LOCUS       NM_001008409            3620 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens tubulin tyrosine ligase like 9 (TTLL9), transcript
            variant 1, mRNA.
ACCESSION   NM_001008409 XM_092778
VERSION     NM_001008409.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3620)
  AUTHORS   Kubo,T., Yanagisawa,H.A., Liu,Z., Shibuya,R., Hirono,M. and
            Kamiya,R.
  TITLE     A conserved flagella-associated protein in Chlamydomonas, FAP234,
            is essential for axonemal localization of tubulin polyglutamylase
            TTLL9
  JOURNAL   Mol Biol Cell 25 (1), 107-117 (2014)
   PUBMED   24196831
REFERENCE   2  (bases 1 to 3620)
  AUTHORS   Janke,C., Rogowski,K., Wloga,D., Regnard,C., Kajava,A.V.,
            Strub,J.M., Temurak,N., van Dijk,J., Boucher,D., van Dorsselaer,A.,
            Suryavanshi,S., Gaertig,J. and Edde,B.
  TITLE     Tubulin polyglutamylase enzymes are members of the TTL domain
            protein family
  JOURNAL   Science 308 (5729), 1758-1762 (2005)
   PUBMED   15890843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL160175.5, DC311815.1, AK093491.1, BC036213.1 and AL031658.11.
            
            On Aug 13, 2020 this sequence version replaced NM_001008409.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2148874,
                              SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000535842.6/ ENSP00000442515.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL160175.5         165420-165422
            4-68                DC311815.1         1-65
            69-1675             AK093491.1         2-1608
            1676-2523           BC036213.1         1126-1973
            2524-2524           AL031658.11        56250-56250
            2525-2919           BC036213.1         1975-2369
            2920-2920           AL031658.11        56646-56646
            2921-3579           BC036213.1         2371-3029
            3580-3620           AL031658.11        57306-57346
FEATURES             Location/Qualifiers
     source          1..3620
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..3620
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /note="tubulin tyrosine ligase like 9"
                     /db_xref="GeneID:164395"
                     /db_xref="HGNC:HGNC:16118"
                     /db_xref="MIM:619838"
     exon            1..316
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     exon            317..390
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1641
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable tubulin polyglutamylase TTLL9; tubulin--tyrosine
                     ligase-like protein 9; tubulin tyrosine ligase-like
                     family, member 9"
                     /codon_start=1
                     /product="probable tubulin polyglutamylase TTLL9 isoform
                     1"
                     /protein_id="NP_001008409.1"
                     /db_xref="CCDS:CCDS42863.1"
                     /db_xref="GeneID:164395"
                     /db_xref="HGNC:HGNC:16118"
                     /db_xref="MIM:619838"
                     /translation="MVPSREALLGPGTTAIRCPKKLQNQNYKGHGLSKGKEREQRASI
                     RFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFR
                     NHYELTRKNYMVKNLKRFRKQLEREAGKLEAAKCDFFPKTFEMPCEYHLFVEEFRKNP
                     GITWIMKPVARSQGKGIFLFRRLKDIVDWRKDTRSSDDQKDDIPVENYVAQRYIENPY
                     LIGGRKFDLRVYVLVMSVFAECLLWSGHRRQDVHLTNVAVQKTSPDYHPKKGCKWTLQ
                     RFRQYLASKHGPEAVETLFRDIDNIFVKSLQSVQKVIISDKHCFELYGYDILIDQDLK
                     PWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGREKRVGGFDLMWNDGP
                     VSREEGAPDLSGMGNFVTNTHLGCVNDRKKQLRQLFCSLQVQKKASS"
     exon            391..434
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     exon            435..527
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     exon            528..639
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     exon            640..825
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     exon            826..894
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     exon            895..985
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1026
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1069
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1128
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1325
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1439
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1564
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..3620
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3559..3564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /note="hexamer: AATAAA"
     polyA_site      3579
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /note="major polyA site"
     polyA_site      3620
                     /gene="TTLL9"
                     /gene_synonym="C20orf125"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgccgg gcccacggcc cgcgggacaa cggcagtttg ttggggccgc gtggggccgc
       61 cacctccgga ggtgggggcg ggggccttac cccaccctgg caccggcagg cgcgggcgga
      121 tggggggatg tcgcctagag ccccccggcc ggcccacaaa ctcccgtccc ccttccggct
      181 ctgcctggac gtccctgcgg gccccggggg aaagcaccca acttctcccg cctcggcttc
      241 tagcagaaac gtgacggggc tggactttga tcgccgaggg ctctctgctc ttcagagtct
      301 gcttggaacg ggataagagg gatggtgcca tccagggaag ctctgctggg accaggcaca
      361 actgccatta ggtgccccaa gaaattacag aaccaaaatt acaagggcca tggattgtca
      421 aagggaaaag agcgagagca gagagcatcg atccggttca agaccaccct catgaacaca
      481 ctcatggacg tccttcgcca caggccagga tgggtggaag tgaaggacga aggggagtgg
      541 gatttctact ggtgtgacgt cagctggctc cgggagaact tcgaccacac ctacatggat
      601 gaacatgtgc ggatcagtca cttccggaac cactatgagc tgacccggaa gaactacatg
      661 gtgaagaacc tgaagcggtt ccggaagcag ctggagcgtg aggcaggaaa gctggaggca
      721 gccaagtgtg acttcttccc caaaaccttt gagatgcctt gcgagtacca cctgtttgta
      781 gaggagtttc gcaaaaaccc aggaatcacc tggatcatga agcctgtagc ccggtctcaa
      841 gggaaaggca tcttcctctt ccgtaggctg aaggacatcg tggactggag gaaggacaca
      901 agaagctctg acgaccagaa agatgatatt cccgtggaga actatgtggc tcagcgttac
      961 attgaaaatc cttacctgat aggaggccgc aagtttgacc tgcgtgtcta tgtgctggtg
     1021 atgtcggtgt ttgctgaatg cctgctgtgg tctgggcaca ggagacagga tgttcacctc
     1081 accaacgtgg ctgtgcaaaa aacatctccc gactaccacc caaagaaggg ctgcaagtgg
     1141 acgctgcagc gcttccggca gtacctggcg tccaaacacg ggcccgaggc agtggagaca
     1201 ctcttcaggg acatcgacaa catctttgtc aaaagcctgc agagtgtgca gaaggtgatc
     1261 atcagtgaca agcactgctt cgagctgtac ggctatgaca tcctcatcga ccaggacctc
     1321 aagccgtggc tcctggaggt caatgcgtcc ccatcactga cagccagcag ccaggaagac
     1381 tatgagctca agacctgcct cctggaagac accctgcatg ttgtggacat ggaagcgagg
     1441 ctcacgggaa gggagaagcg agtcgggggc tttgacctca tgtggaatga tggccctgtt
     1501 agcagagagg agggggctcc tgacctgtcg ggaatgggaa actttgtgac caacacacat
     1561 ctcggctgcg tcaacgatcg gaagaaacaa ctgaggcagc tcttctgctc ccttcaagtt
     1621 cagaagaaag cttccagttg atccccagct gccaggagga aatcagcctt agcaggtgcc
     1681 acccaggcct cccccccact cccagatccc agcacagcac ctcacagcat tcgcctcccc
     1741 acctccagcc tggcaccagc tttgctggct tagcagctgc agcttactac ctgaattggg
     1801 ccccttggat acctccagcc catccccagg catctttgca ccaggagaca gccaatcact
     1861 gggactgggg gaggtttaac cttgacaaac tgacttggca gttaggccca aagagaacaa
     1921 atacagcaag ttctgctacc cccaggagat catatctaat aaatgagcac aggccctact
     1981 tggagtcact gggcaccagg cctggttccg gggatactgt tggctgcagc caagtcctcc
     2041 tggctttgac acttggatac ctcccaagtc agtgctgaaa aggtccttca ggagcaagag
     2101 tttggaggct aaggaactcg tctttaagct gtgcttacac agcaagcagt tattagattg
     2161 tgtgtttatt gggggcctgg ggaagtactg agccctaaac acatcctctt ctccttgcat
     2221 gtcaggggag cccatggggc tccctgacca tcatctgaaa accagtggga cagggcatcc
     2281 ccatttctca gatggacaag acagaccagg gaggcagagc ttagtgaggg tctctgcaaa
     2341 ggtgcattta tctaagtcag atgggtgact taagtgcttc tctaggcctt gtgtttgaga
     2401 ttgggagctg agccagaaac cggaaaaccc tgggctcatg ggcaggacag cttcgggagt
     2461 tgagtgtgag taaaaatctg ccttttcaca tcttacattg ctaagcttcc tcttggttta
     2521 agaggggttg caacaagact cggggctgtt ggggtaactg ttccaggggg gacttactcc
     2581 ctctaccact ccgcctgctt cagagtagtt tctctggctg caaatggttg aatctgcctg
     2641 cctaggtcaa gcccgaaggg aagacttttg gaaggaaaat actggcaaat ccaagaagtg
     2701 aaccagccga ctttaggaaa gccagaagcc aggctactct agaccttctg ccttcagagc
     2761 atgaggactt ctcccactca tccctgtacc tgaggcacac caacccagac aggtccaggc
     2821 atggactcca ggttccctat ttccagaagg aatgcgatta gctttttttg gcccagcacc
     2881 caccctgcca gggaggaagg ggcaattttc cagtgatgaa attgtgaatc aggcagtcac
     2941 actggacaac atctagcaag gtgaattctg caactcccta ctttatttac attttaaaat
     3001 aagcaatata ttcatacggt ttaaaatcca aagtttacaa aagggtatag ggtgacatct
     3061 ccttccctcc cacctgtgcg ccccaaccct gcaggtgctg ttctgaggga atcacactgt
     3121 gcttgcacaa aaattattag cttataagac accagccttc cccttgcttt cctcacttga
     3181 tgtatcttgg agcttgttcc ttattcttga ttatagttgt atggtattgc actatctgga
     3241 gctaacacct gtgacccaca ctcatgtttt aaaagtttct gcattagtca aaaatattta
     3301 aaaggagatt caacttcaca acccatatgt ctagcttctc ttgaaaacac gtaagaactg
     3361 gccatgacag cctgtgtttc tatgtaacta tgagccagag ccaaggagcg gggggaccag
     3421 gagaggtgtg cccctgccat gctgccattt gttatcaccc gcctgtcaaa tcacaggttt
     3481 atttcaaggc aagaaccatg ttcataggtt gtattctaaa tggagtggcg tgcccttact
     3541 gaaggactag atgaggcaaa taaagactag ttgctgctat tcattcattc agctaacatt
     3601 tattgagccc ttaatgaaca
//
