LOCUS       NM_207312               1518 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tubulin alpha 3e (TUBA3E), mRNA.
ACCESSION   NM_207312
VERSION     NM_207312.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1518)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1518)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1518)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1518)
  AUTHORS   Alazami,A.M., Patel,N., Shamseldin,H.E., Anazi,S., Al-Dosari,M.S.,
            Alzahrani,F., Hijazi,H., Alshammari,M., Aldahmesh,M.A., Salih,M.A.,
            Faqeih,E., Alhashem,A., Bashiri,F.A., Al-Owain,M., Kentab,A.Y.,
            Sogaty,S., Al Tala,S., Temsah,M.H., Tulbah,M., Aljelaify,R.F.,
            Alshahwan,S.A., Seidahmed,M.Z., Alhadid,A.A., Aldhalaan,H.,
            AlQallaf,F., Kurdi,W., Alfadhel,M., Babay,Z., Alsogheer,M.,
            Kaya,N., Al-Hassnan,Z.N., Abdel-Salam,G.M., Al-Sannaa,N., Al
            Mutairi,F., El Khashab,H.Y., Bohlega,S., Jia,X., Nguyen,H.C.,
            Hammami,R., Adly,N., Mohamed,J.Y., Abdulwahab,F., Ibrahim,N.,
            Naim,E.A., Al-Younes,B., Meyer,B.F., Hashem,M., Shaheen,R.,
            Xiong,Y., Abouelhoda,M., Aldeeri,A.A., Monies,D.M. and
            Alkuraya,F.S.
  TITLE     Accelerating novel candidate gene discovery in neurogenetic
            disorders via whole-exome sequencing of prescreened multiplex
            consanguineous families
  JOURNAL   Cell Rep 10 (2), 148-161 (2015)
   PUBMED   25558065
REFERENCE   5  (bases 1 to 1518)
  AUTHORS   Masliah,E., Dumaop,W., Galasko,D. and Desplats,P.
  TITLE     Distinctive patterns of DNA methylation associated with Parkinson
            disease: identification of concordant epigenetic changes in brain
            and peripheral blood leukocytes
  JOURNAL   Epigenetics 8 (10), 1030-1038 (2013)
   PUBMED   23907097
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018804.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_207312.2.
            
            Summary: Microtubules of the eukaryotic cytoskeleton perform
            essential and diverse functions and are composed of a heterodimer
            of alpha and beta tubulin. The genes encoding these microtubule
            constituents are part of the tubulin superfamily, which is composed
            of six distinct families. Genes from the alpha, beta and gamma
            tubulin families are found in all eukaryotes. The alpha and beta
            tubulins represent the major components of microtubules, while
            gamma tubulin plays a critical role in the nucleation of
            microtubule assembly. This gene encodes an alpha tubulin that
            highly conserved among species. A missense mutation in this gene
            has been potentially linked to microlissencephaly and global
            developmental delay. [provided by RefSeq, Jul 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057811.1, SRR5189667.146939.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149178, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312988.9/ ENSP00000318197.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC018804.9         39989-40070
            83-305              AC018804.9         42057-42279
            306-454             AC018804.9         43201-43349
            455-1135            AC018804.9         43962-44642
            1136-1518           AC018804.9         46301-46683
FEATURES             Location/Qualifiers
     source          1..1518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
     gene            1..1518
                     /gene="TUBA3E"
                     /note="tubulin alpha 3e"
                     /db_xref="GeneID:112714"
                     /db_xref="HGNC:HGNC:20765"
                     /db_xref="MIM:619918"
     exon            1..82
                     /gene="TUBA3E"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1432
                     /gene="TUBA3E"
                     /codon_start=1
                     /product="tubulin alpha-3E chain"
                     /protein_id="NP_997195.2"
                     /db_xref="CCDS:CCDS2158.1"
                     /db_xref="GeneID:112714"
                     /db_xref="HGNC:HGNC:20765"
                     /db_xref="MIM:619918"
                     /translation="MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGG
                     GDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAASN
                     YARGHYTIGKEIVDLVLDRIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVD
                     YSKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLD
                     IERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVI
                     SAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIAT
                     IKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLV
                     HKFDLMYAKWAFVHWYVGEGMEEGEFSEAREDLAALEKDCEEVGVDSVEAEAEEGEAY
                     "
     exon            83..305
                     /gene="TUBA3E"
                     /inference="alignment:Splign:2.1.0"
     exon            306..454
                     /gene="TUBA3E"
                     /inference="alignment:Splign:2.1.0"
     exon            455..1135
                     /gene="TUBA3E"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1518
                     /gene="TUBA3E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBA3E"
                     /note="hexamer: ATTAAA"
     polyA_site      1518
                     /gene="TUBA3E"
                     /note="major polyA site"
ORIGIN      
        1 attgcagttg ggcgctcagc agctgtggca gccggttgag gtctggaagt agcgttgggc
       61 tgaagcagcg gagttcgcca tgcgcgagtg tatctctatc cacgtggggc aggcgggtgt
      121 ccagatcggc aatgcctgct gggaactgta ctgccttgaa catggaattc agcccgatgg
      181 tcaaatgcca agtgataaaa ccattggtgg cggggacgac tccttcaaca cgttcttcag
      241 tgagactgga gctggcaagc acgtgcccag agcagtgttt gtggacctgg agcccactgt
      301 ggtcgatgaa gtgcgcacag ggacctacag gcagctcttc cacccagagc agctgatcac
      361 cgggaaggaa gatgcagcca gtaattacgc caggggccat tacaccatcg gcaaggagat
      421 tgttgaccta gtcctggacc ggatccgcaa actggcggat ctgtgcacag gactgcaggg
      481 cttcctcatc ttccacagct ttgggggcgg cactggctct gggttcgcat ctctgctcat
      541 ggagcggctc tcagtggatt acagcaagaa gtccaagcta gagtttgcca tttacccagc
      601 cccccaggtc tccacagccg tggtggagcc ctacaactcc atcctaacca cccacacgac
      661 cctggaacat tctgactgtg ccttcatggt cgacaatgaa gccatctatg acatatgtcg
      721 gcgcaacctg gacattgaac gtcccacgta caccaacctc aatcgcctga ttgggcagat
      781 cgtgtcctcc atcacggcct ccctgcgatt tgatggggcc ctgaatgtgg acttgacgga
      841 attccagacc aacctcgtgc cgtacccccg catccacttc cccctggcca cctacgcccc
      901 agtcatctca gctgagaagg cctaccacga gcagctgtct gtggccgaga tcaccaatgc
      961 ctgcttcgag ccagccaatc agatggtcaa gtgtgaccct cgccatggca agtacatggc
     1021 ctgctgcatg ttgtacaggg gggacgtggt ccccaaagac gtcaatgcgg ccatcgccac
     1081 catcaagacc aagcgcacta tccagtttgt ggattggtgc ccgactggat ttaaggtggg
     1141 cattaactac cagcccccca cagtggtccc cgggggagac ctggccaagg tgcagcgggc
     1201 cgtgtgcatg ctgagcaaca ccacggccat tgcggaggcc tgggcccgcc tggtccataa
     1261 gttcgatctc atgtatgcca agtgggcctt tgtgcactgg tacgtgggcg aaggcatgga
     1321 agagggagag ttctctgagg cccgcgagga cctggcagct ctagagaagg attgtgaaga
     1381 ggtgggcgtg gattccgtgg aagctgaggc tgaagaaggc gaagcatact gaggggaggg
     1441 tgtggtgggt tctcccctgc cacccctagg atggctgctt tcaagttgtt tgcaattaaa
     1501 gattctgtat aaaaccaa
//
