LOCUS       NM_024803               1793 bp    mRNA    linear   PRI 22-MAY-2024
DEFINITION  Homo sapiens tubulin alpha like 3 (TUBAL3), transcript variant 1,
            mRNA.
ACCESSION   NM_024803
VERSION     NM_024803.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1793)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK025318.1 and AL683826.14.
            
            On Nov 22, 2018 this sequence version replaced NM_024803.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.398936.1, AK025318.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380419.8/ ENSP00000369784.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               AK025318.1         5-360
            357-357             AL683826.14        90874-90874         c
            358-596             AK025318.1         362-600
            597-1676            AL683826.14        88690-89769         c
            1677-1793           AK025318.1         1681-1797
FEATURES             Location/Qualifiers
     source          1..1793
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..1793
                     /gene="TUBAL3"
                     /note="tubulin alpha like 3"
                     /db_xref="GeneID:79861"
                     /db_xref="HGNC:HGNC:23534"
                     /db_xref="MIM:620835"
     exon            1..39
                     /gene="TUBAL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1377
                     /gene="TUBAL3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tubulin alpha chain-like 3"
                     /codon_start=1
                     /product="tubulin alpha chain-like 3 isoform 1"
                     /protein_id="NP_079079.1"
                     /db_xref="CCDS:CCDS7066.2"
                     /db_xref="GeneID:79861"
                     /db_xref="HGNC:HGNC:23534"
                     /db_xref="MIM:620835"
                     /translation="MRECLSIHIGQAGIQIGDACWELYCLEHGIQPNGVVLDTQQDQL
                     ENAKMEHTNASFDTFFCETRAGKHVPRALFVDLEPTVIDGIRTGQHRSLFHPEQLLSG
                     KEDAANNYARGRYSVGSEVIDLVLERTRKLAEQCGGLQGFLIFRSFGGGTGSGFTSLL
                     MERLTGEYSRKTKLEFSVYPAPRISTAVVEPYNSVLTTHSTTEHTDCTFMVDNEAVYD
                     ICHRKLGVECPSHASINRLVVQVVSSITASLRFEGPLNVDLIEFQTNLVPYPRIHFPM
                     TAFAPIVSADKAYHEQFSVSDITTACFESSNQLVKCDPRLGKYMACCLLYRGDVVPKE
                     VNAAIAATKSRHSVQFVDWCPTGFKVGINNRPPTVMPGGDLAKVHRSICMLSNTTAIV
                     EAWARLDHKFDLMYAKRAFLHWYLREGMEEAEFLEAREDLAALERDYEEVAQSF"
     exon            40..283
                     /gene="TUBAL3"
                     /inference="alignment:Splign:2.1.0"
     exon            284..432
                     /gene="TUBAL3"
                     /inference="alignment:Splign:2.1.0"
     exon            433..1793
                     /gene="TUBAL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1770..1775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBAL3"
                     /note="hexamer: ATTAAA"
     polyA_site      1793
                     /gene="TUBAL3"
                     /note="major polyA site"
ORIGIN      
        1 attactacag ggcaggaagg gcacgttctc atcagcatga gggagtgcct ttccatccac
       61 atcggtcaag ctggcatcca gattggggac gcctgctggg aactctattg cctggaacat
      121 ggaatccagc caaatggcgt tgttcttgac actcaacagg atcagctgga aaatgcaaaa
      181 atggagcaca caaatgcatc tttcgatacc ttcttctgtg agacaagagc tgggaagcat
      241 gtgcctagag cactcttcgt ggacttggag ccaactgtta tagatgggat ccggacgggc
      301 cagcaccgtt cactcttcca ccccgagcag ctccttagcg gaaaggagga tgctgctaac
      361 aattacgcgc gaggccgtta ctctgtgggg tcggaggtca tcgaccttgt gctggagagg
      421 acccggaagc tggcagaaca gtgtggtgga cttcagggat ttttgatttt ccgaagcttt
      481 ggaggaggca ctggttcagg gtttacgtct ctcttaatgg agaggctcac aggagaatat
      541 agcagaaaga ctaagctgga gttctcggtc tacccagccc ccaggatctc cactgctgtg
      601 gtagagcctt ataactctgt cctcaccacc cactccacca cagagcacac ggactgtacc
      661 ttcatggtgg acaacgaggc cgtctatgat atatgccatc gtaaactcgg tgttgaatgc
      721 ccctctcatg ccagcatcaa tagattggtg gttcaggtgg tatcttccat cactgcctcc
      781 ctccggtttg aagggccctt gaatgtagac ctaattgaat tccagaccaa cctggtacct
      841 tatccgagaa tacatttccc catgacagcc ttcgccccca tcgtctctgc tgacaaagcc
      901 taccatgagc agttctctgt gtcagacatc accactgcct gctttgagtc ctccaaccag
      961 ctggtcaagt gtgatcctcg gcttgggaag tacatggcct gctgcctact ctatagaggg
     1021 gatgtggtcc ccaaggaagt gaatgcagca atcgcagcca cgaagtcgag gcactctgtt
     1081 cagtttgtag attggtgtcc aactggtttc aaggtgggca tcaacaatcg gccgcccacg
     1141 gtgatgccgg gtggggacct ggccaaagtc caccggtcca tctgcatgct gagcaacacc
     1201 acggcgattg tggaggcctg ggcccgcctg gaccacaagt ttgacctcat gtacgccaag
     1261 agagcatttc tgcactggta cctcagagaa ggcatggaag aagcagagtt cttggaggcc
     1321 agggaagatc tggcagccct ggagagggac tatgaggaag tggcgcaaag tttctgaggc
     1381 atgtatgatg ggtgcaaatg aatgtcaagt taaaatggca tgttttcttt tcaagccgtt
     1441 atatgcctag tgggtagttc ccctgatgag cagaaaaatg aactcaaatc aggcaagact
     1501 ctaggttcca cactaaatta agtgggtcag taccaacaat gaacacatta tttcctggtc
     1561 tactggtaca agtcagctct gctacctggg agcctttgga agcttagagt cctttgaact
     1621 gctgagtcac ttctaggtgg gatttttttg ttttaccaag agacaatgaa atcctgaagt
     1681 ttatgctttt cctttctggt accggaagta gaaaacagca catgttgatt acgaatgttt
     1741 tttcccccat gtctacattt tttacactga ttaaatcata aatattttca gta
//
