LOCUS       NM_001039199            6224 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens alpha tocopherol transfer protein like (TTPAL),
            transcript variant 2, mRNA.
ACCESSION   NM_001039199
VERSION     NM_001039199.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6224)
  AUTHORS   Arikan Soylemez,E.S.S., Soylemez,Z., Cilekar,M., Arikan,Y.,
            Tokyol,C., Kenger,I.H. and Solak,M.
  TITLE     Investigation of the expression levels of CDH1, FHIT, PTEN, and
            TTPAL genes in colorectal tumors
  JOURNAL   Turk J Med Sci 52 (1), 124-130 (2022)
   PUBMED   36161592
  REMARK    GeneRIF: Investigation of the expression levels of CDH1, FHIT,
            PTEN, and TTPAL genes in colorectal tumors.
REFERENCE   2  (bases 1 to 6224)
  AUTHORS   Liu,W., Gou,H., Wang,X., Li,X., Hu,X., Su,H., Li,S. and Yu,J.
  TITLE     TTPAL promotes gastric tumorigenesis by directly targeting NNMT to
            activate PI3K/AKT signaling
  JOURNAL   Oncogene 40 (49), 6666-6679 (2021)
   PUBMED   34642500
  REMARK    GeneRIF: TTPAL promotes gastric tumorigenesis by directly targeting
            NNMT to activate PI3K/AKT signaling.
REFERENCE   3  (bases 1 to 6224)
  AUTHORS   Gou,H., Liang,J.Q., Zhang,L., Chen,H., Zhang,Y., Li,R., Wang,X.,
            Ji,J., Tong,J.H., To,K.F., Sung,J.J.Y., Chan,F.K.L., Fang,J.Y. and
            Yu,J.
  TITLE     TTPAL Promotes Colorectal Tumorigenesis by Stabilizing TRIP6 to
            Activate Wnt/beta-Catenin Signaling
  JOURNAL   Cancer Res 79 (13), 3332-3346 (2019)
   PUBMED   31018940
  REMARK    GeneRIF: High TTPAL expression is associated with Colorectal
            Tumorigenesis.
REFERENCE   4  (bases 1 to 6224)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 6224)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL132772.14, BP351602.1, AK314045.1 and Z97053.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001039199.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1, and encodes isoform 1. Variants 1 and 2
            encode the same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.260490.1, CR936621.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262605.9/ ENSP00000262605.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL132772.14        76477-76488
            13-179              BP351602.1         3-169
            180-1162            AK314045.1         127-1109
            1163-6224           Z97053.2           6448-11509
FEATURES             Location/Qualifiers
     source          1..6224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..6224
                     /gene="TTPAL"
                     /gene_synonym="C20orf121"
                     /note="alpha tocopherol transfer protein like"
                     /db_xref="GeneID:79183"
                     /db_xref="HGNC:HGNC:16114"
     exon            1..118
                     /gene="TTPAL"
                     /gene_synonym="C20orf121"
                     /inference="alignment:Splign:2.1.0"
     exon            119..578
                     /gene="TTPAL"
                     /gene_synonym="C20orf121"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1162
                     /gene="TTPAL"
                     /gene_synonym="C20orf121"
                     /note="isoform 1 is encoded by transcript variant 2;
                     tocopherol (alpha) transfer protein-like"
                     /codon_start=1
                     /product="alpha-tocopherol transfer protein-like isoform
                     1"
                     /protein_id="NP_001034288.1"
                     /db_xref="CCDS:CCDS13332.2"
                     /db_xref="GeneID:79183"
                     /db_xref="HGNC:HGNC:16114"
                     /translation="MSEESDSLRTSPSVASLSENELPPPPEPPGYVCSLTEDLVTKAR
                     EELQEKPEWRLRDVQALRDMVRKEYPNLSTSLDDAFLLRFLRARKFDYDRALQLLVNY
                     HSCRRSWPEVFNNLKPSALKDVLASGFLTVLPHTDPRGCHVVCIRPDRWIPSNYPITE
                     NIRAIYLTLEKLIQSEETQVNGIVILADYKGVSLSKASHFGPFIAKKVIGILQDGFPI
                     RIKAVHVVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLNSLHTNLPRSILPKEYGG
                     TAGELDTATWNAVLLASEDDFVKEFCQPVPACDSILGQTLLPEGLTSDAQCDDSLRAV
                     KSQLYSCY"
     exon            579..772
                     /gene="TTPAL"
                     /gene_synonym="C20orf121"
                     /inference="alignment:Splign:2.1.0"
     exon            773..883
                     /gene="TTPAL"
                     /gene_synonym="C20orf121"
                     /inference="alignment:Splign:2.1.0"
     exon            884..6224
                     /gene="TTPAL"
                     /gene_synonym="C20orf121"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6202..6207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTPAL"
                     /gene_synonym="C20orf121"
                     /note="hexamer: AATAAA"
     polyA_site      6224
                     /gene="TTPAL"
                     /gene_synonym="C20orf121"
                     /note="major polyA site"
ORIGIN      
        1 gtcacttccg gcgcgagagg ccgggcaggc cgggcaggga gtgcgggtcg gttctgcgtg
       61 cgctgccgga cgaggctccc gccgccgatt gacccgcgct ccgcccgtag tcgggccggg
      121 accttggtag ctaatgtccg aagaaagtga ctctctgaga accagccctt ctgtggcctc
      181 actctctgaa aatgagctgc caccaccacc tgagcctccg ggctatgtgt gctcactgac
      241 agaagacctg gtcaccaaag cccgggaaga gctgcaggaa aagccggaat ggagacttcg
      301 agatgtgcag gcccttcgtg acatggtgcg gaaggagtac cccaacctga gcacatccct
      361 cgacgatgcc ttcctgctgc gcttcctccg agcccgcaag tttgattacg accgggccct
      421 gcagctcctc gtcaactacc acagctgtag aagaagctgg cccgaagtct tcaataactt
      481 gaagccatca gccttaaaag atgtccttgc ttccgggttc ctcaccgtgc tgccccacac
      541 tgaccccagg ggctgccatg tcgtctgcat ccgcccagac agatggatac caagcaacta
      601 tccaattact gaaaacatcc gagccatata cttgacctta gaaaaactca ttcagtctga
      661 agaaacccag gtgaatggaa ttgtaattct tgcagactac aaaggagtga gtttatcaaa
      721 agcatctcac tttggccctt ttatagccaa aaaggtgatt ggcatcctcc aggatggttt
      781 ccccattcgg ataaaagcag tccatgtggt gaatgaacct cgaatattta aaggcatttt
      841 tgccatcata aaaccatttc taaaggagaa aatagcaaac agattcttcc tccatgggtc
      901 tgacttgaac tctctccaca caaaccttcc aagaagcatc ctccccaagg agtatggggg
      961 cacggctggg gagctggaca ctgccacctg gaacgcggta ctgctggctt cagaagacga
     1021 ttttgtgaaa gagttctgcc aacctgttcc tgcctgtgac agcatcctgg gccagacgct
     1081 gctgcccgag ggcctgacct cagatgcaca gtgtgacgac tccttgcgag ctgtgaagtc
     1141 acagctgtac tcctgctact agcccgtccc ccagggtcac catctttaat tcttttcctt
     1201 cttttctttg gagaggcaca aggagaattt aagggtccat ggattcagtc ttgctccttg
     1261 taattaaact gcaggatgga ggaacagcct gagatatgag catgagccca ttttggggta
     1321 agcctttggt tactttaatt actccatgga agacatggaa aatgtcccca ctgattctta
     1381 aacatttgga atcccagtct gcaactatta atctggaggc tatatctatt ttgttttgct
     1441 ttttggttgg ggggtggtga tctggttctt acacatcttg gaagcaagaa caatcaggac
     1501 caaagtcact ttgatcccac ttttccagga gaaaaaccac ctgtttggcc agtgagaact
     1561 acttgtatga aataatttgg ccaaaccttc agtgtgacca aatgtgagac tgggagtttg
     1621 tgtttttcac aggaacccta agtatagacc tctgctgctc atcaggaaac ttactggaga
     1681 tgaaggcccc agctgttgtc accgggtttg gaaagcacct taactgaatc atgtaagcat
     1741 caggacataa gcagcacttt gtggtcaaat gtggaagccg gagacttcaa agcacctctg
     1801 ggacccactg gttgaagttt gcaatagaaa cttaagtttt cccaaatcca taaagcctta
     1861 gccctggttc tcaatagaat cagggaccta gcaggaaatg attttactca acctaaaatg
     1921 ctggatccca ggcccgtgta gctataagaa ttctggcctg gatcccaggt gtacaactat
     1981 ggacaagata tgggcctcta ctttctcctc tataaaatga ggctggatga aatgtcagct
     2041 agggccattt tggctgctga ggctctggga tttggtttag ttactgaatg ttagattttc
     2101 tgcctagaaa gataactatc tagatacaag tggttggatc ctgtttttgt ttgtggtaca
     2161 tgtgtctttc caagagagat gtgtcaccaa ttagccctgc ctttaaagaa actattatgt
     2221 gtattcctgg gactcactga caccaatttt ctttttatag tgatggttca attttgaaaa
     2281 gatggctttt gtgaggccag gttaaggtga ccaggatctt gtatgatgaa ttccttccat
     2341 ccctgagact ctggtactat attgtaaacc tggctacagt agttaattac ttgagattct
     2401 ttaattttgg tctctgagct gggcgtggtg gttcatgcct gtaatcccag cactttggga
     2461 ggccaaggtg tgcggatcac aaggtcagga gttcgagacc cgcctggcca agatggtgaa
     2521 accccatctc tactaaaaat acaaaaatta gctgggcgtg gtggcgggct cctgtagtcc
     2581 cagctactcg ggaggctgag gcagaagaat cacgtgaacc caggaggcag aagtggcagt
     2641 gagccaagat cgcaccactg cactccagcc tgggcgacag agcaagactc tgcctcaaaa
     2701 aaaaaaaaaa aaaaaaaaaa tttttttttt tttggtctct ggaaatgaac acaagggcag
     2761 gttattcctg ggtcacttct gggcccccct gccctcccag ccccacttga gtttctctct
     2821 ctggtgtggg tgaaccagtc agcctgaatg ttctgcattt cagcacttta gaacctccct
     2881 gtgaagattt tagccttagc ccaaacatca aattagacgg ttcacatgat ggtttttgac
     2941 ctatttcctt tctaatgtat tccacatgat catggtgtta aatagtgaaa agtactgtgt
     3001 tgtgtgtgca ccttctccgt gcatttatta gactaaccag tcaagcagac agctcagtta
     3061 gggagaaaac aatactctga aatttgaagg ccaatctgtt gttactaagc tgtttatctc
     3121 tattgccttt ttaaatgtct ggataagttg ttggtggaaa ttaagttact taacctcatt
     3181 aataccaatt ctagagaaag ttcttttcac catggatagt aaccctggat cctctacggt
     3241 actggctgag ctggaagtgc caaaaagcac tcctggctgc ttctggttcc atctgatgat
     3301 gatgtgacac acactgctga aaaggcccaa gcagggcaag tgggatggct gaaggaggga
     3361 aggagggggt tcagaaccca ctggcctgga tgggagaact gggtggaggc ttccccaaga
     3421 gggaagacag ataaacaaaa caaaacaaaa actgggtaaa gaggaatgaa tcactcagcc
     3481 ctgatgtttc aattctacac tgcattcctg gccagtcgca tttgttttaa tgcaggcatg
     3541 gccacagctc tcctagagaa ttatctcaaa gaccagaagg gacctggaga ggcctatttc
     3601 ttaggttttt ccagttggac aaggaaggag tggtttcact cagcttctag aaggagttgg
     3661 agcctaagtt tatctgcctc cgggagctgc ttgctttgtt ttggctccga agaggtatca
     3721 gatagttttg acacctcagg aaacttgaac caagctgtga aaccaagacc tccctgcgtg
     3781 aaaatcaagg tggtctcctt gtggcttcac caggatgttt gtgtcaggct gtctcagcag
     3841 ggtggggaat gaccagccag ggagcacagt gagccttact cagcactggg gagcgcactg
     3901 gtgaggcaaa cccatgaacc tcaagaactg ggagtatgtt ccttcaggga gaagttctgg
     3961 cccattgcac aaacacttgg aaattaactt ttccctaaat tcaagatagt gtggtgtcgg
     4021 aaggaaatgg gacagtaaat taggagacgc gggctccacc tttaccttac tacgtggcct
     4081 ttgatgagct ggcttaacat ccctgagtga ttccatgata gagatctata ctccaaactt
     4141 tattcctggt atctagttgg cttcactgcc acagacactg tactctctct ttttagaagt
     4201 ttttttcctt ttttttcccc ctcaattggc ttatttagta aatttaggtc tgaatgaatt
     4261 ggtacctaaa agcttccaaa tctatacatt tcagaatatg ggaattttct tcctcttctt
     4321 cccccatatc ccaacatgga attctggaaa actgtgcctc ttcccctgtt ctgccttcat
     4381 gggggagaga ctggatgaaa tctacaaaaa cagccaaaag tgccaccctg gcttcatgtc
     4441 ttgaatttct aacttgctct tggcaaaggt cgctttattt tttaattttt ttccttgcat
     4501 tttctttttt attctattgc tgctgcaaaa attaaggcaa aagtagcttt cgatctttca
     4561 tatttcatcc tggtttcaca aggagtcact tatcttagga ggtctgtaag tcaggttaca
     4621 aggccgggag cggtggctca cacctgtaat cccaacactt tgagcggctg aggtgggtgt
     4681 atcacctgaa gtccggagtt tgagaccagc ctggccaaca tggtgaaacc ccgtctctac
     4741 taaaaataca aaaaattggc tgggcatggt ggtgggtgcc tgtaatccca gctacttggg
     4801 aagctgaagc aggagaatca cttaaaccca ggtggcggag gttgcagtga gccgacatcg
     4861 cgccattgca ctccagcctg ggtgacgagt gaaactccat ctcaaaaata aaaattgaaa
     4921 aatcaggtta caaaacacca tttttcccga aataagacaa taagaggctt ttctctgaat
     4981 tcctttatat tgagcctttc agaattctcc ctgggtgggc aatttcttta aatagtattt
     5041 gaccctcaga tcaatcctgg gaattttttt catttgggta gcaaaagcta gagtattgct
     5101 gtggcgatta taatactttt aaaaagtttt accattttaa agttgccaac atttaattaa
     5161 ggttttcctt tgaagcctcc tttaatttag ggagtaaaat gttagctaaa ccaattatat
     5221 actatatact atacactgta tctcctgtgg ccatgagagg tgtggctata ccgaacagaa
     5281 acatgcctac tgttcaggaa agatgtcagt tctggtaaca cctctctgta ttgggatctg
     5341 ttaattttgt aaatctaaat tcttctgctc ttggccaggt gcagtagttc atgccctgta
     5401 atcctagaac tttgggaggc tgaagggggg gcggatcatt tgaggtcagg agtttgagac
     5461 cagcctggcc aacatggtga aaccccatct ctactaaaaa gtacaaaaat tagctgggtg
     5521 tggtggtgcg tgcctgtaat cccaactact tgggaggctg aggcaggaga atcgcttgaa
     5581 cctgggaggc agcggttgca gtaagccaag actatgccac tgcactcccg cctgggtgac
     5641 aaagcaatat tctgtgtcaa ataaataaat tcattcttct gctctcctga cttagagaaa
     5701 tggtttgctt aaaatgctag taacaaacat cacagtcaac aggagcttgc ttcatgcgaa
     5761 ggatcaatgt gatttgtgga tggagatgat agtgatgaaa ttcctgtttc atggggctgt
     5821 ttttcttttc atctcactgg gcagcaggtt tagtgaggca gtgagatgct gctgctgtgg
     5881 attcttgtag ctatgcctcg gcttcttggc atatcaggta ggaacctgtt acaagtgaaa
     5941 tacttgaaac ctctctgacc aagagcctct gatggagtgg gaggtgagct aattctctga
     6001 ccagcttggg gcactgtttc agccactggt cacattcctt gcttcaaact gaaattcagt
     6061 ttggctttga gtatagggat acatggtgga ttcatgtact tcagtgtttg ttttgaccaa
     6121 agtttatttt tctagtgcat tttctaagtc aaagtggtga aaatatgtaa taattttagt
     6181 atgcatgact cagtctgaaa caataaaaat ctctgaaaaa tgtg
//
