LOCUS       NM_006082               1627 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens tubulin alpha 1b (TUBA1B), mRNA.
ACCESSION   NM_006082
VERSION     NM_006082.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1627)
  AUTHORS   Fu,G., Yan,S., Khoo,C.J., Chao,V.C., Liu,Z., Mukhi,M., Hervas,R.,
            Li,X.D. and Ti,S.C.
  TITLE     Integrated regulation of tubulin tyrosination and microtubule
            stability by human alpha-tubulin isotypes
  JOURNAL   Cell Rep 42 (6), 112653 (2023)
   PUBMED   37379209
  REMARK    GeneRIF: Integrated regulation of tubulin tyrosination and
            microtubule stability by human alpha-tubulin isotypes.
REFERENCE   2  (bases 1 to 1627)
  AUTHORS   Pang,X.L., Du,H.F., Nie,F., Yang,X.G. and Xu,Y.
  TITLE     Tubulin Alpha-1b as a Potential Biomarker for Lung Adenocarcinoma
            Diagnosis and Prognosis
  JOURNAL   Technol Cancer Res Treat 22, 15330338231178391 (2023)
   PUBMED   37489256
  REMARK    GeneRIF: Tubulin Alpha-1b as a Potential Biomarker for Lung
            Adenocarcinoma Diagnosis and Prognosis.
REFERENCE   3  (bases 1 to 1627)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 1627)
  AUTHORS   LaFrance,B.J., Roostalu,J., Henkin,G., Greber,B.J., Zhang,R.,
            Normanno,D., McCollum,C.O., Surrey,T. and Nogales,E.
  TITLE     Structural transitions in the GTP cap visualized by cryo-electron
            microscopy of catalytically inactive microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (2) (2022)
   PUBMED   34996871
REFERENCE   5  (bases 1 to 1627)
  AUTHORS   Hu,J., Han,C., Zhong,J., Liu,H., Liu,R., Luo,W., Chen,P. and
            Ling,F.
  TITLE     Dynamic Network Biomarker of Pre-Exhausted CD8+ T Cells Contributed
            to T Cell Exhaustion in Colorectal Cancer
  JOURNAL   Front Immunol 12, 691142 (2021)
   PUBMED   34434188
  REMARK    GeneRIF: Dynamic Network Biomarker of Pre-Exhausted CD8(+) T Cells
            Contributed to T Cell Exhaustion in Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1627)
  AUTHORS   Kapeller,R., Toker,A., Cantley,L.C. and Carpenter,C.L.
  TITLE     Phosphoinositide 3-kinase binds constitutively to
            alpha/beta-tubulin and binds to gamma-tubulin in response to
            insulin
  JOURNAL   J Biol Chem 270 (43), 25985-25991 (1995)
   PUBMED   7592789
REFERENCE   7  (bases 1 to 1627)
  AUTHORS   Alexandrova,N., Niklinski,J., Bliskovsky,V., Otterson,G.A.,
            Blake,M., Kaye,F.J. and Zajac-Kaye,M.
  TITLE     The N-terminal domain of c-Myc associates with alpha-tubulin and
            microtubules in vivo and in vitro
  JOURNAL   Mol Cell Biol 15 (9), 5188-5195 (1995)
   PUBMED   7651436
REFERENCE   8  (bases 1 to 1627)
  AUTHORS   Venter,J.C.
  TITLE     Identification of new human receptor and transporter genes by high
            throughput cDNA (EST) sequencing
  JOURNAL   J Pharm Pharmacol 45 Suppl 1, 355-360 (1993)
   PUBMED   8098743
  REMARK    Review article
REFERENCE   9  (bases 1 to 1627)
  AUTHORS   Szasz,J., Yaffe,M.B. and Sternlicht,H.
  TITLE     Site-directed mutagenesis of alpha-tubulin. Reductive methylation
            studies of the Lys 394 region
  JOURNAL   Biophys J 64 (3), 792-802 (1993)
   PUBMED   8097117
REFERENCE   10 (bases 1 to 1627)
  AUTHORS   Cowan,N.J., Dobner,P.R., Fuchs,E.V. and Cleveland,D.W.
  TITLE     Expression of human alpha-tubulin genes: interspecies conservation
            of 3' untranslated regions
  JOURNAL   Mol Cell Biol 3 (10), 1738-1745 (1983)
   PUBMED   6646120
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF979331.1, AK098635.1 and BC006481.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006082.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026516.1, AK026632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336023.9/ ENSP00000336799.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                BF979331.1         137-234
            99-1623             AK098635.1         99-1623
            1624-1627           BC006481.1         1610-1613
FEATURES             Location/Qualifiers
     source          1..1627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..1627
                     /gene="TUBA1B"
                     /gene_synonym="K-ALPHA-1"
                     /note="tubulin alpha 1b"
                     /db_xref="GeneID:10376"
                     /db_xref="HGNC:HGNC:18809"
                     /db_xref="MIM:602530"
     exon            1..98
                     /gene="TUBA1B"
                     /gene_synonym="K-ALPHA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1451
                     /gene="TUBA1B"
                     /gene_synonym="K-ALPHA-1"
                     /note="tubulin, alpha, ubiquitous; alpha tubulin; tubulin
                     K-alpha-1; alpha-tubulin ubiquitous; tubulin
                     alpha-ubiquitous chain"
                     /codon_start=1
                     /product="tubulin alpha-1B chain"
                     /protein_id="NP_006073.2"
                     /db_xref="CCDS:CCDS31792.1"
                     /db_xref="GeneID:10376"
                     /db_xref="HGNC:HGNC:18809"
                     /db_xref="MIM:602530"
                     /translation="MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGG
                     GDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANN
                     YARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVD
                     YGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLD
                     IERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVI
                     SAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAT
                     IKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLD
                     HKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEE
                     Y"
     exon            99..321
                     /gene="TUBA1B"
                     /gene_synonym="K-ALPHA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..470
                     /gene="TUBA1B"
                     /gene_synonym="K-ALPHA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..1627
                     /gene="TUBA1B"
                     /gene_synonym="K-ALPHA-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1606..1611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUBA1B"
                     /gene_synonym="K-ALPHA-1"
                     /note="hexamer: AGTAAA"
     polyA_site      1627
                     /gene="TUBA1B"
                     /gene_synonym="K-ALPHA-1"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgttac ttacctcgac tcttagcttg tcggggacgg taaccgggac ccggtgtctg
       61 ctcctgtcgc cttcgcctcc taatccctag ccactatgcg tgagtgcatc tccatccacg
      121 ttggccaggc tggtgtccag attggcaatg cctgctggga gctctactgc ctggaacacg
      181 gcatccagcc cgatggccag atgccaagtg acaagaccat tgggggagga gatgactcct
      241 tcaacacctt cttcagtgag acgggcgctg gcaagcacgt gccccgggct gtgtttgtag
      301 acttggaacc cacagtcatt gatgaagttc gcactggcac ctaccgccag ctcttccacc
      361 ctgagcagct catcacaggc aaggaagatg ctgccaataa ctatgcccga gggcactaca
      421 ccattggcaa ggagatcatt gaccttgtgt tggaccgaat tcgcaagctg gctgaccagt
      481 gcaccggtct tcagggcttc ttggttttcc acagctttgg tgggggaact ggttctgggt
      541 tcacctccct gctcatggaa cgtctctcag ttgattatgg caagaagtcc aagctggagt
      601 tctccattta cccagcaccc caggtttcca cagctgtagt tgagccctac aactccatcc
      661 tcaccaccca caccaccctg gagcactctg attgtgcctt catggtagac aatgaggcca
      721 tctatgacat ctgtcgtaga aacctcgata tcgagcgccc aacctacact aaccttaacc
      781 gccttattag ccagattgtg tcctccatca ctgcttccct gagatttgat ggagccctga
      841 atgttgacct gacagaattc cagaccaacc tggtgcccta cccccgcatc cacttccctc
      901 tggccacata tgcccctgtc atctctgctg agaaagccta ccatgaacag ctttctgtag
      961 cagagatcac caatgcttgc tttgagccag ccaaccagat ggtgaaatgt gaccctcgcc
     1021 atggtaaata catggcttgc tgcctgttgt accgtggtga cgtggttccc aaagatgtca
     1081 atgctgccat tgccaccatc aaaaccaagc gcagcatcca gtttgtggat tggtgcccca
     1141 ctggcttcaa ggttggcatc aactaccagc ctcccactgt ggtgcctggt ggagacctgg
     1201 ccaaggtaca gagagctgtg tgcatgctga gcaacaccac agccattgct gaggcctggg
     1261 ctcgcctgga ccacaagttt gacctgatgt atgccaagcg tgcctttgtt cactggtacg
     1321 tgggtgaggg gatggaggaa ggcgagtttt cagaggcccg tgaagatatg gctgcccttg
     1381 agaaggatta tgaggaggtt ggtgtggatt ctgttgaagg agagggtgag gaagaaggag
     1441 aggaatacta attatccatt ccttttggcc ctgcagcatg tcatgctccc agaatttcag
     1501 cttcagctta actgacagac gttaaagctt tctggttaga ttgttttcac ttggtgatca
     1561 tgtcttttcc atgtgtacct gtaatatttt tccatcatat ctcaaagtaa agtcattaac
     1621 atcaaaa
//
