcttag
      361 tgactcacac agttcccagg gactctgctc tatgagagag aatgaggcat atcaagcatc
      421 ttgcaaagaa agattcttca gtgaggagga gaatggagtt ccaattgccc gggctgttct
      481 tgttgacatg gaacccaaag ttatcaatca aatgctgtca aaggctgccc agtctggcca
      541 atggaaatat ggtcaacatg catgcttctg tcaaaaacaa ggttctggaa acaactgggc
      601 atatggttac tctgttcatg gacccaggca tgaagaatct ataatgaaca taatccggaa
      661 ggaagtggag aaatgtgact ctttcagtgg ttttttcatc ataatgagta tggctggggg
      721 cacaggatca ggattaggag ctttcgttac acagaattta gaagatcagt actcaaactc
      781 attgaaaatg aatcagatta tttggcctta tggaactggt gaggttattg ttcaaaacta
      841 caactccatt ttgacacttt ctcacttgta ccgatcttca gacgccctcc ttcttcatga
      901 gaatgatgcc atccataaga tctgtgcaaa actgatgaat atcaagcaga tctcctttag
      961 tgatatcaat caagtcctcg cacatcagct gggaagtgtg ttccagccta cttattctgc
     1021 agaaagctca tttcactaca gacgaaatcc actaggagac ttaatggagc atttagttcc
     1081 ccatcctgaa ttcaagatgc tgagtgttcg taacattcct cacatgtctg agaattcatt
     1141 ggcatacacc acatttactt gggctggcct cctcaagcat ttgagacaga tgctcatttc
     1201 taatgcaaag atggaagaag gtattgatag gcatgtatgg cctcctttat caggacttcc
     1261 tcctcttagt aaaatgtctc tcaacaagga cctgcatttt aacacttcca ttgctaactt
     1321 ggtcattctt cgtgggaaag atgtgcaaag tgcagatgtg gagggattta aagatccagc
     1381 tctgtatact tcctggttga agcctgttaa tgctttcaac gtgtggaaaa cccagcgggc
     1441 ctttagcaaa tatgagaagt ctgcagtgtt ggtcagcaac agccagttct tagtaaaacc
     1501 acttgatatg attgttggga aggcatggaa tatgtttgct tcaaaagcct acattcatca
     1561 gtacacaaaa tttggaatcg aagaagagga ctttttagac agtttcacgt cattagagca
     1621 ggttgttgcc agttactgta atctctgatc ttgaacaatg ggaaaagtat accttaaggc
     1681 atttctggac taaaatattt tcaatactat tttctctgta aagttttcaa agttctccat
     1741 cctggctaac acggtgaaac accgtctcta ccagaaaata caaaaaatta gccaggcgcg
     1801 gtggcgggtg cctgtagtcc cagctactcg ggaggctgag gcaggagaat gacgtgaacc
     1861 caggaggcgg agcttgcagt gagccgagat cgcgccactg cactccagcc tgggcgacag
     1921 agcgagactc cgtctcaaaa aaaaaaaaaa aaaaaaatgt tttcaaagtt ccattctgtt
     1981 aaagtaacca cgtagaatgc tgagtctatt ctgcatacta tgcccacaga aaaggaagaa
     2041 aactttttaa aatggagaat cgcatgtttt caatgaaaac attcacttgg tatttcattt
     2101 gtaagaaaaa aaaatggtgc ttttataaag aactttgggg aaacactttg ctgaaatgtt
     2161 gggactctgg aactagccaa gaaaagagaa tattctcttt gtctacatgt tcctaaatct
     2221 ttactccaaa acaactccaa aaacaactca caaagcatga accaaacttt cacagcataa
     2281 tttcaagcta aggaattgta attctgtact taatatattc atgtttgaaa tgaatgcttt
     2341 gaaccacagg agggagatgt tgtcaaatgc tacagtgtga acatgtattt tgaatattct
     2401 gtaacagggc aagtttccac tctaagcagc tatttaaaaa taaatatgag gattttggta
     2461 ataaatgctt atgcttaagt acaaaagtaa a
//
