LOCUS       NM_001350317            2651 bp    mRNA    linear   PRI 18-FEB-2024
DEFINITION  Homo sapiens tubulin tyrosine ligase like 8 (TTLL8), mRNA.
ACCESSION   NM_001350317 XM_017029176
VERSION     NM_001350317.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2651)
  AUTHORS   Janke,C., Rogowski,K., Wloga,D., Regnard,C., Kajava,A.V.,
            Strub,J.M., Temurak,N., van Dijk,J., Boucher,D., van Dorsselaer,A.,
            Suryavanshi,S., Gaertig,J. and Edde,B.
  TITLE     Tubulin polyglutamylase enzymes are members of the TTL domain
            protein family
  JOURNAL   Science 308 (5729), 1758-1762 (2005)
   PUBMED   15890843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL022327.17.
            
            On Apr 19, 2022 this sequence version replaced NM_001350317.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000433387.2/ ENSP00000392252.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AL022327.17        70863-71007         c
            146-250             AL022327.17        69578-69682         c
            251-342             AL022327.17        67943-68034         c
            343-481             AL022327.17        62818-62956         c
            482-555             AL022327.17        61958-62031         c
            556-684             AL022327.17        59877-60005         c
            685-799             AL022327.17        58565-58679         c
            800-934             AL022327.17        57964-58098         c
            935-1121            AL022327.17        54330-54516         c
            1122-1270           AL022327.17        47066-47214         c
            1271-1514           AL022327.17        45911-46154         c
            1515-1938           AL022327.17        44395-44818         c
            1939-2434           AL022327.17        43139-43634         c
            2435-2651           AL022327.17        31284-31500         c
FEATURES             Location/Qualifiers
     source          1..2651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..2651
                     /gene="TTLL8"
                     /note="tubulin tyrosine ligase like 8"
                     /db_xref="GeneID:164714"
                     /db_xref="HGNC:HGNC:34000"
                     /db_xref="MIM:619193"
     exon            1..145
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
     exon            146..250
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2442
                     /gene="TTLL8"
                     /note="tubulin--tyrosine ligase-like protein 8; tubulin
                     tyrosine ligase-like family, member 8"
                     /codon_start=1
                     /product="protein monoglycylase TTLL8"
                     /protein_id="NP_001337246.1"
                     /db_xref="CCDS:CCDS93183.1"
                     /db_xref="GeneID:164714"
                     /db_xref="HGNC:HGNC:34000"
                     /db_xref="MIM:619193"
                     /translation="MEPERKGLSLASSSDGDGREENKLKQGISQDLASSSRLDRYKIA
                     RQLTEKAIKEKKIFSIYGHYPVVRAALRRKGWVEKKFHFLPKVIPDVEDEGARVNDDT
                     CAKVKENQEMALEKTDNIHDVMSRLVKNEMPYLLWTIKRDIIDYHSLTYDQMLNHYAK
                     TASFTTKIGLCVNMRSLPWYVPANPDSFFPRCYSLCTESEQQEFLEDFRRTMASSILK
                     WVVSHQSCSRSSRSKPRDQREEAGSSDLSSRQDAENAEAKLRGLPGQLVDIACKVCQA
                     YLGQLEHEDIDTSADAVEDLTEAEWEDLTQQYYSLVHGDAFISNSRNYFSQCQALLNR
                     ITSVNPQTDIDGLRNIWIIKPAAKSRGRDIVCMDRVEEILELAAADHPLSRDNKWVVQ
                     KYIETPLLICDTKFDIRQWFLVTDWNPLTIWFYKESYLRFSTQRFSLDKLDSAIHLCN
                     NAVQKYLKNDVGRSPLLPAHNMWTSTRFQEYLQRQGRGAVWGSVIYPSMKKAIAHAMK
                     VAQDHVEPRKNSFELYGADFVLGRDFRPWLIEINSSPTMHPSTPVTAQLCAQVQEDTI
                     KVAVDRSCDIGNFELLWRQPVVEPPPFSGSDLCVAGVSVRRARRQVLPVCNLKASASL
                     LDAQPLKARGPSAMPDPAQGPPSPALQRDLGLKEEKGLPLALLAPLRGAAESGGAAQP
                     TRTKAAGKVELPACPCRHVDSQAPNTGVPVAQPAKSWDPNQLNAHPLEPVLRGLKTAE
                     GALRPPPGGKGS"
     exon            251..342
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
     exon            343..481
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
     exon            482..555
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
     exon            556..684
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
     exon            685..799
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
     exon            800..934
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1121
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1270
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1514
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1938
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2434
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2651
                     /gene="TTLL8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgccgcc gctgcacagc ccgaggccac gggcccagca gccgccgcac cgggggtgca
       61 caatgcgcgt ggccgcccca gcacgttgtc ccaggcaacc ccaggaagcc gggcggcgca
      121 gcgcgagcca ctgacccggt ccccggggtc agaggagcaa agggcaagct gtcggaggcc
      181 agtatggaac cagagaggaa ggggctatcg ttggcttctt cttcagatgg agacgggaga
      241 gaagaaaata aattaaaaca aggaatttcc caagacttgg cttcttcctc cagattagac
      301 agatacaaaa tagcaaggca gttaacagaa aaagcaatca aggagaagaa gattttctct
      361 atctacggac actacccggt ggtccgggcc gctctgcgaa ggaagggctg ggtagagaag
      421 aagttccact ttttgcccaa ggtcattccg gatgtcgagg atgaaggcgc ccgggtcaat
      481 gatgatacat gtgccaaagt caaagaaaat caagaaatgg ctttggagaa aacagacaac
      541 atccacgacg tgatgtctag gttggtaaaa aatgagatgc cgtacctcct ctggaccatc
      601 aagagggaca tcattgacta tcacagcctg acctacgacc agatgctgaa ccactacgca
      661 aagacagcct ccttcaccac caagatcggg ctgtgcgtga acatgcggag cctgccctgg
      721 tacgtcccgg ccaaccccga ctccttcttc ccacgctgct acagcctctg caccgagagt
      781 gagcagcagg agttcctgga agacttccgg cgcaccatgg catccagcat cctcaagtgg
      841 gtggtcagcc accagagctg cagcaggagc agcagaagca agcccaggga ccagagggag
      901 gaggccggga gcagcgacct gagcagcagg caagatgctg aaaatgctga ggcaaagctc
      961 aggggcctcc cggggcagct tgtggacatc gcgtgcaagg tgtgccaggc ctacctgggg
     1021 cagctggagc atgaggacat cgacacgtca gcagatgccg tggaggacct cactgaggcc
     1081 gagtgggagg acctgaccca gcagtactac tccctcgttc atggcgatgc tttcatctcc
     1141 aattcaagaa attacttttc gcagtgccag gctctgctga atagaatcac gtctgtgaac
     1201 cctcagacgg acattgacgg gctccggaac atctggatta taaagcccgc ggccaagtcc
     1261 cggggccgag acatagtgtg catggaccgt gtggaggaga tcctggagct ggcagctgca
     1321 gaccaccctc tttccaggga caacaagtgg gtggtccaga agtacatcga gacgccgctg
     1381 ctcatctgtg acaccaagtt cgacatcaga cagtggttcc tcgtcacgga ctggaacccc
     1441 ctgaccatct ggttctacaa ggagagttac ttgcggttct caactcagcg cttctccctg
     1501 gacaagctgg acagcgccat ccacctgtgc aacaacgccg tccagaagta cctgaagaat
     1561 gatgtgggcc gcagccccct gctgcccgca cacaacatgt ggaccagcac caggttccag
     1621 gagtacctgc agcgccaggg ccgtggcgcc gtgtggggca gcgtcatcta cccgtccatg
     1681 aagaaggcca tcgcccacgc catgaaggtg gcccaggacc acgtggagcc tcgcaagaac
     1741 agctttgagc tctacggggc tgacttcgtc cttgggaggg acttcaggcc ctggctgatc
     1801 gagatcaatt ccagccccac catgcacccg tccacgccgg tcacggccca gctgtgtgca
     1861 caggtgcagg aggacaccat caaggtggcc gtggaccgca gctgtgacat cggcaacttc
     1921 gagctcctgt ggaggcagcc ggtggttgag ccgcccccat tcagcgggtc cgacctctgc
     1981 gtggcgggcg tcagtgtgag gagagccagg aggcaggtgc tgcccgtctg caacctcaag
     2041 gcctcggcct cgctgttgga cgcgcagccg ctgaaggcac ggggcccctc ggccatgcca
     2101 gaccctgccc agggaccccc atcaccagct ctccagcggg acttgggact gaaggaagag
     2161 aaggggctcc ccctggcctt gctggcaccc ttaagggggg cagccgagag cggtggagcc
     2221 gcacagccca cccgcaccaa agctgctggg aaggtggagc tcccggcctg cccctgtcgc
     2281 cacgtggaca gtcaggcccc aaacaccggt gtccccgtag cccagcccgc caaaagctgg
     2341 gatccaaacc agctaaatgc gcacccgctg gagcctgtgc tgcggggcct gaagacagca
     2401 gagggcgcgc tgcgtccgcc gcccggagga aaaggttcat gacagcgtca gattctctgc
     2461 agcaggagta caggttgcag ccactctccc gccgaacatt gaatacgtct ttccaccatc
     2521 ttgtctttgc tgtggctctg ggaaaatcag cagagtcagc catcactctc caaggggagc
     2581 tgtcagttct atctgccagc ttttgagtgt tcagtttgat ttttacttat tcaacctgga
     2641 atttgaatgt c
//
