LOCUS       NM_001358689            1562 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens tubulin beta 8B (TUBB8B), transcript variant 1, mRNA.
ACCESSION   NM_001358689
VERSION     NM_001358689.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1562)
  AUTHORS   van Geel,M., Eichler,E.E., Beck,A.F., Shan,Z., Haaf,T., van der
            Maarel,S.M., Frants,R.R. and de Jong,P.J.
  TITLE     A cascade of complex subtelomeric duplications during the evolution
            of the hominoid and Old World monkey genomes
  JOURNAL   Am J Hum Genet 70 (1), 269-278 (2002)
   PUBMED   11731935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001005.6.
            
            On Jan 6, 2021 this sequence version replaced NM_001358689.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2148874, SAMEA2151119
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000308911.9/ ENSP00000496713.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AP001005.6         33541-33655         c
            116-224             AP001005.6         33169-33277         c
            225-335             AP001005.6         32980-33090         c
            336-1562            AP001005.6         31261-32487         c
FEATURES             Location/Qualifiers
     source          1..1562
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.32"
     gene            1..1562
                     /gene="TUBB8B"
                     /gene_synonym="TUBB8P12"
                     /note="tubulin beta 8B"
                     /db_xref="GeneID:260334"
                     /db_xref="HGNC:HGNC:24983"
     exon            1..115
                     /gene="TUBB8B"
                     /gene_synonym="TUBB8P12"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1393
                     /gene="TUBB8B"
                     /gene_synonym="TUBB8P12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     HSA18p11 beta-tubulin 4Q pseudogene; tubulin beta 8
                     pseudogene 12; Tubulin beta-8 chain-like protein
                     LOC260334"
                     /codon_start=1
                     /product="tubulin beta 8B isoform 1"
                     /protein_id="NP_001345618.1"
                     /db_xref="CCDS:CCDS86657.1"
                     /db_xref="GeneID:260334"
                     /db_xref="HGNC:HGNC:24983"
                     /translation="MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQL
                     ERINVHHHEASGGRYVPRAVLVDLEPGTMDSVHSGPFGQVFRPDNFISGQCGAGNNWA
                     KGRYTEGAELTESVMDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP
                     DRIINTFSILPSPKVSDTVVEPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLP
                     TPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSR
                     GSQQYRALTVAELTQQMFDAKNMMAACDPRHGCYLTVAAIFRGRMPMREVDEQMFNIQ
                     DKNSSYFADWFPDNVKTAVCDIPPRGLKMSATFIGNNAAIQELFTCVSEQFTAMFRRK
                     AFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDEEYAEEEVA"
     exon            116..224
                     /gene="TUBB8B"
                     /gene_synonym="TUBB8P12"
                     /inference="alignment:Splign:2.1.0"
     exon            225..335
                     /gene="TUBB8B"
                     /gene_synonym="TUBB8P12"
                     /inference="alignment:Splign:2.1.0"
     exon            336..1562
                     /gene="TUBB8B"
                     /gene_synonym="TUBB8P12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcgcgtc tgctcctcct tctcgcgctt ctgctgccgc cctaatcctg ccttggccat
       61 gagggaaatc gtgctcacgc agaccgggca gtgcgggaac cagatcggcg ccaagttctg
      121 ggaggtgatc tctgatgaac atgccatcga ctccgctggc acctaccacg gggacagcca
      181 cctgcagctg gagcgcatca acgtgcacca ccacgaggcc agcggtggca ggtacgtgcc
      241 ccgcgctgtg ctcgtggatc tggagccggg caccatggac tctgtgcact cggggccctt
      301 cgggcaggtc ttcaggccag acaacttcat ttccggtcag tgtggggccg gaaacaactg
      361 ggccaaggga cgctacacag aaggcgcgga gctgacggag tcagtgatgg acgttgtcag
      421 aaaggaggct gagagctgtg actgcctgca gggtttccag ctgacccact ccctgggtgg
      481 ggggactggg tctgggatgg gtacccttct cattagtaag atccgggagg agtacccaga
      541 caggatcata aacacattca gcatcctgcc ctcgcccaag gtgtcggaca ccgtggtgga
      601 gccctacaac gccaccctct cagtccacca gctcatagaa aacgcggatg agaccttctg
      661 catagataac gaagcgctat atgacatatg ttccaggacc ctaaaactgc ccacacccac
      721 ctatggtgac ctgaaccacc tggtgtctgc taccatgagt ggggtcacca catgcctgcg
      781 cttcccaggc cagctgaatg ctgacctgcg gaagctggcc gtgaacatgg tcccgtttcc
      841 ccggctgcat ttcttcatgc ccggctttgc cccactgacc agccggggca gccagcagta
      901 ccgggccttg actgtggctg agctcaccca gcagatgttt gatgctaaga acatgatggc
      961 tgcctgtgac ccccgtcacg gctgctacct aacggtggct gccattttca ggggtcgcat
     1021 gcccatgagg gaggtggatg aacaaatgtt caacattcaa gataagaaca gcagctactt
     1081 tgctgactgg ttccccgaca acgtaaaaac agccgtctgt gacatcccac cccgggggct
     1141 aaaaatgtca gccaccttca ttgggaataa tgcggccatc caggaactct tcacatgtgt
     1201 ctcagagcag tttacagcaa tgttcaggcg caaggccttc ctccactggt acacgggcga
     1261 gggcatggat gagatggaat tcaccgaggc cgagagcaac atgaacgacc tggtgtctga
     1321 atatcagcaa tatcaggatg ccacggccga ggaggaggag gatgaggagt atgccgagga
     1381 ggaggtggcc tagaactctc cttttctagg taaagggggg aagcagtgtg gattctttac
     1441 tgtgttctga cagccatgtg tcactatacg cttgttaatt tgtgtcttca catctcctgc
     1501 tgcgttttaa agcattttta tagtatgcgg ttttgactaa taaagtattc tcacagcatc
     1561 tg
//
