LOCUS       NM_177972               6445 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens TUB bipartite transcription factor (TUB), transcript
            variant 2, mRNA.
ACCESSION   NM_177972
VERSION     NM_177972.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6445)
  AUTHORS   Xu,W., Xu,M., Yin,Q., Liu,C., Cao,Q., Deng,Y., Liu,S. and He,G.
  TITLE     A novel homozygous TUB mutation associated with autosomal recessive
            retinitis pigmentosa in a consanguineous Chinese family
  JOURNAL   BMC Med Genomics 16 (1), 9 (2023)
   PUBMED   36650547
  REMARK    GeneRIF: A novel homozygous TUB mutation associated with autosomal
            recessive retinitis pigmentosa in a consanguineous Chinese family.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6445)
  AUTHORS   Ziccardi,L., Niceta,M., Stellacci,E., Ciolfi,A., Tatti,M.,
            Bruselles,A., Mancini,C., Barbano,L., Cecchetti,S., Costanzo,E.,
            Cappa,M., Parravano,M., Varano,M., Tartaglia,M. and Cordeddu,V.
  TITLE     Biallelic Inactivating TUB Variants Cause Retinal Ciliopathy
            Impairing Biogenesis and the Structure of the Primary Cilium
  JOURNAL   Int J Mol Sci 23 (23), 14656 (2022)
   PUBMED   36498982
  REMARK    GeneRIF: Biallelic Inactivating TUB Variants Cause Retinal
            Ciliopathy Impairing Biogenesis and the Structure of the Primary
            Cilium.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6445)
  AUTHORS   Chalazan,B., Palm,D., Sridhar,A., Lee,C., Argos,M., Daviglus,M.,
            Rehman,J., Konda,S. and Darbar,D.
  TITLE     Common genetic variants associated with obesity in an
            African-American and Hispanic/Latino population
  JOURNAL   PLoS One 16 (5), e0250697 (2021)
   PUBMED   33983957
  REMARK    GeneRIF: Common genetic variants associated with obesity in an
            African-American and Hispanic/Latino population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6445)
  AUTHORS   Wang,P., Wang,Z., Zhang,M., Wu,Q. and Shi,F.
  TITLE     Lnc-OIP5-AS1 exacerbates aorta wall injury during the development
            of aortic dissection through upregulating TUB via sponging
            miR-143-3p
  JOURNAL   Life Sci 271, 119199 (2021)
   PUBMED   33577845
  REMARK    GeneRIF: Lnc-OIP5-AS1 exacerbates aorta wall injury during the
            development of aortic dissection through upregulating TUB via
            sponging miR-143-3p.
REFERENCE   5  (bases 1 to 6445)
  AUTHORS   Sailani,M.R., Jahanbani,F., Abbott,C.W., Lee,H., Zia,A., Rego,S.,
            Winkelmann,J., Hopfner,F., Khan,T.N., Katsanis,N., Muller,S.H.,
            Berg,D., Lyman,K.M., Mychajliw,C., Deuschl,G., Bernstein,J.A.,
            Kuhlenbaumer,G. and Snyder,M.P.
  TITLE     Candidate variants in TUB are associated with familial tremor
  JOURNAL   PLoS Genet 16 (9), e1009010 (2020)
   PUBMED   32956375
  REMARK    GeneRIF: Candidate variants in TUB are associated with familial
            tremor.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6445)
  AUTHORS   He,W., Ikeda,S., Bronson,R.T., Yan,G., Nishina,P.M., North,M.A. and
            Naggert,J.K.
  TITLE     GFP-tagged expression and immunohistochemical studies to determine
            the subcellular localization of the tubby gene family members
  JOURNAL   Brain Res Mol Brain Res 81 (1-2), 109-117 (2000)
   PUBMED   11000483
REFERENCE   7  (bases 1 to 6445)
  AUTHORS   Boggon,T.J., Shan,W.S., Santagata,S., Myers,S.C. and Shapiro,L.
  TITLE     Implication of tubby proteins as transcription factors by
            structure-based functional analysis
  JOURNAL   Science 286 (5447), 2119-2125 (1999)
   PUBMED   10591637
  REMARK    GeneRIF: Crystal structure of the core domain of the mouse Tubby
            protein.
REFERENCE   8  (bases 1 to 6445)
  AUTHORS   Kapeller,R., Moriarty,A., Strauss,A., Stubdal,H., Theriault,K.,
            Siebert,E., Chickering,T., Morgenstern,J.P., Tartaglia,L.A. and
            Lillie,J.
  TITLE     Tyrosine phosphorylation of tub and its association with Src
            homology 2 domain-containing proteins implicate tub in
            intracellular signaling by insulin
  JOURNAL   J Biol Chem 274 (35), 24980-24986 (1999)
   PUBMED   10455176
REFERENCE   9  (bases 1 to 6445)
  AUTHORS   North,M.A., Naggert,J.K., Yan,Y., Noben-Trauth,K. and Nishina,P.M.
  TITLE     Molecular characterization of TUB, TULP1, and TULP2, members of the
            novel tubby gene family and their possible relation to ocular
            diseases
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 3128-3133 (1997)
   PUBMED   9096357
REFERENCE   10 (bases 1 to 6445)
  AUTHORS   Kleyn,P.W., Fan,W., Kovats,S.G., Lee,J.J., Pulido,J.C., Wu,Y.,
            Berkemeier,L.R., Misumi,D.J., Holmgren,L., Charlat,O., Woolf,E.A.,
            Tayber,O., Brody,T., Shu,P., Hawkins,F., Kennedy,B., Baldini,L.,
            Ebeling,C., Alperin,G.D., Deeds,J., Lakey,N.D., Culpepper,J.,
            Chen,H., Glucksmann-Kuis,M.A., Carlson,G.A., Duyk,G.M. and
            Moore,K.J.
  TITLE     Identification and characterization of the mouse obesity gene
            tubby: a member of a novel gene family
  JOURNAL   Cell 85 (2), 281-290 (1996)
   PUBMED   8612280
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC116456.12, U54644.1,
            BM992151.1 and BM679358.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2019 this sequence version replaced NM_177972.2.
            
            Summary: This gene encodes a member of the Tubby family of
            bipartite transcription factors. The encoded protein may play a
            role in obesity and sensorineural degradation. The crystal
            structure has been determined for a similar protein in mouse, and
            it functions as a membrane-bound transcription regulator that
            translocates to the nucleus in response to phosphoinositide
            hydrolysis. Two transcript variants encoding distinct isoforms have
            been identified for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding region compared to variant 1. This results in a shorter
            isoform (b) with a distinct N-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2564845.1,
                                           SRR14038195.1427971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299506.3/ ENSP00000299506.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC116456.12        108653-108886
            235-1983            U54644.1           87-1835
            1984-6150           AC116456.12        129224-133390
            6151-6309           BM992151.1         18-176              c
            6310-6445           BM679358.1         15-150              c
FEATURES             Location/Qualifiers
     source          1..6445
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..6445
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /note="TUB bipartite transcription factor"
                     /db_xref="GeneID:7275"
                     /db_xref="HGNC:HGNC:12406"
                     /db_xref="MIM:601197"
     exon            1..338
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1821
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /note="isoform b is encoded by transcript variant 2; tubby
                     protein homolog; tubby homologue; tubby bipartite
                     transcription factor"
                     /codon_start=1
                     /product="tubby protein homolog isoform b"
                     /protein_id="NP_813977.1"
                     /db_xref="CCDS:CCDS7787.1"
                     /db_xref="GeneID:7275"
                     /db_xref="HGNC:HGNC:12406"
                     /db_xref="MIM:601197"
                     /translation="MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQE
                     PLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPT
                     APASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSD
                     HAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTR
                     PSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGM
                     DRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRS
                     NLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGM
                     NMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQA
                     SVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE"
     exon            339..390
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /inference="alignment:Splign:2.1.0"
     exon            391..553
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /inference="alignment:Splign:2.1.0"
     exon            554..697
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /inference="alignment:Splign:2.1.0"
     exon            698..865
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /inference="alignment:Splign:2.1.0"
     exon            866..987
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1185
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1298
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1416
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1515
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1687
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..6445
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6289..6294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /note="hexamer: AATAAA"
     polyA_site      6309
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /note="major polyA site"
     regulatory      6423..6428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /note="hexamer: ATTAAA"
     polyA_site      6445
                     /gene="TUB"
                     /gene_synonym="rd5; RDOB"
                     /note="major polyA site"
ORIGIN      
        1 actcccgcct tggcgccaga ggggcgcggg acggtgcggt cggcctcccc gcctccacgc
       61 gcgcgcacga cccgcgcact cccggagctt cgcccatctc gcctcgccgc gccgcgcagg
      121 cagccgctcg cagagccagc agccggggcc ctggcgtgca gcgcgggcct cggcggggcc
      181 cagcgccccg gcccgggagg atgcggcccg gggcggcccg ggagctgagc agggcccccg
      241 cgccggcccc tccgggcccc ggcctccaga gccgcagcca ccgccccgcc cccgagagac
      301 atgacttcca agccgcattc cgactggatt ccctacagtg tcttagatga tgagggcaga
      361 aacctgaggc agcagaagct tgatcggcag cgggccctgc tggagcagaa gcagaagaag
      421 aagcgccagg agcccctgat ggtgcaggcc aatgcagatg ggcggccccg gagccggcgg
      481 gcccggcagt cagaggaaca agcccccctg gtggagtcct acctcagcag cagtggcagc
      541 accagctacc aagttcaaga ggccgactca ctcgccagtg tgcagctggg agccacgcgc
      601 ccaacagcac cagcttcagc caagagaacc aaggcggcag ctacagcagg gggccagggt
      661 ggcgccgcta ggaaggagaa gaagggaaag cacaaaggca ccagcgggcc agcagcactg
      721 gcagaagaca agtctgaggc ccaaggccca gtgcagattc tgactgtggg ccagtcagac
      781 cacgcccagg acgcagggga gacggcagct ggtgggggcg aacggcccag cgggcaggat
      841 ctccgtgcca cgatgcagag gaagggcatc tccagcagca tgagctttga cgaggatgag
      901 gaggatgagg aggagaatag ctccagctcc tcccagctaa atagtaacac ccgccccagc
      961 tctgctacta gcaggaagtc cgtcagggag gcagcctcag cccctagccc aacagctcca
     1021 gagcaaccag tggacgttga ggtccaggat cttgaggagt ttgcactgag gccggccccc
     1081 cagggtatca ccatcaaatg ccgcatcact cgggacaaga aagggatgga ccggggcatg
     1141 taccccacct actttctgca cctggaccgt gaggatggga agaaggtgtt cctcctggcg
     1201 ggaaggaaga gaaagaagag taaaacttcc aattacctca tctctgtgga cccaacagac
     1261 ttgtctcgag gaggggacag ctatatcggg aaactgcggt ccaacttgat gggcaccaag
     1321 ttcactgttt atgacaatgg agtcaaccct cagaaggcct catcctccac tttggaaagt
     1381 ggaaccttac gtcaggagct ggcagctgtg tgctacgaga caaacgtctt aggcttcaag
     1441 gggcctcgga agatgagcgt gattgtccca ggcatgaaca tggttcatga gagagtctct
     1501 atccgccccc gcaacgagca tgagacactg ctagcacgct ggcagaataa gaacacggag
     1561 agtatcatcg agctgcaaaa caagacacct gtctggaatg atgacacaca gtcctatgta
     1621 ctcaacttcc atgggcgcgt cacacaggcc tccgtgaaga acttccagat catccatggc
     1681 aatgacccgg actacatcgt gatgcagttt ggccgggtag cagaggatgt gttcaccatg
     1741 gattacaact acccgctgtg tgcactgcag gcctttgcca ttgccctgtc cagcttcgac
     1801 agcaagctgg cgtgcgagta gaggcctctt cgtgcccttt ggggttgccc agcctggagc
     1861 ggagcttgcc tgcctgcctg tggagacagc cctgcctatc ctctgtatat aggccttccg
     1921 ccagatgaag ctttggccct cagtgggctc cctggcccag ccagccagga actggctcct
     1981 ttgcctctgc tactgaggca ggggagtagt ggagagcggg tgggtgggtg tgaagggatg
     2041 agaataattc tttccatgcc acgagatcaa cacacactcc cacccttggg gtagtagtgt
     2101 gttgtagtcg tacttaccaa gctgagcaac ctcttcagct gggaaggccg caagaggcat
     2161 agagggagag gaagcacact gcagggctgc tgtggcccag tcgtccgctc agccaaggag
     2221 tcagatggca atgggtactc cagcaggtag gggcacagtg aatgtgtgta tgtatgaagg
     2281 ccacatcaac tttatgtagc aaagggcttg gtggccaagc ctggccctta aacaactgca
     2341 gaaagccctt caacttcaga aggcctcact caagcctgag agaagttggg agggtggtgg
     2401 ggacaggtaa gtggcaggac cctgtcagga ttgcaggtgc ctggcttgct gtggctatgg
     2461 gaatcagctg gtggctaggt ttctagcgca tttgatttct ccaggtttgc tgtgtctcac
     2521 agaggcagta ggaacccagc tctcagggct gtcttggtgg atgggccctg caagacacag
     2581 gctcagcatg cagaagtgca tgaacagggt ccctggatca gggttgttct gggagtcctg
     2641 tcagcttccc caggagctct ctgctgagca gcccagcaca acccccagga aacacaaatg
     2701 gggtccaggt caccagcctg actgcacaca gctaggcatg cctgggaatc ctgctgccag
     2761 agaaccattc ccaagccatg gcatgctcct tgaagaatct ctcctctctc tctctctctg
     2821 gaaagaccca actttctcac tgctgtcagc caagtcatgg ttggtaacca tgtaggttct
     2881 tgggagggaa tgggacaggg tgaataaagc agggaatatt ttagaaccac aagagatcag
     2941 cagtggcagg acccttagga atctagtaca accttgttgc tttaggtgag tcacactcag
     3001 aaaatggggc ttgccctggg tcacctagct ggttaatggc agcattcaga acttcaagtt
     3061 ctcttgattt ctttgttccc actgtccccc aagaaactag tatctctggc ctcctggggg
     3121 cccattctgc atgccctccc cacttccccc gattcagaga cttagaagca tcagagttga
     3181 taaattagat tgaaaccatt ccagtaggaa atcaggcagt tccctgttga aagttgtctg
     3241 gctttttgca cgtgagtatg atccaggatt ggcctgtgtc tggcccctcc gcgagggcta
     3301 ctcagcagta agcaggcctt agtacggctg ctgcacactt ctcggtctag gtgggagaga
     3361 gtgcataaag gttctggggc tgggcctgag cctaactccc tccactaccg ctatttctcc
     3421 ttggatggca ccatccaccc tgcaggcttg ggaactgtaa gctcaagctt ttgctcattt
     3481 gtcatttacc ctggtggagg cttcttgccc agatagagat ctgaaattgg tgggaagcaa
     3541 gcaggggtcg taccttgctt tagagtagat gtttggaaaa gctaagtaga aattttttaa
     3601 aatagaagtt gtattttaaa cgtgttaggc tttataggtg aaggacttgt tttgacttaa
     3661 gtagaagtaa tatgctctca tttctttgta atctagattt tcctatgttg aatgcttaaa
     3721 gcaaggcata cctgtcctag caggatctgc ccacacctcg gccgtacatc tctgtgagag
     3781 accccctcca acgattagct tttgcaacat ggtccagttt ctagagggca ctagaacttt
     3841 gtgccagcgc tggcgagata ccatggtgcc atcctccttt ctatagttcc agtttagccc
     3901 ttccctgcct ttaaggagaa gagatcttca tggtgacatt tgagatgatg gaaactagat
     3961 cgtctctaat gttaggtcaa gctatttctc tggatctatg attttaagat agaacaggct
     4021 ggttctgagt tctggtgaga cggagacccc ggtggcagtg gaaaaatcag aagcacaaag
     4081 gaaaactctt ggcctctgct ttctcctgta gcacaaagag ggagttggct ggatcttttg
     4141 gtggagtcag gaaagacagg ctgagctttc tagcctaagt gtggagaagg atagcctcag
     4201 ccacaaaact ctgtcaggca ttgaatgaca agcatcagta gctgagtgca ctcctggtga
     4261 tcctggtttt ccttgaccac tggccctggg gccatgggtg catggactcg taaagctgct
     4321 agggccccta gaaaccacct gggttcagcc tctcccacaa taagagttct tgcccttcat
     4381 accctctacc tggatggatg gtctttgggc agggaattaa tgacagaatg agcagtccct
     4441 aatggtattg ggcagttggg agtgagttta ggcagcttct ctgtaaccgc ttctggggcc
     4501 acaccccaaa actctacacc ctctgcccca gaacaattct gcagagtggt gaagttcact
     4561 tccccaactc ttctccaagt ctagctttcc tttccttctg gctccaaggt gctctgtgtc
     4621 cgtctgtgta tgtgtgtgtc tgtgcgtctg tgtgtttatt tggggaaaag ggcaatcagc
     4681 aatcaactga ggtttcttaa ttgtgattat attcctgaga atgaatgagt aggaaaggaa
     4741 taaggatgtt gttatgatcg cctgtggatt ttgtccattc atctcatgct ctctgaacag
     4801 aaggtatacc tgggaagata ccagcttttt ctctcagggt tctgagtcag aggacaccat
     4861 ccaagaatgt tgttagcttt tcagttcccg ctctgcattg cctgaaaaaa ctggtatgtt
     4921 gcacgtatgc ttttggttga aattgaacat actctagtga atgtgcctta aaaatcaaga
     4981 cactagttca gaggaagcac ataatgtcca gatctatggc gaacacaggt gttggaagcc
     5041 aggactgtga taatcagaag ctataagaga actttcggag cctgcctcct tcagtgacaa
     5101 gtagggcaca aaattctaga agcagaaggt tgtttttttt tttttttctc cattctgaaa
     5161 atagcaggac atttacctct taaataaact tagcatttag aggtaattct aaatttaaca
     5221 agtgacaggg ttggtttcaa agaaaaaggt ccatgctttg cttacaatgg agtctgcagt
     5281 gaggggagat gctgggatag ccatttccat ggctctgtta tgcaagcaca aatttcatct
     5341 cctagatgga cttcctggtt ttctcttact gcagtaacac tggccttccc ttctctaatt
     5401 ccttacccca gctgcggcat ccctgtgtta actcaggatg ccaagtggcc ctcagattac
     5461 acttctccag atagctgaat gagtctgctt tcactgtgac tgggacctga atgacctgca
     5521 gtcagggccc agagttggga ctctatacta ccctgggctc tggtctgtag gtttgtagta
     5581 gccaccggta ataagccaag ggctaggctc ttgtttgagt ttatggccac ctggaatttt
     5641 cagtcatctc atgatacagg cgggaggggc agaacagata gattacgaca ggtttggttt
     5701 ttaaattttc caaccaagtg gaaaggcaag ttggtcttat agaaagcact actgcactta
     5761 gtagctatgt gattttgagc aaaccacata atctctctag gtccattttc ctaaccacaa
     5821 gataaagatg ttacattgtc aaagcttgcc gtaggatttg gggtgaatga aaattattcc
     5881 ttgctttcat cactaccttt atagctctca tcactacctt tatagctcat cactgtgcct
     5941 ttttttcttt cctaagaaag acatcacatc cctctcctct cctcctctgt gctcctgtcc
     6001 ctccctcccc ctagcaaggt ccaggcaaag ctggagatga ggctgagatc cagagtttcc
     6061 tagaacgcaa cttaggatgg ctaggaaagg gaagcctgac tgctcggtca ggagggtgca
     6121 gtatctcttg ctgggaacac agccagtttt cacaatgcct agactgtgta tgtctatttg
     6181 cacaagattg tcttttccta ttttggagtg gtcagacatt ttatttttgt tcaagattat
     6241 ctggcgtttt agacaaattt gcaaaactgt gcttttattg actttttgaa taaactttgg
     6301 tattctggag caaatgtatt tatttattgg tatgtgcaat gacaaacttg gtattttccc
     6361 atgttgacat tatgtatgtt gtagaattta gtgtttgtct aagtacacac atatatcaac
     6421 aaattaaact tgaatcgttt caaca
//
