LOCUS       NM_032704               2823 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens tubulin alpha 1c (TUBA1C), transcript variant 5, mRNA.
ACCESSION   NM_032704
VERSION     NM_032704.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2823)
  AUTHORS   Wang,H., Cui,H., Yang,X. and Peng,L.
  TITLE     TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric
            cancer progression
  JOURNAL   BMC Cancer 23 (1), 258 (2023)
   PUBMED   36941595
  REMARK    GeneRIF: TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes
            gastric cancer progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2823)
  AUTHORS   Hu,X., Zhu,H., Chen,B., He,X., Shen,Y., Zhang,X., Xu,Y. and Xu,X.
  TITLE     The oncogenic role of tubulin alpha-1c chain in human tumours
  JOURNAL   BMC Cancer 22 (1), 498 (2022)
   PUBMED   35513790
  REMARK    GeneRIF: The oncogenic role of tubulin alpha-1c chain in human
            tumours.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2823)
  AUTHORS   Wu,Z., Sun,S., Fan,R. and Wang,Z.
  TITLE     Tubulin alpha 1c promotes aerobic glycolysis and cell growth
            through upregulation of yes association protein expression in
            breast cancer
  JOURNAL   Anticancer Drugs 33 (2), 132-141 (2022)
   PUBMED   34845165
  REMARK    GeneRIF: Tubulin alpha 1c promotes aerobic glycolysis and cell
            growth through upregulation of yes association protein expression
            in breast cancer.
REFERENCE   4  (bases 1 to 2823)
  AUTHORS   Gui,S., Chen,P., Liu,Y., Chen,Q., Cheng,T., Lv,S., Zhou,T.,
            Song,Z., Xiao,J., He,W., Yuan,S. and Cheng,Z.
  TITLE     TUBA1C expression promotes proliferation by regulating the cell
            cycle and indicates poor prognosis in glioma
  JOURNAL   Biochem Biophys Res Commun 577, 130-138 (2021)
   PUBMED   34517210
  REMARK    GeneRIF: TUBA1C expression promotes proliferation by regulating the
            cell cycle and indicates poor prognosis in glioma.
REFERENCE   5  (bases 1 to 2823)
  AUTHORS   Ge,L.P., Jin,X., Yang,Y.S., Liu,X.Y., Shao,Z.M., Di,G.H. and
            Jiang,Y.Z.
  TITLE     Tektin4 loss promotes triple-negative breast cancer metastasis
            through HDAC6-mediated tubulin deacetylation and increases
            sensitivity to HDAC6 inhibitor
  JOURNAL   Oncogene 40 (12), 2323-2334 (2021)
   PUBMED   33654196
  REMARK    GeneRIF: Tektin4 loss promotes triple-negative breast cancer
            metastasis through HDAC6-mediated tubulin deacetylation and
            increases sensitivity to HDAC6 inhibitor.
REFERENCE   6  (bases 1 to 2823)
  AUTHORS   Chen,D., Wang,M., Zhou,S. and Zhou,Q.
  TITLE     HIV-1 Tat targets microtubules to induce apoptosis, a process
            promoted by the pro-apoptotic Bcl-2 relative Bim
  JOURNAL   EMBO J 21 (24), 6801-6810 (2002)
   PUBMED   12486001
REFERENCE   7  (bases 1 to 2823)
  AUTHORS   Irobi,J., Nelis,E., Verhoeven,K., De Vriendt,E., Dierick,I., De
            Jonghe,P., Van Broeckhoven,C. and Timmerman,V.
  TITLE     Mutation analysis of 12 candidate genes for distal hereditary motor
            neuropathy type II (distal HMN II) linked to 12q24.3
  JOURNAL   J Peripher Nerv Syst 7 (2), 87-95 (2002)
   PUBMED   12090300
REFERENCE   8  (bases 1 to 2823)
  AUTHORS   Watts,N.R., Sackett,D.L., Ward,R.D., Miller,M.W., Wingfield,P.T.,
            Stahl,S.S. and Steven,A.C.
  TITLE     HIV-1 rev depolymerizes microtubules to form stable bilayered rings
  JOURNAL   J Cell Biol 150 (2), 349-360 (2000)
   PUBMED   10908577
REFERENCE   9  (bases 1 to 2823)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   10 (bases 1 to 2823)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC005946.1, AC125611.4 and AW150119.1.
            
            On Jun 2, 2019 this sequence version replaced NM_032704.4.
            
            Transcript Variant: This variant (5) contains an alternate first
            exon in place of the first exon of variant 1. The resulting isoform
            (c) has a shorter and distinct N-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005946.1, AK223024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301072.11/ ENSP00000301072.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-948               BC005946.1         1-948
            949-949             AC125611.4         174847-174847       c
            950-1542            BC005946.1         950-1542
            1543-1543           AC125611.4         174253-174253       c
            1544-1561           AW150119.1         9-26                c
            1562-2823           AC125611.4         172973-174234       c
FEATURES             Location/Qualifiers
     source          1..2823
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..2823
                     /gene="TUBA1C"
                     /gene_synonym="bcm948; TUBA6"
                     /note="tubulin alpha 1c"
                     /db_xref="GeneID:84790"
                     /db_xref="HGNC:HGNC:20768"
     exon            1..103
                     /gene="TUBA1C"
                     /gene_synonym="bcm948; TUBA6"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1450
                     /gene="TUBA1C"
                     /gene_synonym="bcm948; TUBA6"
                     /note="isoform c is encoded by transcript variant 5;
                     tubulin, alpha 6; tubulin alpha-1C chain; alpha-tubulin 6;
                     tubulin alpha-6 chain"
                     /codon_start=1
                     /product="tubulin alpha-1C chain isoform c"
                     /protein_id="NP_116093.1"
                     /db_xref="CCDS:CCDS8782.1"
                     /db_xref="GeneID:84790"
                     /db_xref="HGNC:HGNC:20768"
                     /translation="MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGG
                     GDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANN
                     YARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD
                     YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLD
                     IERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVI
                     SAEKAYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAT
                     IKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAVAEAWARLD
                     HKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGADSADGEDEGEEY"
     exon            104..326
                     /gene="TUBA1C"
                     /gene_synonym="bcm948; TUBA6"
                     /inference="alignment:Splign:2.1.0"
     exon            327..475
                     /gene="TUBA1C"
                     /gene_synonym="bcm948; TUBA6"
                     /inference="alignment:Splign:2.1.0"
     exon            476..2823
                     /gene="TUBA1C"
                     /gene_synonym="bcm948; TUBA6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1532..1537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBA1C"
                     /gene_synonym="bcm948; TUBA6"
                     /note="hexamer: AATAAA"
     polyA_site      1557
                     /gene="TUBA1C"
                     /gene_synonym="bcm948; TUBA6"
                     /note="major polyA site"
     regulatory      2803..2808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBA1C"
                     /gene_synonym="bcm948; TUBA6"
                     /note="hexamer: AATAAA"
     polyA_site      2823
                     /gene="TUBA1C"
                     /gene_synonym="bcm948; TUBA6"
ORIGIN      
        1 actacttctc ccccggactc cttggtagtc tgttagtggg agatccttgt tgccgtccct
       61 tcgcctcctt caccgccgca gaccccttca agttctagtc atgcgtgagt gcatctccat
      121 ccacgttggc caggctggtg tccagattgg caatgcctgc tgggagctct actgcctgga
      181 acacggcatc cagcccgatg gccagatgcc aagtgacaag accattgggg gaggagatga
      241 ttccttcaac accttcttca gtgaaacggg tgctggcaag catgtgcccc gggcagtgtt
      301 tgtagacttg gaacccacag tcattgatga agttcgcact ggcacttacc gccagctctt
      361 ccaccctgag caactcatca caggcaagga agatgctgcc aataactatg cccgagggca
      421 ctacaccatt ggcaaggaga tcattgacct cgtgttggac cgaattcgca agctggctga
      481 ccagtgcacc ggtcttcagg gcttcttggt tttccacagc tttggtgggg gaactggttc
      541 tgggttcacc tcgctgctca tggaacgtct ctcagttgat tatggcaaga agtccaagct
      601 ggagttctcc atttacccgg cgccccaggt ttccacagct gtagttgagc cctacaactc
      661 catcctcacc acccacacca ccctggagca ctctgattgt gccttcatgg tagacaatga
      721 ggccatctat gacatctgtc gtagaaacct cgatatcgag cgcccaacct acactaacct
      781 taaccgcctt attagccaga ttgtgtcctc catcactgct tccctgagat ttgatggagc
      841 cctgaatgtt gacctgacag aattccagac caacctggtg ccctaccccc gcatccactt
      901 ccctctggcc acatatgccc ctgtcatctc tgctgagaaa gcctaccacg aacagcttac
      961 tgtagcagag atcaccaatg cttgctttga gccagccaac cagatggtga aatgtgaccc
     1021 tcgccatggt aaatacatgg cttgctgcct gttataccgt ggtgacgtgg ttcccaaaga
     1081 tgtcaatgct gccattgcca ccatcaaaac caagcgtacc atccagtttg tggattggtg
     1141 ccccactggc ttcaaggttg gcattaatta ccagcctccc actgtggtgc ctggcggaga
     1201 cctggccaag gtacagagag ctgtgtgcat gctgagcaat accacagctg ttgccgaggc
     1261 ctgggctcgc ctggaccaca agtttgacct gatgtatgcc aagcgtgcct ttgttcactg
     1321 gtacgtgggt gaggggatgg aggaaggcga gttttcagag gcccgtgagg acatggctgc
     1381 ccttgagaag gattatgagg aggttggagc agatagtgct gacggagagg atgagggtga
     1441 agagtattaa cctgtgtgct gtacttttac actcctttgt cttggaactg tcttattttt
     1501 gttctgtaaa tgtctattgc cgtaaattgt taataaaatt gaagtttcca ttttaaatgt
     1561 cgagctgact taaatacttg atccagttaa agttggatgt atgaggctgg tagatgaaac
     1621 cacctgagtc gagggtcttg ctctgtcacc caggctggag tgcagtggca tgataataca
     1681 tagctcattg cagcctcgag ctcctggact catgtgattc tcctgcttca gcctcctaag
     1741 tagctgggga ctgcaggtgc acaccaccat gcccagctat ttttatttct tgtagagatg
     1801 gggccttgct atgctgccca gggtggtctt caactggctt caagtgatcc tcctgcctca
     1861 acctctcaaa gttttgatta taggcatgag ccactgccca gcttcttggt ttatctgttt
     1921 aatttgggcc tgaattaagt ggttatagaa tcattttgta agtgaggaaa cgggttcaga
     1981 ttgagccagt gcttctctaa ctaaaatgga tgtgaatcac ctgtagatat taaaatgcag
     2041 gtttggggtc aacctggtgg ctcatgcact tcgggaggcc aagttgggtg gatcacgagc
     2101 ccaggaattc gagaccagcc tgggcaacat ggtgaaaacc catctctacc aaaacaaaaa
     2161 tttgcatgct gtgatggcac ctgcctatag gtgggaggac cacctgagcc caaggaggtt
     2221 gaggtagtga gccatgattg caccactgca ttccagcctg ggtgacggag acccctgact
     2281 ctcaaattta aaaacaaaat gcaggttcta attctatagg cttgaggtga ggcttcagac
     2341 acgtcttaaa ttttttttct ttgagatggt ctctttccca ggctgcagtg caatggcacc
     2401 atcatagctc acccccacct tgacctgggc taagccatcc tcccacctca gcctcccaag
     2461 tagccaggac tacaggtgtg ttccaccatg cctggctgat tcttgtaatt tttttttttt
     2521 tttttttttt tttttttggt agagatgggg ttttgccatg ttgcttaggc tggccttgaa
     2581 ctcctgggct caggcaatcc tgcctcagcc tcccaaagtg ctgggattac aggagtgagc
     2641 cactacacct ggcccctaga tacgtttttt aataacctcc caaatgatgc tgttggtctg
     2701 atgtgaccac atgtacagta gcaaagggtt agataacagt aactgctgga gccaaaattc
     2761 aagtgcccag ccacactgcc agaactattg ctgtcagtct ttaataaagt attagtcaca
     2821 cga
//
