LOCUS       NM_178012               1922 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens tubulin beta 2B class IIb (TUBB2B), mRNA.
ACCESSION   NM_178012
VERSION     NM_178012.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1922)
  AUTHORS   Wang,X., Shi,J., Huang,M., Chen,J., Dan,J., Tang,Y., Guo,Z., He,X.
            and Zhao,Q.
  TITLE     TUBB2B facilitates progression of hepatocellular carcinoma by
            regulating cholesterol metabolism through targeting HNF4A/CYP27A1
  JOURNAL   Cell Death Dis 14 (3), 179 (2023)
   PUBMED   36872411
  REMARK    GeneRIF: TUBB2B facilitates progression of hepatocellular carcinoma
            by regulating cholesterol metabolism through targeting
            HNF4A/CYP27A1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1922)
  AUTHORS   Dekker,J., Diderich,K.E.M., Schot,R., Husen,S.C., Dremmen,M.H.G.,
            Go,A.T.J.I., Weerts,M.J.A., van Slegtenhorst,M.A. and
            Mancini,G.M.S.
  TITLE     A novel family illustrating the mild phenotypic spectrum of TUBB2B
            variants
  JOURNAL   Eur J Paediatr Neurol 35, 35-39 (2021)
   PUBMED   34592644
  REMARK    GeneRIF: A novel family illustrating the mild phenotypic spectrum
            of TUBB2B variants.
REFERENCE   3  (bases 1 to 1922)
  AUTHORS   Liotti,A., La Civita,E., Cennamo,M., Crocetto,F., Ferro,M.,
            Guadagno,E., Insabato,L., Imbimbo,C., Palmieri,A., Mirone,V.,
            Liguoro,P., Formisano,P., Beguinot,F. and Terracciano,D.
  TITLE     Periprostatic adipose tissue promotes prostate cancer resistance to
            docetaxel by paracrine IGF-1 upregulation of TUBB2B beta-tubulin
            isoform
  JOURNAL   Prostate 81 (7), 407-417 (2021)
   PUBMED   33734457
  REMARK    GeneRIF: Periprostatic adipose tissue promotes prostate cancer
            resistance to docetaxel by paracrine IGF-1 upregulation of TUBB2B
            beta-tubulin isoform.
REFERENCE   4  (bases 1 to 1922)
  AUTHORS   Liu,J. and Li,Y.
  TITLE     Upregulation of MAPK10, TUBB2B and RASL11B may contribute to the
            development of neuroblastoma
  JOURNAL   Mol Med Rep 20 (4), 3475-3486 (2019)
   PUBMED   31432180
  REMARK    GeneRIF: the present study identified a novel significant
            association between the increased expression levels of MAPK10,
            TUBB2B and RASL11B, and neuroblastoma cells.
REFERENCE   5  (bases 1 to 1922)
  AUTHORS   Cucchiarelli,V., Hiser,L., Smith,H., Frankfurter,A., Spano,A.,
            Correia,J.J. and Lobert,S.
  TITLE     Beta-tubulin isotype classes II and V expression patterns in
            nonsmall cell lung carcinomas
  JOURNAL   Cell Motil Cytoskeleton 65 (8), 675-685 (2008)
   PUBMED   18613117
  REMARK    GeneRIF: The data suggest that the ratio of beta-tubulin classes II
            and V mRNA could be useful as a biomarker for NSCLC tumor
            differentiation and/or NSCLC aggressiveness.
REFERENCE   6  (bases 1 to 1922)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 1922)
  AUTHORS   Bernard-Marty,C., Treilleux,I., Dumontet,C., Cardoso,F.,
            Fellous,A., Gancberg,D., Bissery,M.C., Paesmans,M., Larsimont,D.,
            Piccart,M.J. and Di Leo,A.
  TITLE     Microtubule-associated parameters as predictive markers of
            docetaxel activity in advanced breast cancer patients: results of a
            pilot study
  JOURNAL   Clin Breast Cancer 3 (5), 341-345 (2002)
   PUBMED   12533264
  REMARK    GeneRIF: The class II beta-tubulin isotype seems to be a promising
            predictive marker of docetaxel activity in the treatment of breast
            neoplasms.
REFERENCE   8  (bases 1 to 1922)
  AUTHORS   Bahi-Buisson,N. and Maillard,C.
  TITLE     Tubulinopathies Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27010057
REFERENCE   9  (bases 1 to 1922)
  AUTHORS   Whitman,M.C., Jurgens,J.A., Hunter,D.G. and Engle,E.C.
  TITLE     Congenital Fibrosis of the Extraocular Muscles Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301522
REFERENCE   10 (bases 1 to 1922)
  AUTHORS   Lee,M.G., Lewis,S.A., Wilde,C.D. and Cowan,N.J.
  TITLE     Evolutionary history of a multigene family: an expressed human
            beta-tubulin gene and three processed pseudogenes
  JOURNAL   Cell 33 (2), 477-487 (1983)
   PUBMED   6688039
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC001352.2, BC063610.1 and
            BX419454.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_178012.4.
            
            Summary: The protein encoded by this gene is a beta isoform of
            tubulin, which binds GTP and is a major component of microtubules.
            This gene is highly similar to TUBB2A and TUBB2C. Defects in this
            gene are a cause of asymmetric polymicrogyria. [provided by RefSeq,
            Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1110950.1,
                                           SRR3476690.375028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2153733
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259818.8/ ENSP00000259818.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BC001352.2         82-97
            17-1607             BC063610.1         1-1591
            1608-1922           BX419454.2         287-601
FEATURES             Location/Qualifiers
     source          1..1922
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.2"
     gene            1..1922
                     /gene="TUBB2B"
                     /gene_synonym="bA506K6.1; CDCBM7; PMGYSA"
                     /note="tubulin beta 2B class IIb"
                     /db_xref="GeneID:347733"
                     /db_xref="HGNC:HGNC:30829"
                     /db_xref="MIM:612850"
     exon            1..167
                     /gene="TUBB2B"
                     /gene_synonym="bA506K6.1; CDCBM7; PMGYSA"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1448
                     /gene="TUBB2B"
                     /gene_synonym="bA506K6.1; CDCBM7; PMGYSA"
                     /note="class IIb beta-tubulin; tubulin, beta polypeptide
                     paralog; class II beta-tubulin isotype; tubulin, beta 2B;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="tubulin beta-2B chain"
                     /protein_id="NP_821080.1"
                     /db_xref="CCDS:CCDS4485.1"
                     /db_xref="GeneID:347733"
                     /db_xref="HGNC:HGNC:30829"
                     /db_xref="MIM:612850"
                     /translation="MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQL
                     ERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWA
                     KGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP
                     DRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLT
                     TPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSR
                     GSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQ
                     NKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRK
                     AFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA"
     exon            168..276
                     /gene="TUBB2B"
                     /gene_synonym="bA506K6.1; CDCBM7; PMGYSA"
                     /inference="alignment:Splign:2.1.0"
     exon            277..387
                     /gene="TUBB2B"
                     /gene_synonym="bA506K6.1; CDCBM7; PMGYSA"
                     /inference="alignment:Splign:2.1.0"
     exon            388..1922
                     /gene="TUBB2B"
                     /gene_synonym="bA506K6.1; CDCBM7; PMGYSA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1684..1689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBB2B"
                     /gene_synonym="bA506K6.1; CDCBM7; PMGYSA"
                     /note="hexamer: CATAAA"
     polyA_site      1703
                     /gene="TUBB2B"
                     /gene_synonym="bA506K6.1; CDCBM7; PMGYSA"
                     /note="major polyA site"
     regulatory      1902..1907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBB2B"
                     /gene_synonym="bA506K6.1; CDCBM7; PMGYSA"
                     /note="hexamer: AATAAA"
     polyA_site      1922
                     /gene="TUBB2B"
                     /gene_synonym="bA506K6.1; CDCBM7; PMGYSA"
ORIGIN      
        1 ctcagcccgt cggttcccga gcgccttccc ggtgaccccg cagtgggtgt gtgaggggag
       61 gacggacaga cccagacgcc gccggaccag gaggacgctg acgaggcacc atgcgtgaga
      121 tcgtgcacat ccaggcgggc cagtgcggca accagatcgg cgccaagttt tgggaggtca
      181 tcagtgatga gcatgggatt gaccccactg gcagttacca tggagacagt gatttgcagc
      241 tggagagaat caatgtttac tacaatgaag ccactggtaa caaatatgtt cctcgggcca
      301 tcctcgtgga tctggagcca ggcacgatgg attcggttag gtctggacca ttcggccaga
      361 tcttcagacc agacaatttc gtgtttggcc agagtggagc cgggaataac tgggccaagg
      421 gccactacac agagggagcc gagctggtcg actcggtcct ggatgtggtg aggaaggagt
      481 cagagagctg tgactgtctc cagggcttcc agctgaccca ctctctgggg ggcggcacgg
      541 ggtccgggat gggcaccctg ctcatcagca agatccggga agagtaccca gaccgcatca
      601 tgaacacctt cagcgtcatg ccctcaccca aggtgtcaga cacggtggtg gagccctaca
      661 acgccaccct ctcggtccac cagctggtgg aaaacacaga tgaaacctac tgcattgaca
      721 acgaggccct gtatgacatc tgcttccgca ccctgaagct gaccaccccc acctacgggg
      781 acctcaacca cctggtgtcg gccaccatga gcggggtcac cacctgcctg cgcttcccgg
      841 gccagctgaa cgcagacctg cgcaagctgg cggtgaacat ggtgcccttc cctcgcctgc
      901 acttcttcat gcccggcttc gcgcccctga ccagccgggg cagccagcag taccgggcgc
      961 tcacggtgcc cgagctcacc cagcagatgt tcgactccaa gaacatgatg gccgcctgcg
     1021 acccgcgcca cggccgctac ctgacggtgg ctgccatctt ccggggccgc atgtccatga
     1081 aggaggtgga cgagcagatg ctcaacgtgc agaacaagaa cagcagctac ttcgtggagt
     1141 ggatccccaa caacgtgaag acggccgtgt gcgacatccc gccccgcggc ctgaagatgt
     1201 cggccacctt catcggcaac agcacggcca tccaggagct gttcaagcgc atctccgagc
     1261 agttcacggc catgttccgg cgcaaggcct tcctgcactg gtacacgggc gagggcatgg
     1321 acgagatgga gttcaccgag gccgagagca acatgaacga cctggtgtcc gagtaccagc
     1381 agtaccagga cgccacggcc gacgaacaag gggagttcga ggaggaggag ggcgaggacg
     1441 aggcgtagat gcccccgcga gacgggttag ggaaagcgga ggaggaaagc gagggggtgg
     1501 ggggcttccc gggacgataa cctggcagtg gaaggaaaga agcatggtct actttaggtg
     1561 tgcgctgggt ctctggtgct cttcactgtt gcctgtcact ttttttttcc ttttttgtaa
     1621 tattgatgac atcaatgtaa catttgagat atttctgaat tactgttgta atggctaaaa
     1681 tcacataaac gtttgtgtcg gaatggtgtc ctctctttct cttccttttt ctctttatta
     1741 acgatttaaa tgtaactttc tgaacacatt gcattgaatt cttcctttaa caaaaagcaa
     1801 aggcgtaggt aaaagctcaa atgaatttat tctttcggta tggtaaaatt gaaccaatca
     1861 cagttaagat gagagatcaa cctgagtttt aaaatacctt taataaatat tagttgaaaa
     1921 aa
//
