LOCUS       NM_025250               4805 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens tweety family member 3 (TTYH3), mRNA.
ACCESSION   NM_025250 XM_166523 XM_374388
VERSION     NM_025250.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4805)
  AUTHORS   Huang,X., Li,Q., Zheng,X. and Jiang,C.
  TITLE     TTYH3 Promotes Cervical Cancer Progression by Activating the
            Wnt/beta-Catenin Signaling Pathway
  JOURNAL   Cancer Invest 42 (8), 726-739 (2024)
   PUBMED   39189652
  REMARK    GeneRIF: TTYH3 Promotes Cervical Cancer Progression by Activating
            the Wnt/beta-Catenin Signaling Pathway.
REFERENCE   2  (bases 1 to 4805)
  AUTHORS   Cao,Y., Zhou,Z., He,S. and Liu,W.
  TITLE     TTYH3 promotes the malignant progression of oral squamous cell
            carcinoma SCC-9 cells by regulating tumor-associated macrophage
            polarization
  JOURNAL   Arch Oral Biol 165, 106028 (2024)
   PUBMED   38908074
  REMARK    GeneRIF: TTYH3 promotes the malignant progression of oral squamous
            cell carcinoma SCC-9 cells by regulating tumor-associated
            macrophage polarization.
REFERENCE   3  (bases 1 to 4805)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   4  (bases 1 to 4805)
  AUTHORS   Biswas,P.K., Kwak,Y., Kim,A., Seok,J., Kwak,H.J., Lee,M.,
            Dayem,A.A., Song,K., Park,J.Y., Park,K.S., Shin,H.J. and Cho,S.G.
  TITLE     TTYH3 Modulates Bladder Cancer Proliferation and Metastasis via
            FGFR1/H-Ras/A-Raf/MEK/ERK Pathway
  JOURNAL   Int J Mol Sci 23 (18), 10496 (2022)
   PUBMED   36142409
  REMARK    GeneRIF: TTYH3 Modulates Bladder Cancer Proliferation and
            Metastasis via FGFR1/H-Ras/A-Raf/MEK/ERK Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4805)
  AUTHORS   Wang,Y., Xie,Y., Dong,B., Xue,W., Chen,S., Mitsuo,S., Zou,H.,
            Feng,Y., Ma,K., Dong,Q., Cao,J. and Zhu,C.
  TITLE     The TTYH3/MK5 Positive Feedback Loop regulates Tumor Progression
            via GSK3-beta/beta-catenin signaling in HCC
  JOURNAL   Int J Biol Sci 18 (10), 4053-4070 (2022)
   PUBMED   35844789
  REMARK    GeneRIF: The TTYH3/MK5 Positive Feedback Loop regulates Tumor
            Progression via GSK3-beta/beta-catenin signaling in HCC.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4805)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 4805)
  AUTHORS   He,Y., Hryciw,D.H., Carroll,M.L., Myers,S.A., Whitbread,A.K.,
            Kumar,S., Poronnik,P. and Hooper,J.D.
  TITLE     The ubiquitin-protein ligase Nedd4-2 differentially interacts with
            and regulates members of the Tweety family of chloride ion channels
  JOURNAL   J Biol Chem 283 (35), 24000-24010 (2008)
   PUBMED   18577513
  REMARK    GeneRIF: Nedd4-2 differentially interacts with and regulates
            TTYH1-3
REFERENCE   8  (bases 1 to 4805)
  AUTHORS   He,Y., Ramsay,A.J., Hunt,M.L., Whitbread,A.K., Myers,S.A. and
            Hooper,J.D.
  TITLE     N-glycosylation analysis of the human Tweety family of putative
            chloride ion channels supports a penta-spanning membrane
            arrangement: impact of N-glycosylation on cellular processing of
            Tweety homologue 2 (TTYH2)
  JOURNAL   Biochem J 412 (1), 45-55 (2008)
   PUBMED   18260827
REFERENCE   9  (bases 1 to 4805)
  AUTHORS   Suzuki,M.
  TITLE     The Drosophila tweety family: molecular candidates for
            large-conductance Ca2+-activated Cl- channels
  JOURNAL   Exp Physiol 91 (1), 141-147 (2006)
   PUBMED   16219661
  REMARK    Review article
REFERENCE   10 (bases 1 to 4805)
  AUTHORS   Suzuki,M. and Mizuno,A.
  TITLE     A novel human Cl(-) channel family related to Drosophila flightless
            locus
  JOURNAL   J Biol Chem 279 (21), 22461-22468 (2004)
   PUBMED   15010458
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL522452.3, AB051478.2,
            AK074158.1, AK124608.1, AF318350.1, BC069027.1 and BC041603.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025250.2.
            
            Summary: This gene encodes a member of the tweety family of
            proteins. Members of this family function as chloride anion
            channels. The encoded protein functions as a calcium(2+)-activated
            large conductance chloride(-) channel. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC152447.1, AB051478.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258796.12/ ENSP00000258796.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL522452.3         18-22
            6-2684              AB051478.2         18-2696
            2685-2685           AK074158.1         2010-2010
            2686-2820           AK124608.1         2146-2280
            2821-2871           AF318350.1         1482-1532
            2872-3184           BC069027.1         32-344
            3185-3409           BC041603.1         275-499
            3410-3832           BC069027.1         570-992
            3833-4502           BC041603.1         923-1592
            4503-4805           BC069027.1         1663-1965
FEATURES             Location/Qualifiers
     source          1..4805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..4805
                     /gene="TTYH3"
                     /note="tweety family member 3"
                     /db_xref="GeneID:80727"
                     /db_xref="HGNC:HGNC:22222"
                     /db_xref="MIM:608919"
     exon            1..293
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1742
                     /gene="TTYH3"
                     /note="hTTY3; tweety homolog 3; volume-regulated anion
                     channel subunit TTYH3"
                     /codon_start=1
                     /product="protein tweety homolog 3"
                     /protein_id="NP_079526.1"
                     /db_xref="CCDS:CCDS34588.1"
                     /db_xref="GeneID:80727"
                     /db_xref="HGNC:HGNC:22222"
                     /db_xref="MIM:608919"
                     /translation="MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQALL
                     LLGAAALACLALDLLFLLFYSFWLCCRRRKSEEHLDADCCCTAWCVIIATLVCSAGIA
                     VGFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAVGLNHTAEPSLQTLERQLAG
                     RPEPLRAVQRLQGLLETLLGYTAAIPFWRNTAVSLEVLAEQVDLYDWYRWLGYLGLLL
                     LDVIICLLVLVGLIRSSKGILVGVCLLGVLALVISWGALGLELAVSVGSSDFCVDPDA
                     YVTKMVEEYSVLSGDILQYYLACSPRAANPFQQKLSGSHKALVEMQDVVAELLRTVPW
                     EQPATKDPLLRVQEVLNGTEVNLQHLTALVDCRSLHLDYVQALTGFCYDGVEGLIYLA
                     LFSFVTALMFSSIVCSVPHTWQQKRGPDEDGEEEAAPGPRQAHDSLYRVHMPSLYSCG
                     SSYGSETSIPAAAHTVSNAPVTEYMSQNANFQNPRCENTPLIGRESPPPSYTSSMRAK
                     YLATSQPRPDSSGSH"
     exon            294..463
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     exon            464..575
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     exon            576..796
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     exon            797..892
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     exon            893..965
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1041
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1097
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1190
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1283
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1420
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1594
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1670
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..4805
                     /gene="TTYH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4787..4792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTYH3"
                     /note="hexamer: AATAAA"
     polyA_site      4805
                     /gene="TTYH3"
                     /note="major polyA site"
ORIGIN      
        1 gcggagccga gcgcagccga gccgggccga gccgggccgg gccgggccca ggagcgcgcg
       61 gatgatgcgg gcggccaggc gggggtcgac gggtccctga agcccgcgcc ccgggccagc
      121 aagggagccc cgcgcaggcc gcgcgcatcc ggaggcggcc gggccccgcc atggccgggg
      181 tcagctacgc ggcgccctgg tgggtgagcc tcctgcaccg gctgccccac ttcgacctga
      241 gctgggaggc cactagcagc cagttccggc ccgaggacac cgactaccag caggccctgc
      301 tgctcctggg ggccgccgcc ctggcctgcc tcgccctgga cctcctcttc ctgctcttct
      361 actccttctg gctgtgctgc cggcggcgca agagcgagga gcacctggac gccgactgct
      421 gctgcacggc ctggtgtgtc atcatcgcca cgctggtgtg cagcgccggc atcgcagtgg
      481 gattctacgg caacggggag accagtgatg gcatccatag ggccacctac tcgctccgcc
      541 acgccaaccg cacggtggcc ggggtccagg accgcgtgtg ggacacggcg gtggggctga
      601 accacacggc ggagcccagc ctgcagaccc tggagcggca gctggccggg cggcccgagc
      661 ccctgcgagc cgtacagagg ctgcagggcc tgctggagac gctgctgggc tacacggccg
      721 ccatcccctt ttggaggaac acggcggtgt cgctggaggt gctggcggag caggtggatc
      781 tctacgactg gtacaggtgg ctgggctacc tgggcctgct gctgctggac gtcatcatct
      841 gcctcctggt gctggttggc ctcatccgca gctccaaggg catcctggtg ggggtctgcc
      901 tgctgggagt cctggccctg gtcatcagct ggggcgcgct gggcttggag ctggctgtgt
      961 ccgtgggctc cagcgacttc tgtgtggacc ctgacgccta cgtgaccaaa atggtggagg
     1021 agtactcggt gctgagtggg gacatcctgc agtactacct ggcctgctcg ccccgcgccg
     1081 ccaacccctt ccagcagaag ctgtcgggca gccacaaggc actggtggag atgcaggatg
     1141 tcgtggctga gcttctgagg accgtcccct gggagcagcc ggccactaag gaccccctcc
     1201 tccgcgtcca ggaggtgctg aatggcacgg aggtgaacct gcagcacctc accgccctgg
     1261 tggactgccg cagcctgcat ctggactacg tgcaagcgct gaccggcttc tgctatgacg
     1321 gcgtggaggg cctcatctac ctggccctct tctccttcgt cacagccctc atgttcagct
     1381 ccatcgtctg cagcgtcccg cacacctggc agcaaaagag aggccctgat gaggacgggg
     1441 aggaggaggc cgctccaggg ccgcggcagg cgcacgacag cctctaccgc gtccacatgc
     1501 ccagcctgta cagctgtggc agcagctacg gcagtgagac cagcatcccg gccgcggccc
     1561 acaccgtcag caacgccccg gtcactgagt acatgagcca gaacgctaat ttccagaacc
     1621 cccgctgtga gaacacccca ctcattgggc gcgagtcccc gccgccctca tacacctcca
     1681 gcatgagagc caaatacctc gccacgagcc agcctcgccc tgactccagc ggcagccact
     1741 agaccgcgcc cggcagccac ccaccccacg tgccaacttc ccctccccgt gccagcactg
     1801 ccgcttccac ctgggccacc caccggaccc tcgcacgccg tgccaggcct gccccagacg
     1861 cgtctgcagg ccgcttgccc tcctgtcccc tccccgcagg ggcacagtgg agacgcaggg
     1921 gctctgggcc cgtaccgcca actcgggtca cacctgaacg ctgctgccag ccgatgcccc
     1981 agccctgcac gccacccact atcccggcac gctccctctg cagatggtcg ccgcacctac
     2041 aagccctggc cgcacccaac ctgtgttgtt gccgcccggc ccttccctcc acagctctcc
     2101 ttcctcccgc ccggcacttc tgtggacccc ttcttagttc acaggcacgg ctggggccgc
     2161 tctgtgctgg cgcctgctgg ccactgaggg acagggacac gtgccacctg ctcatctctg
     2221 ccctgaggtc accccgtggt ccctccacgt gcccatctct ctgcagtgcc ctcctcgcct
     2281 gtgcagcccg cccacccaca ggctcacccc tcctgccggc tgccagaggc cccctccagc
     2341 agggcctctc tccgttgccc cagcttcact ctctccctca gcacctgccc tgctggaggc
     2401 cccagccctc cgtggacagc aggggccacg tggagcccgg gccgctcacc cgccacccag
     2461 tgctggccgc cttcttggtg ccaaaccccc ttcccccacc cagagactgg gcagctgtgt
     2521 ctggttcgtt ctttgcacta accacatttg tcatctctag ggcaggctgg ggctgcgggc
     2581 tgagggggac cgctggcacc ccccttccct cccttcttgg ttccatttcc atccatgaca
     2641 ggtacagcat cccaggagcc cggcctgagg ggctggaccc gagccggctg tgaacatccc
     2701 tcagcccctg ctgtcccccc ttgggactaa ccactaacct cacccccaaa ctccacgggt
     2761 gcccctagct ggcccagagc cggcagtgtg agcccaagtc cgggctggag ccgaggccgg
     2821 agcagctgtc tgggagtcaa ggctgcagta gcgtttcttc atggggtgct ccagggggtg
     2881 ccacagaccg acaggcagcc caagggcctg gacacccctc cccaggcagg tgctgcccca
     2941 ggaggactgt cctcgggaat gaacctcccg cgggctttgg actgaggtcc ctgtggcctc
     3001 ggtctcctcc ccatgaagtg ggagcgaggc tccccaatgg tgcttttggc tttagtgtac
     3061 gatgtttgct gtgcttcccg ccgtggaggg cagagccacc ccacatcagg atcggacgtg
     3121 ctacccctcc cggtcccggc cctggcccag ccagcccagc cctcgaggct cgatgcctgt
     3181 gccaaggcca ggggcagcca gagggcagct ggatggccac gtgcaggggt caaggctggg
     3241 ccctgcagtg gggcgggccg ccagccccag cagtttacag acgcatggct cttcctccca
     3301 gagcagccgg cagctacctg gaccggaaat gtcctcatcc cctccctggg gccaggctct
     3361 gccctggcct tcctctgtga acccctcctt tctttgtgct ggtgtctggg accaaaaagg
     3421 gggaatatgg gagggcagag tggggagggg agtccatggg cctggggccc caagccgggg
     3481 cgtctgagct ccccaggcat gaccaaacct cagtggaggg gcctctgctt caggccccgc
     3541 ctggctgaca ttctgagccc ccctcggagg ccccgccaca gccaacctgc ccagtctttc
     3601 ctctgggctt gacccgccag gggagttctc caggcctagg gccaggagag aggccctggc
     3661 accctggcgt gggtgcccgc caaacgccct gcgaccgctc agaagcacaa atgctgtcca
     3721 tggccgtgag gctgcctgcc aggtgaatgg acatagcgtg agaggcggtg aggccagggc
     3781 ttccagcctc gtgctgtctc gggactcctg accgtggtgt gcgtgtgtgc ccgtctgtga
     3841 ctttctactc accaaggttg aagaaaggaa acggggaaaa tcaaaagggg ttcaaacccc
     3901 acctcagtag gtggagggga gcgcctgcca ttggttgtat ttttgttctg agttttcggt
     3961 gccgtgttcc taactactcc atcccatgac ctcgccacac ctactggggc atctggctgg
     4021 tgcctgctgc catggccagc ccccactctc accctgcaca gggggtcttg cagcccccag
     4081 gcccacagcc tcgttgggag gacagggtgg ccctggggac aagagggagg agcccagggg
     4141 cttacctcac tgagagtgct ccccagcagg catccactac cccagggccc cccacatgtc
     4201 atggcaaggt tggtagtgaa tgggcctggt tgggagcagc ccctggccca ttgcccaccc
     4261 acccatctca ctatgcaatt cgagttccaa gcaacatttg ctcctgccct ggggccagct
     4321 ctgccccagc cctgagaggg gtggtgaggc agccccctgg accccagaac cccagacaag
     4381 ggggcaggcg ggggaccagg gcctctcctg tgggatcttt gttttgtgtt taaccataat
     4441 ggttgtgtac tgaaccactt catatttgtt atatataata tatatatata taatctcctt
     4501 aagactcagc ctcctggttt acccccccgg cctgggcatc tgacctcccc caccccagtg
     4561 tgatttaaca tccaggaact gaggcctgaa ccattttgca tttccccctc ctccagcctc
     4621 tgtagggcca tggctgtatg tactgtcgct gtgttttttt gtttttttag aactgggttt
     4681 gggggctgat ttttatttct ttgggggctt tttttcttgg caaatactaa aaatctcgtc
     4741 aatgtaattt ctgtggtttc tattcagctt gggtttcatg ttttaaaata aattttaaaa
     4801 agcaa
//
